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Tytuł:
Neuroendocrine Carcinoma of the Head and Neck – review of literature
Autorzy:
Berger, G
Dawidziuk, T
Chyczewski, L
Powiązania:
https://bibliotekanauki.pl/articles/1401521.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
neuroendocrine carcinoma
head and neck
Opis:
Neuroendocrine carcinoma is a rare neoplasm, and its most common location in the head and neck area is the larynx, especially the epiglottis and the supraglottic region. The first case of neuroendocrine carcinoma of the larynx was reported in 1969 by Goldman et al. Expression of the two crucial markers, synaptophysin and chromogranin, along with neural cell adhesion molecule (CD56) should be mentioned among the neuroendocrine features detected on immunohistochemistry. Human papilloma virus (HPV16/18) infection in the laryngeal neuroendocrine carcinoma can be one of the causal factors, and the detection of HPV should be considered as a standard procedure for the diagnosis and treatment.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2016, 5, 4; 16-21
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical manifestation of malignant lymphomas of the head and neck region
Autorzy:
Bojanowska-Poźniak, Katarzyna
Nurkowska, Monika
Danilewicz, Marian
Pietruszewska, Wioletta
Powiązania:
https://bibliotekanauki.pl/articles/1398500.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
malignant lymphoma
head and neck neoplasm
extranodal lymphoma
Opis:
Introduction: Malignant lymphoma (ML) is a neoplasm caused by clonal expansion of undifferentiated B, T and NK-lymphoid cells. WHO classification divides lymphomas into two main types, i.e. Hodgkin lymphoma (HL), and non-Hodgkin lymphoma (NHL), with numerous subtypes. The majority of MLs are localized in lymph nodes, but extranodal locations are also possible. MLs represent approximately 3-5% of all malignant neoplasms in Poland, but their incidence has been increasing in recent years, especially in young patients. The objective of the study was to evaluate clinical manifestations and diagnostic process in patients with malignant lymphomas of the head and neck region as diagnosed in the Department of Otorhinolaryngology of the Medical University of Lodz in years 2013-2017. Material and method: 30 patients diagnosed with malignant lymphomas of the head and neck region at the Departbadament of Otorhinolaryngology of the Medical University of Lodz in 2013-2017. Results: The study group consisted of 8 cases of nodal lymphomas and 22 cases of extranodal lymphomas. In 29 cases B-cell lymphomas were diagnosed. The most common symptoms included lymphadenopathy or neck tumor. Other symptoms were associated with the location of tumors in particular body organs. The diagnosis was based on histopathological examination of biopsy (needle or surgical) samples. Conclusion: Malignant lymphomas should be taken into account during differential diagnosis of the tumor or lymphadenopathy of the neck. The diagnosis is difficult because of the nonspecificity of symptoms and the need for interdisciplinary cooperation of many specialists.
Źródło:
Polish Journal of Otolaryngology; 2017, 71, 6; 14-21
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Odczyn popromienny u chorych na nowotwory regionu głowy i szyi w diagnozie i terapii logopedycznej
Radioreaction In Patients With head and neck tumours In Diagnosis And Speech Therapy
Autorzy:
Buczyńska, Izabela
Powiązania:
https://bibliotekanauki.pl/articles/695856.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
radioterapia chorych na nowotwory regionu głowy i szyi
odczyn popromienny
terapia logopedyczna
radiation therapy of head and neck cancer
radioreaction complications
speech therapy
Opis:
Radiotherapy plays a crucial role in head and neck cancers/tumours treatment. Radical treatment with ionizing radiation is associated with the occurrence of radioreaction. The most common complications in the early or late phase of the disease are: swallowing disorders, dry mouth, and a need to change the diet. The aim of this paper is to discuss pathogenesis, risk factors and radiation prophylaxis in diagnosis and speech therapy. Logopedic exercises, stimulation of facial skeleton, oral hygiene, skin care and a fortified diet help to reduce the level of complications and inhibit the side effects of radiation therapy.
