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Tytuł:
Viral hepatitis C in Poland in the Silesian Province between 2005–2014
Autorzy:
Braczkowska, B.
Kowalska, M.
Barański, K.
Mendera-Bożek, U.
Powiązania:
https://bibliotekanauki.pl/articles/2081675.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
Silesia
hepatitis C
epidemiology
Polska
Opis:
Introduction and objective. Viral hepatitis C remains one of the major health and social problems related to infectious diseases in Poland. The aim of the study was assessment of the registered changes in the incidence of HCV in the Silesian Province of western Poland during the last 10 years, including age, gender and place of residence. Materials and method. A retrospective analysis was performed of the HCV incidence between 2005–2014 in the Silesian Province. The crude and standardized incidence rates were calculated for males and females in each year. Subsequently, the territorial diversity of the epidemiological situation in the districts was assessed by calculating the average incidence rate over the entire study period. Results. Incidence rates calculated according to the case definition of 2005 ranged between 5.95/100000 in 2005 to 10.36/100000 in 2014. Analysis of the structure of the incidence showed that during the analyzed period, the majority of hepatitis C cases were related to males (52.5%) rather than females (47.5%), and hepatitis C was more prevalent in younger males (aged 20–49) and older females (aged over 50). After excluding the effect of age, the standardized rates were twice as low, compared to the crude incidence rates. Conclusions. An increase in the HCV incidence rate was observed in males and females. It is obvious that the detection of additional cases will entail the need to provide funding for the treatment of more patients, which should be included in the map of regional health needs in the coming years. Our study demonstrates the temporal and spatial variability of HCV incidence in the Silesian Province of Poland. The observed increase in the crude and standardized rates suggests that the current registry system of HCV in Poland is more effective now. The current situation is comparable with the data in other EU countries.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 2; 224-228
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Existing and future therapeutic options for hepatitis C virus infection.
Autorzy:
Bretner, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1041462.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
antiviral agents
hepatitis C virus
Opis:
Hepatitis C virus (HCV) infection is an important cause of chronic hepatitis, cirrhosis, hepatocellular carcinoma and liver failure worldwide. Chronic hepatitis C virus infection is treated with interferon-a (IFN-α), pegylated interferon-α (PEG-IFNα) alone or in combination with ribavirin; however, a significant fraction of patients either fail to respond or relapse after cessation of therapy. Efforts to identify and develop highly specific and potent HCV inhibitors have intensified recently. Each of the virally encoded replication enzymes has been a focus of studies as well as viral receptors and the host immune system. This review summarizes recent progress in the search for novel anti-HCV agents.
Źródło:
Acta Biochimica Polonica; 2005, 52, 1; 57-70
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of tunicamycin on the biogenesis of hepatitis C virus glycoproteins
Autorzy:
Reszka, Natalia
Krol, Ewelina
Patel, Arvind
Szewczyk, Boguslaw
Powiązania:
https://bibliotekanauki.pl/articles/1040320.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
glycoproteins
glycosylation inhibition
hepatitis C virus
tunicamycin
Opis:
Hepatitis C virus (HCV) infects humans, with a prevalence around 3% of population, causing acute and chronic hepatitis and hepatocellular carcinoma. We studied the effect of inhibition of glycosylation on the assembly of the HCV particle. HCV possesses two envelope glycoproteins E1 and E2 that are highly modified by N-glycans. These glycan residues are crucial for viral entry and maturation of the progeny. Here, we examined the influence of inhibition of N-glycosylation on expression of E1 and E2. Since the propagation of HCV in cell culture is limited, we used a recombinant baculovirus producing viral-like particles in insect cells. Our data showed that blocking of N-glycan transfer to the nascent polypeptide chain with the antibiotic tunicamycin resulted in the loss of E1 and E2. We also found that a dose of tunicamycin that did not influence the cell viability significantly reduced the E2 level in infected cells. The results indicate that blocking of glycosylation at an early step efficiently reduces the assembly of HCV virions. Thus, we suggest that derivatives of tunicamycin that preferentially block glycosylation of viral proteins may become potential therapeutic agents against HCV.
