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    Wyświetlanie 1-37 z 37
    Tytuł:
    Report from the analysis of implementiation of 4th Head and Neck Cancer Awareness Week in Department of Otolaryngology in Międzyleski Hospital in Warsaw
    Autorzy:
    Dżaman, Karolina
    Piskadło–Zborowska, Karolina
    Pietniczka–Załęska, Mirosława
    Powiązania:
    https://bibliotekanauki.pl/articles/1398499.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    European Head and Neck Cancer Awareness Week
    head and neck tumors
    Opis:
    Introduction: The aim of the study was to analyze the profile of patients who reported for free screening examinations during the 4th European Head and Neck Cancer Awareness Week to the Department of Otolaryngology, Miedzylesie Specialist Hospital, Warsaw, Poland. Material and methods: We enrolled 225 patients, aged 26-92 years (mean, 63 years). There were 149 women (66%) and 76 men (34%). All patients filled out a survey regarding risk factors of head and neck cancer (HNC), including symptoms and lifestyle characteristics. Subsequently, all participants underwent a complete laryngological examination. Results: Among the studied patients, we found the following lifestyle-related risk factors of HNC: tobacco use (22%), alcohol use more than 1 time per week (12%), oral sex (17%), multiple sexual partners (10%), rare dental checkups (24%), and dental prostheses (45%). The most frequent symptoms that prompted the patients to report for screening exams were as follows: chronic hoarseness (64%), xerostomia (39%), dysphagia (37%), nasal congestion (6%), and neck tumor (5%). Further imaging studies were ordered in 15 patients (7%), fiberoscopy in 25 (11%), and lesion excision in 18 (8%). Among the studied patients, 17 were referred for further oncological treatment, of whom 14 had benign tumors and 4 malignant tumors. Conclusions: The Head and Neck Cancer Awareness campaign increased the awareness of HNC, and it should systematically encompass people at increased risk. By implementing this program in our department, we were able to detect and initiate early treatment in 7.5% of the screened people. However, appropriate workup and treatment require funding and therefore systemic measures should be taken to enable a wide implementation of such screening programs.
    Źródło:
    Polish Journal of Otolaryngology; 2017, 71, 6; 35-39
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Neuroendocrine Carcinoma of the Head and Neck – review of literature
    Autorzy:
    Berger, G
    Dawidziuk, T
    Chyczewski, L
    Powiązania:
    https://bibliotekanauki.pl/articles/1401521.pdf
    Data publikacji:
    2016
    Wydawca:
    Index Copernicus International
    Tematy:
    neuroendocrine carcinoma
    head and neck
    Opis:
    Neuroendocrine carcinoma is a rare neoplasm, and its most common location in the head and neck area is the larynx, especially the epiglottis and the supraglottic region. The first case of neuroendocrine carcinoma of the larynx was reported in 1969 by Goldman et al. Expression of the two crucial markers, synaptophysin and chromogranin, along with neural cell adhesion molecule (CD56) should be mentioned among the neuroendocrine features detected on immunohistochemistry. Human papilloma virus (HPV16/18) infection in the laryngeal neuroendocrine carcinoma can be one of the causal factors, and the detection of HPV should be considered as a standard procedure for the diagnosis and treatment.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2016, 5, 4; 16-21
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Tumor of the pharynx – an unexpected diagnosis
    Autorzy:
    Ura-Sabat, Katarzyna
    Domka, Wojciech
    Gamrot-Wrzoł, Marta
    Szuber, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/454943.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    head and neck,
    haemangioma
    diagnosis
    treatment
    Opis:
    Introduction. Head and neck haemangiomas occur quite rarely. These are benign lesions, often involving the pharynx and larynx. They almost always pose a diagnostic and therapeutic problem. Case description. This paper describes the case of an asymptomatic internal carotid artery aneurysm manifested by a throat tumour. A 78-year old woman with sudden deafness and vertigo was additionally diagnosed with a throat tumour. After radiological diagnosis of a haemangioma, the patient refused surgery. This article presents diagnostic methods and various types of treatments for head and neck haemangiomas. Attention was paid to the possibility of serious complications when deciding on surgical intervention of haemangiomas without a confirmed diagnosis. Conclusion. Suspicion of head and neck haemangiomas necessitates using all available diagnostic methods. The treatment plan should take into account the pace of progression, the patient’s age and co-morbid conditions. .
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 1; 78-81
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Dermoidal cysts of head and neck in children
    Autorzy:
    Piszcz, Małgorzata
    Skotnicka, Bożena
    Hassmann-Poznańska, Elżbieta
    Gościk, Elżbieta
    Reszeć, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1401794.pdf
    Data publikacji:
    2015
    Wydawca:
    Index Copernicus International
    Tematy:
    dermoid cysts
    head and neck
    children
    Opis:
    Introduction: Dermoid cysts are benign epidermal tumors; in 7% of cases, they are located in the head and neck region. They are lesions of congenital origin, mostly presenting within the midline of the body. About 70% of cases are diagnosed before the age of 5 years. Methods: A retrospective analysis of medical data of children with dermoid cysts located within the head and neck region treated in the Department of Pediatric Otolaryngology in Bialystok in the period of 1994-2014 was performed. A review of relevant literature was presented. Results: A total of 17 patients were included in this study, with a mean age of 8.9 years; 76.5% of the study population was female. Dermoid cysts were mostly located in the anterior neck region and the floor of the mouth (76%). US and CT imaging scans were used in diagnostics. No recurrences were observed after surgical excision. Conclusion: Dermoid cysts should be taken into consideration when diagnosing head and neck masses in pediatric patients.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2015, 4, 2; 66-70
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ocena wiedzy pacjentów na temat czynników ryzyka związanych ze stylem życia, a występowanie chorób nowotworowych głowy i szyi
    Risk factors related to lifestyle affecting the occurrence of head and neck cancer
    Autorzy:
    Karbowiak, Urszula
    Serzysko, Bogusława
    Powiązania:
    https://bibliotekanauki.pl/articles/1029873.pdf
    Data publikacji:
    2018
    Wydawca:
    Państwowa Uczelnia Zawodowa we Włocławku
    Tematy:
    head and neck cancer
    lifestyle
    quality of life
    Opis:
    Introduction. Cancer is a complex pathological process that develops in the human body, destroying healthy cells progressively and leading to significant limitations in functioning and severe pain, sometimes persissitng even with the aid of painkillers. Cancerous diseases of the head and neck organs significantly reduce the quality of life compared to the population of healthy people. Aim. The aim of this study was to show whether smoking, alcohol and HPV are risk factors for head and neck cancer. Materials and methods. The study was conducted among 149 patients diagnosed with head and neck cancer in the Clinical Outpatient Center of Oncology Center in Gliwice with the consent of this heaktcare facility. The study used a questionnaire containing 38 questions. The study was carried out from November 2016 to January 2017. Results. The analysis of the results did not confirm that smoking, alcohol and HPV are the main risk factors for head and neck cancer. A large number of respodents did not answer the questions , which suggests patients' lack of knowledge or their denial of the harmfulness of the above-mentioned addictions. Conclusions. The majority of respondents were aware of the harmfulness of smoking and its effect on the development of cancer. However, they were not aware of the impact of drinking alcohol on the development of cancer. Most of the subjects knew what HPV is. However, the majority of respondents did not know that HPV belongs to oncogenic viruses. Smoking cigarettes differentiated their awareness of the impact of smoking on the development of cancer.
    Wstęp. Choroba nowotworowa to złożony proces patologiczny, który rozwija się w ludzkim organizmie, który niszcząc zdrowe komórki prowadzi progresywnie do znacznych ograniczeń w funkcjonowaniu oraz znacznych dolegliwości bólowych, czasem nieustępujących po lekach przeciwbólowych. Choroba nowotworowa narządów głowy i szyi w znaczny sposób obniża jakość życia w porównaniu do populacji osób zdrowych. Cel. Celem tego badania była ocena wiedzy pacjentów na temat czynników ryzyka związanych ze stylem życia, a występowaniem chorób nowotworowych głowy i szyi. Materiał i metody. Badanie przeprowadzono wśród 149 pacjentów, u których rozpoznano chorobę nowotworową głowy i szyi w Przyklinicznej Przychodni Centrum Onkologii w Gliwicach za zgodą tejże palcówki. W badaniu posłużono się autorska ankietą zawierającą w 38 pytań. Badanie realizowano od listopada 2016 r. do stycznia 2017r. Wyniki. Analiza wyników nie potwierdziła, że palenie wyrobów tytoniowych, picie alkoholu i wirus HPV są głównymi czynnikami ryzyka chorób nowotworowych głowy i szyi. Spora ilość zaznaczanych odpowiedzi to nie udzielenie odpowiedzi, co sugeruje o braku wiedzy pacjentów lub wyparcia przez nich szkodliwości w/w nałogów. Wnioski. Badani w zdecydowanej większości byli świadomi szkodliwości palenia papierosów i jego wpływu na powstanie choroby nowotworowej. Nie mieli natomiast świadomości wpływu picia alkoholu na rozwój choroby nowotworowej. Większość badanych wiedziała, czym jest wirus HPV. Natomiast badani w większości nie mieli wiedzy, że wirus HPV należy do onkogennych. Palenie papierosów kiedykolwiek przez badanych różnicowało ich świadomość wpływu palenia papierosów na powstanie choroby nowotworowej.
