Temat: human cell - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Transgenic mammalian species, generated by somatic cell cloning, in biomedicine, biopharmaceutical industry and human nutrition/dietetics - recent achievements
Autorzy:: Samiec, M.
Skrzyszowska, M.
Powiązania:: https://bibliotekanauki.pl/articles/31809.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: transgenic mammal
somatic cell
cell cloning
transgenesis
mammary gland
biomedicine
biopharmaceutical industry
human nutrition
dietetics
Opis:: Somatic cell cloning technology in mammals promotes the multiplication of productively-valuable genetically engineered individuals, and consequently allows also for standardization of transgenic farm animal-derived products, which, in the context of market requirements, will have growing significance. Gene farming is one of the most promising areas in modern biotechnology. The use of live bioreactors for the expression of human genes in the lactating mammary gland of transgenic animals seems to be the most cost-effective method for the production/processing of valuable recombinant therapeutic proteins. Among the transgenic farm livestock species used so far, cattle, goats, sheep, pigs and rabbits are useful candidates for the expression of tens to hundreds of grams of genetically- engineered proteins or xenogeneic biopreparations in the milk. At the beginning of the new millennium, a revolution in the treatment of disease is taking shape due to the emergence of new therapies based on recombinant human proteins. The ever-growing demand for such pharmaceutical or nutriceutical proteins is an important driving force for the development of safe and large-scale production platforms. The aim of this paper is to present an overall survey of the state of the art in investigations which provide the current knowledge for deciphering the possibilities of practical application of the transgenic mammalian species generated by somatic cell cloning in biomedicine, the biopharmaceutical industry, human nutrition/dietetics and agriculture.
Źródło:: Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Tissue engineering of bone: the role of osteoblasts in osteogenesis and peri-implant bone healing
Autorzy:: Wróbel, E.
Witkowska-Zimny, M.
Powiązania:: https://bibliotekanauki.pl/articles/284980.pdf
Data publikacji:: 2013
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: bone tissue engineering
osteoblasts
human bone-derived cells
peri-implant bone healing
osteogenesis
cell culture
Opis:: Osteoblasts are cells of mesenchymal origin, which rebuild resorbed bone by synthesizing bone matrix proteins and by inducing bone matrix mineralization. Osteoblasts play a crucial role in creating and maintenance of healthy bone architecture, bone repair, and peri-implant bone healing (osseointegration). These bone-forming cells are also involved in regulation of osteoclasts function, and hence bone resorption in osteoclastogenesis process. We have presented our own studies on the subsequent stages of differentiation of Human Bone-Derived Cells (HBDCs) that could be a good candidate as an autogenous source for reconstruction and rebuilding of own patient's bone using tissue engineering methods. In this review we discussed the biology of osteoblasts, compared with the HBDCs cultures, under the influence of growth factors (FGF-2, TGF-ß, IGF, PDGF) and hormones (PTH, 1,25-dihydroxyvitamin D3, leptin). Our review is also focused on the participation of intercellular adhesion proteins (cadherins, claudins, connexin, 'OsteoMacs'), transcription factors (Cbfal, Msx-2, Osx, ATF4), and others molecules (RANKL, OPG, BMP2, lactofferin, PPARY) in modulating osteoblasts functions on the basis of current reports, throwing new light on the involvement of osteoblasts during osteogenesis and peri-implant bone healing.
Źródło:: Engineering of Biomaterials; 2013, 16, 119; 2-7
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: The effect of oxytocin on hCG action in phosphoinositide turnover in porcine myometrial smooth muscle cells
Autorzy:: Kisielewska, J
Ziecik, A.J.
Powiązania:: https://bibliotekanauki.pl/articles/69570.pdf
Data publikacji:: 1995
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: pig
endometrium
inositol phosphate
cell
mice
myometrium
human myometrium cell
rat
porcine uterus
mouse
phosphoinositide turnover
porcine endometrium
oxytocin
bovine endometrium
smooth muscle
rabbit
hormone
Źródło:: Journal of Physiology and Pharmacology; 1995, 46, 3
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Thapsigargin inhibits the effects of noradrenaline and high [Ca2]0 on kinetics but not on amplitude of contraction in the single myocytes of guinea pig heart
Autorzy:: Janiak, R
Lewartowski, B.