Źródło:
Acta Biochimica Polonica; 2010, 57, 4; 541-546
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Risk behaviours associated with hepatitis C infection: application of a syndemic effects framework in NHANES
Autorzy:
Stefanac, Sinisa
Haider, Sandra
Dorner, Thomas
McDermott, Daragh
Ilie, Petre
Powiązania:
https://bibliotekanauki.pl/articles/1491142.pdf
Data publikacji:
2021-04-05
Wydawca:
Atena Research Association
Tematy:
Hepatitis C Virus
Syndemic
Intravenous Drug Use
Risk
Disparity
Opis:
Objectives: To apply syndemic theory to investigate the risk of hepatitis C virus (HCV) infection in the US population. Methods: National representative data were from the National Health and Nutrition Examination Survey. We extracted and aggregated data on HCV antibody test, sociodemographic characteristics, alcohol and drug use, depression, sexual behaviour and sexually transmitted illnesses from 2005-2006 to 2011-2012. The study sample was restricted to men and women aged 20-59 years given the upper age limit of the risk factors used for the analysis. Results: Overall, 11,593 people were included in the analysis (52.2% female). Higher prevalence of HCV, excessive alcohol consumption and drug use were found in men. Men also had higher odds of HCV in comparison to women among younger (20-39 years old) OR 1.37 (95%CI 1.36-1.37) and middle-aged adults (40-59 years old) OR 2.04 (95%CI 2.03-2.04). Among younger adults, non-Hispanic black and Hispanic people were found to have a lower likelihood of testing positive, OR 0.35 (95%CI 0.35-0.35) and OR 0.30 (95%CI 0.30-0.30), respectively. However, in the middle-aged adults non-Hispanic black people were found to have a higher likelihood of testing positive OR 1.45 (95%CI 1.45-1.46). Analysis showed that for each additional risk factor associated with HCV infection there is an additional increase in the risk OR 1.55 (95%CI 1.55-1.55). Conclusions: For every additional risk factor for HCV a person is exposed to, the overall risk of HCV increases.
Źródło:
Atena Journal of Public Health; 2021, 3; 5-5
2695-5911
Pojawia się w:
Atena Journal of Public Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The assessment of knowledge about viral hepatitis among Polish society
Autorzy:
Ślusarz, Krystian
Szczygieł, Katarzyna
Sobala-Szczygieł, Barbara
Jaroszewicz, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1065218.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
HAV infection
HBV infection
HCV infection
knowledge assessment
viral hepatitis A
viral hepatitis B
viral hepatitis C
Opis:
Viral hepatitis is caused by viruses, the most important of which are hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV). New discoveries and new therapeutic options result in better and better results of treatment. However, the public's awareness of the occurrence of these diseases and the detection of infections as soon as possible is still important, what is associated with better outcomes. In order to assess the basic knowledge about viral hepatitis among Polish society, an online survey spread throughout Poland and covering mainly young people was created. 2205 responses were collected and analyzed. On the basis of the results obtained, it can be concluded that Polish youth have little knowledge about viral hepatitis, what is associated with less awareness of the possibility of infection.
Źródło:
World Scientific News; 2019, 135; 1-13
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hepatitis C - new developments in the studies of the viral life cycle
Autorzy:
Rychłowska, Małgorzata
Bieńkowska-Szewczyk, Krystyna
Powiązania:
https://bibliotekanauki.pl/articles/1040855.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hepatitis C virus
HCV replicons
HCVcc-cell culture-derived
HCV pseudoparticles
Opis:
Hepatitis C virus (HCV) is a causative agent of chronic liver disease leading to cirrhosis, liver failure and hepatocellular carcinoma. The prevalence of HCV is estimated as 3% of the world population and the virus is a major public health problem all over the world. For over 16 years, since HCV had been discovered, studies of the mechanisms of the viral life cycle and virus-host interactions have been hampered by the lack of a cell culture system allowing the virus to be grown in laboratory conditions. However, in recent years some new model systems to study HCV have been developed. The major breakthrough of the last two years was the cell culture system for maintaining the virus in an adapted hepatocyte-derived cell line. This review describes the techniques and applications of most of the in vitro systems and animal models currently used for working with hepatitis C virus.
