Temat: head and neck cancer - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Report from the analysis of implementiation of 4th Head and Neck Cancer Awareness Week in Department of Otolaryngology in Międzyleski Hospital in Warsaw
Autorzy:: Dżaman, Karolina
Piskadło–Zborowska, Karolina
Pietniczka–Załęska, Mirosława
Powiązania:: https://bibliotekanauki.pl/articles/1398499.pdf
Data publikacji:: 2017
Wydawca:: Index Copernicus International
Tematy:: European Head and Neck Cancer Awareness Week
head and neck tumors
Opis:: Introduction: The aim of the study was to analyze the profile of patients who reported for free screening examinations during the 4th European Head and Neck Cancer Awareness Week to the Department of Otolaryngology, Miedzylesie Specialist Hospital, Warsaw, Poland. Material and methods: We enrolled 225 patients, aged 26-92 years (mean, 63 years). There were 149 women (66%) and 76 men (34%). All patients filled out a survey regarding risk factors of head and neck cancer (HNC), including symptoms and lifestyle characteristics. Subsequently, all participants underwent a complete laryngological examination. Results: Among the studied patients, we found the following lifestyle-related risk factors of HNC: tobacco use (22%), alcohol use more than 1 time per week (12%), oral sex (17%), multiple sexual partners (10%), rare dental checkups (24%), and dental prostheses (45%). The most frequent symptoms that prompted the patients to report for screening exams were as follows: chronic hoarseness (64%), xerostomia (39%), dysphagia (37%), nasal congestion (6%), and neck tumor (5%). Further imaging studies were ordered in 15 patients (7%), fiberoscopy in 25 (11%), and lesion excision in 18 (8%). Among the studied patients, 17 were referred for further oncological treatment, of whom 14 had benign tumors and 4 malignant tumors. Conclusions: The Head and Neck Cancer Awareness campaign increased the awareness of HNC, and it should systematically encompass people at increased risk. By implementing this program in our department, we were able to detect and initiate early treatment in 7.5% of the screened people. However, appropriate workup and treatment require funding and therefore systemic measures should be taken to enable a wide implementation of such screening programs.
Źródło:: Polish Journal of Otolaryngology; 2017, 71, 6; 35-39
0030-6657
2300-8423
Pojawia się w:: Polish Journal of Otolaryngology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Ocena wiedzy pacjentów na temat czynników ryzyka związanych ze stylem życia, a występowanie chorób nowotworowych głowy i szyi
Risk factors related to lifestyle affecting the occurrence of head and neck cancer
Autorzy:: Karbowiak, Urszula
Serzysko, Bogusława
Powiązania:: https://bibliotekanauki.pl/articles/1029873.pdf
Data publikacji:: 2018
Wydawca:: Państwowa Uczelnia Zawodowa we Włocławku
Tematy:: head and neck cancer
lifestyle
quality of life
Opis:: Introduction. Cancer is a complex pathological process that develops in the human body, destroying healthy cells progressively and leading to significant limitations in functioning and severe pain, sometimes persissitng even with the aid of painkillers. Cancerous diseases of the head and neck organs significantly reduce the quality of life compared to the population of healthy people. Aim. The aim of this study was to show whether smoking, alcohol and HPV are risk factors for head and neck cancer. Materials and methods. The study was conducted among 149 patients diagnosed with head and neck cancer in the Clinical Outpatient Center of Oncology Center in Gliwice with the consent of this heaktcare facility. The study used a questionnaire containing 38 questions. The study was carried out from November 2016 to January 2017. Results. The analysis of the results did not confirm that smoking, alcohol and HPV are the main risk factors for head and neck cancer. A large number of respodents did not answer the questions , which suggests patients' lack of knowledge or their denial of the harmfulness of the above-mentioned addictions. Conclusions. The majority of respondents were aware of the harmfulness of smoking and its effect on the development of cancer. However, they were not aware of the impact of drinking alcohol on the development of cancer. Most of the subjects knew what HPV is. However, the majority of respondents did not know that HPV belongs to oncogenic viruses. Smoking cigarettes differentiated their awareness of the impact of smoking on the development of cancer.
Wstęp. Choroba nowotworowa to złożony proces patologiczny, który rozwija się w ludzkim organizmie, który niszcząc zdrowe komórki prowadzi progresywnie do znacznych ograniczeń w funkcjonowaniu oraz znacznych dolegliwości bólowych, czasem nieustępujących po lekach przeciwbólowych. Choroba nowotworowa narządów głowy i szyi w znaczny sposób obniża jakość życia w porównaniu do populacji osób zdrowych. Cel. Celem tego badania była ocena wiedzy pacjentów na temat czynników ryzyka związanych ze stylem życia, a występowaniem chorób nowotworowych głowy i szyi. Materiał i metody. Badanie przeprowadzono wśród 149 pacjentów, u których rozpoznano chorobę nowotworową głowy i szyi w Przyklinicznej Przychodni Centrum Onkologii w Gliwicach za zgodą tejże palcówki. W badaniu posłużono się autorska ankietą zawierającą w 38 pytań. Badanie realizowano od listopada 2016 r. do stycznia 2017r. Wyniki. Analiza wyników nie potwierdziła, że palenie wyrobów tytoniowych, picie alkoholu i wirus HPV są głównymi czynnikami ryzyka chorób nowotworowych głowy i szyi. Spora ilość zaznaczanych odpowiedzi to nie udzielenie odpowiedzi, co sugeruje o braku wiedzy pacjentów lub wyparcia przez nich szkodliwości w/w nałogów. Wnioski. Badani w zdecydowanej większości byli świadomi szkodliwości palenia papierosów i jego wpływu na powstanie choroby nowotworowej. Nie mieli natomiast świadomości wpływu picia alkoholu na rozwój choroby nowotworowej. Większość badanych wiedziała, czym jest wirus HPV. Natomiast badani w większości nie mieli wiedzy, że wirus HPV należy do onkogennych. Palenie papierosów kiedykolwiek przez badanych różnicowało ich świadomość wpływu palenia papierosów na powstanie choroby nowotworowej.