    Źródło:
    Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2018, 3, 2; 9-26
    2451-1846
    Pojawia się w:
    Innowacje w Pielęgniarstwie i Naukach o Zdrowiu
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical manifestation of malignant lymphomas of the head and neck region
    Autorzy:
    Bojanowska-Poźniak, Katarzyna
    Nurkowska, Monika
    Danilewicz, Marian
    Pietruszewska, Wioletta
    Powiązania:
    https://bibliotekanauki.pl/articles/1398500.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    malignant lymphoma
    head and neck neoplasm
    extranodal lymphoma
    Opis:
    Introduction: Malignant lymphoma (ML) is a neoplasm caused by clonal expansion of undifferentiated B, T and NK-lymphoid cells. WHO classification divides lymphomas into two main types, i.e. Hodgkin lymphoma (HL), and non-Hodgkin lymphoma (NHL), with numerous subtypes. The majority of MLs are localized in lymph nodes, but extranodal locations are also possible. MLs represent approximately 3-5% of all malignant neoplasms in Poland, but their incidence has been increasing in recent years, especially in young patients. The objective of the study was to evaluate clinical manifestations and diagnostic process in patients with malignant lymphomas of the head and neck region as diagnosed in the Department of Otorhinolaryngology of the Medical University of Lodz in years 2013-2017. Material and method: 30 patients diagnosed with malignant lymphomas of the head and neck region at the Departbadament of Otorhinolaryngology of the Medical University of Lodz in 2013-2017. Results: The study group consisted of 8 cases of nodal lymphomas and 22 cases of extranodal lymphomas. In 29 cases B-cell lymphomas were diagnosed. The most common symptoms included lymphadenopathy or neck tumor. Other symptoms were associated with the location of tumors in particular body organs. The diagnosis was based on histopathological examination of biopsy (needle or surgical) samples. Conclusion: Malignant lymphomas should be taken into account during differential diagnosis of the tumor or lymphadenopathy of the neck. The diagnosis is difficult because of the nonspecificity of symptoms and the need for interdisciplinary cooperation of many specialists.
    Źródło:
    Polish Journal of Otolaryngology; 2017, 71, 6; 14-21
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of copper(II) the activity of glutathione peroxidase in patients with head and neck cancer
    Autorzy:
    Malinowska, Katarzyna
    Morawiec-Sztandera, Alina
    Majsterek, Ireneusz
    Kaczmarczyk, Dariusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1398625.pdf
    Data publikacji:
    2016
    Wydawca:
    Index Copernicus International
    Tematy:
    pyrazole complex
    glutathione peroxidase
    head and neck cancer
    Opis:
    Introduction: Head and neck squamous cell carcinoma (HNSCC) accounts for about 6% of all malignant cancers. In the epidemiology of oral cavity neoplasm, important risk factors include: tobacco smoking, alcohol abuse, bad oral hygiene, papilloma virus infection, riboflavin and iron deficiency. Objective: The objective of the investigation was a synthesis of Cu(II) complex and the evaluation of antioxidative enzymatic barrier in red blood cells of patients with head and neck tumor as well as in the control group. Materials and methods: For the investigation conduction, a consent of Bioethics Committee number RNN/142/09/KB was obtained. Blood for the examination was obtained from the patients of the Dapartment of Head and Neck Neoplasms Surgery Medical University of Łódź. The experiment was conducted on the group of 40 patients with HNSCC and 40 healthy people, using spectrophotometric method, glutathione peroxidase was marked. Results: The investigation was conducted on the hemolysate obtained from the patients that were divided into two groups – a study group (1 and 2), which consisted of patients diagnosed with head and neck cancer and a control group (1 and 2) – healthy people. A significant statistical result for GPX occurred in control-1 and study-1 group with complex compound Cu(II) (p<0,001). Conclusions: Presented research prove, that complex compound Cis-dichlorobis(N1-hydroxymethyl-3methylpyrazole-κN2)copper (II) has an impact on the activity of the antioxidative GPX enzyme.
    Źródło:
    Polish Journal of Otolaryngology; 2016, 70, 6; 20-25
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of criteria for elective tracheostomy in head and neck cancer surgery
    Autorzy:
    Kissin, Filip
    Rysz, Maciej
    Budziszewska, Magdalena
    Krajewski, Romuald
    Powiązania:
    https://bibliotekanauki.pl/articles/1397292.pdf
    Data publikacji:
    2021
    Wydawca:
    Index Copernicus International
    Tematy:
    elective tracheostomy
    head and neck surgery
    postoperative complications
    Opis:
    Elective tracheostomy before resection of a malignancy in head and neck region assures unobstructed ventilation during postoperative period but is associated with an increased risk of complications. We aimed to evaluate retrospectively, how the application of elective tracheostomy scales would influence the frequency of tracheostomy in comparison with preoperative clinical judgement. In 205 patients operated on from 2013 till 2017, theresection of a malignancy involved suprahyoid or pharyngeal muscles, neck dissection and flap reconstruction. The decision on elective tracheostomy was made on the clinical basis. Score for each patient in 3 published scales was calculated. In the study group 76 patients had elective tracheostomy at the outset of a resection procedure. Among 129 patients without elective tracheostomy, 9 had tracheostomy in the postoperative period. Indications for elective tracheostomy were calculated for scale I, II and III. Only in 120 patients the decision whether to perform elective tracheostomy would be identical in each scale. Our results suggest that decisions to perform elective tracheostomy based on 3 scales show low specificity. The factors used in the published scales should be evaluated in a prospective multicenter study
    Źródło:
    Polish Journal of Otolaryngology; 2021, 75, 4; 20-26
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of age and comorbidities on the outcomes of surgical treatment with free tissue transfer: a retrospective study
    Autorzy:
    Czesak, Małgorzata
    Sobol, Maria
    Bruzgielewicz, Antoni
    Niemczyk, Kazimierz
    Osuch-Wójcikiewicz, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1397380.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    elderly patient
    head and neck cancer
    reconstructive surgery
    Opis:
    Introduction: Microvascular free tissue transfer enables the reconstruction of complex head and neck defects. The aim of the study was to assess the results of treatment of patients undergoing reconstructive surgery and to identify factors affecting these results, with particular reference to patient’s age. Materials and Methods: All patients who underwent free-flap head and neck reconstruction in our institution between 2010 and 2017 were included in this retrospective study. A series of 66 patients met the inclusion criteria and were divided into 2 age groups: group G1 aged <65 years (n = 41) and group G2 aged ≥65 years (n = 25). Minor local complications and general complications as well as comorbidities were analyzed. Results: No correlation was found between advanced age and the risk of free flap failure as well as the incidence of local minor complications. General complications were more frequent in the G2 group (32%) than in the G1 group (19.5%), although this is not a statistically significant difference. A statistically significant difference was found between the age and the patient’s health status according to ASA (P = 0.010). In the younger low-risk group, 12 patients (29.3%) had general and local complications, while in the older low-risk group only 1 (4%). General and local complications were found in 5 (12.2%) high-risk G1 patients and in 7 (28%) high-risk G2 patients. Conclusion(s): Patients with advanced head and neck malignant tumors should undergo reconstructive microsurgery regardless of age.