Powiązania:: https://bibliotekanauki.pl/articles/69734.pdf
Data publikacji:: 1995
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: cell isolation
sarcoplasmic reticulum
cardiac myocyte
human physiology
noradrenaline
guinea pig
single myocyte
heart
thapsigargin
Źródło:: Journal of Physiology and Pharmacology; 1995, 46, 1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Synthesis and in vitro anticancer activity of N-alkyl phosphoramidate monoesters of 3N-azido-3N-deoxythymidine (AZT)
Autorzy:: Czajkowska-Wojciechowska, E.
Singh, A.
Trznadel, R.
Ruszkowski, P.
Celewicz, L.
Powiązania:: https://bibliotekanauki.pl/articles/81295.pdf
Data publikacji:: 2019
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: anticancer activity
N-alkyl phosphoramidate monoester
3N-azido-3N-deoxythymidine
human cell line
cancer cell line
cervical cancer
HeLa cell line
KB cell
MCF-7 cell line
dermal fibroblast
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 1
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Status embrionów ludzkich na tle zdolności patentowej wynalazków biotechnologicznych
The status of the human embryo in the context of the patentability of biotechnological inventions
Autorzy:: Bressa, Karolina
Powiązania:: https://bibliotekanauki.pl/articles/684729.pdf
Data publikacji:: 2015
Wydawca:: Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:: human embryo
pluripotent cells
patents
directive 98/44/WE
case C-34/10 Oliver Brustle vs Greenpeace eV
case C-364/13 International Stem Cell Corporation vs Comptroller General of Patents
Opis:: This article presents an overview of the issues surrounding the patenting of inventions concerning the use of the human body, the status of the human embryo and the admissibility of patenting human embryos. In his analysis, the author refers to the provisions of directive 98/44/EC of the European Parliament and of the Council from the 6th July 1998 on the legal protection of biotechnological inventions, which is the main European Union legal act on patenting biological material. Issues discussed in this article refer to article 5 of the above-mentioned directive, according to which the human body, at the various stages of its formation and development, cannot constitute a patentableinvention.
Źródło:: Adam Mickiewicz University Law Review; 2015, 5; 85-94
2450-0976
Pojawia się w:: Adam Mickiewicz University Law Review
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Sp1 mediates phorbol ester (PMA)-induced expression of membrane-bound guanylyl cyclase GC-A in human monocytic THP-1 cells
Autorzy:: Mitkiewicz, Małgorzata
Bac, Bernadeta
Kuropatwa, Marianna
Kurowska, Ewa
Matuszyk, Janusz
Siednienko, Jakub
Powiązania:: https://bibliotekanauki.pl/articles/1038369.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: membrane-bound guanylyl cyclase type A
phorbol 12-myristate 13-acetate
human monocytic cell line THP-1
protein kinases
Sp1 transcription factor
Opis:: Cyclic guanosine monophosphate (cGMP) is synthesized by two types of enzymes: particulate (membrane-bound) guanylyl cyclases (pGCs) and soluble (cytosolic) guanylyl cyclases (sGCs). sGCs are primarily activated by binding of nitric oxide to their prosthetic heme group while pGCs are activated by binding of peptide ligands to their extracellular domains. One of them, pGC type A (GC-A) is activated by atrial and brain natriuretic peptides (ANP and BNP, respectively). Human monocytes isolated from peripheral blood mononuclear cells have been found to display sGC expression without concomitant expression of GC-A. However, GC-A activity appears in monocytes under certain conditions but a molecular mechanism of GC-A expression is still poorly understood. In this report we show that phorbol ester (PMA) induces transcription of a gene encoding GC-A in human monocytic THP-1 cells. Moreover, we find that PMA-treated THP-1 cells raise cGMP content following treatment with ANP. Studies using pharmacological inhibitors of protein kinases suggest involvement of protein kinase C (PKC), mitogen extracellular kinases (MEK1/2), and extracellular signal-regulated kinases (ERK1/2) in PMA-induced expression of the GC-A encoding gene in THP-1 cells. Finally, we show that PMA stimulates binding of Sp1 transcription factor to GC-rich DNA sequences and mithramycin A (a selective Sp1 inhibitor) inhibits expression of the GC-A mRNA in PMA-treated THP-1 cells. Taken together, our findings suggest that the PMA-stimulated PKC and MEK/ERK signaling pathways induce Sp1-mediated transcription of the GC-A encoding gene in human monocytic THP-1 cells.
