- Tytuł:
- Robust Identification Approach to Individualized Anemia Model
- Autorzy:
-
Akabua, E.
Inanc, T.
Gaweda, A.
Brier, M. E.
Kim, S.
Zurada, J. M. - Powiązania:
- https://bibliotekanauki.pl/articles/108768.pdf
- Data publikacji:
- 2011
- Wydawca:
- Społeczna Akademia Nauk w Łodzi
- Tematy:
-
hemoglobin
robust identification
Carathéodory-Fejér problem
erythropoeitin
anemia management - Opis:
- Over ninety percent of End Stage Renal Disease (ESRD) patients suffer from anemia due to insufficient endogenous production of human erythropoietin. Until the advent of Recombinant Human Erythropoietin (r-HuEPO) over 30 years ago, patients with ESRD were treated mainly with multiple blood transfusions. The high cost of r-HuEPO in addition to the narrow margin between an effective do-sage and toxicity in drug administration calls for optimal dosage strategy capable of minimizing cost and toxicity while at the same time achieving the desired do-sage outcome. It is well known from control theory that a controller can be de-signed for any plant provided there is readily available a valid model for such a plant. We present Robust Identification procedure, a dimensionality reduction technique capable of capturing the inherent dynamics of anemia patients; conse-quently producing individualized model suitable for robust control synthesis and any other controller design methodologies.
- Źródło:
-
Journal of Applied Computer Science Methods; 2011, 3 No. 2; 65-75
1689-9636 - Pojawia się w:
- Journal of Applied Computer Science Methods
- Dostawca treści:
- Biblioteka Nauki
Artykuł