    Źródło:
    Polish Journal of Otolaryngology; 2020, 74, 4; 8-12
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The impact of radiotherapy on the quality of life in patients with early-stage clinical head and neck cancer
    Autorzy:
    Milecki, Jakub
    Żmijewska-Tomczak, Małgorzata
    Osmola, Krzysztof
    Wierzbicka, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/23203207.pdf
    Data publikacji:
    2021-05-07
    Wydawca:
    Index Copernicus International
    Tematy:
    head and neck cancer
    Quality of life
    radiotherapy
    Opis:
    Introduction: Radiotherapy (RT) for patients with head and neck squamous cell carcinoma (HNSCC) affects vital functions related to the irradiation volume of the head and neck region and, in addition, has a negative impact on social functioning, thereby significantly impairing patients’ quality of life (QoL). Aim: The aim of this study was to assess changes in the quality of life in patients with head and neck cancer treated with curative RT at 12 months after completion of RT. The aim of this study was to assess the differences between the baseline QoL of patients with early clinical stage HNSCC and at 12 months after curative/radical RT. Material and methods: The prospective clinical study included 92 patients in good general condition (ECOG 0–1 – Eastern Cooperative Oncology Group performance status), without regional or distant metastases, diagnosed with pathomorphologically confirmed early-stage head and neck squamous cell carcinoma treated with definitive RT. All patients participating in the study signed an informed consent form. QoL was assessed using the standard EORTC QLQ-C30 and QLQH&N35 questionnaires. In addition, information on clinical aspects and data relating to socio-demographic factors were obtained from each patient. Statistical analysis was performed using a statistical package (SPSS 17.0). T-test was used for dependent and independent samples. A general linear model was used for repeated measures. Results: Patients’ QoL deteriorated significantly after definitive RT. Worse QoL Core-30 scores in patients 12 months after the end of RT, compared with baseline QoL, before the start of RT, were observed in domains such as physical performance, fulfillment of life roles, cognitive functioning, loss of appetite, fatigue and constipation. For the QLQ-H&N35 questionnaires, patients 12 months after the end of RT reported problems in relation to aspects of life such as senses, mouth opening, dry mouth, thick saliva, pain, and weight loss. Conclusion: RT, even in early clinical stage head and neck cancer, has a negative impact on QoL, despite modern treatment techniques.
    Źródło:
    Polish Journal of Otolaryngology; 2021, 75, 5; 1-8
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma
    Autorzy:
    Jelonek, Karol
    Wojakowska, Anna
    Marczak, Lukasz
    Muer, Annika
    Tinhofer-Keilholz, Ingeborg
    Lysek-Gladysinska, Malgorzata
    Widlak, Piotr
    Pietrowska, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/1039103.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    exosomes
    head and neck cancer
    ionizing radiation
    proteome
    radiobiology
    Opis:
    Exosomes are membrane vesicles of endocytic origin that participate in inter-cellular communication. Environmental and physiological conditions affect composition of secreted exosomes, their abundance and potential influence on recipient cells. Here, we analyzed protein component of exosomes released in vitro from cells exposed to ionizing radiation (2Gy dose) and compared their content with composition of exosomes released from control not irradiated cells. Exosomes secreted from FaDu cells originating from human squamous head and neck cell carcinoma were analyzed using LC-MS/MS approach. We have found that exposure to ionizing radiation resulted in gross changes in exosomal cargo. There were 217 proteins identified in exosomes from control cells and 384 proteins identified in exosomes from irradiated cells, including 148 "common" proteins, 236 proteins detected specifically after irradiation and 69 proteins not detected after irradiation. Among proteins specifically overrepresented in exosomes from irradiated cells were those involved in transcription, translation, protein turnover, cell division and cell signaling. This indicated that exosomal cargo reflected radiation-induced changes in cellular processes like transient suppression of transcription and translation or stress-induced signaling.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 2; 265-272
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of cone beam computed tomography in ENT and reconstructive head and neck surgery – literature review and own experience
    Autorzy:
    Piotrowska-Seweryn, Agnieszka
    Krakowczyk, Łukasz
    Maciejewski, Adam
    Kaniszewska-Dorsz, Żaneta
    Markowski, Jarosław
    Pietrauszka, Kornelia
    Goroszkiewicz, Karolina
    Powiązania:
    https://bibliotekanauki.pl/articles/1399645.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    computed tomography
    ENT
    free flap
    head and neck
    reconstruction
    Opis:
    CBCT is a relatively new diagnostic imaging method. It was first used in 1982 at the Mayo Clinic Biodynamics Research Laboratory [1], and has been commercially used in dentistry since 2001. It differs from multidetector computed tomography in terms of implementation technique and some parameters. A low dose of radiation is its greatest advantage, thanks to which many specialists, including ENT doctors and reconstructive surgeons, are more willing to use it. In otorhinolaryngology, CBCT is applied in pre- and perioperative diagnostics in both rhinology and otology. In reconstructive surgery, CBCT facilitates precise planning of the flap and intraoperatively allows a perfect match of the reconstructed tissue elements. In the article, the authors present current information on CBCT in ENT obtained on the basis of a review of Polish and foreign literature and share their own experience in its application in reconstructive surgery within the craniofacial region.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2019, 8, 3; 1-7
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Microvascular nose reconstruction after extended tumor resection
    Autorzy:
    Krakowczyk, Łukasz
    Szymczyk, Cezary
    Wierzgoń, Janusz
    Oleś, Krzysztof
    Smyczek, Dominika
    Ulczok, Rafał
    Donocik, Karolina
    Hadasik, Grzegorz
    Piotrowska, Agnieszka
    Maciejewski, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1391900.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    free flaps
    head and neck
    nasal cancer
    nasal reconstruction
    Opis:
    Introduction: The nose is the central and probably the most important organ of the face. In view of the three-dimensional shape and variety of tissues, reconstructive surgery after tumor resection in this anatomical region requires the surgeon’s knowledge of anatomy. Materials and Method: In the years 2010–2019, 48 patients were treated in the Oncological and Reconstructive Surgery Clinic for extended nasal tumors, which required the use of free microvascular flaps after resection for functional and aesthetic supply of anatomical structures of the nose. Results: In 48 patients, a total of 92 free microvascular flaps were used for nasal reconstruction including: radial forearm free flap in 24 patients, radial forearm free flap with radial bone in 14 patients, auricular free flap in 16 patients, radial forearm free flap in combination with auricle free flap in 7 patients, double auricular free flap in 6 patients, radial forearm free flap in combination with double auricular free flap in 4 patients. Total necrosis of the free flap was noted in 4 cases, partial in 6 patients. Conclusions: The presented surgical techniques using microvascular free flaps constitute a recognized method of treatment and should be used in everyday surgeon practice. The results demonstrated in this article allow to obtain optimal functional and aesthetic effects.
    Źródło:
    Polish Journal of Surgery; 2020, 92, 5; 1-7
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    THE EFFECT OF NICLOSAMIDE ON THE HEAD AND NECK CARCINOMA CELLS SURVIVAL AND THE EXPRESSION OF WNT/β-CATENIN SIGNALING AND GLYCOLYSIS PATHWAY COMPONENTS
    Autorzy:
    Kleszcz, Robert
    Paluszczak, Jarosław
    Baer-Dubowska, Wanda
    Powiązania:
    https://bibliotekanauki.pl/articles/895272.pdf
    Data publikacji:
    2019-08-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    Wnt signaling
    glycolysis
    β-catenin
    niclosamide
    head and neck carcinoma
    Opis:
    The aim of this study was to evaluate the effect of niclosamide, an antihelminthic drug recently identified as potential anti-cancer agent, on head and neck squamous carcinoma cells (HNSCC) viability, cell cycle distribution and apoptosis. The expression of key components of Wnt (CTNNB1, GSK-3β, CCND1, c-MYC, MMP7, BIRC5, Axin2) and glycolysis (GLUT1, MCT1, HK2, PFKM, PKM2, PDHA1, PDK1, LDHA) pathways was also examined to assess possible involvement in niclosamide anti-carcinogenic activity. HNSCC cells (FaDu, BICR6, H314 lines) were used in the research. Niclosamide treatment affected hypopharyngeal FaDu cells to the most extent (IC50 = 0.40 µM), while H314 cells derived from the floor of mouth were the least sensitive (IC50 = 0.94 µM). In FaDu cells the increased percentage of the cells in the S phase was observed along with the induction of apoptosis. Treatment with niclosamide in FaDu cells reduced the expression of MMP7 and the majority of glycolytic genes except increased LDHA. These results indicate that niclosamide is efficient inhibitor of HNSCC cells viability, however this effect depends on the cell type. In FaDu cells, the most sensitive to its anti-proliferative effect and prone to cell cycle arrest and apoptosis, this effect might be related to slightly modulation of canonical Wnt signaling and increased expression of LDHA.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 661-669
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    THE COMPARISON OF THE EFFECTS OF PANOBINOSTAT AND PKF118-310 ON β-CATENIN-DEPENDENT TRANSCRIPTION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA CELL LINES