Źródło:: Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2018, 3, 2; 9-26
2451-1846
Pojawia się w:: Innowacje w Pielęgniarstwie i Naukach o Zdrowiu
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Effect of copper(II) the activity of glutathione peroxidase in patients with head and neck cancer
Autorzy:: Malinowska, Katarzyna
Morawiec-Sztandera, Alina
Majsterek, Ireneusz
Kaczmarczyk, Dariusz
Powiązania:: https://bibliotekanauki.pl/articles/1398625.pdf
Data publikacji:: 2016
Wydawca:: Index Copernicus International
Tematy:: pyrazole complex
glutathione peroxidase
head and neck cancer
Opis:: Introduction: Head and neck squamous cell carcinoma (HNSCC) accounts for about 6% of all malignant cancers. In the epidemiology of oral cavity neoplasm, important risk factors include: tobacco smoking, alcohol abuse, bad oral hygiene, papilloma virus infection, riboflavin and iron deficiency. Objective: The objective of the investigation was a synthesis of Cu(II) complex and the evaluation of antioxidative enzymatic barrier in red blood cells of patients with head and neck tumor as well as in the control group. Materials and methods: For the investigation conduction, a consent of Bioethics Committee number RNN/142/09/KB was obtained. Blood for the examination was obtained from the patients of the Dapartment of Head and Neck Neoplasms Surgery Medical University of Łódź. The experiment was conducted on the group of 40 patients with HNSCC and 40 healthy people, using spectrophotometric method, glutathione peroxidase was marked. Results: The investigation was conducted on the hemolysate obtained from the patients that were divided into two groups – a study group (1 and 2), which consisted of patients diagnosed with head and neck cancer and a control group (1 and 2) – healthy people. A significant statistical result for GPX occurred in control-1 and study-1 group with complex compound Cu(II) (p<0,001). Conclusions: Presented research prove, that complex compound Cis-dichlorobis(N1-hydroxymethyl-3methylpyrazole-κN2)copper (II) has an impact on the activity of the antioxidative GPX enzyme.
Źródło:: Polish Journal of Otolaryngology; 2016, 70, 6; 20-25
0030-6657
2300-8423
Pojawia się w:: Polish Journal of Otolaryngology
Dostawca treści:: Biblioteka Nauki

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Tytuł:: The influence of age and comorbidities on the outcomes of surgical treatment with free tissue transfer: a retrospective study
Autorzy:: Czesak, Małgorzata
Sobol, Maria
Bruzgielewicz, Antoni
Niemczyk, Kazimierz
Osuch-Wójcikiewicz, Ewa
Powiązania:: https://bibliotekanauki.pl/articles/1397380.pdf
Data publikacji:: 2020
Wydawca:: Index Copernicus International
Tematy:: elderly patient
head and neck cancer
reconstructive surgery
Opis:: Introduction: Microvascular free tissue transfer enables the reconstruction of complex head and neck defects. The aim of the study was to assess the results of treatment of patients undergoing reconstructive surgery and to identify factors affecting these results, with particular reference to patient’s age. Materials and Methods: All patients who underwent free-flap head and neck reconstruction in our institution between 2010 and 2017 were included in this retrospective study. A series of 66 patients met the inclusion criteria and were divided into 2 age groups: group G1 aged <65 years (n = 41) and group G2 aged ≥65 years (n = 25). Minor local complications and general complications as well as comorbidities were analyzed. Results: No correlation was found between advanced age and the risk of free flap failure as well as the incidence of local minor complications. General complications were more frequent in the G2 group (32%) than in the G1 group (19.5%), although this is not a statistically significant difference. A statistically significant difference was found between the age and the patient’s health status according to ASA (P = 0.010). In the younger low-risk group, 12 patients (29.3%) had general and local complications, while in the older low-risk group only 1 (4%). General and local complications were found in 5 (12.2%) high-risk G1 patients and in 7 (28%) high-risk G2 patients. Conclusion(s): Patients with advanced head and neck malignant tumors should undergo reconstructive microsurgery regardless of age.
