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Tytuł:
Therapeutic problems in patients with congenital adrenal hyperplasia from 11-β-hydroxylase deficiency
Problemy terapeutyczne u pacjentek z wrodzonym przerostem nadnerczy z niedoboru 11-β-hydroksylazy
Autorzy:
Ptak, Anita
Podyma, Katarzyna
Kajdaniuk, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/31339335.pdf
Data publikacji:
2024-05-13
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
hypertension
hirsutism
congenital adrenal hyperplasia
glucocorticosteroid therapy
nadciśnienie tętnicze
hirsutyzm
wrodzony przerost nadnerczy
glikokortykosteroidoterapia
Opis:
Congenital adrenal hyperplasia (CAH) with 11-β-hydroxylase deficiency accounts for a small percentage of the overall incidence of this disease in the population. The described case of two sisters touches on the therapeutic problems encountered during the treatment of this rare condition. The authors present the problem of selecting appropriate substitutive doses of glucocorticosteroids that will ensure good control of blood pressure and protect against the development of organ complications caused by hypertension and maintain hirsutism at an acceptable level, with as few complications of the applied treatment as possible. The article emphasizes the role of patient–physician cooperation, which is essential to achieve the therapeutic goals.
Wrodzony przerost nadnerczy (congenital adrenal hyperplasia – CAH) z niedoborem 11-β-hydroksylazy stanowi niewielki procent ogólnej częstości występowania CAH w populacji. Opisywany przypadek dwóch sióstr dotyka problemów terapeutycznych napotykanych w czasie leczenia tego rzadkiego schorzenia. Autorzy przedstawiają trudności związane z doborem odpowiednich dawek substytucyjnych glikokortykosteroidów, które zapewnią dobrą kontrolę ciśnienia tętniczego i zapobiegną rozwojowi powikłań narządowych wywołanych nadciśnieniem tętniczym, a także utrzymają hirsutyzm na akceptowalnym poziomie przy jak najmniejszej liczbie powikłań stosowanego leczenia. W pracy podkreślono rolę współpracy na linii pacjent–lekarz, niezbędnej do osiągnięcia założonych celów terapeutycznych.
Źródło:
Annales Academiae Medicae Silesiensis; 2024, 78; 113-117
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zastosowanie palmy sabałowej w terapii łagodnego przerostu prostaty
The use of saw palmetto in the treatment of benign prostatic hyperplasia
Autorzy:
Zielińska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/11340522.pdf
Data publikacji:
2023-09-01
Wydawca:
Wydawnictwo Naukowe Medyk sp. z o.o.
Tematy:
prostata
łagodny rozrost gruczołu krokowego
palma sabałowa
kwasy tłuszczowe
prostate
benign prostatic hyperplasia
saw palmetto
fatty acids
Opis:
Palma sabałowa (Serenoa repens, bocznia piłkowana, Saw palmetto) pochodzi z południowo-wschodniej Ameryki Północnej, głównie z Florydy. W fitoterapii stosowany jest ekstrakt z jagód zawierający 85–90% kwasów tłuszczowych (m.in. kaprylowy, palmitynowy, oleinowy) oraz steroli, takich jak beta-sitosterol. Ekstrakt powszechnie spożywany jest jako suplement we wspomaganiu leczenia objawów ze strony dolnych dróg moczowych u mężczyzn oraz w łagodnym przeroście prostaty. Pomimo dużej liczby publikacji, niejasna jest jego potencjalna rola w leczeniu tych schorzeń. Jednak wielu specjalistów zaleca stosowanie preparatów zawierających wysokiej jakości lipidowo-sterolowy ekstrakt z palmy jako terapię wspomagającą w przypadku łagodnych do umiarkowanych objawów.
Saw palmetto (Serenoa repens) is native to the southeast regions of North America, especially abundant in Florida. The extract from its berries is used in phytotherapy, containing 85–90% of fatty acids (including caprylic, palmitic, oleic acids) and sterols such as beta-sitosterol. Lipidosterolic extract is commonly consumed as a supplement to support the treatment of lower urinary tract symptoms in men and benign prostatic hyperplasia. Despite the large number of publications, uncertainty remains about its potential role in the treatment of these conditions. However, many specialists recommend the use of preparations containing high-quality lipidosterolic palm extract as an adjunctive therapy for mild to moderate symptoms.