Źródło:: Acta Biochimica Polonica; 2018, 65, 3; 409-414
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Selected pathogenic characteristics of fungi from the genus Candida
Autorzy:: Modrzewska, B.
Kurnatowski, P.
Powiązania:: https://bibliotekanauki.pl/articles/5927.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: pathogenic fungi
fungi
Candida
virulence factor
hypha
tropism
biofilm formation
phenotypic switching
human disease
host cell
host-pathogen relationship
fungal infection
Źródło:: Annals of Parasitology; 2013, 59, 2
0043-5163
Pojawia się w:: Annals of Parasitology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Search for mouse gene related to GA733 human tumor antigen gene
Autorzy:: Zielewicz, J
Skrzypczak, M.
Wojcierowski, J.
Powiązania:: https://bibliotekanauki.pl/articles/2048195.pdf
Data publikacji:: 1995
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: human antigen
glycoprotein
human genetics
mice
gene sequence
adenocarcinoma
cancer therapy
electrophoresis
carcinoma cell
bacteriophage
antigen
gene
mouse
oncoantigen
hybridization
tumour etiology
tumour
DNA
Opis:: Human antigen GA733-1, defined as 40 kDa cell glycoprotein, is one of the antigens associated with gastrointestinal carcinomas. Its studies may contribute to the tumor etiology and therapy effects in animal model.
Źródło:: Journal of Applied Genetics; 1995, 36, 3; 273-277
1234-1983
Pojawia się w:: Journal of Applied Genetics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Role of iron in pathogenesis of Parkinson disease
Autorzy:: Galazka-Friedman, J.
Friedman, A.
Powiązania:: https://bibliotekanauki.pl/articles/80638.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: cell membrane
electron microscopy
ELISA test
ferritin
free radical
human brain
iron
lipid peroxidation
liver
neurodegeneration
oxidative stress
Parkinson's disease
pathogenesis
substantia nigra
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Phthalates - widespread occurrence and the effect on male gametes. Part 1. General characteristics, sources and human exposure
Autorzy:: Dobrzynska, M.M.
Powiązania:: https://bibliotekanauki.pl/articles/871923.pdf
Data publikacji:: 2016
Wydawca:: Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:: phthalate
occurrence
male
germ cell
human tissue
concentration
excretion
phthalate source
human exposure
Opis:: Phthalates are widely present in human environment. Widespead exposure to those agents, which are compounds of numerous daily use products, is unavoidable. In the current paper following phthalates benzylbutyl phthalate (BBP), din- butyl phthalate (DBP), di(2-ethylhexyl)phthalate (DEHP), diethyl phthalate (DEP), di-isononyl phthalate (DINP) are described. Phthalates mainly enter to the composition of plastic goods, like boxes and containers for storage of foods, toys, medical devices, and also cosmetics, personal care products, as well as paints, vanishes, printing inks. This paper describes the occurence of individual phthalates in the environment (water, air) and in different products. During production, transportation, manufacturing of goods and improper disposal, phthalates released into soil, water and air. For example indoor air included 13 mg/m3 phthalates, where 72 % of all constitutes DEP (2.29 mg/m3), BBP (3.97 mg/m3) and DEHP (2.43 mg/m3). Exposure to phthalates take place mainly by ingestion or inhalation air or through the skin. Presence of phthalates were observed in numerous food products and is connected with migration of those compounds from food storage containers to preserved food. They could mirgate to salivia during sucking and chewing of toys and this way increased exposure to of children. The results of studies regarding to concentration of phthalates in human tissues and excretions are also described. The level of phthalates were measured in numerous of human biological samples. For example, DEHP, DEP and DBP were detected at levels of 5.71 mg/L in blood serum, of 0.30 mg/L in semen and of 0.72 mg/kg in fat samples.
