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    Wyświetlanie 1-8 z 8
    Tytuł:
    Antinociceptive effect of MAS MT in rats
    Autorzy:
    Rykaczewska-Czerwinska, M.
    Radosz, A.
    Szymanowska-Dziubasik, K.
    Konopinska, D.
    Plech, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/55342.pdf
    Data publikacji:
    2008
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    Tenebrio molitor
    antinociceptive effect
    rat
    larva
    brain
    neuropeptide
    insect neuropeptide
    Manduca sexta
    proctolin
    myotropin
    biological activity
    peptide chain
    peptide
    Opis:
    MAS MT is a myotropic decapeptide isolated from Manduca sexta. This peptide exerts stimulatory effect on insects heart-beat frequency. The present study was undertaken in order to determine a probable antinociceptive effect in rats of native synthetic decapeptide, MAS MT-I and its two analogs, heptapeptides MAS MT-II and MAS MT-III. All these peptides were applied directly into the lateral brain ventricle (icv) at three doses: 10, 25 and 50 nmol. The analgesic (antinociceptive) effect was evaluated by a tail immersion test. It was found that two doses of MAS MT-I: 25 and 50 nmol induced significant antinociceptive effect, while MAS MT-II and MAS MT-III exert a less antinociceptive effect in comparison with native MAS MT-I. Prior icv administration of naloxone, an opioid antagonist weakly blocked MAS MT-I effect. We conclude that antinociceptive effect of MAS MT-I in rats is not mediated by central opioid system.
    Źródło:
    Pestycydy; 2008, 3-4; 139-146
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of haloperidol [HAL] on leucopyrokinin [LPK]-induced biphasic hyper- and hypothermic effect in rats
    Autorzy:
    Rykaczewska-Czerwinska, M.
    Konopinska, D.
    Plech, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/55086.pdf
    Data publikacji:
    2008
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    haloperidol
    rectal temperature
    insect
    hyperthermia effect
    rat
    leucopyrokinin
    neuropeptide
    hypothermia effect
    Opis:
    The aim of present study was to evaluate mechanisms involved in thermomodulatory effect LPK in rats.Experiments were performed on adult Wistar male rats. LPK was applied either intracerebroventricularly (icv), or intraperitoneally (ip) using the similar program and technique of experiments as in our previous study. We confirmed in this paper the results of our previous reports that icv administration LPK at the dose of 20 nmol induced evident significant rectal hypothermia, while lower dose LPK of 1 nmol icv exerted significant hyperthermic effect. Peripherally applied LPK at the range of doses 10-100 nmol/100 g ip displayed slight bimodal (hyperthermic and hypothermic) effect on rectal temperature. Prior administration of haloperidol, an antagonist of central dopamine receptors blocked both effects LPK applied either icv or ip. Obtained results indicate that both hypothermic and hyperthermic effects LPK are also modulated by central dopaminergic receptors.
    Źródło:
    Pestycydy; 2008, 1-2; 101-108
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    trans-Pro isosteres in the development of non-selective and selective mimetic agonists of insect pyrokinin neuropeptides: A review
    Autorzy:
    Nachman, R.J.
    Powiązania:
    https://bibliotekanauki.pl/articles/55206.pdf
    Data publikacji:
    2009
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    diapause hormone
    physiological process
    melanization
    pupariation
    pheromonotropin
    neuropeptide
    pyrokinin family
    pheromone
    diapause break
    pheromone biosynthesis activating neuropeptide
    insect
    reddish colouration hormone
    peptide
    Opis:
    The pyrokinin (PK) family plays a multifunctional role in an array of important physiological processes in a variety of insects. A PK active core analog containing an (E)-alkene, transPro isosteric component was evaluated in five disparate PK bioassays and/or in a recombinant PK receptor cell line, representing six different insect species. The assays included pheromone biosynthesis in the moth Heliothis peltigera, melanization in the larval Spodoptera littoralis, pupariation acceleration in the larval fly Neobellieria bullata, diapause termination in the moth Heliothis zea, and hindgut contraction in the cockroach Leucophaea maderae. This constrained analog demonstrated unselective agonist activity that approached, matched, or exceeded the activity of parent PK peptides of equal length in all six PK assays. The results provide strong evidence for the orientation of Pro and the core conformation adopted by PK neuropeptides during interaction with disparate PK receptors. A PK active core analog incorporating a second transPro motif, the dihydroimidazoline moiety, was found to demonstrate pure, selective agonism in the melanotropic bioassay, with no significant activity in three other PK bioassays. Both types of transPro isosteric analogs feature modification adjacent to the primary tissue-bound peptidase hydrolysis site that is expected to enhance biostability over natural PK peptides. The research further identifies two novel scaffolds with which to design either selective or non-selective mimetic PK analogs as potential leads in the development of environmentally favorable pest management agents capable of disrupting PK-regulated systems.
