Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "head and neck" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-15 z 37
Tytuł:
Antioxidative assessment of new trans-palladium (II) complexes in head and neck cancer
Autorzy:
Malinowska, Katarzyna
Kaczmarczyk, Dariusz
Zajdel, Radosław
Merecz-Sadowska, Anna
Olszewski, Jurek
Majczyk, Małgorzata
Nowak-Zduńczyk, Alicja
Zielińska-Bliźniewska, Hanna
Powiązania:
https://bibliotekanauki.pl/articles/1397298.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
antioxidant enzymes
head and neck cancer
oxidative stress
Pd (II) complexes
reactive oxygen species
Opis:
Background: Head and neck neoplasms stand for 6% of all malignant neoplasms worldwide. Chemotherapy has limited use due to the biological properties of the tumor (in the majority of cases moderately and poorly differentiated squamous cell carcinoma). The fundamental molecule used in treatment is cisplatin and its derivates, that can be associated with fluorouracil. The new chemotherapeutic agents are not in common use during the treatment of head and neck malignancies. However, the use of low molecular weight complexes Pd (II) carries the potential of being more effective in therapy. Material and Methods: Fifty-one patients, 30 men and 21 women (aged 52.9 ± 12.1 years) with head and neck cancer were included in the study. Fifty-one healthy subjects, 31 men and 20 women, (aged 54.1 ± 14.7 years) years formed the control group. Antioxidant enzymes, superoxide dismutase, and catalase activities in erythrocytes were examined. Results: An increased level of antioxidant enzymes was seen in the blood samples from patients with head and neck cancer after incubation with Pd (II) complex. In the group we obtained a statistically significant result p = <0.001. Discussion: That project may contribute to the development of new, more efficient head and neck cancer treatment strategies. In our opinion, the results can be used in the future to develop a valuable prognostic marker of the disease. This is important because the initial phase of cancer is asymptomatic. The search for factors involved in pathogenesis translates into economic benefits and makes therapy more effectiveness through the reduction of treatment expenses.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 1; 23-28
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of cone beam computed tomography in ENT and reconstructive head and neck surgery – literature review and own experience
Autorzy:
Piotrowska-Seweryn, Agnieszka
Krakowczyk, Łukasz
Maciejewski, Adam
Kaniszewska-Dorsz, Żaneta
Markowski, Jarosław
Pietrauszka, Kornelia
Goroszkiewicz, Karolina
Powiązania:
https://bibliotekanauki.pl/articles/1399645.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
computed tomography
ENT
free flap
head and neck
reconstruction
Opis:
CBCT is a relatively new diagnostic imaging method. It was first used in 1982 at the Mayo Clinic Biodynamics Research Laboratory [1], and has been commercially used in dentistry since 2001. It differs from multidetector computed tomography in terms of implementation technique and some parameters. A low dose of radiation is its greatest advantage, thanks to which many specialists, including ENT doctors and reconstructive surgeons, are more willing to use it. In otorhinolaryngology, CBCT is applied in pre- and perioperative diagnostics in both rhinology and otology. In reconstructive surgery, CBCT facilitates precise planning of the flap and intraoperatively allows a perfect match of the reconstructed tissue elements. In the article, the authors present current information on CBCT in ENT obtained on the basis of a review of Polish and foreign literature and share their own experience in its application in reconstructive surgery within the craniofacial region.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2019, 8, 3; 1-7
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population
Autorzy:
Gogolewska, Monika
Kabziński, Jacek
Majsterek, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/23381296.pdf
Data publikacji:
2023-12-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
xenobiotics
head and neck cancer
CYP1A
NAT2
CYP2D
NAT1
Opis:
Objectives Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics. Material and Methods In group of 280 patients with HNC, the occurrence of polymorphic variants in NAT1(rs72554606), NAT2(rs1799930), CYP1A(rs1799814), CYP2D(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed. Results The results indicated an increased risk of HNC in NAT1 polymorphisms in the GC genotype (OR = 1.772, 95% CI: 1.184–2.651, p = 0.005) and NAT2 polymorphism in the GA genotype (OR = 1.506, 95% CI: 1.023–2.216, p = 0.037). The protective phenomenon in the CYP1A polymorphism the GT genotype (OR = 0.587, 95% CI: 0.381–0.903, p = 0.015) and the TT genotype (OR = 0.268, 95% CI: 0.159–0.452, p = 0.001). The coexistence of GA-GC polymorphisms (OR = 2.687, 95% CI: 1.387–5.205, p = 0.003) in NAT2-NAT1 genes increases the risk of HNC. Risk-reducing effect in the polymorphism GG-GT (OR = 0.340, 95% CI: 0.149–0.800, p = 0.011), GG-TT (OR = 0.077, 95% CI: 0.028–0.215, p < 0.0001), GA-TT (OR = 0.250, 95% CI: 0.100–0.622, p = 0.002), AA-GT (OR = 0.276, 95% CI: 0.112–0.676, p = 0.002) in NAT2-CYP1A genes. In the CYP2D-CYP1A genes in the polymorphisms CT-CC (OR = 0.338, 95% CI: 0.132–0.870, p = 0.020), TT-GG (OR = 0.100, 95% CI: 0.027–0.359, p = 0.001), TT-GC (OR = 0.190, 95% CI: 0.072–0.502, p = 0.0004), TT-CC (OR = 0.305, 95% CI: 0.107–0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989–10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003–2.464, p = 0.047). Conclusions The CYP1A polymorphism shows a protective association with HNC. On the other hand, NAT2, NAT1 polymorphism influence the susceptibility to developing HNC. The coexistence of the NAT2-NAT1 genotypes increases the risk of HNC. In contrast, NAT1-CYP1A and CYP1A-CYP2D reduce this risk. Smoking and alcohol consumption increase the incidence of HNC.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2023, 36, 6; 812-824
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
BERBERINE INDUCES AUTOPHAGY, APOPTOSIS AND MODULATES MIR-155 IN HEAD AND NECK SQUAMOUS CARCINOMA CELLS.
Autorzy:
Xue, Kai
Zhang, Binbin
He, Jingchuan
Powiązania:
https://bibliotekanauki.pl/articles/895286.pdf
Data publikacji:
2020-06-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
apoptosis
miR-155
Autophagy
berberine
Head and Neck cancer cells
Opis:
Berberine (BBR) an active natural plant alkaloid extracted from Coptidis rhizoma, displays potent anticancer activity over a variety of cancer cell lines. The cytotoxic activity of BBR in cancer cells is attributed to persuade, programmed cell death characterized by the release of cytochrome c, accompanied by activation of caspase-3 and caspase-9. In the present study, we evaluated BBR significantly reduces the cell viability and clonogenic property of head and neck squamous carcinoma (HNSC) cells. Our results revealed that BBR simultaneously induces apoptosis and autophagy in HNSC cells. Mechanistically, BBR induces autophagy in HNSC cells which were confirmed by acridine orange (AO) staining by visualization of prominent orange red color acidic autophagosomes in the cytoplasm. However, immunoblotting shows the steady conversion of MAP-LC-3I to LC-3II with concomitant degradation of autophagy substrate protein SQSTM1/p62. Annexin V FITC staining analysis by flow cytometry revealed a significant induction of apoptosis at higher doses of BBR. Furthermore, the immunoblotting analysis revealed a prominent cleavage of proapoptotic proteins procaspase-3 and PARP1 at higher doses of BBR. Additionally, we found significant upregulation and downregulation of tumor suppressor microRNA-155 (miR-155) and oncogenic miR-21 respectively, when HNSC cells were exposed to higher doses of BBR. In conclusion, these results demonstrate that BBR exhibits a significant anti-proliferative effect with the simultaneous induction of autophagy and apoptosis and modulates miRNA expression in HNSC cells.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 485-494
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical manifestation of malignant lymphomas of the head and neck region
Autorzy:
Bojanowska-Poźniak, Katarzyna
Nurkowska, Monika
Danilewicz, Marian
Pietruszewska, Wioletta
Powiązania:
https://bibliotekanauki.pl/articles/1398500.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
malignant lymphoma
head and neck neoplasm
extranodal lymphoma
Opis:
Introduction: Malignant lymphoma (ML) is a neoplasm caused by clonal expansion of undifferentiated B, T and NK-lymphoid cells. WHO classification divides lymphomas into two main types, i.e. Hodgkin lymphoma (HL), and non-Hodgkin lymphoma (NHL), with numerous subtypes. The majority of MLs are localized in lymph nodes, but extranodal locations are also possible. MLs represent approximately 3-5% of all malignant neoplasms in Poland, but their incidence has been increasing in recent years, especially in young patients. The objective of the study was to evaluate clinical manifestations and diagnostic process in patients with malignant lymphomas of the head and neck region as diagnosed in the Department of Otorhinolaryngology of the Medical University of Lodz in years 2013-2017. Material and method: 30 patients diagnosed with malignant lymphomas of the head and neck region at the Departbadament of Otorhinolaryngology of the Medical University of Lodz in 2013-2017. Results: The study group consisted of 8 cases of nodal lymphomas and 22 cases of extranodal lymphomas. In 29 cases B-cell lymphomas were diagnosed. The most common symptoms included lymphadenopathy or neck tumor. Other symptoms were associated with the location of tumors in particular body organs. The diagnosis was based on histopathological examination of biopsy (needle or surgical) samples. Conclusion: Malignant lymphomas should be taken into account during differential diagnosis of the tumor or lymphadenopathy of the neck. The diagnosis is difficult because of the nonspecificity of symptoms and the need for interdisciplinary cooperation of many specialists.