Źródło:
Acta Biochimica Polonica; 2007, 54, 4; 703-715
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Circular dichroism analysis for multidomain proteins: studies of the irreversible unfolding of Hepatitis C virus helicase
Autorzy:
Gozdek, Agnieszka
Stankiewicz-Drogoń, Anna
Poznański, Jarosław
Boguszewska-Chachulska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1040814.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Lumry-Eyring model
Hepatitis C virus
protein unfolding
circular dichroism
NS3 helicase
Opis:
The non-structural protein 3 (NS3) of Hepatitis C virus (HCV) is a bifunctional enzyme with RNA-dependent NTPase/RNA helicase and serine protease activities, and thus represents a promising target for anti-HCV therapy. These functions are performed by two distinct moieties; the N-terminal protease domain and the C-terminal helicase domain that further folds into three structural subdomains. To obtain lower molecular mass proteins suitable for nuclear magnetic resonance studies of helicase-inhibitor complexes, helicase domains 1, 2, and 1+2 devoid of a hydrophobic β-loop were overexpressed and purified. Circular dichroism studies were carried out to confirm the secondary structure content and to determine thermodynamic parameters describing the stability of the proteins. Both thermal and GuHCl-induced unfolding experiments confirmed the multidomain organization of the helicase. The unfolding transition observed for domain 1+2 was in agreement with the model of two well-resolved successive steps corresponding to the independent unfolding of domains 1 and 2, respectively. In the case of the full-length helicase, the presence of domain 3 remarkably changed the transition profile, leading to fast and irreversible transformation of partially unfolded protein.
Źródło:
Acta Biochimica Polonica; 2008, 55, 1; 57-66
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Simple and non-invasive liver fibrosis stage prediction method
Autorzy:
Orczyk, T.
Pałys, M.
Porwik, P.
Musialik, J.
Błońska-Fajfrowska, B.
Powiązania:
https://bibliotekanauki.pl/articles/333411.pdf
Data publikacji:
2011
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
zwłóknienie wątroby
wirusowe zapalenie wątroby typu C
przewidywanie etapu
liver fibrosis
hepatitis C
stage prediction
Opis:
In this paper a simple and non-expensive indirect fibrosis stage prediction method is described. Presented method is non-invasive and is based on the results of the generic blood tests. The method is based on a statistical analysis of wide range of blood tests results supported with the experience of hepatologists.
Źródło:
Journal of Medical Informatics & Technologies; 2011, 17; 227-231
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stan wiedzy na temat wirusowego zapalenia wątroby typu B i C wśród młodzieży ponadgimnazjalnej
Hepatitis B and C knowledge among secondary school students
Autorzy:
Tomaszek, Lucyna
Matusiak, Monika
Mrowiec, Karolina
Powiązania:
https://bibliotekanauki.pl/articles/527042.pdf
Data publikacji:
2017
Wydawca:
Krakowska Akademia im. Andrzeja Frycza Modrzewskiego
Tematy:
wirusowe zapalenie wątroby typu B
wirusowe zapalenie wątroby typu C
poziom wiedzy
młodzież ponadgimnazjalna
hepatitis B
hepatitis C
knowledge
secondary school students
Opis:
Wprowadzenie: Wirusy HBV i HCV należą do najczęstszych przyczyn wirusowego zapalenia wątroby (WZW). Przewlekłe formy zakażenia mogą prowadzić do marskości wątroby oraz raka wątrobowokomórkowego, a w konsekwencji do śmierci. Z literatury przedmiotu wynika, że młode pokolenie nie posiada odpowiedniego zasobu wiedzy na ten temat, a brak świadomości ryzyka zakażenia wirusem HBV i HCV stwarza warunki do niekontrolowanej transmisji tych wirusów. Celem pracy była ocena poziomu wiedzy uczniów szkół ponadgimnazjalnych na temat WZW typu B i typu C. Materiał i metody: Badanie przeprowadzono wśród 250 uczniów szkół ponadgimnazjalnych za pomocą autorskiego kwestionariusza ankiety. Do analizy statystycznej użyto testów: U Manna-Whitneya, Kruskala-Wallisa, korelacji liniowej r Pearsona. Przyjęto istotność statystyczną na poziomie p<0,05. Wyniki: Największy odsetek badanych (54%) cechuje się niskim poziomem wiedzy nt. WZW typu B i C. Uczniowie nie mają świadomości, że WZW jest chorobą zakaźną i wirusy HBV oraz HCV mogą przetrwać poza organizmem człowieka. Nie wiedzą również, czy byli szczepieni przeciw WZW typu B, i błędnie uważają, że istnieje szczepionka przeciw wirusowi HCV. Tylko 4% badanych uczniów wykazało się wysokim poziomem wiedzy na ten temat. Istotnie większą wiedzę mają uczniowie płci żeńskiej (p=0,006) oraz mieszkańcy wsi (p=0,024). Głównym źródłem wiedzy jest Internet (55% odpowiedzi). Wnioski: Ogólny poziom wiedzy uczniów szkół ponadgimnazjalnych nt. WZW typu B i C jest niski. Wiedzę badanych determinuje płeć i miejsce zamieszkania, a jej głównym źródłem jest Internet.