    Autorzy:
    Paluszczak, Jarosław
    Kleszcz, Robert
    Witczak, Olga
    Krajka-Kuźniak, Violetta
    Powiązania:
    https://bibliotekanauki.pl/articles/895659.pdf
    Data publikacji:
    2020-02-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    Wnt signaling
    head and neck cancer
    panobinostat
    PKF118-310
    Opis:
    Advanced head and neck squamous cell cancers (HNSCC) have unfavorable prognosis and new therapeutic options are necessary to improve treatment outcomes. The Wnt pathway plays an important role in the pathogenesis and progression of HNSCC. The aim of this study was to assess the effects of a histone deacetylase inhibitor – panobinostat on Wnt-dependent gene expression and on cell migration. Cell viability in HNSCC cell lines (BICR6, CAL27, FaDu, H314, SCC-25) was evaluated by MTT assay. The expression of β-catenin-target genes was assessed by qPCR and TCF/LEF-dependent reporter assay. Protein content was evaluated by Western blot. Cell migration was analyzed by the wound healing assay. Panobinostat showed differential modulation of gene expression. It reduced the level of Axin2 in CAL27 and SCC-25 cells but upregulated its expression in BICR6 and H314 cell lines. Moreover, it diminished the expression of MMP7 in BICR6, H314 and CAL27 cell lines. In contrast, the inhibitor of β-catenin transcriptional activity – PKF118-310 down-regulated the expression of β-catenin-target genes in HNSCC cell lines. Interestingly, panobinostat had opposite effects on cell migration in CAL27 and FaDu where it inhibited or stimulated migration, respectively. On the other hand, PKF118-310 reduced cell migration. The anti-cancer effects of panobinostat in HNSCC cells are rather not related to the inhibition of Wnt signaling. PKF118-310 attenuates Wnt signaling, but only in a limited number of HNSCC cell lines. Importantly, the inhibition of Wnt pathway reduces the capacity of cells for migration suggesting that it may potentially therapeutically reduce cell invasion.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 77-88
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Review of surgical techniques for the reconstruction of the maxillofacial region used in the Department of Maxillo-Facial Surgery in Rzeszów
    Autorzy:
    Frańczak, Jan
    Pakla, Paweł
    Brodowski, Robert
    Stopyra, Wojciech
    Burdzy, Danuta
    Lewandowski, Bogumił
    Powiązania:
    https://bibliotekanauki.pl/articles/454921.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    reconstructive surgery
    microsurgery
    surgical flaps
    cancer of head and neck
    Opis:
    Postoperative reconstruction of tissue loss within the head and neck after extensive resections due to malignant neoplasms or traumas has always been a challenge for maxillo-facial surgeons or ENT physicians. Due to the complex anatomical structure of the head and neck region, every patient requires an individual approach and there is no standard method of management appropriate for all patients. The number of patients treated for malignancy is increasing year by year. The possibility of performing extensive resections in the head and neck region are conditioned by appropriate reconstruction. Aim. The aim of the paper is to present the reconstructive methods used in the Clinical Department of Maxillofacial Surgery, F. Chopin Hospital No. 1 in Rzeszow. A short review of the most commonly used flaps is presented, taking into account their advantages, disadvantages and surgical technique in terms of their usefulness in daily clinical practice.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 3; 273-278
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fibromatosis aggressiva of parapharyngeal space – a case report and review of literature.
    Autorzy:
    Piotrowska, Angelika
    Rzepakowska, Anna
    Chęciński, Piotr
    Niemczyk, Kazimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1400253.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    desmoid-type fibromatosis
    parapharyngeal space tumor
    head and neck neoplasms
    Opis:
    Desmoid fibromatosis is defined as a rare fibroblastic proliferation. Although histologically benign, desmoids are locally invasive and associated with a high local recurrence rate. When located in the head and neck region, fibromatosis tends to be more aggressive and associated with significant morbidity, which may be attributed to the proximity of the vital structures. We report a case of 33-year-old woman with aggressive fibromatosis of parapharyngeal space. Complete surgical excision of the lesion was performed and the postoperative period was without complications. The patient remains under careful follow-up and there is no recurrence of the disease.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2017, 6, 2; 10-15
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of MGMT polymorphisms rs12917 and rs11016879 in head and neck cancer risk and prognosis
    Autorzy:
    Kiczmer, Paweł
    Prawdzic Seńkowska, Alicja
    Strzelczyk, Joanna
    Szydło, Błażej
    Biernacki, Krzysztof
    Osadnik, Tadeusz
    Krakowczyk, Łukasz
    Ostrowska, Zofia
    Powiązania:
    https://bibliotekanauki.pl/articles/1038528.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    MGMT
    head and neck cancer
    polymorphism
    rs12917
    rs11016879
    Opis:
    Head and neck squamous cell carcinoma (HNSCC) is one of the leading cancers by incidence worldwide. The risk of these cancers is strictly associated with alkylation factors present in tobacco smoke. The crucial role in preventing DNA alkylation is played by O6-methylguanine-DNA methyltransferase (MGMT). Dysfunction or lack of MGMT is associated with an increased risk of cancer. The aim of the study was to assess the influence of MGMT polymorphisms: rs12917 and rs11016879 on HNSCC risk and course. The study consisted of 69 HNSCC patients and 242 healthy individuals. Case samples were taken from resected tumour tissue. The control group comprised samples of epithelial cells collected from mucous membranes using swabs. DNA samples were genotyped by employing the 5' nuclease assay for allelic discrimination using TaqMan SNP Genotyping Assays. The significance between distributions of genotypes and alleles was tested using Pearson's χ2 test analysis. Our results indicated that the MGMT rs12917 TT genotype increases the risk of HNSCC. The MGMT rs11016879 AG genotype and A allele were associated with increased HNSCC risk. We noted higher risk of nodal metastasis in rs11016879 AA homozygotes. Mechanisms leading to MGMT enzymatic defect are unknown and hence further studies need to be carried out. Our data suggest that the examined polymorphisms may be considered as potential prognostic factors for HNSCC risk and outcome. Further studies are necessary to verify our results.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 87-92
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    BERBERINE INDUCES AUTOPHAGY, APOPTOSIS AND MODULATES MIR-155 IN HEAD AND NECK SQUAMOUS CARCINOMA CELLS.
    Autorzy:
    Xue, Kai
    Zhang, Binbin
    He, Jingchuan
    Powiązania:
    https://bibliotekanauki.pl/articles/895286.pdf
    Data publikacji:
    2020-06-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    apoptosis
    miR-155
    Autophagy
    berberine
    Head and Neck cancer cells
    Opis:
    Berberine (BBR) an active natural plant alkaloid extracted from Coptidis rhizoma, displays potent anticancer activity over a variety of cancer cell lines. The cytotoxic activity of BBR in cancer cells is attributed to persuade, programmed cell death characterized by the release of cytochrome c, accompanied by activation of caspase-3 and caspase-9. In the present study, we evaluated BBR significantly reduces the cell viability and clonogenic property of head and neck squamous carcinoma (HNSC) cells. Our results revealed that BBR simultaneously induces apoptosis and autophagy in HNSC cells. Mechanistically, BBR induces autophagy in HNSC cells which were confirmed by acridine orange (AO) staining by visualization of prominent orange red color acidic autophagosomes in the cytoplasm. However, immunoblotting shows the steady conversion of MAP-LC-3I to LC-3II with concomitant degradation of autophagy substrate protein SQSTM1/p62. Annexin V FITC staining analysis by flow cytometry revealed a significant induction of apoptosis at higher doses of BBR. Furthermore, the immunoblotting analysis revealed a prominent cleavage of proapoptotic proteins procaspase-3 and PARP1 at higher doses of BBR. Additionally, we found significant upregulation and downregulation of tumor suppressor microRNA-155 (miR-155) and oncogenic miR-21 respectively, when HNSC cells were exposed to higher doses of BBR. In conclusion, these results demonstrate that BBR exhibits a significant anti-proliferative effect with the simultaneous induction of autophagy and apoptosis and modulates miRNA expression in HNSC cells.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 485-494
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Serum and saliva levels of matrix metalloproteinase 3 and 9 in pharynx and larynx cancer
    Autorzy:
    Polz-Dacewicz, Małgorzata
    Maciąg, Paweł
    Kliszczewska, Ewa
    Rolniak, Łukasz
    Powiązania:
    https://bibliotekanauki.pl/articles/972529.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    matrix metalloproteinases
    larynx cancer
    throat cancer
    head and neck cancer
    Opis:
    Introduction and objective. Matrix metalloproteinases (MMPs) are proteolytic enzymes responsible for the decomposition of extracellular matrix elements. They play an important role during embryogenesis, wound healing, endometrial epithelial exfoliation, the formation of new blood vessels, and also during cancer development. Throat and larynx tumours are included in a large group of head and neck cancers. These tumours are characterized by a poor prognosis. Despite advances in medical science, cancer treatment is difficult and often ineffective. The aim of the study was to evaluate the level of MMP-3 and MMP-9 in the serum and saliva of patients with pharynx and larynx tumours. Materials and method. Samples of saliva and serum were collected from 60 patients with larynx or throat cancer. Twenty patients without cancer comprised the control group. MMPs in saliva and serum were determined by the ELISA method. Results. In the study group, concentrations of MMP-3 in saliva were from 0.2 – 77.6 ng/ml. Patients with malignant tumours had higher saliva MMP-3 levels than healthy subjects. The concentration of MMP-3 in the serum of the study group ranged from 10.9 – 200.00 ng/ml, which was also higher than in the control group. There were no statistically significant difference in the MMP-9 level between the study and control groups (both in serum and saliva). Conclusions. This study is another element that shows the phenomena taking place at the cellular level during oncological disease. In serum and saliva samples, higher values of MMP3 were found in patients with cancer. The increase in the concentration of this enzyme in the risk group may be used for early detection of tumour transformation and evaluation of treatment.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 106-110
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Instrumental evaluation of dysphagia after oropharyngeal cancer surgery with free flap reconstruction
    Autorzy:
    Jamróz, Barbra
    Chmielewska, Joanna
    Milewska, Magdalena
    Niemczyk, Kazimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1401527.pdf
    Data publikacji:
    2016
    Wydawca:
    Index Copernicus International
    Tematy:
    FEES
    VFS
    dysphagia
    head and neck cancer
    free flap reconstruction
    Opis:
    Introduction: Assessment of usefulness of instrumental method of evaluation of dysphagia in creating a therapeutic plan among patients after oropharyngeal cancer surgery with free flap reconstruction. Material and Method: Seven patients after oropharyngeal cancer surgery with free flap reconstruction hospitalized from January to September 2016 in the ENT Department of Warsaw Medical University were included in this study. All patients underwent few times after surgery: clinical swallowing examination, water swallowing screening test and fiberoptic endoscopic evaluation of swallowing and/or videofluoroscopy. Results: All patients were diagnosed with dysphagia and had unitentional weight loss (average 5,9% of initial weight during 3 months). In water swallowing test only three participant achieved negative score for 5 ml, and two for 10 ml, 20 ml and 90 ml of water. Fiberoptic endoscopic evaluation of swallowing was analyzed for swallowing patterns and laryngeal pathology. FEES showed following abnormalities: aspiration (saliva, liquid), penetration (puree, liquid), premature swallowing (liquid, puree) and multiswallowing (liquid, puree, solid food), retention (saliva, puree, liquid, solid food). Videofluroscopy showed on the first place problems with oral phase of swallowing: difficulty forming and propeling bolus, tongue pumping movements, oral cavity residue, premature spillage and delayed oral onset. During the pharyngeal phase we observed: residue in valleculae and piriform sinuses, reduced laryngeal elevation, penetration and aspiration, multiple swallows. Conclusion: Instrumental assessment of swallowing helps during diagnostic and therapeutic process of patients with dysphagia after oncological treatment. a.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2016, 5, 4; 22-28
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ionizing radiation affects profile of serum metabolites: increased level of 3-hydroxybutyric acid in serum of cancer patients treated with radiotherapy
    Autorzy:
    Roś-Mazurczyk, Małgorzata
    Wojakowska, Anna
    Marczak, Łukasz
    Polański, Krzysztof
    Pietrowska, Monika
    Jelonek, Karol
    Domińczyk, Iwona
    Hajduk, Agata
    Rutkowski, Tomasz
    Składowski, Krzysztof
    Widłak, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1038706.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    head and neck cancer
    mass spectrometry
    metabolomics
    radiation response
    serum metabolome
    Opis:
    Radiotherapy causes molecular changes observed at the level of body fluids, which are potential biomarker candidates for assessment of radiation exposure. Here we analyzed radiotherapy-induced changes in a profile of small metabolites detected in sera of head and neck cancer patients using the gas chromatography coupled with mass spectrometry approach. There were about 20 compounds, including carboxylic acids, sugars, amines and amino acids, whose levels significantly differed between pre-treatment and post-treatment samples. Among metabolites upregulated by radiotherapy there was 3-hydroxybutyric acid, whose level increased about three times in post-treatment samples. Moreover, compounds affected by irradiation were associated with several metabolic pathways, including protein biosynthesis and amino acid metabolism.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 189-193
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Enteral feedıng vıdeo traınıng for the relatıves of head and neck cancer patıents: evaluatıon of ıts ımpact on knowledge and practıce
    Autorzy:
    Günay Ismailoğlu, Elif
    Orkun, Nilay
    Zaybak, Ayten
    Çepken Kanlıoğlu, Makbule
    Powiązania:
    https://bibliotekanauki.pl/articles/1918968.pdf
    Data publikacji:
    2021-06-14
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    enteral feding
    head and neck cancer
    patient
    patient relatives
    video training
    Opis:
    Purpose: The purpose of the study was to examine the effect of using videos during enteral feeding training on the level of relevant knowledge and practice. Materials and methods: A randomized controlled quasi-experimental, post-test research design was used. We included 33 patients and relatives in the video group while 31 patients their relatives in the control group. In video group, the video recording was shown to the relatives in addition to verbal training however only verbal training was given in the control group. The relatives’ level of knowledge and practice score was evaluated. Results: Mean enteral feeding knowledge scores of patient relatives were found to be 76.7 ± 7.97 in the video group and 42.1 ± 12.57 in the control group. Mean enteral feeding practice scores were as follows: 19.64 ± 3.3 for the video group and 13 ± 3.63 for the control group. Conclusions: It was concluded that the enteral feeding training provided by using the video method increased the knowledge and practice levels of patient relatives. Implications for Practice: Video material prepared for the clinic will be a guide for clinical nurses and help them in their enteral feeding training and care planning.
    Źródło:
    Progress in Health Sciences; 2021, 11(1); 15-22
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Updated National Comprehensive Cancer Network guidelines for treatment of head and neck cancers 2010-2017
    Autorzy:
    Wierzbicka, Małgorzata
    Napierała, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1398501.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    head and neck cancers treatment guidelines
    biological therapy
    personalized treatment
    recommendations
    Opis:
    Introduction: The diagnostic and therapeutic recommendations have been changing over the years to improve treatment outcomes and quality of life of Head and Neck Cancer (HNC) patients. Aim: The aim of this study was to present currently recommended Head and Neck Cancer treatment guidelines based on the literature review with particular emphasis on novel approaches the NCCN algorithms. Material and methods: The review of literature covering articles published in the last five years and pointing out essential changes in HNC treatment regarding evidence based medicine. The study focused on the analysis of novel approaches for the particular primaries, the implementation of biological therapies and personalized cancer therapies. Results: Updates in the oncological NCCN guidelines for all ENT primaries except major salivary glands and subglottis are based on knowledge derived from the basic sciences, clinical trials and the best evidence available currently. The latest recommendations emphasize value of biological therapies use.
    Źródło:
    Polish Journal of Otolaryngology; 2017, 71, 6; 1-6
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Health-related quality of life in oropharyngeal cancer survivors – a population-based study
    Autorzy:
    Guenzel, Thomas
    Walliczek-Dworschak, U
    Teymoortash, A
    Singer, S
    Eichler, M
    Wilhelm, T
    Schimmer, M
    Franzen, A
    Powiązania:
    https://bibliotekanauki.pl/articles/1398253.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    EORTC
    oropharynx
    tonsil
    tongue
    cancer
    head and neck
    quality of life
    Opis:
    Objective: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments. Subjects and methods: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. Results: A total of 263 survivors completed the questionnaires (28% responses). Forty-five of them had undergone surgery, 20 had received definitive radiotherapy or chemo-radiotherapy, 85 surgery plus adjuvant radiotherapy, and 111 surgery plus adjuvant chemo-radiotherapy. Survivors who had received adjuvant radiotherapy and surgery reported significantly more problems with swallowing (B=13.43 [95% Confidence Interval (CI) 1.83-25.03]), senses (B=24,91 [CI 11.86-37.97]), eating (B=16.91 [CI 3.46-30.36]), dry mouth (B=26.42 [CI 12.17-40.67]), sticky saliva (B=22.37 [CI 6.23-38.50]) and nutritional supplements (B=18.59 [CI 0.62-36.56]) than those who had received surgery only. Survivors who had received adjuvant chemo-radiotherapy and surgery reported significantly many more problems with dry mouth (B=34.15 [CI 18.91-49.39]) and sticky saliva (B=22.90 [CI 5.65-40.16]), and fewer problems with physical functioning (B=-12.07 [CI 0.49-23-64]). Conclusion: Survivors who participated in this survey and who had undergone surgery alone reported in some head- and neck-specific domains a better health-related quality of life than patients who had undergone multi-modal treatment or adjuvant radiotherapy.
