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Tytuł:
A universal flu vaccine
Autorzy:
Kesik-Brodacka, Malgorzata
Plucienniczak, Grazyna
Powiązania:
https://bibliotekanauki.pl/articles/1039259.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
universal vaccine
flu vaccine
influenza virus
Opis:
Influenza is a global health concern. The single most effective way of protecting people against influenza infection and disease is vaccination. However, currently available vaccines against influenza induce only strain-specific immunity, and do not elicit long-lasting serum antibody titers. Therefore, they are ineffective in the case of possible pandemics. There is an urgent need for a new generation vaccine which would induce broad and long-lasting immune protection against antigenically distinct flu viruses. The paper presents recent achievements and the challenges in the field of universal vaccine construction.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 523-530
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antivirals - current trends in fighting influenza
Autorzy:
Król, Ewelina
Rychłowska, Małgorzata
Szewczyk, Bogusław
Powiązania:
https://bibliotekanauki.pl/articles/1039254.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza virus
antivirals
novel anti-influenza drugs
antiviral therapy
inhibitors
Opis:
Influenza virus infection is a major source of morbidity and mortality worldwide. Due to the variable effectiveness of existing vaccines, especially in the early stages of an epidemic, antiviral drugs represent the first line of defense against the virus. Currently, there are two major classes of anti-influenza drugs approved by the FDA for clinical use: M2 protein inhibitors (amantadine and rimantadine) and neuraminidase inhibitors (zanamivir and oseltamivir). However, increasing resistance to these available influenza antivirals among circulating influenza viruses highlights the need to develop alternative approaches for the prevention and/or treatment of influenza. This review presents an overview of currently available drugs for influenza treatment as well as summarizes some new antiviral strategies that are now being tested covering agents targeting both the viral proteins and the host-virus interaction. We discuss their mechanisms of action, resistance and the therapeutic potential as new antiviral drug for use in future influenza pandemics. Additionally, combination therapy based on these drugs is also described.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 495-504
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method
Autorzy:
Radomski, Jan
Słonimski, Piotr
Zagórski-Ostoja, Włodzimierz
Borowicz, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1039244.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ISSCOR descriptors
phylogenetic analysis
influenza virus
hemagglutinin
phylogenetic maps
Opis:
Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we consider application of the ISSCOR-PCA method for analyses of large sets of homologous genes to be a worthwhile addition to a toolbox of genomics - allowing for a rapid diagnostics of trends, and ultimately even aiding an early warning of newly emerging epidemiological threats.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 441-451
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Electrochemical biosensors for detection of avian influenza virus - current status and future trends
Autorzy:
Grabowska, Iwona
Malecka, Kamila
Jarocka, Urszula
Radecki, Jerzy
Radecka, Hanna
Powiązania:
https://bibliotekanauki.pl/articles/1039249.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
electrochemical biosensors
genosensors
immunosensors
electrochemical detection
avian influenza virus
Opis:
Electrochemical biosensors have emerged as reliable analytical devices suitable for pathogen detection. Low cost, small sample requirement and possibility of miniaturization justifies their increasing development. Thus, we report in this review on the state of the art of avian influenza virus detection with genosensors and immunosensors working by an electrochemical mode. Their working principles focusing on the physical properties of the transducer, the immobilization chemistry, as well as new trends including incorporation of nanoparticles will be presented. Then, we critically review the detection of avian influenza virus in the complex matrices that use electrochemical biosensors and compare them with traditionally applied methods such as ELISA or Western blot.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 471-478
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detection and differentiation of Newcastle disease virus and influenza virus by using duplex real-time PCR
Autorzy:
Nidzworski, Dawid
Wasilewska, Edyta
Smietanka, Krzysztof
Szewczyk, Bogusław
Minta, Zenon
Powiązania:
https://bibliotekanauki.pl/articles/1039554.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Newcastle disease virus
influenza virus
detection
differentiation
real-time PCR
duplex
Opis:
