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    Wyświetlanie 1-8 z 8
    Tytuł:
    A New Method for Assessing Haemolysis in a Rotary Blood Pump Using Large Eddy Simulations (LES)
    Autorzy:
    Szwast, M.
    Moskal, A.
    Piątkiewicz, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/185020.pdf
    Data publikacji:
    2017
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    rotary blood pump
    large eddy simulations
    haemolysis
    obrotowa pompa krwi
    duże symulacje wirów
    hemoliza
    Opis:
    The opportunity to assess haemolysis in a designed artificial heart seems to be one of the most important stages in construction. We propose a new method for assessing haemolysis level in a rotary blood pump. This method is based on CFD calculations using large eddy simulations (LES). This paper presents an approach to haemolysis estimation and shows examples of numerical simulation. Our method does not determine the value of haemolysis but allows for comparison of haemolysis levels between different artificial heart constructions.
    Źródło:
    Chemical and Process Engineering; 2017, 38, 2; 231-239
    0208-6425
    2300-1925
    Pojawia się w:
    Chemical and Process Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cyclization and antimicrobial evolution of 1,3,4-oxadiazoles by carbohydrazide
    Autorzy:
    Godhani, Dinesh R.
    Mulani, Vishal B.
    Mehta, Jignasu P.
    Powiązania:
    https://bibliotekanauki.pl/articles/1063054.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    1
    3
    4-oxadiazole
    antimicrobial activity
    cytotoxicity
    dihydropyrimidine
    haemolysis
    Opis:
    A series of dihydropyrimidine substituted 1,3,4-oxadiazole derivatives was synthesized by cyclization of carbohydrazide by phosphoryl chloride and benzoic acid in acidic condition. The structures were perceived on the establishment of spectral tools and their purity by elemental analysis. Every compound was primary assessed for their in vitro antimicrobial activities against 5 bacterial strains viz [Staphylococcus aureus (MRSA; ATCC 43300), Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922), Acinetobacter baumannii (ATCC 19606), Pseudomonas aeruginosa (ATCC 27853)] and 2 fungi Strains viz. [Candida albicans (ATCC 90028), Cryptococcus neoformans var. grubii (H99; ATCC 208821)]. Some compounds displayed significant antimicrobial activity, out of 15 compounds, 11 compounds indicated promising antifungal activities without any indications of human cells cytotoxic [Hk: Human Embryonic Kidney cells (ATCC CRL-1573)] and haemolytic activity [RBC (ARCBS 5400 00150)].
    Źródło:
    World Scientific News; 2019, 124, 2; 304-311
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of carboxymethylated pyridoindoles on free radical-induced haemolysis of rat erythrocytes in vitro
    Autorzy:
    Juskova, Maria
    Snirc, Vladimir
    Krizanova, Ludmila
    Stefek, Milan
    Powiązania:
    https://bibliotekanauki.pl/articles/1040396.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    pyridoindoles
    aldose reductase inhibitors
    antioxidants
    haemolysis
    erythrocytes
    oxidative stress
    Opis:
    Recently novel carboxymethylated pyridoindoles, analogues of the efficient chain-breaking antioxidant stobadine, have been designed, synthesised and characterised as bifunctional compounds with joint antioxidant/aldose reductase inhibitory activities with the potential of preventing diabetic complications. The critical property for the efficacy of the novel aldose reductase inhibitors in vivo is their ability to penetrate into target tissues. In this study, the issue was addressed by measuring the antioxidant activity of compounds 1 [(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid] and 2 [(±)-2-benzyl-(4a,9b)-cis-1,2,3,4,4a,9b-hexahydro-1H-pyrido[4,3-b] indole-8-yl acetic acid] in the cellular system of intact erythrocytes exposed to peroxyl radicals generated by thermal degradation of the azoinitiator 2,2'-azobis(2-amidinopropane) hydrochloride (AAPH) in vitro. Isolated washed rat erythrocytes were incubated in the presence of the azoinitiator AAPH and the compounds tested for increasing periods of time up to 4 h at 37 °C. The degree of haemolysis was determined by absorbance of the haemoglobin released. The onset of AAPH-induced haemolysis was found to be shifted from the starting zero point by the time interval assigned as a lag period. In the presence of the compounds studied the lag period was prolonged significantly. The free radical-initiated haemolysis was retarded by the compounds studied with decreasing efficiency: stobadine > compound 1 ~ Trolox > compound 2. The results have demonstrated an antioxidant activity of the novel carboxymethylated pyridoindoles developed as potential agents for multitarget pharmacology of diabetic complications.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 2; 153-156
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Gemini (dimeric) surfactant perturbation of the human erythrocyte.