    Źródło:
    Polish Journal of Otolaryngology; 2018, 72, 2; 30-35
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Retrospective evaluation of risk factors for oral cavity and oropharynx cancers in patients under the program of head and neck cancers prevention
    Autorzy:
    Kowalski, Andrzej
    Olszewski, Jurek
    Zielińska-Bliźniewska, Hanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1397748.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    Head and Neck Cancer Prophylaxis Program
    oral cavity
    oropharynx cancer
    risk factors
    Opis:
    Introduction: The aim of the study was to analyze the risk factors for oral cavity and pharyngeal cancer in people examined under the Head and Neck Cancer Prophylaxis Program. Material and methods: The study was conducted in a total of 300 patients, including 186 women and 114 men, as part of the Head and Neck Cancer Prevention Program in 2014–2018. Before the laryngological examination, the patients completed a demographic and medical questionnaire regarding the risk factors of head and neck cancer, including education, reported disease symptoms, smoking addiction, number of cigarettes smoked daily, alcohol consumption, frequency of visits in a dental office, oral hygiene measures, number of sexual partners, oral sex, family medical history of head and neck cancer. Results: The subjects reported the following symptoms: hoarseness 43.33%, difficulty swallowing 21.33%, pain or mouth burning 20.33% and other symptoms were observed in 46.33%. The main dental symptoms were: bleeding from the gums during teeth brushing in 48.89%, dry mouth 45.56%. Currently 20.33% of respondents smoke, whereas 54% of patients smoked in the past. In the analyzed material, the majority (80%) consumed alcoholic beverages. 27.67% of respondents admitted having oral sex, including 24.73% of women and 32.46% of men. After performing the extended diagnostics, the tumor was found in 10% of the subjects. C onclusions: Statistical significance of differences was found: between hoarseness and alcohol consumption, both in women and in men, between hoarseness and smoking in women, between difficulty in swallowing and smoking in women, between burning/pain in the mouth and smoking in men, between hoarseness and the cultivation of oral sex in men, between the difficulty of swallowing and the practice of oral sex in the studied men and between burning/pain in the oral cavity and the occurrence of malignancy.
    Źródło:
    Polish Journal of Otolaryngology; 2019, 73, 6; 24-31
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immunotherapy of head and neck squamous cell carcinoma (HNSCC). Immune checkpoint blockade
    Autorzy:
    Przybylski, Krzysztof
    Majchrzak, Ewa
    Weselik, Liucija
    Golusiński, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/1398281.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    head and neck squamouscell carcinoma
    immunotherapy
    CTLA - 4
    PD - 1
    nivolumab
    pembrolizumab
    Opis:
    Treating patients with squamous cell carcinoma of the head and neck is a significant problem. There is an increase in the incidence of malignant neoplasms in this region. Surgery, radiotherapy and chemotherapy are often not sufficient methods of treatment. Thorough analysis of processes occurring in the tumor microenvironment has allowed to distinguish three stages that make up the reaction of the human body to hostile antigens, which are tumor antigens. Understanding these mechanisms has resulted in the introduction of a new term immune-oncology. It is an area of cancer treatment that focuses on use of the patient’s immune system to combat the disease. Immunotherapy has had positive effects in cancer patients. The use of immune checkpoint inhibitors, such as anti-CTLA-4 and PD-1 monoclonal antibodies has enabled the modulation of T cell functions, consequently eliminating immunosuppression in the tumor microenvironment. Clinical trials were conducted using nivolumab and ipilimumab, which confirmed their clinical usefulness. The approval by FDA of nivolumab in treatment of recurrent and metastatic squamous cell carcinoma of the head and neck has increased the overall survival time of patients as well as disease free survival. Statistical data indicate an advantage of immunotherapy over other treatment methods at an advanced stage of cancer. This work aims to discuss basic issues related to immunotherapy, in particular immunotherapy in patients with squamous cell carcinoma of the head and neck.
    Źródło:
    Polish Journal of Otolaryngology; 2018, 72, 6; 10-16
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Virtual surgical planning and cone beam computed tomography in reconstruction of head and neck tumors – pilot study
    Autorzy:
    Krakowczyk, Łukasz
    Piotrowska-Seweryn, Agnieszka
    Szymczyk, Cezary
    Wierzgoń, Janusz
    Oleś, Krzysztof
    Ulczok, Rafał
    Donocik, Karolina
    Dowgierd, Krzysztof
    Maciejewski, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1397270.pdf
    Data publikacji:
    2021
    Wydawca:
    Index Copernicus International
    Tematy:
    cone beam computed tomography
    free flap
    head and neck
    reconstruction
    virtual surgical planning
    Opis:
    Introduction: The aim of the study was to prove that a combination of visual surgical planning (VSP) and cone beam computed tomography (CBCT) is an optimal technique in fibular free flap reconstructions after complex tumor resections in the head and neck region and that it leads to better functional and aesthetic outcomes. Material and method: Six patients (3 females, 3 males) with head and neck tumors were included in the study. The region concerned midface in 2 cases and mandible in 4 patients. On the basis of computed tomography of the head, fibular free flap (FFF) reconstruction was planned with the VSP technique. The 3D-printed models were prepared. At the beginning of the operation and a few minutes after the reconstruction, an xCAT CBCT by XORAN was performed. Minor corrections of the angles of the reconstructed bony parts were made where needed. The time of the operation was assessed for each case. Functional and cosmetic results were evaluated in a 1-year follow-up. Results: The mean time of operation was 6 hours and 48 minutes, which was approximately 1hour and 40 minutes less than standard reconstructive surgery. Functional recovery was achieved in all patients. Aesthetic result was unsatisfactory for 2 patients due to insufficient soft tissue masses of FFF. Conclusions: The authors claim that intraoperative CBCT imaging, regardless of the cost, improves the accuracy of aesthetic outcome of reconstructive surgeries based on VSP, especially in the region of the midface and the mandible. Further studies on a higher number of subjects are required.
    Źródło:
    Polish Journal of Otolaryngology; 2021, 75, 2; 28-33
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests.
    Autorzy:
    Palyvoda, Olena
    Polańska, Joanna
    Wygoda, Andrzej
    Rzeszowska-Wolny, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1043662.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ionizing radiation
    DNA damage
    human lymphocytes
    comet assay
    head and neck tumors
    DNA repair
    Opis:
    A population study is reported in which the DNA damage induced by γ-radiation (2 Gy) and the kinetics of the subsequent repair were estimated by the comet and micronucleus assays in isolated lymphocytes of 82 healthy donors and patients with head and neck cancer before radiotherapy. The parameters of background and radiation-induced DNA damage, rate of repair, and residual non-repaired damage were measured by comet assay, and the repair kinetics for every donor were computer-fitted to an exponential curve. The level of background DNA damage before irradiation measured by comet assay as well as the level of micronuclei were significantly higher in the head and neck cancer patient group than in the healthy donors, while the parameters of repair were widely scattered in both groups. Cancer patient group contained significantly more individuals, whose irradiated lymphocytes showed high DNA damage, low repair rate and high non-repaired DNA damage level. Lymphocytes of donors belonging to this subgroup showed significantly lower inhibition of cell cycle after irradiation.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 1; 181-190
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antioxidative assessment of new trans-palladium (II) complexes in head and neck cancer
    Autorzy:
    Malinowska, Katarzyna
    Kaczmarczyk, Dariusz
    Zajdel, Radosław
    Merecz-Sadowska, Anna
    Olszewski, Jurek
    Majczyk, Małgorzata
    Nowak-Zduńczyk, Alicja
    Zielińska-Bliźniewska, Hanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1397298.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    antioxidant enzymes
    head and neck cancer
    oxidative stress
    Pd (II) complexes
    reactive oxygen species
    Opis:
    Background: Head and neck neoplasms stand for 6% of all malignant neoplasms worldwide. Chemotherapy has limited use due to the biological properties of the tumor (in the majority of cases moderately and poorly differentiated squamous cell carcinoma). The fundamental molecule used in treatment is cisplatin and its derivates, that can be associated with fluorouracil. The new chemotherapeutic agents are not in common use during the treatment of head and neck malignancies. However, the use of low molecular weight complexes Pd (II) carries the potential of being more effective in therapy. Material and Methods: Fifty-one patients, 30 men and 21 women (aged 52.9 ± 12.1 years) with head and neck cancer were included in the study. Fifty-one healthy subjects, 31 men and 20 women, (aged 54.1 ± 14.7 years) years formed the control group. Antioxidant enzymes, superoxide dismutase, and catalase activities in erythrocytes were examined. Results: An increased level of antioxidant enzymes was seen in the blood samples from patients with head and neck cancer after incubation with Pd (II) complex. In the group we obtained a statistically significant result p = <0.001. Discussion: That project may contribute to the development of new, more efficient head and neck cancer treatment strategies. In our opinion, the results can be used in the future to develop a valuable prognostic marker of the disease. This is important because the initial phase of cancer is asymptomatic. The search for factors involved in pathogenesis translates into economic benefits and makes therapy more effectiveness through the reduction of treatment expenses.