Źródło:
Polish Journal of Otolaryngology; 2017, 71, 6; 14-21
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical manifestations of granulomatosis with polyangiitis (GPA) in dermatology and otolaryngology
Autorzy:
Ziuzia, Laura
Dobrzyński, Paweł
Sobolewski, Piotr
Walecka-Herniczek, Irena
Powiązania:
https://bibliotekanauki.pl/articles/1400276.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
granulomatosis with polyangitis
head and neck
rhinosinusitis
otitis media
sensineurinal leasing loss
subglottic stenosis
cutaneous changes
ocular changes
oral changes
Opis:
The diseases caused by vasculitis are rare. The difficulties in diagnosis may be due to this low frequency, as well as to rather slow development and various symptoms and locations of the symptoms. In the diagnosis of the vasculitis one should consider all of the clinical features, for they may include diagnostic criteria for various clinical entities.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2017, 6, 2; 8-14
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of criteria for elective tracheostomy in head and neck cancer surgery
Autorzy:
Kissin, Filip
Rysz, Maciej
Budziszewska, Magdalena
Krajewski, Romuald
Powiązania:
https://bibliotekanauki.pl/articles/1397292.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
elective tracheostomy
head and neck surgery
postoperative complications
Opis:
Elective tracheostomy before resection of a malignancy in head and neck region assures unobstructed ventilation during postoperative period but is associated with an increased risk of complications. We aimed to evaluate retrospectively, how the application of elective tracheostomy scales would influence the frequency of tracheostomy in comparison with preoperative clinical judgement. In 205 patients operated on from 2013 till 2017, theresection of a malignancy involved suprahyoid or pharyngeal muscles, neck dissection and flap reconstruction. The decision on elective tracheostomy was made on the clinical basis. Score for each patient in 3 published scales was calculated. In the study group 76 patients had elective tracheostomy at the outset of a resection procedure. Among 129 patients without elective tracheostomy, 9 had tracheostomy in the postoperative period. Indications for elective tracheostomy were calculated for scale I, II and III. Only in 120 patients the decision whether to perform elective tracheostomy would be identical in each scale. Our results suggest that decisions to perform elective tracheostomy based on 3 scales show low specificity. The factors used in the published scales should be evaluated in a prospective multicenter study
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 4; 20-26
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dermoidal cysts of head and neck in children
Autorzy:
Piszcz, Małgorzata
Skotnicka, Bożena
Hassmann-Poznańska, Elżbieta
Gościk, Elżbieta
Reszeć, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1401794.pdf
Data publikacji:
2015
Wydawca:
Index Copernicus International
Tematy:
dermoid cysts
head and neck
children
Opis:
Introduction: Dermoid cysts are benign epidermal tumors; in 7% of cases, they are located in the head and neck region. They are lesions of congenital origin, mostly presenting within the midline of the body. About 70% of cases are diagnosed before the age of 5 years. Methods: A retrospective analysis of medical data of children with dermoid cysts located within the head and neck region treated in the Department of Pediatric Otolaryngology in Bialystok in the period of 1994-2014 was performed. A review of relevant literature was presented. Results: A total of 17 patients were included in this study, with a mean age of 8.9 years; 76.5% of the study population was female. Dermoid cysts were mostly located in the anterior neck region and the floor of the mouth (76%). US and CT imaging scans were used in diagnostics. No recurrences were observed after surgical excision. Conclusion: Dermoid cysts should be taken into consideration when diagnosing head and neck masses in pediatric patients.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2015, 4, 2; 66-70
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests.
