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Wyświetlanie 1-15 z 99
Tytuł:
Rape glucosinolates and alfalfa saponins as allelopathic factors for lettuce seeds germination
Autorzy:
Waligora, D
Powiązania:
https://bibliotekanauki.pl/articles/66032.pdf
Data publikacji:
1997
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
glucosinolate
allelopathic factor
development
root hair
allelopathy
seed
germination
seed germination
oilseed rape
alfalfa
saponin
seedling growth
lettuce
Opis:
Secondary plant substances - glucosinolates and saponins reduced seed germination and seedling growth of lettuce. Saponins showed greater inhibitory effect on both germination and growth of lettuce seedlings than glucosinolates. The effect depended on the concentration of these compounds in the ground. Tested compounds caused abbreviation of roots, browning their tips and prevented root hair development.
Testowano wpływ roślinnych metabolitów wtórnych: saponin lucerny i glukozynolanów rzepaku na kiełkowanie nasion sałaty. Stwierdzono hamujący wpływ obu badanych związków na kiełkowanie. Znacznie silniejsze działanie wykazywały saponiny, przy czym efekt ten zależny był od ich stężenia w podłożu. Badane związki wpływały nie tylko na liczbę skiełkowanych nasion, ale również na wygląd siewek (skrócenie korzonków, brunatnienie ich końców, brak włośników).
Źródło:
Journal of Plant Protection Research; 1997, 37, 1-2
1427-4345
Pojawia się w:
Journal of Plant Protection Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Does senile impairment of cholinergic system in rats concern only disturbances in cholinergic phenotype or the progressive degeneration of neuronal cell bodies?
Autorzy:
Niewiadomska, Grażyna
Wyrzykowska, Jolanta
Chechłacz, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1044354.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cholinergic neurons morphology and phenotype
aging
nerve growth factor
plasticity
basal forebrain
Opis:
The trophic effect of continuous intraventricular infusion of nerve growth factor (NGF) on morphology of the basal forebrain (BF) cholinergic neurons was tested in 4- and 28-month-old male Wistar rats. All studies were conducted using behaviorally uncharacterized animals from the same breeding colony. Immunohistochemical procedure for choline acetyltransferase (ChAT) and p75NTR receptor has been applied to identify cholinergic cells in the structures of basal forebrain (BF). Using a quantitative image analyzer, morphometric and densitometric parameters of ChAT- and p75NTR-positive cells were measured immediately after cessation of NGF infusion. In 28-month-old non-treated rats the number of intensively ChAT-positive cells in all forebrain structures was reduced by 50-70% as compared with young animals. The remaining ChAT-positive cells appeared shrunken and the neuropil staining was markedly reduced. In contrast, the same neurons when stained for p75NTR were numerous and distinctly visible with perfect morphology. Analysis of Nissl stained sections also showed that 28-month-old rats did not display significant losses of neuronal cell bodies. NGF restored the number of intensely stained ChAT-positive cells to about 90% of that for young controls and caused a significant increase in size of those cells in 28-month-old rats as compared with the control, age-matched group. NGF did not influence the morphology of p75NTR-positive neurons, which were well labeled, irrespective of treatment and age of the rats. In 4-month-old rats, NGF infusion decreased the intensity of both ChAT and p75NTR immunostaining. These data provide some evidence for preservation of BF cholinergic neurons from atrophy during aging and indicate that senile impairment of the cholinergic system in rats concerns decrease in ChAT-protein expression rather than an acute degeneration of neuronal cell bodies. Treatment with NGF resulted in restoration of cholinergic phenotype in the BF neurons of aged rats. However, the present study also rises issue of possible detrimental effects of NGF in young normal animals.
Źródło:
Acta Biochimica Polonica; 2000, 47, 2; 313-330
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Endogenous nitric oxide proves not to be involved in the inhibition by IL-1beta of TGF-alpha-stimulated proliferation of RGM1 cells
Autorzy:
Ishikawa, M.
Tsukimi, Y.
Ogawa, T.
Okabe, S.
Powiązania:
https://bibliotekanauki.pl/articles/70156.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
epidermal growth factor
interleukin 1
interleukin
cell
proliferation
DNA synthesis
nitric oxide
gastric mucosal cell
rat
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor
Autorzy:
Brzozowski, T.
Konturek, P.C.
Konturek, S.J.
Pajdo, R.
Schuppan, D.
Drozdowicz, D.
Ptak, A.
Pawlik, M.
Nakamura, T.
Hahn, E.G.
