Temat: individual susceptibility - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Usefulness of biomarkers as intermediate endpoints in health risks posed by occupational lead exposure
Autorzy:: Borghini, Andrea
Gianicolo, Emilio Antonio
Andreassi, Maria Grazia
Powiązania:: https://bibliotekanauki.pl/articles/2177066.pdf
Data publikacji:: 2015-10-16
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: biomarkers
occupational exposure
lead
individual susceptibility
genotoxic effects
health risk
Opis:: The article concerns potential harmful effects of exposure to lead. Although the occurrence of severe lead poisoning has receded in several countries, occupational exposure resulting in moderate and clinically symptomatic toxicity is still common. An earlier and precise characterization of an individual response is obligatory in order to assess the possible risks for human health. Biomarkers may fill important gaps in the path from exposure to a disease. Specifically speaking, emerging (DNA double strand breaks and telomeric DNA erosion) and validated (micronuclei induction and chromosomal aberrations) biomarkers of genotoxicity seem to provide evidence for the assessment of molecular and cellular damage. Moreover, identiﬁcation of genetic variability with a key role in modulating genotoxic damage may help minimize risks for susceptible subjects. Further investigations are naturally needed to properly define their diagnostic and/or prognostic value as “early warning” signs of a long-term risk for a subsequent clinically overt disease.
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2016, 29, 2; 167-178
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: New trends in the prevention of occupational noise-induced hearing loss
Autorzy:: Sliwinska-Kowalska, Mariola
Powiązania:: https://bibliotekanauki.pl/articles/2116178.pdf
Data publikacji:: 2020-10-20
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: predictive models
cochlear neuropathy
temporary threshold shift
individual susceptibility to noise
speech in noise
medical guidelines
Opis:: Noise exposure during lifespan is one of the main causes of hearing loss. The highest risk of noise-induced hearing loss (NIHL) is related to exposures in the workplace, and affects about 7% of the population. Occupational NIHL is irreversible, thus its prevention must be considered a priority. Although current hearing conservation programs (HCPs) have proved to be very beneficial, the incidence of occupational NIHL is still high, reaching about 18% of overexposed workers. This paper reviews recent research on the effects of noise on hearing in pursuit of more effective methods for the prevention of occupational NIHL. The paper discusses the translational significance of noise-induced cochlear neuropathy, as recently shown in animals, and the concept of hidden hearing loss in relation to current NIHL damage risk criteria. The anticipated advantages of monitoring the incidents of the temporary threshold shift (TTS) in workers exposed to high levels of noise have been analyzed in regard to the preclinical diagnostics of NIHL, i.e., at the stage when hearing loss is still reversible. The challenges, such as introducing speech-in-noise audiometry and TTS computational predictive models into HCPs, have been discussed. Finally, the paper underscores the need to develop personalized medical guidelines for the prevention of NIHL and to account for several NIHL risk factors other than these included in the ISO 1999:2013 model. Implementing the steps mentioned above would presumably further reduce the incidence of occupational NIHL, as well as associated social costs.
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2020, 33, 6; 841-848
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki

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