Autorzy:
Palyvoda, Olena
Polańska, Joanna
Wygoda, Andrzej
Rzeszowska-Wolny, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1043662.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ionizing radiation
DNA damage
human lymphocytes
comet assay
head and neck tumors
DNA repair
Opis:
A population study is reported in which the DNA damage induced by γ-radiation (2 Gy) and the kinetics of the subsequent repair were estimated by the comet and micronucleus assays in isolated lymphocytes of 82 healthy donors and patients with head and neck cancer before radiotherapy. The parameters of background and radiation-induced DNA damage, rate of repair, and residual non-repaired damage were measured by comet assay, and the repair kinetics for every donor were computer-fitted to an exponential curve. The level of background DNA damage before irradiation measured by comet assay as well as the level of micronuclei were significantly higher in the head and neck cancer patient group than in the healthy donors, while the parameters of repair were widely scattered in both groups. Cancer patient group contained significantly more individuals, whose irradiated lymphocytes showed high DNA damage, low repair rate and high non-repaired DNA damage level. Lymphocytes of donors belonging to this subgroup showed significantly lower inhibition of cell cycle after irradiation.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 181-190
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of copper(II) the activity of glutathione peroxidase in patients with head and neck cancer
Autorzy:
Malinowska, Katarzyna
Morawiec-Sztandera, Alina
Majsterek, Ireneusz
Kaczmarczyk, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/1398625.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
pyrazole complex
glutathione peroxidase
head and neck cancer
Opis:
Introduction: Head and neck squamous cell carcinoma (HNSCC) accounts for about 6% of all malignant cancers. In the epidemiology of oral cavity neoplasm, important risk factors include: tobacco smoking, alcohol abuse, bad oral hygiene, papilloma virus infection, riboflavin and iron deficiency. Objective: The objective of the investigation was a synthesis of Cu(II) complex and the evaluation of antioxidative enzymatic barrier in red blood cells of patients with head and neck tumor as well as in the control group. Materials and methods: For the investigation conduction, a consent of Bioethics Committee number RNN/142/09/KB was obtained. Blood for the examination was obtained from the patients of the Dapartment of Head and Neck Neoplasms Surgery Medical University of Łódź. The experiment was conducted on the group of 40 patients with HNSCC and 40 healthy people, using spectrophotometric method, glutathione peroxidase was marked. Results: The investigation was conducted on the hemolysate obtained from the patients that were divided into two groups – a study group (1 and 2), which consisted of patients diagnosed with head and neck cancer and a control group (1 and 2) – healthy people. A significant statistical result for GPX occurred in control-1 and study-1 group with complex compound Cu(II) (p<0,001). Conclusions: Presented research prove, that complex compound Cis-dichlorobis(N1-hydroxymethyl-3methylpyrazole-κN2)copper (II) has an impact on the activity of the antioxidative GPX enzyme.
Źródło:
Polish Journal of Otolaryngology; 2016, 70, 6; 20-25
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enteral feedıng vıdeo traınıng for the relatıves of head and neck cancer patıents: evaluatıon of ıts ımpact on knowledge and practıce
Autorzy:
Günay Ismailoğlu, Elif
Orkun, Nilay
Zaybak, Ayten
Çepken Kanlıoğlu, Makbule
Powiązania:
https://bibliotekanauki.pl/articles/1918968.pdf
Data publikacji:
2021-06-14
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
enteral feding
head and neck cancer
patient
patient relatives
video training
Opis:
Purpose: The purpose of the study was to examine the effect of using videos during enteral feeding training on the level of relevant knowledge and practice. Materials and methods: A randomized controlled quasi-experimental, post-test research design was used. We included 33 patients and relatives in the video group while 31 patients their relatives in the control group. In video group, the video recording was shown to the relatives in addition to verbal training however only verbal training was given in the control group. The relatives’ level of knowledge and practice score was evaluated. Results: Mean enteral feeding knowledge scores of patient relatives were found to be 76.7 ± 7.97 in the video group and 42.1 ± 12.57 in the control group. Mean enteral feeding practice scores were as follows: 19.64 ± 3.3 for the video group and 13 ± 3.63 for the control group. Conclusions: It was concluded that the enteral feeding training provided by using the video method increased the knowledge and practice levels of patient relatives. Implications for Practice: Video material prepared for the clinic will be a guide for clinical nurses and help them in their enteral feeding training and care planning.
Źródło:
Progress in Health Sciences; 2021, 11(1); 15-22
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fibromatosis aggressiva of parapharyngeal space – a case report and review of literature.