Introduction: HBV and HCV are among the most common causes of viral hepatitis. Chronic forms of infection may lead to liver cirrhosis and hepatocellular carcinoma, and therefore death. From the literature it shows that the young generation does not have the right amount of knowledge on the subject, and lack of awareness of infection with HBV and HCV creates conditions for uncontrolled transmission of these viruses. The purpose of this study was to assess hepatitis B and C knowledge among secondary school students’. Material and methods: The study was conducted among the students enrolled in a upper secondary schools (N=250). In order to gather information a personal questionnaire was used. Statistical analysis was performed with Mann-Whitney U test, the Kruskal-Wallis test, Pearson correlation coeffi cient. P-values less than 0.05 were considered statistically signifi cant. Results: The largest percentage of respondents (54%) was characterized by a low level of knowledge about hepatitis B and C. Students are not aware that hepatitis is an infectious disease and viruses, HBV and HCV can survive outside the human organism. They do not know whether they were vaccinated against hepatitis B and mistakenly believe that there is a vaccine against HCV. Only 4% of the students showed a high level of knowledge on the subject. Indeed, more knowledgeable students are female (p=0.006) and rural residents (p=0.024). The main source of information is the Internet (55% of responses). Conclusions: General knowledge of secondary school students about hepatitis B and C is low. Students’ knowledge is determined by the gender and place of residence, and its main source is the Internet.
Źródło:
Państwo i Społeczeństwo; 2017, 4; 41-53
1643-8299
2451-0858
Pojawia się w:
Państwo i Społeczeństwo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hepatitis C virus epidemiology and prevention in Polish and Swiss population – similar and contrasting experiences
Autorzy:
Sakem, Benjamin
Madaliński, Kazimierz
Nydegger, Urs
Stępień, Małgorzata
Godzik, Paulina
Kołakowska, Agnieszka
Risch, Lorenz
Risch, Martin
Zakrzewska, Karolina
Rosińska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/990971.pdf
Data publikacji:
2016
Wydawca:
Instytut Medycyny Wsi
Tematy:
hepatitis c
acute and chronic hcv infection
epidemiological data
poland and switzerland
consequences of infection
access to treatment
Opis:
Objective. The aim of the study was to review available data on HCV in Poland and Switzerland, in order to compare the two European countries with respect to epidemiological situation and efficiency of the response systems. Materials and method. A search of registries, published and grey literature was performed to assemble data on prevalence, rate of detection of new cases, identified risk factors for transmission, mortality due to HCV, prevalence of HCC and the consequent liver transplantations, as well as data on treatment in Poland and Switzerland. Results. Overall, the prevalence of anti-HCV antibodies was similar, not exceeding 1%. However, the major transmission routes of HCV infections were different: medical procedures in Poland and drug injections in Switzerland. By combining the available information it was also possible to demonstrate important differences in efficiency of the response systems. There was approximately 1 new diagnosis per 100 estimated undiagnosed cases in the population in Poland per year, compared to 6 in Switzerland, and the treatment rate per 100 estimated active infections was 2 and 4, respectively. Conclusions. Scaling up of the diagnosis and treatment is necessary in both countries; however, the means to achieve this might differ, taking into account the higher concentration of the infections in risk groups in Switzerland than in Poland.
Źródło:
Annals of Agricultural and Environmental Medicine; 2016, 23, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 16

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