- Tytuł:
- The effect of chitosan on the synthesis of l-s-nitrosocysteine that participates in the regulation of the m2 pyruvate kinase isoenzyme activity associated with ehrlich ascites cells proliferation in vitro
- Autorzy:
-
Ignacak, Jan
Zagajewski, Jacek
Pałka, Iwona
Wiśniewska-Wrona, Maria
Niekraszewicz, Antoni - Powiązania:
- https://bibliotekanauki.pl/articles/1035527.pdf
- Data publikacji:
- 2010
- Wydawca:
- Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
- Tematy:
-
L-S-nitrosocysteine
L-cysteine
inhibition of EAT cell proliferation
microcrystalline chitosan
pyruvate kinase M2 isoenzyme - Opis:
- L-S-nitrosocysteine formation in EAT tumor cells and normal CRL-1636 cells incubated with microcrystalline chitosan was confirmed by RP-HPLC. The metabolite was identified based on UV-VIS spectra. The formation of L-S-nitrosocysteine in EAT tumor cells contributes to decreasing the level of L-cysteine in these cells. L-cysteine as an effector of the bifunctional M2 isoenzyme of pyruvate kinase (PK) initiates its histone kinase activity, which is responsible for histone H1 phosphorylation. A decrease of L-cysteine level in EAT tumor cells contributes to lack of histone H1 phosphorylation by the M2 PK isoenzyme and by the same token to inhibition of EAT cell proliferation.
- Źródło:
-
Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 149-158
1896-5644 - Pojawia się w:
- Progress on Chemistry and Application of Chitin and its Derivatives
- Dostawca treści:
- Biblioteka Nauki
Artykuł