Źródło:: Polish Journal of Otolaryngology; 2020, 74, 4; 8-12
0030-6657
2300-8423
Pojawia się w:: Polish Journal of Otolaryngology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: The impact of radiotherapy on the quality of life in patients with early-stage clinical head and neck cancer
Autorzy:: Milecki, Jakub
Żmijewska-Tomczak, Małgorzata
Osmola, Krzysztof
Wierzbicka, Małgorzata
Powiązania:: https://bibliotekanauki.pl/articles/23203207.pdf
Data publikacji:: 2021-05-07
Wydawca:: Index Copernicus International
Tematy:: head and neck cancer
Quality of life
radiotherapy
Opis:: Introduction: Radiotherapy (RT) for patients with head and neck squamous cell carcinoma (HNSCC) affects vital functions related to the irradiation volume of the head and neck region and, in addition, has a negative impact on social functioning, thereby significantly impairing patients’ quality of life (QoL). Aim: The aim of this study was to assess changes in the quality of life in patients with head and neck cancer treated with curative RT at 12 months after completion of RT. The aim of this study was to assess the differences between the baseline QoL of patients with early clinical stage HNSCC and at 12 months after curative/radical RT. Material and methods: The prospective clinical study included 92 patients in good general condition (ECOG 0–1 – Eastern Cooperative Oncology Group performance status), without regional or distant metastases, diagnosed with pathomorphologically confirmed early-stage head and neck squamous cell carcinoma treated with definitive RT. All patients participating in the study signed an informed consent form. QoL was assessed using the standard EORTC QLQ-C30 and QLQH&N35 questionnaires. In addition, information on clinical aspects and data relating to socio-demographic factors were obtained from each patient. Statistical analysis was performed using a statistical package (SPSS 17.0). T-test was used for dependent and independent samples. A general linear model was used for repeated measures. Results: Patients’ QoL deteriorated significantly after definitive RT. Worse QoL Core-30 scores in patients 12 months after the end of RT, compared with baseline QoL, before the start of RT, were observed in domains such as physical performance, fulfillment of life roles, cognitive functioning, loss of appetite, fatigue and constipation. For the QLQ-H&N35 questionnaires, patients 12 months after the end of RT reported problems in relation to aspects of life such as senses, mouth opening, dry mouth, thick saliva, pain, and weight loss. Conclusion: RT, even in early clinical stage head and neck cancer, has a negative impact on QoL, despite modern treatment techniques.
Źródło:: Polish Journal of Otolaryngology; 2021, 75, 5; 1-8
0030-6657
2300-8423
Pojawia się w:: Polish Journal of Otolaryngology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Serum and saliva levels of matrix metalloproteinase 3 and 9 in pharynx and larynx cancer
Autorzy:: Polz-Dacewicz, Małgorzata
Maciąg, Paweł
Kliszczewska, Ewa
Rolniak, Łukasz
Powiązania:: https://bibliotekanauki.pl/articles/972529.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: matrix metalloproteinases
larynx cancer
throat cancer
head and neck cancer
Opis:: Introduction and objective. Matrix metalloproteinases (MMPs) are proteolytic enzymes responsible for the decomposition of extracellular matrix elements. They play an important role during embryogenesis, wound healing, endometrial epithelial exfoliation, the formation of new blood vessels, and also during cancer development. Throat and larynx tumours are included in a large group of head and neck cancers. These tumours are characterized by a poor prognosis. Despite advances in medical science, cancer treatment is difficult and often ineffective. The aim of the study was to evaluate the level of MMP-3 and MMP-9 in the serum and saliva of patients with pharynx and larynx tumours. Materials and method. Samples of saliva and serum were collected from 60 patients with larynx or throat cancer. Twenty patients without cancer comprised the control group. MMPs in saliva and serum were determined by the ELISA method. Results. In the study group, concentrations of MMP-3 in saliva were from 0.2 – 77.6 ng/ml. Patients with malignant tumours had higher saliva MMP-3 levels than healthy subjects. The concentration of MMP-3 in the serum of the study group ranged from 10.9 – 200.00 ng/ml, which was also higher than in the control group. There were no statistically significant difference in the MMP-9 level between the study and control groups (both in serum and saliva). Conclusions. This study is another element that shows the phenomena taking place at the cellular level during oncological disease. In serum and saliva samples, higher values of MMP3 were found in patients with cancer. The increase in the concentration of this enzyme in the risk group may be used for early detection of tumour transformation and evaluation of treatment.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 106-110
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma
Autorzy:: Jelonek, Karol
Wojakowska, Anna
Marczak, Lukasz
Muer, Annika
Tinhofer-Keilholz, Ingeborg
Lysek-Gladysinska, Malgorzata
Widlak, Piotr
Pietrowska, Monika
Powiązania:: https://bibliotekanauki.pl/articles/1039103.pdf
Data publikacji:: 2015
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: exosomes
head and neck cancer
ionizing radiation
proteome
radiobiology
Opis:: Exosomes are membrane vesicles of endocytic origin that participate in inter-cellular communication. Environmental and physiological conditions affect composition of secreted exosomes, their abundance and potential influence on recipient cells. Here, we analyzed protein component of exosomes released in vitro from cells exposed to ionizing radiation (2Gy dose) and compared their content with composition of exosomes released from control not irradiated cells. Exosomes secreted from FaDu cells originating from human squamous head and neck cell carcinoma were analyzed using LC-MS/MS approach. We have found that exposure to ionizing radiation resulted in gross changes in exosomal cargo. There were 217 proteins identified in exosomes from control cells and 384 proteins identified in exosomes from irradiated cells, including 148 "common" proteins, 236 proteins detected specifically after irradiation and 69 proteins not detected after irradiation. Among proteins specifically overrepresented in exosomes from irradiated cells were those involved in transcription, translation, protein turnover, cell division and cell signaling. This indicated that exosomal cargo reflected radiation-induced changes in cellular processes like transient suppression of transcription and translation or stress-induced signaling.