    Autorzy:
    Dubnièková, Martina
    Bobrowska-Hägerstrand, Malgorzata
    Söderström, Thomas
    Igliè, Aleš
    Hägerstrand, Henry
    Powiązania:
    https://bibliotekanauki.pl/articles/1044306.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    TEM
    flow cytometry
    protection against hypotonic haemolysis
    exovesiculation
    human erythrocyte
    detergent
    cationic amphiphile
    shape alteration
    haemolysis
    Opis:
    We studied the ability of di-cationic gemini surfactantsdi (amphiphiles), i.e. 1,4-butanediammonium-N,N-dialkyl-N,N,N',N'-tetramethyl bromides (Di-Cm-di-QAS (s = 4), where m = 8,11,13,16 and s = the number of alkyl groups in the spacer) to induce shape alteration, vesiculation, haemolysis and phosphatidylserine exposure in human erythrocytes, and to protect erythrocytes against hypotonic haemolysis. At high sublytic concentrations the Di-Cm-di-QAS (s = 4) amphiphiles rapidly induced echinocytic (spiculated) shapes and a release of exovesicles, mainly in the form of tubes, from the cell surface. Following 60 min incubation erythrocytes were sphero-echinocytic and a few cells with invaginations/endovesicles were observed. No phosphatidylserine exposure was detected. The haemolytic potency increased with an increase of the alkyl chain length. At sublytic concentrations the Di-Cm-di-QAS (s = 4) amphiphiles protected erythrocytes against hypotonic haemolysis. It is suggested that the Di-Cm-di-QAS (s = 4) amphiphiles perturb the membrane in a similar way as single-chain cationic amphiphiles, but that they do not easily translocate to the inner membrane leaflet.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 3; 651-660
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Haemocompatibility and cytotoxic studies of non-metallic composite materials modified with magnetic nano and microparticles
    Autorzy:
    Szymonowicz, M.
    Rybak, Z.
    Fraczek-Szczypta, A.
    Paluch, D.
    Rusak, A.
    Nowicka, K.
    Blazewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/306490.pdf
    Data publikacji:
    2015
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    nanokompozyty
    cząstki magnetyczne
    hemoliza
    żywotność komórkowa
    koagulacja
    nanocomposite
    magnetic particles
    polysulfone
    haemolysis
    cell viability
    coagulation systems
    Opis:
    Purpose: Preventing the formation of blood clots on the surface of biomaterials and investigation of the reasons of their formation are the leading topics of the research and development of biomaterials for implants placed into the bloodstream. Biocompatibility and stability of a material in body fluids and direct effect on blood cell counts components are related both to the structure and physico-chemical state of an implant surface. The aim of this study was to determine haemocompatibility and cytotoxicity of polysulfone-based samples containing nano and micro particles of magnetite (Fe3O4). Methods: The polysulfone-based samples modified with nanometric and micrometric magnetite particles were examined. Physicochemical properties of the composites were determined by testing their wettability and surface roughness. The action of haemolytic, activation of coagulation system and cytotoxicity of composites was evaluated. Results: Wettability and roughness of materials were correlated with nanoparticles and microparticles content. In the tests of plasma coagulation system shortening of activated partial thromboplastin time for polysulfone with nano magnetite and with micro magnetite particles was observed in comparison with pure polysulfone. Prothrombine time and thrombine time values as well as fibrinogen concentration were unchanged. Haemolysis values were normal. Morphology and viability of cells were normal. Conclusions: Composites made from polysulfone modified with nanoparticles and microparticles of magnetite cause neither haemolytic nor cytotoxic reaction. These composites evoke plasma endogenous system activation.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2015, 17, 3; 49-58
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and antimicrobial evolution of some new benzotriazole substituted 1,3,4-thiadiazoles
    Autorzy:
    Godhani, Dinesh R.
    Mulani, Vishal B.
    Mehta, Jignasu P.
    Kukadiya, Nipul B.