    Źródło:
    Pestycydy; 2009, 1-4; 33-39
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aspects of the control of diuresis in the blood gorging insect, Rhodnius prolixus
    Autorzy:
    Orchard, J.
    Donini, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/54968.pdf
    Data publikacji:
    2008
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    diuretic hormone
    neurosecretory cell
    blood
    insect
    Malpighian tubule
    Rhodnius prolixus
    gorging insect
    diuresis control
    neuropeptide
    dorsal unpaired median cell
    serotonin
    Opis:
    Post-feeding diuresis in Rhodnius prolixus is neurohormonally controlled by serotonin and at least one peptidergic diuretic hormone (possibly a CRF-related peptide). These appear to be released by two different neurosecretory groups – 5 dorsal unpaired median (DUM) cells and 5-6 lateral neurosecretory cells of the mesothoracic ganglionic mass. The DUM cells co-localize serotonin and the calcitonin-related peptide RhoprDH31. The lateral neurosecretory cells co-localize a CRF-related peptide and a kinin-like peptide. Serotonin and the CRF-related peptide, ZooneDH, each stimulate maximum secretion by the upper Malpighian tubules, whereas only serotonin stimulates KCl reabsorption from the lower Malpighian tubules. RhoprDH31 is only weakly diuretic and Leucokinin 1 has no diuretic activity. Neither stimulates KCl reabsorption. The possible role for multiple diuretic hormones and for co-localization of diuretic factors is discussed.
    Źródło:
    Pestycydy; 2008, 1-2; 61-66
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A beta-amino acid pyrokinin analog induces irregular pupariation behavior in larvae of the flesh fly Sarcophaga bullata
    Autorzy:
    Nachman, R.J.
    Zubrzak, P.
    Williams, H.
    Strey, A.
    Zdarek, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/54984.pdf
    Data publikacji:
    2008
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    pyrokinin analogue
    Sarcophaga bullata
    insect
    pyrokinin class
    beta-amino acid
    flesh fly
    larva
    pupariation process
    neuropeptide
    Opis:
    The developmental process of pupariation is accelerated by members of the pyrokinin class of neuropeptides in larvae of the flesh fly Sarcophaga bullata. A pyrokinin analog (Ac-Y[β3Phe]TPRLamide), in which a Phe residue is replaced with a β-amino acid, accelerates pupariation in this fly at a potency (0.2 pmol/larva) that matches that of the native pyrokinin factor. At higher concentrations, this β-amino acid pyrokinin analog induces irregular pupariation behavior patterns that are suggestive of neurotoxic properties. Biostable analogs based on this structure may in future provide analog leads with the potential to disrupt the important pupariation process in flies.
    Źródło:
    Pestycydy; 2008, 1-2; 95-100
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of arginine substitutions on the cardioinhibitory activity of the Led-NPF-I neuropeptide
    Autorzy:
    Marciniak, P.
    Slocinska, M.
    Bednarz, P.
    Grodecki, S.
    Konopinska, D.