Źródło:: Acta Biochimica Polonica; 2015, 62, 2; 265-272
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: THE COMPARISON OF THE EFFECTS OF PANOBINOSTAT AND PKF118-310 ON β-CATENIN-DEPENDENT TRANSCRIPTION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA CELL LINES
Autorzy:: Paluszczak, Jarosław
Kleszcz, Robert
Witczak, Olga
Krajka-Kuźniak, Violetta
Powiązania:: https://bibliotekanauki.pl/articles/895659.pdf
Data publikacji:: 2020-02-29
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: Wnt signaling
head and neck cancer
panobinostat
PKF118-310
Opis:: Advanced head and neck squamous cell cancers (HNSCC) have unfavorable prognosis and new therapeutic options are necessary to improve treatment outcomes. The Wnt pathway plays an important role in the pathogenesis and progression of HNSCC. The aim of this study was to assess the effects of a histone deacetylase inhibitor – panobinostat on Wnt-dependent gene expression and on cell migration. Cell viability in HNSCC cell lines (BICR6, CAL27, FaDu, H314, SCC-25) was evaluated by MTT assay. The expression of β-catenin-target genes was assessed by qPCR and TCF/LEF-dependent reporter assay. Protein content was evaluated by Western blot. Cell migration was analyzed by the wound healing assay. Panobinostat showed differential modulation of gene expression. It reduced the level of Axin2 in CAL27 and SCC-25 cells but upregulated its expression in BICR6 and H314 cell lines. Moreover, it diminished the expression of MMP7 in BICR6, H314 and CAL27 cell lines. In contrast, the inhibitor of β-catenin transcriptional activity – PKF118-310 down-regulated the expression of β-catenin-target genes in HNSCC cell lines. Interestingly, panobinostat had opposite effects on cell migration in CAL27 and FaDu where it inhibited or stimulated migration, respectively. On the other hand, PKF118-310 reduced cell migration. The anti-cancer effects of panobinostat in HNSCC cells are rather not related to the inhibition of Wnt signaling. PKF118-310 attenuates Wnt signaling, but only in a limited number of HNSCC cell lines. Importantly, the inhibition of Wnt pathway reduces the capacity of cells for migration suggesting that it may potentially therapeutically reduce cell invasion.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 77-88
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: The role of MGMT polymorphisms rs12917 and rs11016879 in head and neck cancer risk and prognosis
Autorzy:: Kiczmer, Paweł
Prawdzic Seńkowska, Alicja
Strzelczyk, Joanna
Szydło, Błażej
Biernacki, Krzysztof
Osadnik, Tadeusz
Krakowczyk, Łukasz
Ostrowska, Zofia
Powiązania:: https://bibliotekanauki.pl/articles/1038528.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: MGMT
head and neck cancer
polymorphism
rs12917
rs11016879
Opis:: Head and neck squamous cell carcinoma (HNSCC) is one of the leading cancers by incidence worldwide. The risk of these cancers is strictly associated with alkylation factors present in tobacco smoke. The crucial role in preventing DNA alkylation is played by O6-methylguanine-DNA methyltransferase (MGMT). Dysfunction or lack of MGMT is associated with an increased risk of cancer. The aim of the study was to assess the influence of MGMT polymorphisms: rs12917 and rs11016879 on HNSCC risk and course. The study consisted of 69 HNSCC patients and 242 healthy individuals. Case samples were taken from resected tumour tissue. The control group comprised samples of epithelial cells collected from mucous membranes using swabs. DNA samples were genotyped by employing the 5' nuclease assay for allelic discrimination using TaqMan SNP Genotyping Assays. The significance between distributions of genotypes and alleles was tested using Pearson's χ2 test analysis. Our results indicated that the MGMT rs12917 TT genotype increases the risk of HNSCC. The MGMT rs11016879 AG genotype and A allele were associated with increased HNSCC risk. We noted higher risk of nodal metastasis in rs11016879 AA homozygotes. Mechanisms leading to MGMT enzymatic defect are unknown and hence further studies need to be carried out. Our data suggest that the examined polymorphisms may be considered as potential prognostic factors for HNSCC risk and outcome. Further studies are necessary to verify our results.
Źródło:: Acta Biochimica Polonica; 2018, 65, 1; 87-92
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: BERBERINE INDUCES AUTOPHAGY, APOPTOSIS AND MODULATES MIR-155 IN HEAD AND NECK SQUAMOUS CARCINOMA CELLS.
Autorzy:: Xue, Kai
Zhang, Binbin
He, Jingchuan
Powiązania:: https://bibliotekanauki.pl/articles/895286.pdf
Data publikacji:: 2020-06-29
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: apoptosis
miR-155
Autophagy
berberine
Head and Neck cancer cells
Opis:: Berberine (BBR) an active natural plant alkaloid extracted from Coptidis rhizoma, displays potent anticancer activity over a variety of cancer cell lines. The cytotoxic activity of BBR in cancer cells is attributed to persuade, programmed cell death characterized by the release of cytochrome c, accompanied by activation of caspase-3 and caspase-9. In the present study, we evaluated BBR significantly reduces the cell viability and clonogenic property of head and neck squamous carcinoma (HNSC) cells. Our results revealed that BBR simultaneously induces apoptosis and autophagy in HNSC cells. Mechanistically, BBR induces autophagy in HNSC cells which were confirmed by acridine orange (AO) staining by visualization of prominent orange red color acidic autophagosomes in the cytoplasm. However, immunoblotting shows the steady conversion of MAP-LC-3I to LC-3II with concomitant degradation of autophagy substrate protein SQSTM1/p62. Annexin V FITC staining analysis by flow cytometry revealed a significant induction of apoptosis at higher doses of BBR. Furthermore, the immunoblotting analysis revealed a prominent cleavage of proapoptotic proteins procaspase-3 and PARP1 at higher doses of BBR. Additionally, we found significant upregulation and downregulation of tumor suppressor microRNA-155 (miR-155) and oncogenic miR-21 respectively, when HNSC cells were exposed to higher doses of BBR. In conclusion, these results demonstrate that BBR exhibits a significant anti-proliferative effect with the simultaneous induction of autophagy and apoptosis and modulates miRNA expression in HNSC cells.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 485-494