Ftalany są szeroko rozpowszechnione w środowisku człowieka. Powszechne narażenie na te związki, które wchodzą w skład wielu produktów codziennego użytku jest nieuniknione. W niniejszej pracy opisano ftalany butylobenzylu (BBP), dibutylu (DBP) i dietyloheksylu (DEHP), dietlylu (DEP) oraz diizononylu (DINP). Ftalany przede wszytkim wchodzą w skład wyrobów plastikowych, takich jak pojemników do przechowywania żywności, zabawek, wyrobów medycznych oraz kosmetyków środków higieny osobistej, a także farb, lakierów, tuszów drukarskich. W niniejszej pracy opisano występowanie poszczególnych ftalanów w w środowisku (np. w wodzie, powierzu) oraz w różnych produktach. Podczas produkcji, transportu, wyrobu produktów oraz niewłaściwej utylizacji, ftalany przenikają do gleby, wody i powietrza. Na przykład, w powietrzu w pomieszczeniach stwierdzono 13 mg/m3 ftalanów, z których 72% of stanowiły DEP (2,29 mg/m3), BBP (3,97 mg/m3) i DEHP (2,43 mg/m3). Narażenie na ftalany nastepuje głównie drogą pokarmową, inhalacyjną oraz poprzez skórę. Obecność ftalanów stwierdzono w wielu produktach żywnościowych, co jest związane z migracją tych związków z opakowań do przechowywanej w nich żywności. Mogą migrować do śliny podczas ssania i żucia zabawek i w ten sposób powodują zwiększone narażenie niemowląt i małych dzieci. Omówiono także wyniki badań dotyczących stężenia ftalanów w tkankach i wydalinach ludzkich. Stężenie ftalanow mierzone było w różnych thankach ludzkich. Przykładowo, obecność DEHP, DEP i DBP stwierdzono w surowicy krwi (5,71 mg/l), w nasieniu (0,30 mg/l) oraz w tłuszczu (0,72 mg/kg).
Źródło:: Roczniki Państwowego Zakładu Higieny; 2016, 67, 2
0035-7715
Pojawia się w:: Roczniki Państwowego Zakładu Higieny
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Oral squamous cell carcinoma (OSCC) - molecular, viral and bacterial concepts
Autorzy:: Polz-Gruszka, D.
Macielag, P.
Foltyn, S.
Polz-Dacewicz, M.
Powiązania:: https://bibliotekanauki.pl/articles/3323.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: human disease
cancer
oral squamous cell carcinoma
molecular aspect
viral aspect
bacterial concept
genetic abnormality aspect
epigenetic aspect
Opis:: Head and neck cancers constitute the sixth most common malignant tumours worldwide, and are one of the majors problems of global public health. In the oral cavity there are several types of oral cancers, but around 90% are squamous cell carcinoma. Many different risk factors play a role in the etiology of head and neck cancer. The aim of this study is presentation from the aspect of molecular, viral and bacterial infection. Knowledge about all factors which influence the development of these malignances is essential for diagnostics and successful treatment.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Optimization of differentiation time of mesenchymal-stem-cell to tenocyte under a cyclic stretching with a microgrooved culture membrane and selected measurement cells
Autorzy:: Morita, Y.
Yamashita, T.
Toku, Y.
Yu, Y.