    Rosinski, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/55015.pdf
    Data publikacji:
    2009
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    cardioinhibitory activity
    arginine substitution
    mealworm beetle
    Zophobas atratus
    giant mealworm beetle
    Led-NPF-I-peptide
    insect
    beetle
    neuropeptide
    Opis:
    Effects of structural changes on the cardioinhibitory activity of the Led-NPF-I peptide (Ala-Arg-Gly-Pro-Gln-Leu-Arg-Leu-Arg-Phe-amide) were examined by replacing Arg residues in positions 2, 7 and 9. Replacement of L-Arg2 with another basic amino acid, such as Lys, His or D-Arg, did not abolish but rather promoted cardioinhibitory activity in giant mealworm beetle Zophobas atratus Fab. Agonistic peptides were also obtained by substitution of Arg residue in position 7 with Lys or D-Arg, and Arg in position 9 with His or D-Arg, respectively. All these analogues showed stronger cardioinhibitory effects than the native peptide at low concentration (10-9 M), and [Lys7]-, [D-Arg7]- and [D-Arg9]-Led-NPF-I also at the higher concentration (10-6 M). However, substitutions of the Arg residues in position 7 with His or in position 9 with Lys caused a loss of the cardioinhibitory activity. In addition, the replacement of Arg residues in all three positions with Lys or Orn caused a reduction of cardioinhibitory activity, although a single substitution of Arg in positions 2 or 7 with Lys yielded agonistic peptides. We conclude that the Arg2 position in the N-terminal region is more tolerant to structural modification than the other two Arg positions located in the C-terminal region.
    Źródło:
    Pestycydy; 2009, 1-4; 71-78
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The endocrine control of Malpighian tubule secretion: past, present and future
    Autorzy:
    Coast, G.M.
    Powiązania:
    https://bibliotekanauki.pl/articles/55107.pdf
    Data publikacji:
    2008
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    diuretic hormone
    ion transport
    Malpighian tubule secretion
    insect
    biogenic amine
    endocrine control
    diuresis control
    neuropeptide
    primary urine formation
    Opis:
    Work by Ramsay in the 1950’s established the foundations for our current understanding of primary urine production by Malpighian tubules and we now have detailed knowledge of the epithelial transport processes underlying fluid secretion. Identified neuropeptides and biogenic amines have been shown to stimulate fluid secretion and, for some, detailed information is available on the second messenger pathways and transport processes they activate. There are significant gaps in our knowledge, however, particularly concerning the role of identified diuretics in vivo. The hormonal status of many has yet to be established and it is also unclear whether they are used to control different types of diuresis.
    Źródło:
    Pestycydy; 2008, 1-2; 87-94
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biostable analogs of insect kinin and insectatachykinin neuropeptides: A review of novel classes of antifeedants and aphicides
    Autorzy:
    Nachman, R.J.
    Smagghe, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/55075.pdf
    Data publikacji:
    2011
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    fluid secretion
    peptidase resistance
    biostable analog
    insect
    kinin
    insecticide
    neuropeptide
    novel class
    antifeedant
    aphicide
    pea aphid
    Acyrthosiphon pisum
    aphid
    control agent
    Opis:
    Neuropeptides are regulators of critical life processes in insects, but are subject to rapid degradation by peptidases in the hemolymph (blood), tissues and gut. This limitation can be overcome via replacement of peptidase susceptible portions of the insect neuropeptides with non-natural residues or moieties to create analogs with enhanced biostability. Two neuropeptide families, the insect kinins and insectatachykinins, stimulate gut motility and Malpighian tubule fluid secretion in certain insects but unmodified members demonstrate little or no effect when fed to pea aphids (Acyrthosiphon pisum) in an artificial diet. Nonetheless, biostable analogs developed via the strategic introduction of either bulky Aib residues and/or β-amino acids demonstrate potent antifeedant and aphicidal effects when administered orally; whereas other biostable analogs are inactive. Although the precise mechanism of action has not been delineated, the activity may be associated with disruption of the physiological processes that these neuropeptides regulate in insects. The most active of the biostable insect kinin and insectatachykinin analogs show LC50 values of 0.063 nmole/μl (LT50 = 1.68 days) and 0.0085 nmole/μl (LT50 = 1.1 days), respectively; matching or exceeding the potency of some commercially available aphicides. The biostable analogs represent important leads in the development of alternative, environmentally sound aphid control agents.
    Źródło:
    Pestycydy; 2011, 1-4
    0208-8703
    Pojawia się w:
    Pestycydy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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