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Instrumental evaluation of dysphagia after oropharyngeal cancer surgery with free flap reconstruction
Autorzy:: Jamróz, Barbra
Chmielewska, Joanna
Milewska, Magdalena
Niemczyk, Kazimierz
Powiązania:: https://bibliotekanauki.pl/articles/1401527.pdf
Data publikacji:: 2016
Wydawca:: Index Copernicus International
Tematy:: FEES
VFS
dysphagia
head and neck cancer
free flap reconstruction
Opis:: Introduction: Assessment of usefulness of instrumental method of evaluation of dysphagia in creating a therapeutic plan among patients after oropharyngeal cancer surgery with free flap reconstruction. Material and Method: Seven patients after oropharyngeal cancer surgery with free flap reconstruction hospitalized from January to September 2016 in the ENT Department of Warsaw Medical University were included in this study. All patients underwent few times after surgery: clinical swallowing examination, water swallowing screening test and fiberoptic endoscopic evaluation of swallowing and/or videofluoroscopy. Results: All patients were diagnosed with dysphagia and had unitentional weight loss (average 5,9% of initial weight during 3 months). In water swallowing test only three participant achieved negative score for 5 ml, and two for 10 ml, 20 ml and 90 ml of water. Fiberoptic endoscopic evaluation of swallowing was analyzed for swallowing patterns and laryngeal pathology. FEES showed following abnormalities: aspiration (saliva, liquid), penetration (puree, liquid), premature swallowing (liquid, puree) and multiswallowing (liquid, puree, solid food), retention (saliva, puree, liquid, solid food). Videofluroscopy showed on the first place problems with oral phase of swallowing: difficulty forming and propeling bolus, tongue pumping movements, oral cavity residue, premature spillage and delayed oral onset. During the pharyngeal phase we observed: residue in valleculae and piriform sinuses, reduced laryngeal elevation, penetration and aspiration, multiple swallows. Conclusion: Instrumental assessment of swallowing helps during diagnostic and therapeutic process of patients with dysphagia after oncological treatment. a.
Źródło:: Polski Przegląd Otorynolaryngologiczny; 2016, 5, 4; 22-28
2084-5308
2300-7338
Pojawia się w:: Polski Przegląd Otorynolaryngologiczny
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Retrospective evaluation of risk factors for oral cavity and oropharynx cancers in patients under the program of head and neck cancers prevention
Autorzy:: Kowalski, Andrzej
Olszewski, Jurek
Zielińska-Bliźniewska, Hanna
Powiązania:: https://bibliotekanauki.pl/articles/1397748.pdf
Data publikacji:: 2019
Wydawca:: Index Copernicus International
Tematy:: Head and Neck Cancer Prophylaxis Program
oral cavity
oropharynx cancer
risk factors
Opis:: Introduction: The aim of the study was to analyze the risk factors for oral cavity and pharyngeal cancer in people examined under the Head and Neck Cancer Prophylaxis Program. Material and methods: The study was conducted in a total of 300 patients, including 186 women and 114 men, as part of the Head and Neck Cancer Prevention Program in 2014–2018. Before the laryngological examination, the patients completed a demographic and medical questionnaire regarding the risk factors of head and neck cancer, including education, reported disease symptoms, smoking addiction, number of cigarettes smoked daily, alcohol consumption, frequency of visits in a dental office, oral hygiene measures, number of sexual partners, oral sex, family medical history of head and neck cancer. Results: The subjects reported the following symptoms: hoarseness 43.33%, difficulty swallowing 21.33%, pain or mouth burning 20.33% and other symptoms were observed in 46.33%. The main dental symptoms were: bleeding from the gums during teeth brushing in 48.89%, dry mouth 45.56%. Currently 20.33% of respondents smoke, whereas 54% of patients smoked in the past. In the analyzed material, the majority (80%) consumed alcoholic beverages. 27.67% of respondents admitted having oral sex, including 24.73% of women and 32.46% of men. After performing the extended diagnostics, the tumor was found in 10% of the subjects. C onclusions: Statistical significance of differences was found: between hoarseness and alcohol consumption, both in women and in men, between hoarseness and smoking in women, between difficulty in swallowing and smoking in women, between burning/pain in the mouth and smoking in men, between hoarseness and the cultivation of oral sex in men, between the difficulty of swallowing and the practice of oral sex in the studied men and between burning/pain in the oral cavity and the occurrence of malignancy.
Źródło:: Polish Journal of Otolaryngology; 2019, 73, 6; 24-31
0030-6657
2300-8423
Pojawia się w:: Polish Journal of Otolaryngology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Ionizing radiation affects profile of serum metabolites: increased level of 3-hydroxybutyric acid in serum of cancer patients treated with radiotherapy
Autorzy:: Roś-Mazurczyk, Małgorzata
Wojakowska, Anna
Marczak, Łukasz
Polański, Krzysztof
Pietrowska, Monika
Jelonek, Karol
Domińczyk, Iwona
Hajduk, Agata
Rutkowski, Tomasz
Składowski, Krzysztof
Widłak, Piotr
Powiązania:: https://bibliotekanauki.pl/articles/1038706.pdf
Data publikacji:: 2017
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: head and neck cancer
mass spectrometry
metabolomics
radiation response
serum metabolome
Opis:: Radiotherapy causes molecular changes observed at the level of body fluids, which are potential biomarker candidates for assessment of radiation exposure. Here we analyzed radiotherapy-induced changes in a profile of small metabolites detected in sera of head and neck cancer patients using the gas chromatography coupled with mass spectrometry approach. There were about 20 compounds, including carboxylic acids, sugars, amines and amino acids, whose levels significantly differed between pre-treatment and post-treatment samples. Among metabolites upregulated by radiotherapy there was 3-hydroxybutyric acid, whose level increased about three times in post-treatment samples. Moreover, compounds affected by irradiation were associated with several metabolic pathways, including protein biosynthesis and amino acid metabolism.