Newcastle disease virus (NDV), member of the Paramyxoviridae family and avian influenza virus (AIV), member of the Orthomyxoviridae family, are two main avian pathogens causing serious economic problems in poultry health. Both are enveloped, single-stranded, negative-sense RNA viruses and cause similar symptoms, ranging from sub-clinical infections to severe diseases, including decrease in egg production, acute respiratory syndrome, and high mortality. Similar symptoms hinder the differentiation of infection with the two viruses by standard veterinary procedures like clinical examination or necropsy. To overcome this problem, we have developed a new duplex real-time PCR assay for the detection and differentiation of these two viruses. Eighteen NDV strains, fourteen AIV strains, and twelve other (negative control) strains viruses were isolated from allantoic fluids of specific pathogen-free (SPF), embryonated eggs. Four-weeks-old SPF chickens were co-infected with both viruses (NDV - LaSota and AIV - H7N1). Swabs from cloaca and trachea were collected and examined. The results obtained in this study show that by using duplex real-time PCR, it was possible to detect and distinguish both viruses within less than three hours and with high sensitivity, even in case a bird was co-infected. Additionally, the results show the applicability of the real-time PCR assay in laboratory practice for the identification and differentiation of Newcastle disease and influenza A viruses in birds.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 475-480
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antiviral activity of novel oseltamivir derivatives against some influenza virus strains
Autorzy:
Kocik, Janusz
Kołodziej, Marcin
Joniec, Justyna
Kwiatek, Magdalena
Bartoszcze, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1039256.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza virus
neuraminidase inhibitors
oseltamivir
antiviral activity
cytotoxicity
Opis:
The aim of this study was to investigate the in vitro cytotoxicity of oseltamivir derivatives and determine their activity against A/H1N1/PR/8/34 and A/H3N2/HongKong/8/68 - strains of influenza virus. Antiviral activity of these compounds was determined by using two methods. MTT staining was used to assess the viability of MDCK cells infected with influenza viruses and treated with various concentrations of drugs. In parallel, the effect of drugs on viral replication was assessed using the hemagglutination test. The most toxic compounds were: OS-64, OS-35, OS-29, OS-27 and OS-25, whereas OS-11, OS-20 and OS-23 were the least toxic ones. Statistically significant antiviral effect at a higher virus dose was shown by compounds: OS-11, OS-20, OS-27, OS-35, and OS-64. H3N2 virus was sensitive to 10-times lower concentrations of OS-11 and OS-35 than H1N1. At a lower infection dose, the antiviral activity was observed for OS-11, OS 27, OS-35 and OS-20. OS-64 turned out to be effective only at a high concentration. OS-23 showed no antiviral effect.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 509-513
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of mAb6-9-1 monoclonal antibody against hemagglutinin of avian influenza virus H5N1 and its engineered derivative, single-chain variable fragment antibody
Autorzy:
Sawicka, Róża
Siedlecki, Paweł
Kalenik, Barbara
Radomski, Jan
Sączyńska, Violetta
Porębska, Anna
Szewczyk, Bogusław
Sirko, Agnieszka
Góra-Sochacka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1038689.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza virus
monoclonal antibody
scFv
hemagglutinin
antigenic epitope
Opis:
Hemagglutinin (HA), as a major surface antigen of influenza virus, is widely used as a target for production of neutralizing antibodies. Monoclonal antibody, mAb6-9-1, directed against HA of highly pathogenic avian influenza virus A/swan/Poland/305-135V08/2006(H5N1) was purified from mouse hybridoma cells culture and characterized. The antigenic specificity of mAb6-9-1 was verified by testing its cross-reactivity with several variants of HA. The mimotopes recognized by mAb6-9-1 were selected from two types of phage display peptide libraries. The comparative structural model of the HA variant used for antibody generation was developed to further facilitate epitope mapping. Based on the sequences of the affinity- selected polypeptides and the structural model of HA the epitope was located to the region near the receptor binding site (RBS). Such localization of the epitope recognized by mAb6-9-1 is in concordance with its moderate hemagglutination inhibiting activity and its antigenic specificity. Additionally, total RNA isolated from the hybridoma cell line secreting mAb6-9-1 was used for obtaining two variants of cDNA encoding recombinant single-chain variable fragment (scFv) antibody. To ensure high production level and solubility in bacterial expression system, the scFv fragments were produced as chimeric proteins in fusion with thioredoxin or displayed on a phage surface after cloning into the phagemid vector. Specificity and affinity of the recombinant soluble and phage-bound scFv were assayed by suitable variants of ELISA test. The observed differences in specificity were discussed.