Radioterapia zajmuje szczególne miejsce w leczeniu nowotworów regionu głowy i szyi. Radykalne leczenie promieniowaniem jonizującym wiąże się z wystąpieniem odczynu popromiennego. Najczęstszymi powikłaniami są: zaburzenia mowy i połykania, suchość w jamie ustnej i konieczność zmiany diety. Celem artykułu jest omówienie patogenezy, czynników ryzyka i profilaktyki odczynu popromiennego w diagnozie i terapii logopedycznej. Ćwiczenia logopedyczne, stymulacja twarzy, pielęgnacja skóry i wzbogacona dieta wpływają na zmniejszenie skutków ubocznych radioterapii.
Źródło:
Logopaedica Lodziensia; 2018, 2; 35-47
2544-7238
2657-4381
Pojawia się w:
Logopaedica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zaburzenia mowy u pacjentów onkologicznych regionu głowy i szyi w diagnozie i terapii logopedycznej. Studium przypadku
Speech Disorder of the Head and Neck Regions in Diagnosis and Speech Therapy of Oncological Patients. A Case Study
Autorzy:
Buczyńska, Izabela
Powiązania:
https://bibliotekanauki.pl/articles/892731.pdf
Data publikacji:
2020-08-30
Wydawca:
Polskie Towarzystwo Logopedyczne
Tematy:
zaburzenia mowy
diagnoza i terapia logopedyczna
nowotwory regionu głowy i szyi
leczenie onkologiczne
speech disorders
diagnosis and speech therapy
head and neck tumors
oncological treatment
Opis:
Nowotwory regionu głowy i szyi to zmiany chorobowe w obrębie kompleksu ustno-twarzowego. Strukturalne i czynnościowe zaburzenia poszczególnych narządów orogardła powodują trudności w oddychaniu, połykaniu i w wymowie. Celem artykułu jest omówienie zaburzeń mowy u pacjentów onkologicznych regionu głowy i szyi po radykalnych operacjach chirurgiczno-rekonstrukcyjnych. Rodzaj zaburzeń językowych zależy od zaawansowania choroby nowotworowej, zakresu ubytku pooperacyjnego oraz indywidualnych umiejętności kompensacyjnych pacjenta. Największe odchylenia od normy występują w trakcie realizacji głosek [k, g, l, r], natomiast najsłabsze podczas fonacji samogłosek. Nadrzędnym celem logopedycznego postępowania terapeutycznego jest usprawnienie połykania, artykulacji i fonacji oraz umiejętności komunikacyjnych chorego z otoczeniem. Reedukacja czynności prymarnych i sekundarnych pacjenta onkologicznego po przebytym zabiegu rekonstrukcyjnym w obrębie twarzoczaszki sprawia, że współczesna logopedia jest integralną częścią leczenia onkologicznego.
Tumors of the head and neck region are lesions within the orofacial complex. Structural and functional disturbances of individual oropharyngeal structures cause difficulties in breathing, swallowing and pronunciation. The aim of the article is to discuss speech disorders of the head and neck regions in oncological patients after radical reconstructive surgery. The type of a linguistic disorder depends on the severity of the neoplastic disease, the extent of the postoperative loss and individual patient compensation skills. The greatest deviations from the norm occur during the implementation of sounds such as [k, g, l] and the smallest happen during phonation of vowels. The primary aim of speech therapy is to improve such skills as swallowing, articulation, phonation and communication of the patient with the environment. Re-education of the primary and secondary functions in the case of oncological patients after reconstructive surgery in the craniofacial region makes modern speech therapy an integral part of the oncological treatment.