Źródło:: Acta Biochimica Polonica; 2017, 64, 1; 189-193
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Enteral feedıng vıdeo traınıng for the relatıves of head and neck cancer patıents: evaluatıon of ıts ımpact on knowledge and practıce
Autorzy:: Günay Ismailoğlu, Elif
Orkun, Nilay
Zaybak, Ayten
Çepken Kanlıoğlu, Makbule
Powiązania:: https://bibliotekanauki.pl/articles/1918968.pdf
Data publikacji:: 2021-06-14
Wydawca:: Uniwersytet Medyczny w Białymstoku
Tematy:: enteral feding
head and neck cancer
patient
patient relatives
video training
Opis:: Purpose: The purpose of the study was to examine the effect of using videos during enteral feeding training on the level of relevant knowledge and practice. Materials and methods: A randomized controlled quasi-experimental, post-test research design was used. We included 33 patients and relatives in the video group while 31 patients their relatives in the control group. In video group, the video recording was shown to the relatives in addition to verbal training however only verbal training was given in the control group. The relatives’ level of knowledge and practice score was evaluated. Results: Mean enteral feeding knowledge scores of patient relatives were found to be 76.7 ± 7.97 in the video group and 42.1 ± 12.57 in the control group. Mean enteral feeding practice scores were as follows: 19.64 ± 3.3 for the video group and 13 ± 3.63 for the control group. Conclusions: It was concluded that the enteral feeding training provided by using the video method increased the knowledge and practice levels of patient relatives. Implications for Practice: Video material prepared for the clinic will be a guide for clinical nurses and help them in their enteral feeding training and care planning.
Źródło:: Progress in Health Sciences; 2021, 11(1); 15-22
2083-1617
Pojawia się w:: Progress in Health Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Antioxidative assessment of new trans-palladium (II) complexes in head and neck cancer
Autorzy:: Malinowska, Katarzyna
Kaczmarczyk, Dariusz
Zajdel, Radosław
Merecz-Sadowska, Anna
Olszewski, Jurek
Majczyk, Małgorzata
Nowak-Zduńczyk, Alicja
Zielińska-Bliźniewska, Hanna
Powiązania:: https://bibliotekanauki.pl/articles/1397298.pdf
Data publikacji:: 2020
Wydawca:: Index Copernicus International
Tematy:: antioxidant enzymes
head and neck cancer
oxidative stress
Pd (II) complexes
reactive oxygen species
Opis:: Background: Head and neck neoplasms stand for 6% of all malignant neoplasms worldwide. Chemotherapy has limited use due to the biological properties of the tumor (in the majority of cases moderately and poorly differentiated squamous cell carcinoma). The fundamental molecule used in treatment is cisplatin and its derivates, that can be associated with fluorouracil. The new chemotherapeutic agents are not in common use during the treatment of head and neck malignancies. However, the use of low molecular weight complexes Pd (II) carries the potential of being more effective in therapy. Material and Methods: Fifty-one patients, 30 men and 21 women (aged 52.9 ± 12.1 years) with head and neck cancer were included in the study. Fifty-one healthy subjects, 31 men and 20 women, (aged 54.1 ± 14.7 years) years formed the control group. Antioxidant enzymes, superoxide dismutase, and catalase activities in erythrocytes were examined. Results: An increased level of antioxidant enzymes was seen in the blood samples from patients with head and neck cancer after incubation with Pd (II) complex. In the group we obtained a statistically significant result p = <0.001. Discussion: That project may contribute to the development of new, more efficient head and neck cancer treatment strategies. In our opinion, the results can be used in the future to develop a valuable prognostic marker of the disease. This is important because the initial phase of cancer is asymptomatic. The search for factors involved in pathogenesis translates into economic benefits and makes therapy more effectiveness through the reduction of treatment expenses.
Źródło:: Polish Journal of Otolaryngology; 2020, 74, 1; 23-28
0030-6657
2300-8423
Pojawia się w:: Polish Journal of Otolaryngology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 16.