Powiązania:: https://bibliotekanauki.pl/articles/307018.pdf
Data publikacji:: 2018
Wydawca:: Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:: różnicowanie
kości
stymulacja mechaniczna
hBMSC
cyclic stretch
differentiation
differentiation time
human bone marrow-derived mesenchymal stem cell
mechanical stimulus
tenocyte
Opis:: There is a need for efficient stem cell-to-tenocyte differentiation techniques for tendon tissue engineering. More than 1 week is required for tenogenic differentiation with chemical stimuli, including co-culturing. Research has begun to examine the utility of mechanical stimuli, which reduces the differentiation time to several days. However, the precise length of time required to differentiate human bone marrow-derived mesenchymal stem cells (hBMSCs) into tenocytes has not been clarified. Understanding the precise time required is important for future tissue engineering projects. Therefore, in this study, a method was developed to more precisely determine the length of time required to differentiate hBMSCs into tenocytes with cyclic stretching stimulus. Methods: First, it had to be determined how stretching stimulation affected the cells. Microgrooved culture membranes were used to suppress cell orientation behavior. Then, only cells oriented parallel to the microgrooves were selected and evaluated for protein synthesis levels for differentiation. Results: The results revealed that growing cells on the microgrooved membrane and selecting optimally-oriented cells for measurement improved the accuracy of the differentiation evaluation, and that hBMSCs differentiated into tenocytes in approximately 10 h. Conclusions: The differentiation time corresponded to the time required for cellular cytoskeleton reorganization and cellular morphology alterations. This suggests that cells, when subjected to mechanical stimulus, secrete mRNAs and proteins for both cytoskeleton reorganization and differentiation.
Źródło:: Acta of Bioengineering and Biomechanics; 2018, 20, 1; 3-10
1509-409X
2450-6303
Pojawia się w:: Acta of Bioengineering and Biomechanics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Limited pattern of TCR delta chain gene rearrangement on the RNA level in multiple sclerosis
Autorzy:: Nowak, J
Januszkiewicz, D.
Pernak, M.
Hertmanowska, H.
Nowicka-Kujawska, K.
Rembowska, J.
Lewandowski, K.
Nowak, T.
Wender, M.
Powiązania:: https://bibliotekanauki.pl/articles/2041829.pdf
Data publikacji:: 2001
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: patient
human genetics
brain
multiple sclerosis
autoagression
T cell receptor rearrangement
gene rearrangement
RNA level
chain gene
Źródło:: Journal of Applied Genetics; 2001, 42, 4; 531-540
1234-1983
Pojawia się w:: Journal of Applied Genetics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Integrin αv signaling influences phenotype and maturation of primary human osteoblasts on alumina surface
Autorzy:: Wróbel, E.
Witkowska-Zimny, M.
Mrówka, P.
Głodkowska-Mrówka, E.
Powiązania:: https://bibliotekanauki.pl/articles/284664.pdf
Data publikacji:: 2014
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: integrin
human bone-derived cells
osteogenic differentiation
cell adhesion
biomaterial
Opis:: Due to the growing interest in stem cells application in tissue engineering the better understanding of primary human osteoblasts behavior in vitro, on biomaterial surface, is required. Among other molecules integrins may be taken into account as being involved in these phenomena. Integrins are a family of cell adhesion receptors, which may regulate many cellular functions e.g., adhesion, motility, phenotype and cell maturation. The aim of this study was to determine the effect of the biomaterial surfaces and αv integrin signaling pathway on the behavior, phenotype and maturation of human osteoblasts in vitro. Human bone derived cells (HBDCs) obtained from adult femoral bone fragments were cultured on both alumina disks and tissue culture polystyrene (TCPS) dishes. After 7, 14, and 21 days of culture, localization and mRNA expression level of αv integrin subunits and BGLAP (osteocalcin) on polystyrene were analyzed in addition, we treated the cell cultures with monoclonal antibodies against human αv integrin to block its ligand-binding activity, on both alumina and TCPS substrates. We found that the αv integrin was present in focal contacts and cell cytoplasm at subsequent stages of cell maturation and the level of αv integrin mRNA was the highest in mature osteoblasts. Blocking αv integrin transduction pathway caused changes in cell activity and morphology, decreased cells proliferation on TCPS and reduced expression of alkaline phosphatase (ALP) on both materials. The results suggest that αv integrin is involved as an important receptor facilitating osteogenic differentiation.
Źródło:: Engineering of Biomaterials; 2014, 17, 127; 33-39
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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