    Źródło:
    Polish Journal of Otolaryngology; 2020, 74, 1; 23-28
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population
    Autorzy:
    Gogolewska, Monika
    Kabziński, Jacek
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/23381296.pdf
    Data publikacji:
    2023-12-15
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    xenobiotics
    head and neck cancer
    CYP1A
    NAT2
    CYP2D
    NAT1
    Opis:
    Objectives Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics. Material and Methods In group of 280 patients with HNC, the occurrence of polymorphic variants in NAT1(rs72554606), NAT2(rs1799930), CYP1A(rs1799814), CYP2D(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed. Results The results indicated an increased risk of HNC in NAT1 polymorphisms in the GC genotype (OR = 1.772, 95% CI: 1.184–2.651, p = 0.005) and NAT2 polymorphism in the GA genotype (OR = 1.506, 95% CI: 1.023–2.216, p = 0.037). The protective phenomenon in the CYP1A polymorphism the GT genotype (OR = 0.587, 95% CI: 0.381–0.903, p = 0.015) and the TT genotype (OR = 0.268, 95% CI: 0.159–0.452, p = 0.001). The coexistence of GA-GC polymorphisms (OR = 2.687, 95% CI: 1.387–5.205, p = 0.003) in NAT2-NAT1 genes increases the risk of HNC. Risk-reducing effect in the polymorphism GG-GT (OR = 0.340, 95% CI: 0.149–0.800, p = 0.011), GG-TT (OR = 0.077, 95% CI: 0.028–0.215, p < 0.0001), GA-TT (OR = 0.250, 95% CI: 0.100–0.622, p = 0.002), AA-GT (OR = 0.276, 95% CI: 0.112–0.676, p = 0.002) in NAT2-CYP1A genes. In the CYP2D-CYP1A genes in the polymorphisms CT-CC (OR = 0.338, 95% CI: 0.132–0.870, p = 0.020), TT-GG (OR = 0.100, 95% CI: 0.027–0.359, p = 0.001), TT-GC (OR = 0.190, 95% CI: 0.072–0.502, p = 0.0004), TT-CC (OR = 0.305, 95% CI: 0.107–0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989–10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003–2.464, p = 0.047). Conclusions The CYP1A polymorphism shows a protective association with HNC. On the other hand, NAT2, NAT1 polymorphism influence the susceptibility to developing HNC. The coexistence of the NAT2-NAT1 genotypes increases the risk of HNC. In contrast, NAT1-CYP1A and CYP1A-CYP2D reduce this risk. Smoking and alcohol consumption increase the incidence of HNC.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2023, 36, 6; 812-824
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Use of 3D printing in head and neck surgery
    Zastosowanie druku 3D w chirurgii głowy i szyi
    Autorzy:
    Likus, Wirginia
    Nechoritis, Konstantinos
    Różycka-Nechoritis, Aleksandra
    Wilk, Renata
    Hudecki, Andrzej
    Gaweł, Wojciech
    Przytuła-Kandzia, Katarzyna
    Markowski, Jarosław
    Powiązania:
    https://bibliotekanauki.pl/articles/1035511.pdf
    Data publikacji:
    2020
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    3d printing
    otolaryngology
    head and neck
    surgery
    education
    reconstruction
    druk 3d
    otolaryngologia
    głowa i szyja
    chirurgia
    edukacja
    rekonstrukcje
    Opis:
    Currently, 3D printing in medicine does not comprise only prostheses or implants, but also medical modelling and surgical planning. The future of 3D printing is printing combined with tissue bioengineering (bioprinting). Scaffolds made in 3D technology containing living cells are a step to creating tissues and organs. Three-dimensional printing in surgery is now considered the future of reconstructive and regenerative medicine. Head and neck surgery also benefits from advances in 3D printing. In this article, we will describe some of the possibilities offered by 3D printing in the aspect of education, training, and printed prostheses for the needs of head and neck surgery.
    Obecnie druk 3D w medycynie oznacza nie tylko protezy czy implanty, ale także modelowanie medyczne i planowanie chirurgiczne. Przyszłością będzie druk 3D połączony z bioinżynierią tkankową (bioprinting). Rusztowania wykonane w technologii 3D zawierające żywe komórki są krokiem do tworzenia tkanek i narządów. Druk trójwymiarowy w chirurgii uważany jest obecnie za przyszłość medycyny rekonstrukcyjnej i regeneracyjnej, a z dokonań na tym polu korzysta także chirurgia głowy i szyi. W prezentowanym artykule opiszemy niektóre możliwości, jakie daje druk 3D w aspekcie edukacji, szkoleń oraz drukowanych protez na potrzeby chirurgii głowy i szyi.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2020, 74; 99-115
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical manifestations of granulomatosis with polyangiitis (GPA) in dermatology and otolaryngology
    Autorzy:
    Ziuzia, Laura
    Dobrzyński, Paweł
    Sobolewski, Piotr
    Walecka-Herniczek, Irena
    Powiązania:
    https://bibliotekanauki.pl/articles/1400276.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    granulomatosis with polyangitis
    head and neck
    rhinosinusitis
    otitis media
    sensineurinal leasing loss
    subglottic stenosis
    cutaneous changes
    ocular changes
    oral changes
    Opis:
    The diseases caused by vasculitis are rare. The difficulties in diagnosis may be due to this low frequency, as well as to rather slow development and various symptoms and locations of the symptoms. In the diagnosis of the vasculitis one should consider all of the clinical features, for they may include diagnostic criteria for various clinical entities.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2017, 6, 2; 8-14
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Salvage surgery of hypopharyngeal cancer as a second malignancy post radiotherapy and the possibility of digestive track reconstruction – study of three cases and the literature review
    Autorzy:
    Rzepakowska, Anna
    Jasińska, Agnieszka
    Wolniewicz, Maria
    Baranek, Piotr
    Osuch-Wójcikiewicz, Ewa
    Bruzgielewicz, Antoni
    Niemczyk, Kazimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1399615.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    head and neck cancer
    second primary cancer
    hypopharyngeal cancer
    salvage surgery
    digestive tract reconstruction
    radial forearm free flap
    free autologous jejunal flap
    Opis:
    Patients with head and neck cancers have an increased risk of second malignant neoplasm occurrence (25% in long-term follow-up, 4% yearly). Most patients with a primary tumor can be treated with organ-preserving strategies including radiotherapy (RT) or chemoradiotherapy (CRT). Very often after radical surgical excision there are indications for adjuvant radiotherapy. However, if recurrence or second malignancy will develop after definitive primary RT, there are limitation to use therapeutic dose of radiation again for the same area. Salvage surgery is regarded as the only curative option in those cases. In our study we analysed 3 patients, who presented with head and neck second cancer in the area of hypopharynx, within 10-25 years after primary radiotherapy due to oropharyngeal and laryngeal cancer. A total pharyngectomy with larynx preservation and bilateral neck dissection were performed in the first case and the radial forearm free flap (RFFF) was used for reconstruction of the pharynx. Second patient, due to perilaryngeal invasion in radiological images, underwent total pharyngolaryngectomy with selective bilateral cervical lymph nodes dissection and digestive track was restored also with RFFF. The third patient had previously undergone laryngectomy and after total pharyngectomy the free autologous jejunal flap (FAJF) was used for reconstruction. The main goal of reconstruction after salvage surgery due to hypopharyngeal cancer is to reconstruct the digestive tract. The other important aspect is to optimize the anatomy for voice rehabilitation and swallowing. Unfortunately, radiation and chemotherapy impair wound healing, which indicates increased risk of postoperative complications and makes salvage surgery results unpredictable.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2019, 8, 1; 33-39
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Odczyn popromienny u chorych na nowotwory regionu głowy i szyi w diagnozie i terapii logopedycznej
    Radioreaction In Patients With head and neck tumours In Diagnosis And Speech Therapy
    Autorzy:
    Buczyńska, Izabela
    Powiązania:
    https://bibliotekanauki.pl/articles/695856.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    radioterapia chorych na nowotwory regionu głowy i szyi
    odczyn popromienny
    terapia logopedyczna
    radiation therapy of head and neck cancer
    radioreaction complications
    speech therapy
    Opis:
    Radiotherapy plays a crucial role in head and neck cancers/tumours treatment. Radical treatment with ionizing radiation is associated with the occurrence of radioreaction. The most common complications in the early or late phase of the disease are: swallowing disorders, dry mouth, and a need to change the diet. The aim of this paper is to discuss pathogenesis, risk factors and radiation prophylaxis in diagnosis and speech therapy. Logopedic exercises, stimulation of facial skeleton, oral hygiene, skin care and a fortified diet help to reduce the level of complications and inhibit the side effects of radiation therapy.