Tytuł:: Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population
Autorzy:: Gogolewska, Monika
Kabziński, Jacek
Majsterek, Ireneusz
Powiązania:: https://bibliotekanauki.pl/articles/23381296.pdf
Data publikacji:: 2023-12-15
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: xenobiotics
head and neck cancer
CYP1A
NAT2
CYP2D
NAT1
Opis:: Objectives Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics. Material and Methods In group of 280 patients with HNC, the occurrence of polymorphic variants in NAT1(rs72554606), NAT2(rs1799930), CYP1A(rs1799814), CYP2D(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed. Results The results indicated an increased risk of HNC in NAT1 polymorphisms in the GC genotype (OR = 1.772, 95% CI: 1.184–2.651, p = 0.005) and NAT2 polymorphism in the GA genotype (OR = 1.506, 95% CI: 1.023–2.216, p = 0.037). The protective phenomenon in the CYP1A polymorphism the GT genotype (OR = 0.587, 95% CI: 0.381–0.903, p = 0.015) and the TT genotype (OR = 0.268, 95% CI: 0.159–0.452, p = 0.001). The coexistence of GA-GC polymorphisms (OR = 2.687, 95% CI: 1.387–5.205, p = 0.003) in NAT2-NAT1 genes increases the risk of HNC. Risk-reducing effect in the polymorphism GG-GT (OR = 0.340, 95% CI: 0.149–0.800, p = 0.011), GG-TT (OR = 0.077, 95% CI: 0.028–0.215, p < 0.0001), GA-TT (OR = 0.250, 95% CI: 0.100–0.622, p = 0.002), AA-GT (OR = 0.276, 95% CI: 0.112–0.676, p = 0.002) in NAT2-CYP1A genes. In the CYP2D-CYP1A genes in the polymorphisms CT-CC (OR = 0.338, 95% CI: 0.132–0.870, p = 0.020), TT-GG (OR = 0.100, 95% CI: 0.027–0.359, p = 0.001), TT-GC (OR = 0.190, 95% CI: 0.072–0.502, p = 0.0004), TT-CC (OR = 0.305, 95% CI: 0.107–0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989–10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003–2.464, p = 0.047). Conclusions The CYP1A polymorphism shows a protective association with HNC. On the other hand, NAT2, NAT1 polymorphism influence the susceptibility to developing HNC. The coexistence of the NAT2-NAT1 genotypes increases the risk of HNC. In contrast, NAT1-CYP1A and CYP1A-CYP2D reduce this risk. Smoking and alcohol consumption increase the incidence of HNC.
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2023, 36, 6; 812-824
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 17.

Tytuł:: Salvage surgery of hypopharyngeal cancer as a second malignancy post radiotherapy and the possibility of digestive track reconstruction – study of three cases and the literature review
Autorzy:: Rzepakowska, Anna
Jasińska, Agnieszka
Wolniewicz, Maria
Baranek, Piotr
Osuch-Wójcikiewicz, Ewa
Bruzgielewicz, Antoni
Niemczyk, Kazimierz
Powiązania:: https://bibliotekanauki.pl/articles/1399615.pdf
Data publikacji:: 2019
Wydawca:: Index Copernicus International
Tematy:: head and neck cancer
second primary cancer
hypopharyngeal cancer
salvage surgery
digestive tract reconstruction
radial forearm free flap
free autologous jejunal flap
Opis:: Patients with head and neck cancers have an increased risk of second malignant neoplasm occurrence (25% in long-term follow-up, 4% yearly). Most patients with a primary tumor can be treated with organ-preserving strategies including radiotherapy (RT) or chemoradiotherapy (CRT). Very often after radical surgical excision there are indications for adjuvant radiotherapy. However, if recurrence or second malignancy will develop after definitive primary RT, there are limitation to use therapeutic dose of radiation again for the same area. Salvage surgery is regarded as the only curative option in those cases. In our study we analysed 3 patients, who presented with head and neck second cancer in the area of hypopharynx, within 10-25 years after primary radiotherapy due to oropharyngeal and laryngeal cancer. A total pharyngectomy with larynx preservation and bilateral neck dissection were performed in the first case and the radial forearm free flap (RFFF) was used for reconstruction of the pharynx. Second patient, due to perilaryngeal invasion in radiological images, underwent total pharyngolaryngectomy with selective bilateral cervical lymph nodes dissection and digestive track was restored also with RFFF. The third patient had previously undergone laryngectomy and after total pharyngectomy the free autologous jejunal flap (FAJF) was used for reconstruction. The main goal of reconstruction after salvage surgery due to hypopharyngeal cancer is to reconstruct the digestive tract. The other important aspect is to optimize the anatomy for voice rehabilitation and swallowing. Unfortunately, radiation and chemotherapy impair wound healing, which indicates increased risk of postoperative complications and makes salvage surgery results unpredictable.
Źródło:: Polski Przegląd Otorynolaryngologiczny; 2019, 8, 1; 33-39
2084-5308
2300-7338
Pojawia się w:: Polski Przegląd Otorynolaryngologiczny
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 18.

Tytuł:: Odczyn popromienny u chorych na nowotwory regionu głowy i szyi w diagnozie i terapii logopedycznej
Radioreaction In Patients With head and neck tumours In Diagnosis And Speech Therapy
Autorzy:: Buczyńska, Izabela
Powiązania:: https://bibliotekanauki.pl/articles/695856.pdf
Data publikacji:: 2018
Wydawca:: Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:: radioterapia chorych na nowotwory regionu głowy i szyi
odczyn popromienny
terapia logopedyczna
radiation therapy of head and neck cancer
radioreaction complications
speech therapy
Opis:: Radiotherapy plays a crucial role in head and neck cancers/tumours treatment. Radical treatment with ionizing radiation is associated with the occurrence of radioreaction. The most common complications in the early or late phase of the disease are: swallowing disorders, dry mouth, and a need to change the diet. The aim of this paper is to discuss pathogenesis, risk factors and radiation prophylaxis in diagnosis and speech therapy. Logopedic exercises, stimulation of facial skeleton, oral hygiene, skin care and a fortified diet help to reduce the level of complications and inhibit the side effects of radiation therapy.
Radioterapia zajmuje szczególne miejsce w leczeniu nowotworów regionu głowy i szyi. Radykalne leczenie promieniowaniem jonizującym wiąże się z wystąpieniem odczynu popromiennego. Najczęstszymi powikłaniami są: zaburzenia mowy i połykania, suchość w jamie ustnej i konieczność zmiany diety. Celem artykułu jest omówienie patogenezy, czynników ryzyka i profilaktyki odczynu popromiennego w diagnozie i terapii logopedycznej. Ćwiczenia logopedyczne, stymulacja twarzy, pielęgnacja skóry i wzbogacona dieta wpływają na zmniejszenie skutków ubocznych radioterapii.