Źródło:
Lek w Polsce; 2023, 387, 8; 29-33
2353-8597
Pojawia się w:
Lek w Polsce
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
"Nadziąślaki" u psów - klasyfikacja, rozpoznawanie i rokowanie
"Epulides" in dogs - classification, diagnosis and prognosis
Autorzy:
Sapierzyński, Rafał
Powiązania:
https://bibliotekanauki.pl/articles/22180759.pdf
Data publikacji:
2021
Wydawca:
Krajowa Izba Lekarsko-Weterynaryjna
Tematy:
psy
choroby jamy ustnej
nowotwory
klasyfikacja
leczenie
rokowanie
nadziąślaki
rozrost włóknisty dziąseł
włókniak zębotwórczy
szkliwiak kolczystokomórkowy
diagnostyka różnicowa
canine acanthomatous ameloblastoma
fibrous gingival hyperplasia
histopathology
peripheral odontogenic fibroma
dog
prognosis
Opis:
The term “epulis” has been used to describe localized gingival mass or masses, regardless of their nature. This is considered to be only topographical description not specific diagnosis. Epulis includes both non-neoplastic and/or neoplastic processes and microscopic examination of tissue sample is necessary to obtain final diagnosis. Among numerous lesions, gingival fibrous hyperplasia, odontogenic fibroma (formerly called fibrous and osseous epulides), and canine acanthomatous amaloblastoma (formerly called acanthomatous epulis), are most often recognized benign tumors with clinical presentation as “epulis” in dogs. Prevalence, clinical presentations, and microscopic pictures of mentioned lesions were described in this article, as well as some data and guidance concerning prognosis were presented.
Źródło:
Życie Weterynaryjne; 2021, 96, 01; 34-41
0137-6810
Pojawia się w:
Życie Weterynaryjne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of the impact of sodium and potassium metabolism in women undergoing hysteroscopy due to pathological uterine bleeding
Autorzy:
Zielinski, P.
Szeszko, L.
Krupinska, J.
Wrobel, G.
Szeszko, A.
Oszukowski, P.
Powiązania:
https://bibliotekanauki.pl/articles/1192474.pdf
Data publikacji:
2020
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
gynaecology
menstruation
menstrual disorders
abnormal uterine bleeding
kalium
natrium
endomentrial hyperplasia
endometrial polyp
heavy menstruation
uterine fibroids
Opis:
Monitoring the water and electrolyte balance is an integral part of diagnostics and designing an effective therapy of many diseases. Sodium and potassium play a crucial role in the diagnosis of water and electrolyte disorders. The study was conducted to demonstrate the relationship between the occurrence of electrolyte disturbances in women undergoing hysteroscopy due to pathological uterine bleeding. Medical records of 543 patients aged 21-88 (52.8±11.8 years) hospitalized in the Gynecology and Obstetrics Department of the Provincial Specialist Hospital in Biała Podlaska, who underwent hysteroscopic diagnostics due to pathological bleeding from the uterus were collected. 212 women (39.04%) were diagnosed with pathological bleeding from the uterus, 147 women (27.07%) had endomentrial hyperplasia, 104 women (19.15%) were diagnosed with an endometrial polyp, 62 women (11.42%) suffered from heavy menstruations and 18 women (3.3%) had uterine fibroids. The sodium and potassium concentrations were measured using an automated Cobas® 8000 analyzer (Roche). The average concentration of sodium in the serum was 139.84±2.13 mmol L-1 (χ 2 = 35.079; P<0.001), and the average potassium concentration was 4.44±0.37 mmol L-1 (χ 2 = 36.019; P<0.001). Higher values for sodium were recorded in the group of patients with adenomyosis (140.41±2.27 mmol L-1) and patients with uterine fibroids (140.11±1.94) mmol L-1). Statistically significant differences were found in mean sodium concentration values depending on the causes of patients’ hospitalization (H=33.914; P<0.001), and the biggest differences were between patients with ovulation disorders and patients with adenomyosis: 138.86±0.21 mmol L-1 vs. 140.41±2.27 mmol L-1 (Z=5.169; P<0.001). It seems important add measurements of sodium and potassium concentrations to the profile of tests performed in the diagnosis of gynaecological patients referred for hysteroscopy for the reasons presented in the study in order to reduce the risk of complications associated with the loss of these elements.