    Radioterapia zajmuje szczególne miejsce w leczeniu nowotworów regionu głowy i szyi. Radykalne leczenie promieniowaniem jonizującym wiąże się z wystąpieniem odczynu popromiennego. Najczęstszymi powikłaniami są: zaburzenia mowy i połykania, suchość w jamie ustnej i konieczność zmiany diety. Celem artykułu jest omówienie patogenezy, czynników ryzyka i profilaktyki odczynu popromiennego w diagnozie i terapii logopedycznej. Ćwiczenia logopedyczne, stymulacja twarzy, pielęgnacja skóry i wzbogacona dieta wpływają na zmniejszenie skutków ubocznych radioterapii.
    Źródło:
    Logopaedica Lodziensia; 2018, 2; 35-47
    2544-7238
    2657-4381
    Pojawia się w:
    Logopaedica Lodziensia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zaburzenia mowy u pacjentów onkologicznych regionu głowy i szyi w diagnozie i terapii logopedycznej. Studium przypadku
    Speech Disorder of the Head and Neck Regions in Diagnosis and Speech Therapy of Oncological Patients. A Case Study
    Autorzy:
    Buczyńska, Izabela
    Powiązania:
    https://bibliotekanauki.pl/articles/892731.pdf
    Data publikacji:
    2020-08-30
    Wydawca:
    Polskie Towarzystwo Logopedyczne
    Tematy:
    zaburzenia mowy
    diagnoza i terapia logopedyczna
    nowotwory regionu głowy i szyi
    leczenie onkologiczne
    speech disorders
    diagnosis and speech therapy
    head and neck tumors
    oncological treatment
    Opis:
    Nowotwory regionu głowy i szyi to zmiany chorobowe w obrębie kompleksu ustno-twarzowego. Strukturalne i czynnościowe zaburzenia poszczególnych narządów orogardła powodują trudności w oddychaniu, połykaniu i w wymowie. Celem artykułu jest omówienie zaburzeń mowy u pacjentów onkologicznych regionu głowy i szyi po radykalnych operacjach chirurgiczno-rekonstrukcyjnych. Rodzaj zaburzeń językowych zależy od zaawansowania choroby nowotworowej, zakresu ubytku pooperacyjnego oraz indywidualnych umiejętności kompensacyjnych pacjenta. Największe odchylenia od normy występują w trakcie realizacji głosek [k, g, l, r], natomiast najsłabsze podczas fonacji samogłosek. Nadrzędnym celem logopedycznego postępowania terapeutycznego jest usprawnienie połykania, artykulacji i fonacji oraz umiejętności komunikacyjnych chorego z otoczeniem. Reedukacja czynności prymarnych i sekundarnych pacjenta onkologicznego po przebytym zabiegu rekonstrukcyjnym w obrębie twarzoczaszki sprawia, że współczesna logopedia jest integralną częścią leczenia onkologicznego.
    Tumors of the head and neck region are lesions within the orofacial complex. Structural and functional disturbances of individual oropharyngeal structures cause difficulties in breathing, swallowing and pronunciation. The aim of the article is to discuss speech disorders of the head and neck regions in oncological patients after radical reconstructive surgery. The type of a linguistic disorder depends on the severity of the neoplastic disease, the extent of the postoperative loss and individual patient compensation skills. The greatest deviations from the norm occur during the implementation of sounds such as [k, g, l] and the smallest happen during phonation of vowels. The primary aim of speech therapy is to improve such skills as swallowing, articulation, phonation and communication of the patient with the environment. Re-education of the primary and secondary functions in the case of oncological patients after reconstructive surgery in the craniofacial region makes modern speech therapy an integral part of the oncological treatment.
    Źródło:
    Logopedia; 2019, 48, 1; 351-370
    0459-6935
    Pojawia się w:
    Logopedia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Head and neck amyloidosis – a report on five cases
    Amyloidoza w rejonie głowy i szyi – opis serii przypadków
    Autorzy:
    Orłowska, Anna
    Mastalerek, Jan
    Jaskólska, Magdalena
    Rzepakowska, Anna
    Grzybowski, Jakub
    Gotlib, Tomasz
    Niemczyk, Kazimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1399353.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    amyloidosis
    amyloidosis of the nasopharynx
    head and neck amyloidosis
    larynx amyloidosis
    localized amyloidosis
    salivary gland amyloidosis
    tongue amyloidosis
    amyloidoza
    amyloidoza głowy i szyi
    amyloidoza języka
    amyloidoza krtani
    amyloidoza miejscowa
    amyloidoza nosogardła
    amyloidoza ślinianek
    Opis:
    Background: Amyloidosis is a group of diseases caused by the extracellular accumulation of insoluble fibers called amyloid in the tissues and organs. They have a secondary beta-sheet structure, which makes them resistant to proteolysis. In histological examination amyloid deposits stain with Congo red and show an apple-green birefringence in polarized light. Amyloid deposits disturb the function of organs and cause clinical symptoms. Their formation or accumulation in the system may be acquired or inherited. Due to the location of amyloid deposits we distinguish systemic and localized amyloidosis with the formation of tumors (usually from light chains). Case reports: 5 cases of amyloidosis in the head and neck region are presented in this paper. The locations of the amyloid deposits were as follows: larynx, nasopharynx, sublingual and submandibular gland and the tongue. The initial clinical presentation correlated with location of amyloid tumour in our patients. Two patients had history of local recurrence of the disease. Surgical resection and histopathological examination were performed. Sections stained with Congo red confirmed the diagnosis of amyloidosis. Three patients had potential conditions predisposing to amyloidosis: previous radiotherapy, chronic inflammation due to hepatitis C virus infection and graft versus host disease. Conclusion: Amyloidosis should be considered as the cause of symptoms in pathologies of the head and neck region. The diagnosis requires a histopathological examination. The systemic form of the disease must be ruled out in all patients with head and neck amyloidosis. In localized amyloidosis the surgical resection of the lesions is the procedure of choice, however the organ’s functionality should be taken into account.
    Podstawy naukowe: Amyloidoza, czyli skrobawica, to grupa chorób, których wspólną cechą jest pozakomórkowe gromadzenie się w tkankach i narządach nierozpuszczalnych białek o budowie włókienkowej, zwanych amyloidem. Mają one drugorzędową strukturę β-kartki, co czyni je opornymi na proteolizę. W skrawkach histologicznych złogi amyloidu wybarwiają się czerwienią Kongo i wykazują zielone świecenie w świetle spolaryzowanym. Depozyty amyloidu zaburzają funkcje narządów i powodują objawy kliniczne. Ich powstawanie lub gromadzenie się w ustroju może być stanem nabytym lub dziedzicznym. Ze względu na lokalizację złogów amyloidu rozróżniamy: (1) amyloidozę układową, czyli uogólnioną, oraz (2) miejscową z tworzeniem guzów (najczęściej z łańcuchów lekkich immunoglobulin). Opisy przypadków: W niniejszej pracy opisano 5 przypadków amyloidozy w regionie głowy i szyi. Zmiany zlokalizowane były w obrębie: krtani, nosogardła, ślinianki podjęzykowej i podżuchwowej oraz języka. Pacjenci zgłaszali objawy typowe dla procesu rozrostowego obejmującego wymienione narządy. U dwóch osób choroba miała charakter nawrotowy. Zmiany usunięto operacyjnie. Na podstawie badania histopatologicznego pobranych tkanek i charakterystycznego barwienie czerwienią Kongo i Saturna, rozpoznano obecność złogów amyloidu. U trzech pacjentów występowały stany predysponujące do wystąpienia amyloidozy: uprzednia radioterapia, przewlekły stan zapalny związany z zakażeniem wirusem zapalenia wątroby typu C i choroba przeszczep przeciwko gospodarzowi. U chorego z makroglosją rozpoznano postać uogólnioną amyloidozy. Podsumowanie: Amyloidoza może imitować objawy zmian rozrostowych w rejonie głowy i szyi. Jej rozpoznanie wymaga badania histopatologicznego. U każdego chorego z miejscową amyloidozą musi zostać wykluczona postać uogólniona. W przypadku postaci miejscowej, resekcja chirurgiczna zmian jest postępowaniem z wyboru. Należy wziąć pod uwagę zachowanie funkcjonalności narządu.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2019, 8, 2; 32-37
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-37 z 37

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