Źródło:: Logopaedica Lodziensia; 2018, 2; 35-47
2544-7238
2657-4381
Pojawia się w:: Logopaedica Lodziensia
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 19.

Tytuł:: Review of surgical techniques for the reconstruction of the maxillofacial region used in the Department of Maxillo-Facial Surgery in Rzeszów
Autorzy:: Frańczak, Jan
Pakla, Paweł
Brodowski, Robert
Stopyra, Wojciech
Burdzy, Danuta
Lewandowski, Bogumił
Powiązania:: https://bibliotekanauki.pl/articles/454921.pdf
Data publikacji:: 2017
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: reconstructive surgery
microsurgery
surgical flaps
cancer of head and neck
Opis:: Postoperative reconstruction of tissue loss within the head and neck after extensive resections due to malignant neoplasms or traumas has always been a challenge for maxillo-facial surgeons or ENT physicians. Due to the complex anatomical structure of the head and neck region, every patient requires an individual approach and there is no standard method of management appropriate for all patients. The number of patients treated for malignancy is increasing year by year. The possibility of performing extensive resections in the head and neck region are conditioned by appropriate reconstruction. Aim. The aim of the paper is to present the reconstructive methods used in the Clinical Department of Maxillofacial Surgery, F. Chopin Hospital No. 1 in Rzeszow. A short review of the most commonly used flaps is presented, taking into account their advantages, disadvantages and surgical technique in terms of their usefulness in daily clinical practice.
Źródło:: European Journal of Clinical and Experimental Medicine; 2017, 3; 273-278
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 20.

Tytuł:: Microvascular nose reconstruction after extended tumor resection
Autorzy:: Krakowczyk, Łukasz
Szymczyk, Cezary
Wierzgoń, Janusz
Oleś, Krzysztof
Smyczek, Dominika
Ulczok, Rafał
Donocik, Karolina
Hadasik, Grzegorz
Piotrowska, Agnieszka
Maciejewski, Adam
Powiązania:: https://bibliotekanauki.pl/articles/1391900.pdf
Data publikacji:: 2020
Wydawca:: Index Copernicus International
Tematy:: free flaps
head and neck
nasal cancer
nasal reconstruction
Opis:: Introduction: The nose is the central and probably the most important organ of the face. In view of the three-dimensional shape and variety of tissues, reconstructive surgery after tumor resection in this anatomical region requires the surgeon’s knowledge of anatomy. Materials and Method: In the years 2010–2019, 48 patients were treated in the Oncological and Reconstructive Surgery Clinic for extended nasal tumors, which required the use of free microvascular flaps after resection for functional and aesthetic supply of anatomical structures of the nose. Results: In 48 patients, a total of 92 free microvascular flaps were used for nasal reconstruction including: radial forearm free flap in 24 patients, radial forearm free flap with radial bone in 14 patients, auricular free flap in 16 patients, radial forearm free flap in combination with auricle free flap in 7 patients, double auricular free flap in 6 patients, radial forearm free flap in combination with double auricular free flap in 4 patients. Total necrosis of the free flap was noted in 4 cases, partial in 6 patients. Conclusions: The presented surgical techniques using microvascular free flaps constitute a recognized method of treatment and should be used in everyday surgeon practice. The results demonstrated in this article allow to obtain optimal functional and aesthetic effects.
Źródło:: Polish Journal of Surgery; 2020, 92, 5; 1-7
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 21.

Tytuł:: Health-related quality of life in oropharyngeal cancer survivors – a population-based study
Autorzy:: Guenzel, Thomas
Walliczek-Dworschak, U
Teymoortash, A
Singer, S
Eichler, M
Wilhelm, T
Schimmer, M
Franzen, A
Powiązania:: https://bibliotekanauki.pl/articles/1398253.pdf
Data publikacji:: 2018
Wydawca:: Index Copernicus International
Tematy:: EORTC
oropharynx
tonsil
tongue
cancer
head and neck
quality of life
Opis:: Objective: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments. Subjects and methods: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. Results: A total of 263 survivors completed the questionnaires (28% responses). Forty-five of them had undergone surgery, 20 had received definitive radiotherapy or chemo-radiotherapy, 85 surgery plus adjuvant radiotherapy, and 111 surgery plus adjuvant chemo-radiotherapy. Survivors who had received adjuvant radiotherapy and surgery reported significantly more problems with swallowing (B=13.43 [95% Confidence Interval (CI) 1.83-25.03]), senses (B=24,91 [CI 11.86-37.97]), eating (B=16.91 [CI 3.46-30.36]), dry mouth (B=26.42 [CI 12.17-40.67]), sticky saliva (B=22.37 [CI 6.23-38.50]) and nutritional supplements (B=18.59 [CI 0.62-36.56]) than those who had received surgery only. Survivors who had received adjuvant chemo-radiotherapy and surgery reported significantly many more problems with dry mouth (B=34.15 [CI 18.91-49.39]) and sticky saliva (B=22.90 [CI 5.65-40.16]), and fewer problems with physical functioning (B=-12.07 [CI 0.49-23-64]). Conclusion: Survivors who participated in this survey and who had undergone surgery alone reported in some head- and neck-specific domains a better health-related quality of life than patients who had undergone multi-modal treatment or adjuvant radiotherapy.
Źródło:: Polish Journal of Otolaryngology; 2018, 72, 2; 30-35
0030-6657
2300-8423
Pojawia się w:: Polish Journal of Otolaryngology
Dostawca treści:: Biblioteka Nauki

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