Źródło:
Logopedia; 2019, 48, 1; 351-370
0459-6935
Pojawia się w:
Logopedia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of age and comorbidities on the outcomes of surgical treatment with free tissue transfer: a retrospective study
Autorzy:
Czesak, Małgorzata
Sobol, Maria
Bruzgielewicz, Antoni
Niemczyk, Kazimierz
Osuch-Wójcikiewicz, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1397380.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
elderly patient
head and neck cancer
reconstructive surgery
Opis:
Introduction: Microvascular free tissue transfer enables the reconstruction of complex head and neck defects. The aim of the study was to assess the results of treatment of patients undergoing reconstructive surgery and to identify factors affecting these results, with particular reference to patient’s age. Materials and Methods: All patients who underwent free-flap head and neck reconstruction in our institution between 2010 and 2017 were included in this retrospective study. A series of 66 patients met the inclusion criteria and were divided into 2 age groups: group G1 aged <65 years (n = 41) and group G2 aged ≥65 years (n = 25). Minor local complications and general complications as well as comorbidities were analyzed. Results: No correlation was found between advanced age and the risk of free flap failure as well as the incidence of local minor complications. General complications were more frequent in the G2 group (32%) than in the G1 group (19.5%), although this is not a statistically significant difference. A statistically significant difference was found between the age and the patient’s health status according to ASA (P = 0.010). In the younger low-risk group, 12 patients (29.3%) had general and local complications, while in the older low-risk group only 1 (4%). General and local complications were found in 5 (12.2%) high-risk G1 patients and in 7 (28%) high-risk G2 patients. Conclusion(s): Patients with advanced head and neck malignant tumors should undergo reconstructive microsurgery regardless of age.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 4; 8-12
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Report from the analysis of implementiation of 4th Head and Neck Cancer Awareness Week in Department of Otolaryngology in Międzyleski Hospital in Warsaw
Autorzy:
Dżaman, Karolina
Piskadło–Zborowska, Karolina
Pietniczka–Załęska, Mirosława
Powiązania:
https://bibliotekanauki.pl/articles/1398499.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
European Head and Neck Cancer Awareness Week
head and neck tumors
Opis:
Introduction: The aim of the study was to analyze the profile of patients who reported for free screening examinations during the 4th European Head and Neck Cancer Awareness Week to the Department of Otolaryngology, Miedzylesie Specialist Hospital, Warsaw, Poland. Material and methods: We enrolled 225 patients, aged 26-92 years (mean, 63 years). There were 149 women (66%) and 76 men (34%). All patients filled out a survey regarding risk factors of head and neck cancer (HNC), including symptoms and lifestyle characteristics. Subsequently, all participants underwent a complete laryngological examination. Results: Among the studied patients, we found the following lifestyle-related risk factors of HNC: tobacco use (22%), alcohol use more than 1 time per week (12%), oral sex (17%), multiple sexual partners (10%), rare dental checkups (24%), and dental prostheses (45%). The most frequent symptoms that prompted the patients to report for screening exams were as follows: chronic hoarseness (64%), xerostomia (39%), dysphagia (37%), nasal congestion (6%), and neck tumor (5%). Further imaging studies were ordered in 15 patients (7%), fiberoscopy in 25 (11%), and lesion excision in 18 (8%). Among the studied patients, 17 were referred for further oncological treatment, of whom 14 had benign tumors and 4 malignant tumors. Conclusions: The Head and Neck Cancer Awareness campaign increased the awareness of HNC, and it should systematically encompass people at increased risk. By implementing this program in our department, we were able to detect and initiate early treatment in 7.5% of the screened people. However, appropriate workup and treatment require funding and therefore systemic measures should be taken to enable a wide implementation of such screening programs.