Autorzy:
Piotrowska, Angelika
Rzepakowska, Anna
Chęciński, Piotr
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1400253.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
desmoid-type fibromatosis
parapharyngeal space tumor
head and neck neoplasms
Opis:
Desmoid fibromatosis is defined as a rare fibroblastic proliferation. Although histologically benign, desmoids are locally invasive and associated with a high local recurrence rate. When located in the head and neck region, fibromatosis tends to be more aggressive and associated with significant morbidity, which may be attributed to the proximity of the vital structures. We report a case of 33-year-old woman with aggressive fibromatosis of parapharyngeal space. Complete surgical excision of the lesion was performed and the postoperative period was without complications. The patient remains under careful follow-up and there is no recurrence of the disease.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2017, 6, 2; 10-15
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Head and neck amyloidosis – a report on five cases
Amyloidoza w rejonie głowy i szyi – opis serii przypadków
Autorzy:
Orłowska, Anna
Mastalerek, Jan
Jaskólska, Magdalena
Rzepakowska, Anna
Grzybowski, Jakub
Gotlib, Tomasz
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1399353.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
amyloidosis
amyloidosis of the nasopharynx
head and neck amyloidosis
larynx amyloidosis
localized amyloidosis
salivary gland amyloidosis
tongue amyloidosis
amyloidoza
amyloidoza głowy i szyi
amyloidoza języka
amyloidoza krtani
amyloidoza miejscowa
amyloidoza nosogardła
amyloidoza ślinianek
Opis:
Background: Amyloidosis is a group of diseases caused by the extracellular accumulation of insoluble fibers called amyloid in the tissues and organs. They have a secondary beta-sheet structure, which makes them resistant to proteolysis. In histological examination amyloid deposits stain with Congo red and show an apple-green birefringence in polarized light. Amyloid deposits disturb the function of organs and cause clinical symptoms. Their formation or accumulation in the system may be acquired or inherited. Due to the location of amyloid deposits we distinguish systemic and localized amyloidosis with the formation of tumors (usually from light chains). Case reports: 5 cases of amyloidosis in the head and neck region are presented in this paper. The locations of the amyloid deposits were as follows: larynx, nasopharynx, sublingual and submandibular gland and the tongue. The initial clinical presentation correlated with location of amyloid tumour in our patients. Two patients had history of local recurrence of the disease. Surgical resection and histopathological examination were performed. Sections stained with Congo red confirmed the diagnosis of amyloidosis. Three patients had potential conditions predisposing to amyloidosis: previous radiotherapy, chronic inflammation due to hepatitis C virus infection and graft versus host disease. Conclusion: Amyloidosis should be considered as the cause of symptoms in pathologies of the head and neck region. The diagnosis requires a histopathological examination. The systemic form of the disease must be ruled out in all patients with head and neck amyloidosis. In localized amyloidosis the surgical resection of the lesions is the procedure of choice, however the organ’s functionality should be taken into account.
Podstawy naukowe: Amyloidoza, czyli skrobawica, to grupa chorób, których wspólną cechą jest pozakomórkowe gromadzenie się w tkankach i narządach nierozpuszczalnych białek o budowie włókienkowej, zwanych amyloidem. Mają one drugorzędową strukturę β-kartki, co czyni je opornymi na proteolizę. W skrawkach histologicznych złogi amyloidu wybarwiają się czerwienią Kongo i wykazują zielone świecenie w świetle spolaryzowanym. Depozyty amyloidu zaburzają funkcje narządów i powodują objawy kliniczne. Ich powstawanie lub gromadzenie się w ustroju może być stanem nabytym lub dziedzicznym. Ze względu na lokalizację złogów amyloidu rozróżniamy: (1) amyloidozę układową, czyli uogólnioną, oraz (2) miejscową z tworzeniem guzów (najczęściej z łańcuchów lekkich immunoglobulin). Opisy przypadków: W niniejszej pracy opisano 5 przypadków amyloidozy w regionie głowy i szyi. Zmiany zlokalizowane były w obrębie: krtani, nosogardła, ślinianki podjęzykowej i podżuchwowej oraz języka. Pacjenci zgłaszali objawy typowe dla procesu rozrostowego obejmującego wymienione narządy. U dwóch osób choroba miała charakter nawrotowy. Zmiany usunięto operacyjnie. Na podstawie badania histopatologicznego pobranych tkanek i charakterystycznego barwienie czerwienią Kongo i Saturna, rozpoznano obecność złogów amyloidu. U trzech pacjentów występowały stany predysponujące do wystąpienia amyloidozy: uprzednia radioterapia, przewlekły stan zapalny związany z zakażeniem wirusem zapalenia wątroby typu C i choroba przeszczep przeciwko gospodarzowi. U chorego z makroglosją rozpoznano postać uogólnioną amyloidozy. Podsumowanie: Amyloidoza może imitować objawy zmian rozrostowych w rejonie głowy i szyi. Jej rozpoznanie wymaga badania histopatologicznego. U każdego chorego z miejscową amyloidozą musi zostać wykluczona postać uogólniona. W przypadku postaci miejscowej, resekcja chirurgiczna zmian jest postępowaniem z wyboru. Należy wziąć pod uwagę zachowanie funkcjonalności narządu.