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Wyszukujesz frazę "hexosaminidase" wg kryterium: Temat


Wyświetlanie 1-3 z 3
Tytuł:
Isoenzymes of N-acetyl-β-hexosaminidase in complicated pregnancy
Autorzy:
Arciuch, Leszek
Bielecki, Dariusz
Borzym, Małgorzata
Południewski, Grzegorz
Arciszewki, Krzysztof
Różański, Andrzej
Zwierz, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1044458.pdf
Data publikacji:
1999
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
pregnancy
placenta
N-acetyl-β-hexosaminidase
isoenzymes
Opis:
The activity of N-acetyl-β-hexosaminidase was found to be significantly higher in the placentas collected after delivery from women in puerperium with symptoms of prolonged pregnancy or complicated by EPH gestosis, than in placentas from normal pregnancy. Isoelectrofocusing of placenta homogenates showed the presence of isoenzymes A, P and B of N-acetyl-β-hexosaminidase. Different isoenzyme A patterns in homogenates were observed in placentas obtained from normal and prolonged pregnancies and in those complicated by EPH gestosis.
Źródło:
Acta Biochimica Polonica; 1999, 46, 4; 977-983
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of N-acetyl-β-d-hexosaminidase in cholesteatoma tissue
Autorzy:
Olszewska, Ewa
Olszewski, Slawomir
Borzym-Kluczyk, Malgorzata
Zwierz, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1041088.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hexosaminidase
cholesteatoma
HEX activity
normal retroauricular skin
Opis:
Cholesteatoma is a destructive disease characterized by the progressive expansion of keratinizing squamous epithelium in the middle ear and mastoid, and chronic inflammatory reaction of the subepithelial connective tissue. N-Acetyl-β-d-hexosaminidase (HEX) catalyzes the release of terminal non-reducing N-acetyl-d-hexosamine residues acting on glucosides and galactosides in glycoproteins, GM2-gangliosides and glycosaminoglycans (GAGs). In this study the activities of HEX were measured in cholesteatoma tissue and in normal skin to demonstrate a possible role of HEX in bone resorption in the area adjacent to cholesteatoma. Cholesteatomas (n = 21) and normal adult retroauricular skin (controls, n = 21), were collected from patients during surgery due to chronic otitis media. In 20 of 21 specimens a significantly higher activity of HEX was observed in cholesteatoma tissue compared with that in normal skin. Mean release of HEX from the activated cells was 68.55 ± 30.77 nkat/g wet tissue in cholesteatoma and 31.79 ± 10.02 nkat/g wet tissue in skin specimens. It may explain the process of bone resorption in the area adjacent to cholesteatoma, i.e. ossicles or temporal bone. This study suggests that drugs inhibiting HEX activity, such as iminocyclitols, may be useful in cholesteatoma treatment.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 365-370
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determination of lysosomal exoglycosidases in human saliva
Autorzy:
Chojnowska, Sylwia
Zalewska, Anna
Knaś, Małgorzata
Waszkiewicz, Napoleon
Waszkiel, Danuta
Kossakowska, Agnieszka
Zwierz, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1039339.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
β-galactosidase
β-glucuronidase
α-fucosidase
α-mannosidase
N-acetyl-β-D-hexosaminidase
saliva
Opis:
Background: Currently we observe a growing interest in human saliva as a non-invasive material for diagnosis and monitoring of general and oral diseases. Methods: The aim of our study was adaptation of the Marciniak et al. (Marciniak J, Zalewska A, Popko J, Zwierz K, 2006, Clin Chem Lab Med 44: 933-937) method for determination of HEX and GLU activity in synovial fluid, and for determination of: HEX and GLU, as well as MAN, GAL, and FUC activity in human saliva. Results: Under optimal conditions, 10 μl of saliva for HEX, and 30 μl for GLU, MAN, GAL and FUC, were sufficient for determination of human salivary exoglycosidases activity with variation coefficient ranging from 0.89 for GLU to 0.99 for GAL. Conclusion: The adapted method for exoglycosidases activity determination in human saliva is sufficiently sensitive and precise to use in clinical diagnosis.
Źródło:
Acta Biochimica Polonica; 2014, 61, 1; 85-90
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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