Źródło:
Polish Journal of Otolaryngology; 2017, 71, 6; 35-39
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Review of surgical techniques for the reconstruction of the maxillofacial region used in the Department of Maxillo-Facial Surgery in Rzeszów
Autorzy:
Frańczak, Jan
Pakla, Paweł
Brodowski, Robert
Stopyra, Wojciech
Burdzy, Danuta
Lewandowski, Bogumił
Powiązania:
https://bibliotekanauki.pl/articles/454921.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
reconstructive surgery
microsurgery
surgical flaps
cancer of head and neck
Opis:
Postoperative reconstruction of tissue loss within the head and neck after extensive resections due to malignant neoplasms or traumas has always been a challenge for maxillo-facial surgeons or ENT physicians. Due to the complex anatomical structure of the head and neck region, every patient requires an individual approach and there is no standard method of management appropriate for all patients. The number of patients treated for malignancy is increasing year by year. The possibility of performing extensive resections in the head and neck region are conditioned by appropriate reconstruction. Aim. The aim of the paper is to present the reconstructive methods used in the Clinical Department of Maxillofacial Surgery, F. Chopin Hospital No. 1 in Rzeszow. A short review of the most commonly used flaps is presented, taking into account their advantages, disadvantages and surgical technique in terms of their usefulness in daily clinical practice.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 3; 273-278
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population
Autorzy:
Gogolewska, Monika
Kabziński, Jacek
Majsterek, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/23381296.pdf
Data publikacji:
2023-12-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
xenobiotics
head and neck cancer
CYP1A
NAT2
CYP2D
NAT1
Opis:
Objectives Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics. Material and Methods In group of 280 patients with HNC, the occurrence of polymorphic variants in NAT1(rs72554606), NAT2(rs1799930), CYP1A(rs1799814), CYP2D(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed. Results The results indicated an increased risk of HNC in NAT1 polymorphisms in the GC genotype (OR = 1.772, 95% CI: 1.184–2.651, p = 0.005) and NAT2 polymorphism in the GA genotype (OR = 1.506, 95% CI: 1.023–2.216, p = 0.037). The protective phenomenon in the CYP1A polymorphism the GT genotype (OR = 0.587, 95% CI: 0.381–0.903, p = 0.015) and the TT genotype (OR = 0.268, 95% CI: 0.159–0.452, p = 0.001). The coexistence of GA-GC polymorphisms (OR = 2.687, 95% CI: 1.387–5.205, p = 0.003) in NAT2-NAT1 genes increases the risk of HNC. Risk-reducing effect in the polymorphism GG-GT (OR = 0.340, 95% CI: 0.149–0.800, p = 0.011), GG-TT (OR = 0.077, 95% CI: 0.028–0.215, p < 0.0001), GA-TT (OR = 0.250, 95% CI: 0.100–0.622, p = 0.002), AA-GT (OR = 0.276, 95% CI: 0.112–0.676, p = 0.002) in NAT2-CYP1A genes. In the CYP2D-CYP1A genes in the polymorphisms CT-CC (OR = 0.338, 95% CI: 0.132–0.870, p = 0.020), TT-GG (OR = 0.100, 95% CI: 0.027–0.359, p = 0.001), TT-GC (OR = 0.190, 95% CI: 0.072–0.502, p = 0.0004), TT-CC (OR = 0.305, 95% CI: 0.107–0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989–10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003–2.464, p = 0.047). Conclusions The CYP1A polymorphism shows a protective association with HNC. On the other hand, NAT2, NAT1 polymorphism influence the susceptibility to developing HNC. The coexistence of the NAT2-NAT1 genotypes increases the risk of HNC. In contrast, NAT1-CYP1A and CYP1A-CYP2D reduce this risk. Smoking and alcohol consumption increase the incidence of HNC.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2023, 36, 6; 812-824
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Health-related quality of life in oropharyngeal cancer survivors – a population-based study
Autorzy:
Guenzel, Thomas
Walliczek-Dworschak, U
Teymoortash, A
Singer, S
Eichler, M
Wilhelm, T
Schimmer, M
Franzen, A
Powiązania:
https://bibliotekanauki.pl/articles/1398253.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
EORTC
oropharynx
tonsil
tongue
cancer
head and neck
quality of life
Opis:
Objective: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments. Subjects and methods: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. Results: A total of 263 survivors completed the questionnaires (28% responses). Forty-five of them had undergone surgery, 20 had received definitive radiotherapy or chemo-radiotherapy, 85 surgery plus adjuvant radiotherapy, and 111 surgery plus adjuvant chemo-radiotherapy. Survivors who had received adjuvant radiotherapy and surgery reported significantly more problems with swallowing (B=13.43 [95% Confidence Interval (CI) 1.83-25.03]), senses (B=24,91 [CI 11.86-37.97]), eating (B=16.91 [CI 3.46-30.36]), dry mouth (B=26.42 [CI 12.17-40.67]), sticky saliva (B=22.37 [CI 6.23-38.50]) and nutritional supplements (B=18.59 [CI 0.62-36.56]) than those who had received surgery only. Survivors who had received adjuvant chemo-radiotherapy and surgery reported significantly many more problems with dry mouth (B=34.15 [CI 18.91-49.39]) and sticky saliva (B=22.90 [CI 5.65-40.16]), and fewer problems with physical functioning (B=-12.07 [CI 0.49-23-64]). Conclusion: Survivors who participated in this survey and who had undergone surgery alone reported in some head- and neck-specific domains a better health-related quality of life than patients who had undergone multi-modal treatment or adjuvant radiotherapy.
