Temat: high-throughput screening - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: High-throughput screening of stomatal responses to biotic stresses reveals new components of immune signalling
Autorzy:: McLachlan, D.
Bourdais, G.
Zhou, J.
Robatzek, S.
Powiązania:: https://bibliotekanauki.pl/articles/80863.pdf
Data publikacji:: 2013
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: conference
high-throughput screening
stomatal response
biotic stress
abiotic stress
carbon dioxide flux
pathogen-associated molecular pattern
signalling
guard cell
Arabidopsis
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Dynaflow ™ 48, a microfluidic chip solution for increasing throughput and data quality in patch-clamp-based drug screening
Autorzy:: Granfeldt, Daniel
Johansson, Marie-Louise
Sinclair, Jon
Pihl, Johan
Karlsson, Mattias
Powiązania:: https://bibliotekanauki.pl/articles/764995.pdf
Data publikacji:: 2006
Wydawca:: Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:: high throughput
ion channel screening
patch clamp
microfluidics
GABAa receptor
Opis:: Ion channels are transm embrane proteins, found in virtually all cell types throughout the human body. Ion channels underlie neural communication, memory, behavior, every movement and heartbeat, and are as such prone to cause disease if malfunctioning. Therefore ion channels are very important targets in drug discovery. The gold standard technique for obtaining information on ion channel function with high information content and temporal resolution is patch-clamp. The technique measures the minute currents originating from the movement of ions across the cellular membrane, and enables determination of the potency and efficacy of a drug. However, patch-clamp suffers from serious throughput restrictions due to its laborious nature. To address the throughput problems we have developed a microfluidic chip containing 48 microchannels for an extremely rapid, sequential delivery of a large number of completely controlled solution environments to a lifted, patch-clamped cell. In this way, throughput is increased drastically compared to classical patch-clamp perfusion set-ups, with uncompromised data quality. The 48-microchannel chip has been used for the characterization of drugs affecting ligand-gated ion channels including agonists, antagonists and positive modulators with positive effects on both throughput and data quality.
Źródło:: Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2006, 3
1730-2366
2083-8484
Pojawia się w:: Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Virtual screening strategies in drug design – methods and applications
Autorzy:: Bielska, E.
Lucas, X.
Czerwoniec, A.
Kasprzak, J.M.
Kaminska, K.H.
Bujnicki, J.M.
Powiązania:: https://bibliotekanauki.pl/articles/80139.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: virtual screening
drug design method
application
drug discovery
similarity search
drug development
high-throughput screening
medical chemistry
chemical compound
experimental approach
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 3
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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