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2019, 8, 2; 32-37
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Health-related quality of life in oropharyngeal cancer survivors – a population-based study
Autorzy:
Guenzel, Thomas
Walliczek-Dworschak, U
Teymoortash, A
Singer, S
Eichler, M
Wilhelm, T
Schimmer, M
Franzen, A
Powiązania:
https://bibliotekanauki.pl/articles/1398253.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
EORTC
oropharynx
tonsil
tongue
cancer
head and neck
quality of life
Opis:
Objective: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments. Subjects and methods: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. Results: A total of 263 survivors completed the questionnaires (28% responses). Forty-five of them had undergone surgery, 20 had received definitive radiotherapy or chemo-radiotherapy, 85 surgery plus adjuvant radiotherapy, and 111 surgery plus adjuvant chemo-radiotherapy. Survivors who had received adjuvant radiotherapy and surgery reported significantly more problems with swallowing (B=13.43 [95% Confidence Interval (CI) 1.83-25.03]), senses (B=24,91 [CI 11.86-37.97]), eating (B=16.91 [CI 3.46-30.36]), dry mouth (B=26.42 [CI 12.17-40.67]), sticky saliva (B=22.37 [CI 6.23-38.50]) and nutritional supplements (B=18.59 [CI 0.62-36.56]) than those who had received surgery only. Survivors who had received adjuvant chemo-radiotherapy and surgery reported significantly many more problems with dry mouth (B=34.15 [CI 18.91-49.39]) and sticky saliva (B=22.90 [CI 5.65-40.16]), and fewer problems with physical functioning (B=-12.07 [CI 0.49-23-64]). Conclusion: Survivors who participated in this survey and who had undergone surgery alone reported in some head- and neck-specific domains a better health-related quality of life than patients who had undergone multi-modal treatment or adjuvant radiotherapy.
Źródło:
Polish Journal of Otolaryngology; 2018, 72, 2; 30-35
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunotherapy of head and neck squamous cell carcinoma (HNSCC). Immune checkpoint blockade
Autorzy:
Przybylski, Krzysztof
Majchrzak, Ewa
Weselik, Liucija
Golusiński, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1398281.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
head and neck squamouscell carcinoma
immunotherapy
CTLA - 4
PD - 1
nivolumab
pembrolizumab
Opis:
Treating patients with squamous cell carcinoma of the head and neck is a significant problem. There is an increase in the incidence of malignant neoplasms in this region. Surgery, radiotherapy and chemotherapy are often not sufficient methods of treatment. Thorough analysis of processes occurring in the tumor microenvironment has allowed to distinguish three stages that make up the reaction of the human body to hostile antigens, which are tumor antigens. Understanding these mechanisms has resulted in the introduction of a new term immune-oncology. It is an area of cancer treatment that focuses on use of the patient’s immune system to combat the disease. Immunotherapy has had positive effects in cancer patients. The use of immune checkpoint inhibitors, such as anti-CTLA-4 and PD-1 monoclonal antibodies has enabled the modulation of T cell functions, consequently eliminating immunosuppression in the tumor microenvironment. Clinical trials were conducted using nivolumab and ipilimumab, which confirmed their clinical usefulness. The approval by FDA of nivolumab in treatment of recurrent and metastatic squamous cell carcinoma of the head and neck has increased the overall survival time of patients as well as disease free survival. Statistical data indicate an advantage of immunotherapy over other treatment methods at an advanced stage of cancer. This work aims to discuss basic issues related to immunotherapy, in particular immunotherapy in patients with squamous cell carcinoma of the head and neck.
Źródło:
Polish Journal of Otolaryngology; 2018, 72, 6; 10-16
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 37

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies