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Wyszukujesz frazę "insect peptide" wg kryterium: Temat

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    Wyświetlanie 1-7 z 7
    Tytuł:
    Biological evaluation of analogues of an insect neuropeptide proctolin.
    Autorzy:
    Woźnica, Iwona
    Szeszel-Fedorowicz, Wioletta
    Rosiński, Grzegorz
    Konopińska, Danuta
    Powiązania:
    https://bibliotekanauki.pl/articles/1043325.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    proctolin analogues
    proctolin
    insect myotropic peptide proctolin
    Opis:
    Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 1; 115-119
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The search for new biological activities for selected insect peptides
    Autorzy:
    Kuczer, M.
    Dziubasik, K.
    Luczak, M.
    Majewska, A.
    Kamysz, W.
    Saniewska, A.
    Konopinska, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/55140.pdf
    Data publikacji:
    2008
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    antitumour peptide
    antifungal activity
    antiviral peptide
    oostatic peptide
    antiviral activity
    Phoma narcissi
    Botrytis tulipae
    colony growth
    biological property
    antimicrobial activity
    insect peptide
    biological activity
    insect
    peptide
    Opis:
    New biological properties of selected insect peptides are presented. The subjects of the investigation included insect oostatic peptides, like Neb-colloostatin (I) and Neb-TMOF(II), and/or insect peptides with antiviral or antitumor activity, such as alloferon (III) and its analogues modified at position 1 of the peptide chain. In the study was also included the oligopeptide Any-GS (VII) and its truncated analogues. The peptides were tested for antimicrobial activity on a series of bacterial species, antiviral activity against Human Herpes Virus type 1 (HHV-1) in vitro using a Vero cell line, and the growth and development of plant pathogens Phoma narcissi and Botrytis tulipae. The results of the biological investigations indicate that among the peptides investigated, compounds VII and IX inhibit the growth of plant pathogens P. narcissi and B. tulipae, whereas compounds I and II stimulate the mycelium growth of the aforementioned pathogens. Other peptides show slow antimicrobial activity but do not inhibit the replication of HHV-1 in Vero cells.
    Źródło:
    Pestycydy; 2008, 1-2; 5-11
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antibacterial peptides of the moth Galleria mellonella
    Autorzy:
    Mak, Paweł
    Chmiel, Dorota
    Gacek, Grzegorz
    Powiązania:
    https://bibliotekanauki.pl/articles/1044082.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    antibacterial peptide
    bacteriocin
    insect immunity
    hemolymph
    cecropin
    Opis:
    The work describes purification and biochemical characterization of two inducible antimicrobial peptides from the hemolymph of Galleria mellonella. The peptides were isolated by a sequence of reversed-phase chromatography steps from the hemolymph of larvae immunized with viable bacteria. The first peptide is a member of the cecropin family while the second one is rich in proline residues and has a unique sequence.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 4; 1191-1195
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antinociceptive effect of MAS MT in rats
    Autorzy:
    Rykaczewska-Czerwinska, M.
    Radosz, A.
    Szymanowska-Dziubasik, K.
    Konopinska, D.
    Plech, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/55342.pdf
    Data publikacji:
    2008
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    Tenebrio molitor
    antinociceptive effect
    rat
    larva
    brain
    neuropeptide
    insect neuropeptide
    Manduca sexta
    proctolin
    myotropin
    biological activity
    peptide chain
    peptide
    Opis:
    MAS MT is a myotropic decapeptide isolated from Manduca sexta. This peptide exerts stimulatory effect on insects heart-beat frequency. The present study was undertaken in order to determine a probable antinociceptive effect in rats of native synthetic decapeptide, MAS MT-I and its two analogs, heptapeptides MAS MT-II and MAS MT-III. All these peptides were applied directly into the lateral brain ventricle (icv) at three doses: 10, 25 and 50 nmol. The analgesic (antinociceptive) effect was evaluated by a tail immersion test. It was found that two doses of MAS MT-I: 25 and 50 nmol induced significant antinociceptive effect, while MAS MT-II and MAS MT-III exert a less antinociceptive effect in comparison with native MAS MT-I. Prior icv administration of naloxone, an opioid antagonist weakly blocked MAS MT-I effect. We conclude that antinociceptive effect of MAS MT-I in rats is not mediated by central opioid system.
    Źródło:
    Pestycydy; 2008, 3-4; 139-146
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stereochemistry of insect kinin tetrazole analogues and their diuretic activity in crickets.
    Autorzy:
    Nachman, Ronald
    Coast, Geoffrey
    Kaczmarek, Krzysztof
    Williams, Howard
    Zabrocki, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1043327.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    constrained insect kinin analogue
    tetrazole
    diuresis
    cis-peptide bond
    β-turn mimetic
    Opis:
    Insect kinin analogues of the sequence Phe-Phe-ψ[CN4]-Ala-Trp-Gly-NH2 containing (L-Phe2,L-Ala3) and (L-Phe2,D-Ala3) stereochemical variants of the tetrazole moiety, a mimic of the type VI β-turn, demonstrate significant agonist and partial antagonist activity, respectively, in a cricket diuretic bioassay. A comparison of the solution conformations of these two stereochemical variants indicates a structural basis for their divergent bioactivities. The (D-Phe2,D-Ala3) stereochemical variant was synthesized and found to demonstrate significant agonist activity. The results further define stereochemical requirements for the diuretic activity of insect kinins in crickets and provide valuable information for the design of biostable analogues capable of disrupting digestive and diuretic processes in pest insects.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 1; 121-127
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of arginine substitutions on the cardioinhibitory activity of the Led-NPF-I neuropeptide
    Autorzy:
    Marciniak, P.
    Slocinska, M.
    Bednarz, P.
    Grodecki, S.
    Konopinska, D.
    Rosinski, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/55015.pdf
    Data publikacji:
    2009
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    cardioinhibitory activity
    arginine substitution
    mealworm beetle
    Zophobas atratus
    giant mealworm beetle
    Led-NPF-I-peptide
    insect
    beetle
    neuropeptide
    Opis:
    Effects of structural changes on the cardioinhibitory activity of the Led-NPF-I peptide (Ala-Arg-Gly-Pro-Gln-Leu-Arg-Leu-Arg-Phe-amide) were examined by replacing Arg residues in positions 2, 7 and 9. Replacement of L-Arg2 with another basic amino acid, such as Lys, His or D-Arg, did not abolish but rather promoted cardioinhibitory activity in giant mealworm beetle Zophobas atratus Fab. Agonistic peptides were also obtained by substitution of Arg residue in position 7 with Lys or D-Arg, and Arg in position 9 with His or D-Arg, respectively. All these analogues showed stronger cardioinhibitory effects than the native peptide at low concentration (10-9 M), and [Lys7]-, [D-Arg7]- and [D-Arg9]-Led-NPF-I also at the higher concentration (10-6 M). However, substitutions of the Arg residues in position 7 with His or in position 9 with Lys caused a loss of the cardioinhibitory activity. In addition, the replacement of Arg residues in all three positions with Lys or Orn caused a reduction of cardioinhibitory activity, although a single substitution of Arg in positions 2 or 7 with Lys yielded agonistic peptides. We conclude that the Arg2 position in the N-terminal region is more tolerant to structural modification than the other two Arg positions located in the C-terminal region.
    Źródło:
    Pestycydy; 2009, 1-4; 71-78
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    trans-Pro isosteres in the development of non-selective and selective mimetic agonists of insect pyrokinin neuropeptides: A review
    Autorzy:
    Nachman, R.J.
    Powiązania:
    https://bibliotekanauki.pl/articles/55206.pdf
    Data publikacji:
    2009
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    diapause hormone
    physiological process
    melanization
    pupariation
    pheromonotropin
    neuropeptide
    pyrokinin family
    pheromone
    diapause break
    pheromone biosynthesis activating neuropeptide
    insect
    reddish colouration hormone
    peptide
    Opis:
    The pyrokinin (PK) family plays a multifunctional role in an array of important physiological processes in a variety of insects. A PK active core analog containing an (E)-alkene, transPro isosteric component was evaluated in five disparate PK bioassays and/or in a recombinant PK receptor cell line, representing six different insect species. The assays included pheromone biosynthesis in the moth Heliothis peltigera, melanization in the larval Spodoptera littoralis, pupariation acceleration in the larval fly Neobellieria bullata, diapause termination in the moth Heliothis zea, and hindgut contraction in the cockroach Leucophaea maderae. This constrained analog demonstrated unselective agonist activity that approached, matched, or exceeded the activity of parent PK peptides of equal length in all six PK assays. The results provide strong evidence for the orientation of Pro and the core conformation adopted by PK neuropeptides during interaction with disparate PK receptors. A PK active core analog incorporating a second transPro motif, the dihydroimidazoline moiety, was found to demonstrate pure, selective agonism in the melanotropic bioassay, with no significant activity in three other PK bioassays. Both types of transPro isosteric analogs feature modification adjacent to the primary tissue-bound peptidase hydrolysis site that is expected to enhance biostability over natural PK peptides. The research further identifies two novel scaffolds with which to design either selective or non-selective mimetic PK analogs as potential leads in the development of environmentally favorable pest management agents capable of disrupting PK-regulated systems.
    Źródło:
    Pestycydy; 2009, 1-4; 33-39
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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