Źródło:
Polish Journal of Otolaryngology; 2018, 72, 2; 30-35
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enteral feedıng vıdeo traınıng for the relatıves of head and neck cancer patıents: evaluatıon of ıts ımpact on knowledge and practıce
Autorzy:
Günay Ismailoğlu, Elif
Orkun, Nilay
Zaybak, Ayten
Çepken Kanlıoğlu, Makbule
Powiązania:
https://bibliotekanauki.pl/articles/1918968.pdf
Data publikacji:
2021-06-14
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
enteral feding
head and neck cancer
patient
patient relatives
video training
Opis:
Purpose: The purpose of the study was to examine the effect of using videos during enteral feeding training on the level of relevant knowledge and practice. Materials and methods: A randomized controlled quasi-experimental, post-test research design was used. We included 33 patients and relatives in the video group while 31 patients their relatives in the control group. In video group, the video recording was shown to the relatives in addition to verbal training however only verbal training was given in the control group. The relatives’ level of knowledge and practice score was evaluated. Results: Mean enteral feeding knowledge scores of patient relatives were found to be 76.7 ± 7.97 in the video group and 42.1 ± 12.57 in the control group. Mean enteral feeding practice scores were as follows: 19.64 ± 3.3 for the video group and 13 ± 3.63 for the control group. Conclusions: It was concluded that the enteral feeding training provided by using the video method increased the knowledge and practice levels of patient relatives. Implications for Practice: Video material prepared for the clinic will be a guide for clinical nurses and help them in their enteral feeding training and care planning.
Źródło:
Progress in Health Sciences; 2021, 11(1); 15-22
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Instrumental evaluation of dysphagia after oropharyngeal cancer surgery with free flap reconstruction
Autorzy:
Jamróz, Barbra
Chmielewska, Joanna
Milewska, Magdalena
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1401527.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
FEES
VFS
dysphagia
head and neck cancer
free flap reconstruction
Opis:
Introduction: Assessment of usefulness of instrumental method of evaluation of dysphagia in creating a therapeutic plan among patients after oropharyngeal cancer surgery with free flap reconstruction. Material and Method: Seven patients after oropharyngeal cancer surgery with free flap reconstruction hospitalized from January to September 2016 in the ENT Department of Warsaw Medical University were included in this study. All patients underwent few times after surgery: clinical swallowing examination, water swallowing screening test and fiberoptic endoscopic evaluation of swallowing and/or videofluoroscopy. Results: All patients were diagnosed with dysphagia and had unitentional weight loss (average 5,9% of initial weight during 3 months). In water swallowing test only three participant achieved negative score for 5 ml, and two for 10 ml, 20 ml and 90 ml of water. Fiberoptic endoscopic evaluation of swallowing was analyzed for swallowing patterns and laryngeal pathology. FEES showed following abnormalities: aspiration (saliva, liquid), penetration (puree, liquid), premature swallowing (liquid, puree) and multiswallowing (liquid, puree, solid food), retention (saliva, puree, liquid, solid food). Videofluroscopy showed on the first place problems with oral phase of swallowing: difficulty forming and propeling bolus, tongue pumping movements, oral cavity residue, premature spillage and delayed oral onset. During the pharyngeal phase we observed: residue in valleculae and piriform sinuses, reduced laryngeal elevation, penetration and aspiration, multiple swallows. Conclusion: Instrumental assessment of swallowing helps during diagnostic and therapeutic process of patients with dysphagia after oncological treatment. a.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2016, 5, 4; 22-28
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma
Autorzy:
Jelonek, Karol
Wojakowska, Anna
Marczak, Lukasz
Muer, Annika
Tinhofer-Keilholz, Ingeborg
Lysek-Gladysinska, Malgorzata
Widlak, Piotr
Pietrowska, Monika
Powiązania:
https://bibliotekanauki.pl/articles/1039103.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
exosomes
head and neck cancer
ionizing radiation
proteome
radiobiology
Opis:
Exosomes are membrane vesicles of endocytic origin that participate in inter-cellular communication. Environmental and physiological conditions affect composition of secreted exosomes, their abundance and potential influence on recipient cells. Here, we analyzed protein component of exosomes released in vitro from cells exposed to ionizing radiation (2Gy dose) and compared their content with composition of exosomes released from control not irradiated cells. Exosomes secreted from FaDu cells originating from human squamous head and neck cell carcinoma were analyzed using LC-MS/MS approach. We have found that exposure to ionizing radiation resulted in gross changes in exosomal cargo. There were 217 proteins identified in exosomes from control cells and 384 proteins identified in exosomes from irradiated cells, including 148 "common" proteins, 236 proteins detected specifically after irradiation and 69 proteins not detected after irradiation. Among proteins specifically overrepresented in exosomes from irradiated cells were those involved in transcription, translation, protein turnover, cell division and cell signaling. This indicated that exosomal cargo reflected radiation-induced changes in cellular processes like transient suppression of transcription and translation or stress-induced signaling.