Źródło:
Journal of Elementology; 2020, 25, 3; 1199-1212
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of combined ethanol extract of Funtumia africana and Abutilon mauritianum leaves (FAAM) on liver function indices of benign prostatic hyperplasia (BPH) induced rats
Autorzy:
Uroko, R.I.
Adamude, F.A.
Egba, S.I.
Chukwu, C.N.
Asadu, C.L.
Okwara, E.C.
Powiązania:
https://bibliotekanauki.pl/articles/2049077.pdf
Data publikacji:
2020
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
Funtumia africana
Abutilon mauritianum
liver marker enzymes
liver function indices
benign prostatic hyperplasia
enzymy wątrobowe
wskaźniki wątrobowe
łagodny przerost gruczołu krokowego
Opis:
Objective: This study evaluated the effects of combined ethanol extract of Funtumia africana and Abutilon mauritianum leaves (FAAM) on the liver function indices of benign prostatic hyperplasia (BPH) induced rats. Materials and Methods: The study used 30 rats divided into 5 groups, comprising normal control, BPH control, standard control, and BPH induced rats treated with 200 and 600 mg/kg/day of FAAM respectively. Results: The BPH induction caused significant (p<0.05) increases in aspartate transaminase (AST) and alkaline phosphatase (ALP) activities of the BPH control when compared with the normal control. The BPH control also had significantly (p<0.05) reductions in the total protein, albumin and globulin concentrations and significant (p<0.05) elevated total bilirubin and direct bilirubin concentrations relative to the normal control. The FAAM treated BPH-induced rats had non-significantly (p>0.05) reduced AST, and alanine transaminase (ALT) activities relative to the BPH control. The BPH-induced rats treated with 600 mg/kg/day of FAAM had significantly (p<0.05) reduced ALP activities relative to the BPH control. Treatment with FAAM caused significant (p<0.05) increases in the total protein, albumin, globulin concentrations and significant (p<0.05) reductions in the total bilirubin and direct bilirubin concentrations relative to the BPH control. BPH had no observable adverse effects on the liver histomorphology of the rats. Conclusion: The findings of this study indicated that BPH impairs liver functions and treatment of BPH with combined ethanol extract of F. africana and A. mauritianum leaves restore normal liver functions in rats with BPH.
Źródło:
Herba Polonica; 2020, 66, 3; 24-35
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pharmacological properties of fireweed (Epilobium angustifolium L.) and bioavailability of ellagitannins. A review
Autorzy:
Dreger, M.
Adamczak, A.
Seidler-Łożykowska, K.
Wielgus, K.
Powiązania:
https://bibliotekanauki.pl/articles/2049057.pdf
Data publikacji:
2020
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
rosebay willowherb
pharmacology
bioavailability
benign prostatic hyperplasia (BPH)
oenothein B
urolithins
gut microbiota
wierzbówka kiprzyca
farmakologia
biodostępność
oenoteina B
urolityny
mikroflora jelitowa
łagodny rozrost prostaty (BPH)
Opis:
Fireweed (Epilobium angustifolium L.) is a well-known medicinal plant traditionally used in the treatment of urogenital diseases, stomach and liver disorders, skin problems, etc. E. angustifolium extracts show antiandrogenic, antiproliferative, cytotoxic, antioxidant, anti-inflammatory, immunomodulatory, and antimicrobial activities. The unique combination of biological properties demonstrated by the results of some studies indicates that fireweed has a positive effect in benign prostatic hyperplasia (BPH) and potentially in the prostate cancer chemoprevention. However, the efficacy of E. angustifolium phytotherapy is still poorly tested in clinical trials, while numerous beneficial effects of extracts have been documented in the in vitro and in vivo tests. Fireweed is rich in polyphenolic compounds, particularly ellagitannins. Currently, polyphenols are considered to be modulators of beneficial gut microbiota. The literature data support the use of ellagitannins in the prostate cancer chemoprevention, but caution is advised due to the highly variable production of urolithins by the individual microbiota. A better understanding of the microbiota’s role and the mechanisms of its action are crucial for an optimal therapeutic effect. This paper aims to summarize and discuss experimental data concerning pharmacological properties of E. angustifolium and bioavailability of ellagitannins – important bioactive compounds of this plant.
Źródło:
Herba Polonica; 2020, 66, 1; 52-64
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency – management and differentiation in adults
Autorzy:
Nowak, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1066263.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
21-hydroxylase
androgens
congenital adrenal hyperplasia
glucocorticosteroids
Opis:
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is one of the most common autosomal recessive hereditary diseases. The lack of cortisol synthesis leads to excessive stimulation of the adrenal glands by adrenocorticotropic hormone (ACTH). Moreover the impairment of cortisol synthesis results in adrenal hyperplasia and excessive androgen synthesis. Congenital adrenal hyperplasia is characterised by a considerable correlation between the genotype and the phenotype with the type of CYP21A2 gene mutation affecting the severity of 21-hydroxylase deficiency. The clinical manifestations of congenital adrenal hyperplasia in adults result from adrenocortical insufficiency, hyperandrogenism, and the adverse effects of glucocorticosteroids, which are used for the treatment of the syndrome. Non-classic congenital adrenal hyperplasia may sometimes have no clinical manifestation. Patients with classic congenital adrenal hyperplasia experience a wide variety of symptoms, including obesity, hypertension, hyperinsulinaemia, insulin resistance, and hyperleptinaemia. These abnormalities, the same as glucocorticosteroid treatment, promote the development of other diseases, such as metabolic syndrome, diabetes mellulitis, cardiovascular diseases and psychosocial problems. Moreover glucocorticosteroids treatment increases risk of osteoporosis and dermatological disorders. The maladies are more often seen in patients suffering from congenital adrenal hyperplasia syndrome than in the general population. Patients suffering from congenital adrenal hyperplasia require systematic evaluation of biochemical parameters (17-hydroxyprogesterone and androstendion) the same as clinical parameters (body mass index, waist circumference, glucose, lipids, blood pressure). Medical care for patients suffering from congenital adrenal hyperplasia should be provided by reference centres. Patients require cooperation between an endocrinologist, diabetologist, gynaecologist, andrologist, urologist, sexuologist and psychologist.
Źródło:
World Scientific News; 2019, 130; 71-81
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress in proliferative lesions of parathyroid gland
Autorzy:
Deska, Mariusz
Romuk, Ewa
Segiet, Oliwia
Polczyk, Joanna
Buła, Grzegorz
Gawrychowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1392364.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
oxidative stress
primary hyperparathyroidism
parathyroid hyperplasia
parathyroid adenoma
Opis:
Background: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders and defined as excessive secretion of parathormone. PHPT is a risk factor of several cardiovascular diseases, which could be caused by alterations in oxidant-antioxidant balance. Materials and methods: Blood serum collected from 52 consecutive patients with PHPT treated surgically constituted our study material, whereas 36 healthy volunteers were our control group. Oxidative stress was evaluated in both patients and control subjects by assessment of malondialdehyde (MDA) and lipid hydroperoxides (LHP). Antioxidants were evaluated by the measurement of superoxide dismutase (SOD), ceruloplasmin (CER), catalase (CAT), sulfhydryl (SH) groups, glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione transferase activity (GST) and glutathione reductase (GR). Moreover, total antioxidant capacity (TAC) and total oxidative status (TOS) were measured and oxidative stress index (OSI) was calculated. Results: OSI was increased in patients with PHPT when compared to normal controls, whereas TAC was lower in PHPT. The levels of CER, MnSOD, GR, SH groups and MDA were significantly decreased in PHPT. The levels of serum LHP, catalase and SOD were significantly higher in patients with PHPT than in healthy patients. The erythrocyte CAT activity and GST were significantly increased in patients after parathyroidectomy. The erythrocyte GR and GPx were up-regulated postoperatively, whereas SOD activity decreased. Conclusions: In PHPT there are several alterations in the balance between the production of reactive oxygen species and antioxidant defense system.