Źródło:
Acta Biochimica Polonica; 2017, 64, 1; 85-92
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Active surveillance in poultry in Poland for avian influenza subtypes H5 and H7
Autorzy:
Pikuła, Anna
Śmietanka, Krzysztof
Lisowska, Anna
Minta, Zenon
Powiązania:
https://bibliotekanauki.pl/articles/1039246.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
avian influenza virus (AIV)
poultry
surveillance
hemagglutination inhibition test (HI)
Opis:
A serological surveillance programme for avian influenza A virus (AIV) subtype H5 and H7 in poultry was implemented in Poland in 2008-2013 with two main objectives: i) to detect subclinical infections or previous exposures to AIV H5 and H7 subtypes and ii) to demonstrate the AI- free status of Poland. During this period, over 45 000 serum samples from 2833 holdings were examined using the hemagglutination inhibition test (HI). The presence of HI antibodies was detected in 8 breeder geese holdings (7 positive for H5 and 1 positive for H7 AIV) and in 1 breeder duck holding (H5-positive), which represented 0.32% of all investigated holdings. All seropositive flocks were examined by real time RT-PCR with negative results, which substantiated the AI-free status of Poland. Positive results detected in clinically healthy poultry kept in an open range system indicate prior infections with low pathogenic AIV originating from the wild-bird reservoir.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 459-463
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of the host genetic variability in the influenza A virus susceptibility
Autorzy:
Arcanjo, Ana
Mazzocco, Giovanni
de Oliveira, Silviene
Plewczynski, Dariusz
Radomski, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1039238.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Influenza A virus
host-pathogen interactions
Opis:
The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 403-419
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serological surveillance of avian influenza virus and canine distemper virus in captive Siberian Tigers in Northeastern China
Autorzy:
Wang, K.
Wang, H.
Feng, N.
Zhao, Y.
Gao, Y.
Hu, G.
Xia, X.
Powiązania:
https://bibliotekanauki.pl/articles/2087698.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
influenza A virus
canine distemper virus
serological
Siberian Tiger
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 3; 491-495
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A clinical utility of a strip test for influenza A/B and comparison with detection by RT PCR
Autorzy:
Miarka, Maciej
Horban, Andrzej
Maliszewska, Henryka
Biliński, Przemysław
Prus-Kowalczuk, Wanda
Powiązania:
https://bibliotekanauki.pl/articles/1039251.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
A/H1N1/v influenza virus
strip test
influenza RT PCR
Opis:
Introduction and objective: In June 2009 the World Health Organization announced influenza pandemic caused by A/H1N1/v virus. It became crucial to recognize new cases of A/H1N1/v infection. An effective screening diagnostic procedure was needed for patients suffering from influenza-like symptoms for making an initial diagnosis and analyzing epidemiological pattern of infection. We used a strip test for influenza A/B as a screening diagnostic procedure for patients suffering from influenza-like symptoms for making an initial diagnosis. For comparison, RT PCR for detecting A/H1N1/v was performed. The aim of this study was to assess the efficacy and sensitivity of the strip test and its value for making initial diagnosis of influenza A/H1N1/v. Material and methods: Strip testing for the influenza A/B infection was performed on 1123 patients with influenza-like symptoms in the Admission Unit of the Regional Infectious Diseases Hospital in Warsaw. Strip test results were analyzed according to the age of patients and season of the year. For 97 patients strip test results for detecting A/H1N1 infection were compared with those obtained by RT PCR. Results: There were no statistically significant differences found between the methods and strip testing demonstrated sensitivity of 61% and specificity of 71%. Conclusions: No statistically significant differences were found between the two methods, however, strip test had low sensitivity and specificity.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 485-487
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structural biology of the influenza virus fusion peptide
Autorzy:
Worch, Remigiusz
Powiązania:
https://bibliotekanauki.pl/articles/1039239.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza virus
viral entry
membrane fusion
fusion peptide
peptide-lipid interactions
Opis:
The release of influenza RNA inside the host cell occurs through the fusion of two membranes, the viral envelope and that of the cellular endosome. The fusion is mediated by the influenza hemagglutinin protein (HA), in particular by the fusion peptide (HAfp) located in the N-terminal fragment of HA2 subunit. This protein fragment anchors in the internal endosomal membrane, whereas the C-terminal HA2 part comprises a transmembrane domain (TMD) embedded in the viral envelope. A drop of pH in the endosome acts as the main trigger for HA2 large conformational change that leads to anchoring of the fusion peptide, close contact of the membranes and the subsequent fusion. Throughout the years the major research effort was focused on a 20-aminoacid fragment (HAfp1-20), shown by NMR to adopt a 'boomerang'-like structure. However, recent studies showed that extending HAfp1-20 by three highly conserved residues W21-Y22-G23 leads to formation of a unique, tight helical hairpin structure. This review summarizes recently discovered structural aspects of influenza fusion peptides and their relations with the membrane fusion mechanism.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 421-426
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
К вопросу экологии природноочаговых болезней (концептуально-аналитические исследования)
To the issue of the ecology of environmental focal diseases (conceptual-analytical study)
Autorzy:
Golubyatnikov, M.
Sidenko, V.
Powiązania:
https://bibliotekanauki.pl/articles/1032516.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Kazimierza Wielkiego w Bydgoszczy
Tematy:
природноочаговые болезни
вирус гриппа
эпидемический процесс
environmental focal diseases
influenza virus
epidemic processes.