    Powiązania:
    https://bibliotekanauki.pl/articles/1177753.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    antimicrobial activity
    benzotriazole
    cytotoxicity
    haemolysis
    schiff base
    thiadiazole
    Opis:
    A series of novel benzotriazole-substituted 1,3,4-thiadiazole-2(3H)-thione derivatives was synthesized by cyclization of Schiff base. The structures were recognized on the foundation of spectral tools and their purity by elemental analysis. All the compounds were preliminary evaluated for their in vitro antimicrobial activities against five bacterial strains viz [Staphylococcus aureus (MRSA; ATCC 43300), Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922), Acinetobacter baumannii (ATCC 19606), Pseudomonas aeruginosa (ATCC 27853)] and two fungi Strains viz. [Candida albicans (ATCC 90028), Cryptococcus neoformans (ATCC 208821)]. Several compounds exhibited remarkable antimicrobial activity, out of 15 compounds, three compounds viz. 5a, 5g and 5i showed promising antifungal activities with no signs of human cells cytotoxic [HEK293: Human Embryonic Kidney cells (ATCC CRL-1573)] and haemolytic activity [Whole blood (ARCBS 5400 00150)].
    Źródło:
    World Scientific News; 2018, 100; 51-60
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The evaluation of resorbable haemostatic wound dressings in contact with blood in vitro
    Autorzy:
    Szymonowicz, M.
    Kucharska, M.
    Wiśniewska-Wrona, M.
    Dobrzyński, M.
    Kołodziejczyk, K.
    Rybak, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/306978.pdf
    Data publikacji:
    2017
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    opatrunek
    chitozan
    alginian
    mikrofibrydy
    nanofibrydy
    hemoliza
    haemostatic
    dressing
    chitosan-alginate
    nanofibrids
    microfibrids
    haemolysis
    plasmatic clotting system
    Opis:
    Purpose: For many years research has been conducted on the development of resorbable, polymer, haemostatic materials designed to provide first aid and preliminary protection of injuries. The biological properties in vitro of a dressing in powder form called Hemoguard are expected to provide the ability to instantaneously stem bleeding with safe conditions of use. The aim of the study was to evaluate the haemostatic properties of a model of dressing based on micro- and nanofibrids of the chitosan, sodium/calcium alginate and/or carboxymethylcellulose complex. Dressings were prepared by spray-drying and freeze-drying. Methods: Human whole blood was subjected to timed contact with the haemostatic dressing model. Haemolytic action was determined by assaying the degree of haemolysis and evaluating blood cell morphology. Haemostatic action was determined on the basis of selected parameters of plasmatic clotting systems. Results: Dressings prepared by freeze-drying activated the coagulation system. The haemolytic index, plasma haemoglobin concentration values and blood cell morphological shapes were normal. Dressings prepared by spray-drying significantly activated coagulation. Activation of the coagulation process was evidenced by shorter clotting time of the plasma coagulation system and a longer process of clot formation. The dressing was associated with an increased haemolytic index and higher plasma haemoglobin concentration. The morphological shape of blood cells changed. Conclusions: The model of multi-resorbable wound dressings has haemostatic properties. The materials activate the clotting process more quickly than a single-dressing model. Increased activity was found for dressings prepared by spray-drying.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2017, 19, 1; 151-165
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ węgla pirolitycznego na parametry morfologiczne krwi
    Effect of pyrolytic carbon on the morphological parameters of blood
    Autorzy:
    Szymonowicz, M.
    Janus, A.
    Pielka, S.
    Obłąkowska, D.
    Błażewicz, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/286181.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    węgiel pirolityczny
    hemoliza
    wskaźniki czerwonokrwinkowe
    krwinki białe
    płytki krwi
    pyrolytic carbon
    haemolysis
    red cells parameters
    white cells
    platelets
    Opis:
    W pracy przedstawiono analizę ilościową wybranych parametrów morfologicznych krwi po jej czasowym kontakcie z materiałem węglowym LTI. Na podstawie uzyskanych wyników nie stwierdzono zmian w wartościach parametrów układu czerwonokrwinkowego, natomiast zaobserwowano zmiany w wartościach parametrów układu białokrwinkowego i płytkowego. Zaobserwowane zmiany w wartościach parametrów morfologicznych nie przekraczają zakresu wartości referencyjnych dla tych wskaźników.
    A quantitative analysis of selected morphological parameters of blood after its temporal contact with LTI carbon material was presented in the study. The obtained results indicate that the values of parameters of erythrocyte system did not change, while the values of parameters of leukocyte and platelet systems were altered. The changes in the values of parameters did not exceed the range of referential values for these indexes.
    Źródło:
    Engineering of Biomaterials; 2010, 13, no. 96-98; 83-87
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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