Źródło:
Polish Journal of Surgery; 2019, 91, 1; 29-34
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Thermobalancing therapy as a self-management tool
Autorzy:
Allen, Simon
Powiązania:
https://bibliotekanauki.pl/articles/1076998.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
benign prostatic hyperplasia
chronic prostatitis
disease management
kidney stone
thermobalancing therapy
Opis:
People live with one or more chronic diseases, medical and surgical treatments of which may affect their quality of life negatively. Thermobalancing therapy (TT) and Dr Allen’s therapeutic Devices (DATD) for the first time uses own body energy to treat chronic internal diseases. This invention received a US patent. Here we observe condition of people with benign prostatic hyperplasia (BPH), kidney stone disease and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) before and after use of TT and DATD. 10 years of empirical evidence has been studied in people with kidney disease, CP/CPPS and BPH. 2 clinical controlled trials on TT with DATD were conducted. The dynamics of clinical characteristics and parameters, such as pain, urinary symptoms and ultrasound prostate volume (PV), were compared with the no-treatment control groups. 124 men with BPH and 45 men with CP/CPPS used DATD for 6-month period, as mono-therapy, in clinical trials. The outcomes confirmed that TT with DATD reduced pain and PV in men with CP/CPPS and PV and urinary symptoms in men with BPH, while there were no positive changes in the control groups. 4 people with kidney stones, random from the 10-year follow-up, confirmed that after using DATD kidney stones were dissolved without side effects and complications. DATD is a class-1 medical device, which do not need an involvement of notified body, and it is easy use this device. Therefore, people with kidney stones, CP/CPPS and BPH should use DATD, as a tool for self-management in the first place.
Źródło:
World News of Natural Sciences; 2019, 23; 84-93
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Congenital adrenal hyperplasia: clinical symptoms and diagnostic methods
Autorzy:
Podgórski, Rafał
Aebisher, David
Stompor, Monika
Podgórska, Dominika
Mazur, Artur
Powiązania:
https://bibliotekanauki.pl/articles/1038519.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Congenital Adrenal Hyperplasia
CAH
steroidogenesis
21-hydroxylase deficiency
Opis:
The aim of this paper is a straightforward presentation of the steroidogenesis process and the most common type of congenital adrenal hyperplasia (CAH) - 21-hydroxylase deficiency - as well as the analytical diagnostic methods that are used to recognize this disease. CAH is a family of common autosomal recessive disorders characterized by impaired adrenal cortisol biosynthesis with associated androgen excess due to a deficiency of one or more enzymes in the steroidogenesis process within the adrenal cortex. The most common and prototypical example of the CAH disorders group (90-95%) is caused by 21-hydroxylase deficiency. Less frequent types of CAH are 11β-hydroxylase deficiency (up to 8% of cases), 17α-hydroxylase deficiency, 3β-hydroxysteroid dehydrogenase deficiency, P450 oxidoreductase deficiency and StAR deficiencies. In the 21-hydroxylase and 11β-hydroxylase deficiency, only adrenal steroidogenesis is affected, whereas a defect in 3β-hydroxysteroid dehydrogenase or 17α-hydroxylase also involves gonadal steroid biosynthesis. Many countries have introduced newborn screening programs based on immunoassays measuring 17-hydroxyprogesterone from blood spots used for other neonatal screening tests which enable faster diagnosis and treatment of CAH. Currently, chromatographic techniques coupled with mass spectrometry are gaining popularity due to an increase in the reliability of the test results.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 25-33
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Retrospective analysis of reactive hyperplastic lesions in the oral cavity
Autorzy:
Farynowska, Justyna
Błochowiak, Katarzyna
Trzybulska, Dorota
Wyganowska-Świątkowska, Marzena
Powiązania:
https://bibliotekanauki.pl/articles/454761.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
inflammatory fibrous hyperplasia fissuratum granuloma
peripheral giant cell granuloma irritation fibroma
pyogenic granuloma
Opis:
Introduction. Reactive hyperplastic lesions of the oral cavity are non-neoplastic lesions that result from low-grade chronic irritation of the oral mucosa. Objectives. The aim of this study was to present the epidemiological characteristics of reactive lesions. Materials and methods. The study was a retrospective analysis of the medical records of 116 patients with reactive lesions. The tissue specimens were obtained by biopsy. 115 patients underwent an excisional biopsy, whereas in one case an incisional biopsy was performed. Results. The most frequently encountered lesion was inflammatory fibrous hyperplasia (IFH) (n=37, 31.9%), followed by irritation fibroma (IF) (n=36, 31%), pyogenic granuloma (PG) (n=15, 12.9%), fissured granuloma (FG) (n= 14, 12.1%). The lesions were more commonly observed in females (n=70, 60.3%) than in males (n=46, 39.7%) with a ratio of 1.5:1, respectively. The buccal and labial mucosa were the most prevalent sites of reactive lesions. Most of the lesions were between >5 mm and ≤10 mm in diameter except for FGs, which were much bigger. Conclusions. Early detection and elimination of all potentially causative factors and irritants is a crucial matter, especially in the case of the vestibule of the oral cavity, which is the most susceptible area of the oral cavity
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 2; 92-96
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effects of osaterone acetate on clinical signs and prostate volume in dogs with benign prostatic hyperplasia
Autorzy:
Socha, P.