Opis:
К вопросу экологии природноочаговых болезней (концептуально-аналитические исследования) Проведены научно-аналитические исследования по проблеме экологии природноочаговых болезней. Основываясь на современных данных молекулярной биологии, вирусологии, иммунологии и эпидемиологии, авторы полагают, что происхождение биогенетических межвидовых экологических связей основывается на сапронозной природе, в частности, вирусов гриппа. На предадаптивной стадии миграционного процесса может стимулироваться возникновение некоторых вариантов, к которым восприимчивы околоводные птицы, а также отдельные млекопитающие, в том числе и человек. Разработка мер, препятствующих реассортации ныне является основой профилактики этой вирусной инфекции в будущем.
To the issue of the ecology of environmental focal diseases (conceptual-analytical study) There was conducted the scientific-analytical study on the problem of the ecology of environmental focal diseases. Substantiated on the modern data of molecular biology, virology, immunology and epidemiology, the authors suggests that the origin of biogenetic interspecies associations are based on the sapronotic nature of influenza virus, particularly. On the preadaptive stage of migration process there are stimulated the occurrence of the variants whereas the water birds and mammalians, including humans, are susceptible. The development of the measures preventing reassociation is a base of the prevention of this viral infection in the future.
Źródło:
Journal of Health Sciences; 2014, 4, 1; 41-50
1429-9623
Pojawia się w:
Journal of Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Testing of human specimens for the presence of highly pathogenic zoonotic avian influenza virus A [H5N1] in Poland in 2006-2008 - justified or unnecessary steps?
Autorzy:
Romanowska, M
Nowak, I.
Brydak, L.B.
Wojtyla, A.
Powiązania:
https://bibliotekanauki.pl/articles/50626.pdf
Data publikacji:
2009
Wydawca:
Instytut Medycyny Wsi
Tematy:
avian influenza virus type A
zoonosis
influenza
H5N1 subtype
avian influenza
disease outbreak
diagnostic test
Polska
Źródło:
Annals of Agricultural and Environmental Medicine; 2009, 16, 2; 239-247
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zakażenia wirusowe układu oddechowego w środowisku pracy służby zdrowia
Virus infections of the respiratory system in the occupational environment of health care employees
Autorzy:
Roży, A.
Jaguś, P.
Chorostowska-Wynimko, J.
Powiązania:
https://bibliotekanauki.pl/articles/179611.pdf
Data publikacji:
2014
Wydawca:
Centralny Instytut Ochrony Pracy
Tematy:
zakażenia wirusowe
wirusy oddechowe
wirus grypy
personel medyczny
viral infections
respiratory viruses
influenza virus
health care workers
Opis:
Infekcje wirusowe dróg oddechowych stanowią poważny problem zdrowotny i ekonomiczny na całym Świecie wysoka zakaźność tej grupy wirusów bezpośrednio wynika z łatwości transmisji, szczególnie w większych skupiskach ludzkich, takich jak placówki medyczne i oświatowe, duże zakłady pracy czy środki transportu. Ryzyko zakażenia dla tych grup zawodowych, a zwłaszcza pracowników ochrony zdrowia fest więc znacząco wyższe. Konieczne jest świadome stosowanie zasad profilaktyki czynnej (szczepienia ochronne), a w okresie wzrostu zapadalności również profilaktyki biernej (izolacja zakażonych, higiena). Niski poziom wyszczepialności przeciw grypie w populacji polskiej, w tym również wśród pracowników opieki zdrowotnej stanowi istotny problem, niosący znaczące ryzyko dla zdrowotności społeczeństwa i gospodarki kraju.
Respiratory viral infections pose a significant health and economic burden all over the world. Due to their easy transmission. respiratory viruses are highly infective, particularly in the larger human groupings, such as medical and educational facilities, larger industrial units and public transportation. Therefore, respective professional groups are regarded as the high risk population In those groups, in particular in medical staff, the premeditated proactive flu prophylaxis by means of regular immunization is strongly advised. A secondary prophylaxis, the strict isolation of infected patients must be introduced in health care facilities during flu season or epidemic. The unexceptionally low flu vaccination rate in Poland, both in general population and medical staff is of particular concern as a potential serious treat for society's state of health but also country economy.
Źródło:
Bezpieczeństwo Pracy : nauka i praktyka; 2014, 4; 27-29
0137-7043
Pojawia się w:
Bezpieczeństwo Pracy : nauka i praktyka
Dostawca treści:
Biblioteka Nauki
Artykuł
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