Źródło:
Acta Biochimica Polonica; 2015, 62, 2; 265-272
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena wiedzy pacjentów na temat czynników ryzyka związanych ze stylem życia, a występowanie chorób nowotworowych głowy i szyi
Risk factors related to lifestyle affecting the occurrence of head and neck cancer
Autorzy:
Karbowiak, Urszula
Serzysko, Bogusława
Powiązania:
https://bibliotekanauki.pl/articles/1029873.pdf
Data publikacji:
2018
Wydawca:
Państwowa Uczelnia Zawodowa we Włocławku
Tematy:
head and neck cancer
lifestyle
quality of life
Opis:
Introduction. Cancer is a complex pathological process that develops in the human body, destroying healthy cells progressively and leading to significant limitations in functioning and severe pain, sometimes persissitng even with the aid of painkillers. Cancerous diseases of the head and neck organs significantly reduce the quality of life compared to the population of healthy people. Aim. The aim of this study was to show whether smoking, alcohol and HPV are risk factors for head and neck cancer. Materials and methods. The study was conducted among 149 patients diagnosed with head and neck cancer in the Clinical Outpatient Center of Oncology Center in Gliwice with the consent of this heaktcare facility. The study used a questionnaire containing 38 questions. The study was carried out from November 2016 to January 2017. Results. The analysis of the results did not confirm that smoking, alcohol and HPV are the main risk factors for head and neck cancer. A large number of respodents did not answer the questions , which suggests patients' lack of knowledge or their denial of the harmfulness of the above-mentioned addictions. Conclusions. The majority of respondents were aware of the harmfulness of smoking and its effect on the development of cancer. However, they were not aware of the impact of drinking alcohol on the development of cancer. Most of the subjects knew what HPV is. However, the majority of respondents did not know that HPV belongs to oncogenic viruses. Smoking cigarettes differentiated their awareness of the impact of smoking on the development of cancer.
Wstęp. Choroba nowotworowa to złożony proces patologiczny, który rozwija się w ludzkim organizmie, który niszcząc zdrowe komórki prowadzi progresywnie do znacznych ograniczeń w funkcjonowaniu oraz znacznych dolegliwości bólowych, czasem nieustępujących po lekach przeciwbólowych. Choroba nowotworowa narządów głowy i szyi w znaczny sposób obniża jakość życia w porównaniu do populacji osób zdrowych. Cel. Celem tego badania była ocena wiedzy pacjentów na temat czynników ryzyka związanych ze stylem życia, a występowaniem chorób nowotworowych głowy i szyi. Materiał i metody. Badanie przeprowadzono wśród 149 pacjentów, u których rozpoznano chorobę nowotworową głowy i szyi w Przyklinicznej Przychodni Centrum Onkologii w Gliwicach za zgodą tejże palcówki. W badaniu posłużono się autorska ankietą zawierającą w 38 pytań. Badanie realizowano od listopada 2016 r. do stycznia 2017r. Wyniki. Analiza wyników nie potwierdziła, że palenie wyrobów tytoniowych, picie alkoholu i wirus HPV są głównymi czynnikami ryzyka chorób nowotworowych głowy i szyi. Spora ilość zaznaczanych odpowiedzi to nie udzielenie odpowiedzi, co sugeruje o braku wiedzy pacjentów lub wyparcia przez nich szkodliwości w/w nałogów. Wnioski. Badani w zdecydowanej większości byli świadomi szkodliwości palenia papierosów i jego wpływu na powstanie choroby nowotworowej. Nie mieli natomiast świadomości wpływu picia alkoholu na rozwój choroby nowotworowej. Większość badanych wiedziała, czym jest wirus HPV. Natomiast badani w większości nie mieli wiedzy, że wirus HPV należy do onkogennych. Palenie papierosów kiedykolwiek przez badanych różnicowało ich świadomość wpływu palenia papierosów na powstanie choroby nowotworowej.
Źródło:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2018, 3, 2; 9-26
2451-1846
Pojawia się w:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of MGMT polymorphisms rs12917 and rs11016879 in head and neck cancer risk and prognosis
Autorzy:
Kiczmer, Paweł
Prawdzic Seńkowska, Alicja
Strzelczyk, Joanna
Szydło, Błażej
Biernacki, Krzysztof
Osadnik, Tadeusz
Krakowczyk, Łukasz
Ostrowska, Zofia
Powiązania:
https://bibliotekanauki.pl/articles/1038528.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
MGMT
head and neck cancer
polymorphism
rs12917
rs11016879
Opis:
Head and neck squamous cell carcinoma (HNSCC) is one of the leading cancers by incidence worldwide. The risk of these cancers is strictly associated with alkylation factors present in tobacco smoke. The crucial role in preventing DNA alkylation is played by O6-methylguanine-DNA methyltransferase (MGMT). Dysfunction or lack of MGMT is associated with an increased risk of cancer. The aim of the study was to assess the influence of MGMT polymorphisms: rs12917 and rs11016879 on HNSCC risk and course. The study consisted of 69 HNSCC patients and 242 healthy individuals. Case samples were taken from resected tumour tissue. The control group comprised samples of epithelial cells collected from mucous membranes using swabs. DNA samples were genotyped by employing the 5' nuclease assay for allelic discrimination using TaqMan SNP Genotyping Assays. The significance between distributions of genotypes and alleles was tested using Pearson's χ2 test analysis. Our results indicated that the MGMT rs12917 TT genotype increases the risk of HNSCC. The MGMT rs11016879 AG genotype and A allele were associated with increased HNSCC risk. We noted higher risk of nodal metastasis in rs11016879 AA homozygotes. Mechanisms leading to MGMT enzymatic defect are unknown and hence further studies need to be carried out. Our data suggest that the examined polymorphisms may be considered as potential prognostic factors for HNSCC risk and outcome. Further studies are necessary to verify our results.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 87-92
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of criteria for elective tracheostomy in head and neck cancer surgery
Autorzy:
Kissin, Filip
Rysz, Maciej
Budziszewska, Magdalena
Krajewski, Romuald
Powiązania:
https://bibliotekanauki.pl/articles/1397292.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
elective tracheostomy
head and neck surgery
postoperative complications
Opis:
Elective tracheostomy before resection of a malignancy in head and neck region assures unobstructed ventilation during postoperative period but is associated with an increased risk of complications. We aimed to evaluate retrospectively, how the application of elective tracheostomy scales would influence the frequency of tracheostomy in comparison with preoperative clinical judgement. In 205 patients operated on from 2013 till 2017, theresection of a malignancy involved suprahyoid or pharyngeal muscles, neck dissection and flap reconstruction. The decision on elective tracheostomy was made on the clinical basis. Score for each patient in 3 published scales was calculated. In the study group 76 patients had elective tracheostomy at the outset of a resection procedure. Among 129 patients without elective tracheostomy, 9 had tracheostomy in the postoperative period. Indications for elective tracheostomy were calculated for scale I, II and III. Only in 120 patients the decision whether to perform elective tracheostomy would be identical in each scale. Our results suggest that decisions to perform elective tracheostomy based on 3 scales show low specificity. The factors used in the published scales should be evaluated in a prospective multicenter study
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 4; 20-26
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
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