Zduńczyk, S.
Tobolski, D.
Janowski, T.
Powiązania:
https://bibliotekanauki.pl/articles/2087646.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
dogs
benign prostatic hyperplasia
osaterone acetate
prostate volume
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 4; 797-802
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Numerical investigations of the unsteady blood flow in the end-to-side arteriovenous fistula for hemodialysis
Autorzy:
Jodko, D.
Obidowski, D.
Reorowicz, P.
Jóźwik, K.
Powiązania:
https://bibliotekanauki.pl/articles/306702.pdf
Data publikacji:
2016
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
tętniak
anastomoza
choroba zatorowo-zakrzepowa
naprężenie styczne ścian
aneurysm
anastomosis
arteriovenous fistula
thrombosis
wall shear stress
intimal hyperplasia
Opis:
Purpose: The aim of this study was to investigate the blood flow in the end-to-side arteriovenous (a-v) fistula, taking into account its pulsating nature and the patient-specific geometry of blood vessels. Computational Fluid Dynamics (CFD) methods were used for this analysis. Methods: DICOM images of the fistula, obtained from the angio-computed tomography, were a source of the data applied to develop a 3D geometrical model of the fistula. The model was meshed, then the ANSYS CFX v. 15.0 code was used to perform simulations of the flow in the vessels under analysis. Mesh independence tests were conducted. The non-Newtonian rheological model of blood and the Shear Stress Transport model of turbulence were employed. Blood vessel walls were assumed to be rigid. Results: Flow patterns, velocity fields, the volume flow rate, the wall shear stress (WSS) propagation on particular blood vessel walls were shown versus time. The maximal value of the blood velocity was identified in the anastomosis – the place where the artery is connected to the vein. The flow rate was calculated for all veins receiving blood. Conclusions: The blood flow in the geometrically complicated a-v fistula was simulated. The values and oscillations of the WSS are the largest in the anastomosis, much lower in the artery and the lowest in the cephalic vein. A strong influence of the mesh on the results concerning the maximal and area-averaged WSS was shown. The relation between simulations of the pulsating and stationary flow under time-averaged flow conditions was presented.
Źródło:
Acta of Bioengineering and Biomechanics; 2016, 18, 4; 3-13
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Peripheral ossifying fibroma mimicking gingival ulcer: case report
Autorzy:
da Silva, Bruna Machado
Willig, Débora Hautsch
Brown, Michelle Antonette
Machado, Maria Ângela Naval
Powiązania:
https://bibliotekanauki.pl/articles/1401688.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
diagnosis
differential
hyperplasia
oral ulcer
fibroma
ossifying
Opis:
Peripheral ossifying fibroma (POF) is a non-neoplastic lesion, of uncertain aetiology, that originates from the gums or interdental papillae of the anterior maxilla. . It is most prevalent in the anterior maxilla –in women in the second and third decades of life. The lesion is well-defined with a sessile base and a surface similar in colour to mucosa or red, which may be intact or ulcerated. Clinical features do not confirm the diagnosis of this lesion, which requires histopathology. Our patient - B.M.S, a 23-year-old woman sought help of the Symptomatology Clinic at the School of Dentistry of the Federal University of Paraná, complaining of a “cold sore in the gum” for approximately one month. Clinical examination showed an erythematous area with central ulceration in the gingival margin and attached to the buccal region of tooth 22. Periodontal examination showed absence of bleeding, a periodontal pocket and absence of bone loss in the radiographs. There were no relevant findings in the auxiliary studies. Excisional biopsy was taken and the histopathological examination revealed the presence of dense fibrous stroma of collagen fibres, intermingled with fibroblasts, trabecular bone and a few giant cells, confirming the diagnosis. There was recurrence of the lesion. Surgical excision of the recurrent lesion was performed, including the removal of the periosteum and ligament, accompanied by dental scaling. It was concluded that further differential diagnosis was necessary to rule out clinically similar lesions to POF such as fibrous hyperplasia, peripheral giant cell granuloma and pyogenic granuloma. These lesions can mimic ulcers and therefore it is necessary to conduct histopathological examination to make the diagnosis. Furthermore, in order to minimize the tendency of recurrence of POF, it is essential to remove the underlying periosteum and periodontal ligament in addition to biofilm and calculus.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2016, 5, 3; 49-54
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of polymorphisms / mutations of PTEN, CDKN2A, TP53 genes and of hMSH6 gene in endometrial hyperplasia and carcinoma
Analiza polimorfizmów/mutacji genów PTEN, CDKN2A, TP53 oraz genu hMSH6 w rozrostach oraz rakach endometrium
Autorzy:
Bednarek, Michał
Constantinou, Maria
Kałużewski, Bogdan
Powiązania:
https://bibliotekanauki.pl/articles/1032553.pdf
Data publikacji:
2014
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
CDKN2A
PTEN
TP53
endometrial cancer
endometrial hyperplasia
hMSH6.
rozrost endometrium
rak endometrium
pten
cdkn2a
tp53
hmsh6
Opis:
Endometrial cancer belongs to the most frequent malignancies in the female genital organs with a growing incidence trend. The molecular changes, which are specific for particular stages of neoplastic transformation or the histopathological type of neoplasm, have not yet been described in any more uniform way. The goal of the undertaken studies was the evaluation of the polymorphisms / mutations of PTEN, CDKN2A, TP53 suppressor genes and of hMSH6 gene of incorrectly paired base-pairs in a group of female patients with endometrial hyperplasia and endometrial cancer. The studies involved forty-four (44) female patients: five (5) cases, despite the fact that clinical inclusion criteria had been met, no hyperplastic features were confirmed in a histopathological analysis. Twenty-six (26) patients with histopathologically confirmed endometrial hyperplasia and thirteen (13) patients with diagnosed carcinoma of uterine body mucosa were added into the study. The sequencing method was used for the identification of mutations / polymorphisms in MSH6, CDKN2A, PTEN and TP53 genes. Two changes were identified in TP53 gene: R175H G>A (CGC>CAC) polymorphism in exon 5 and R213R (CGA>CGG) synonimic change in exon 6 in 15% of the examined patients (2/13 cases of endometrial cancer). Regarding DNA sequence of exon 3 in MSH6 gene, the following polymorphism was found in 29% of the patients: D180D (GAT>GAC). None of the patients demonstrated any changes, either in DNA sequence of CDKN2A gene or in exons 2, 5, 7 and 8 of the PTEN gene.
Rak endometrium należy do najczęstszych nowotworów złośliwych żeńskich narządów płciowych. Rejestruje się stały wzrost liczby zachorowań. Dotychczas nie zostały jednoznacznie opisane zmiany molekularne, specyficzne dla poszczególnych etapów transformacji nowotworowej lub typu histopatologicznego nowotworu. Celem podjętych badań była analiza polimorfizmów/ mutacji genów supresorowych PTEN, CDKN2A, TP53 oraz genu naprawy błędnie sparowanych zasad hMSH6 w grupie pacjentek z rozrostem endometrium oraz rakiem endometrium. Badaniami objęto 44 pacjentki: w 5 przypadkach, pomimo spełnienia klinicznych kryteriów włączenia, histopatologicznie nie potwierdzono cech rozrostu, do dalszych badań włączono 26 pacjentek z histopatologicznie potwierdzonym rozrostem endometrium oraz 13 pacjentek ze zdiagnozowanym rakiem błony śluzowej trzonu macicy. Do identyfikacji mutacji/polimorfizmów w genach MSH6, CDKN2A, PTEN i TP53 wykorzystano metodę sekwencjonowania. W genie TP53 wykryliśmy dwie zmiany: polimorfizm R175H G>A (CGC>CAC) w egzonie 5 oraz zmianę synonimiczną R213R (CGA>CGG) w egzonie 6 u 15% badanych (2/13 przypadków raka endometrium). W sekwencji DNA egzonu 3 genu MSH6 u 29% pacjentek został wykryty polimorfizm: D180D (GAT>GAC). U żadnej z pacjentek nie została wykryta zmiana w sekwencji DNA genu CDKN2A oraz w egzonach 2; 5; 7 i 8 genu PTEN.
Źródło:
Folia Medica Lodziensia; 2014, 41, 1; 17-32
0071-6731
Pojawia się w:
Folia Medica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 22

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