Powiązania:
https://bibliotekanauki.pl/articles/69750.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
gastric ulcer
gastric blood flow
prostaglandin
ulcer healing
hepatocyte
cyclooxygenase-2
cyclooxygenase-1
growth factor
gastrin
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 4,1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ligands of peroxisome proliferator-activated receptor-γ increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages.
Autorzy:
Jozkowicz, Alicja
Dulak, Jozef
Piatkowska, Ewa
Placha, Wojciech
Dembinska-Kiec, Aldona
Powiązania:
https://bibliotekanauki.pl/articles/1044268.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
angiogenesis
ciglitazone
vascular endothelial growth factor
thiazolidinediones
prostaglandin-J2
peroxisome proliferator-activated receptor-γ
Opis:
Peroxisome proliferator-activated receptors-γ (PPARγ) are ligand-inducible transcription factors of the nuclear hormone receptor superfamily. We examined the effect of PPARγ activation on the generation of vascular endothelial growth factor (VEGF), one of the major angiogenic agents. Rat vascular smooth muscle cells (VSMC) and murine macrophages RAW264.7 were incubated for 24 h with PPARγ activators: prostaglandin J2 and ciglitazone. PPARγ were expressed in VSMC and RAW cells and their activity was upregulated in the presence of PGJ2 and ciglitazone. Incubation of the cells with PPARγ activators significantly augmented the release of VEGF protein into the media, both in resting and in IL-1β- or LPS-stimulated cultures. The higher protein generation was connected with the increased expression of mRNA and transcriptional activation of VEGF promoter. We conclude that the activation of PPARγ upregulates the generation of VEGF and may be involved in the regulation of angiogenesis.
Źródło:
Acta Biochimica Polonica; 2000, 47, 4; 1147-1157
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of local injection with basic fibroblast growth factor (BFGF) and neutralizing antibody to BFGF on gastric ulcer healing, gastric secretion, angiogenesis and gastric blood flow
Autorzy:
Ernst, H.
Konturek, P.C.
Hahn, E.G.
Stosiek, H.P.
Brzozowski, T.
Konturek, S.J.
Powiązania:
https://bibliotekanauki.pl/articles/70161.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
epidermal growth factor
gastric ulcer
gastric blood flow
ulcer healing
basic fibroblast growth factor
gastric secretion
angiogenesis
chronic gastric ulcer
healing
antibody
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relation between expression of TNF alpha, iNOS, VEGF mRNA and development of heart failure after experimental myocardial infarction in rats
Autorzy:
Heba, G.
Krzeminski, T.
Porc, M.
Grzyb, J.
Dembinska-Kiec, A.
Powiązania:
https://bibliotekanauki.pl/articles/69900.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
nitric oxide synthase
tumour necrosis factor-alpha
cytokine
ischaemic myocardium
mRNA
thoracotomy
growth factor
rat
myocardial infarction
vascular endothelial growth factor
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Binding of the basic fibroblast growth factor (bFGF) by soluble components of human umbilical cord.
Autorzy:
Sobolewski, Krzysztof
Bańkowski, Edward
Pałka, Jerzy
Jaworski, Stefan
Powiązania:
https://bibliotekanauki.pl/articles/1043707.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
umbilical cord artery
fibroblast growth factor
Wharton's jelly
pre-eclampsia
EPH-gestosis
Opis:
Pre-eclampsia, the most common pregnancy associated syndrome, is connected with remodelling of extracellular matrix of the umbilical cord tissues. Since the fibroblast growth factor (FGF) is known to be a stimulator of collagen and glycosaminoglycan biosynthesis, one may expect that it plays an important role in such a remodelling. Studies performed on the umbilical cords of 10 control and 10 pre-eclamptic newborns demonstrated that both the umbilical cord arterial wall and Wharton's jelly contain FGF mainly in complexes with the components of different molecular mass. Pre-eclampsia is associated with a decrease of endogenous FGF-binding by soluble high molecular mass components of the umbilical cord. It is suggested that FGF released from these complexes may be actively bound by fibroblasts of the umbilical cord, stimulating them to produce collagen and sulphated glycosaminoglycans.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 999-1004
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carbon monoxide - a "new" gaseous modulator of gene expression.
Autorzy:
Dulak, Józef
Józkowicz, Alicja
Powiązania:
https://bibliotekanauki.pl/articles/1043644.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
angiogenesis
vascular endothelial growth factor
atherosclerosis
nitric oxide
oxidative stress
Opis:
Carbon monoxide (CO) is an odorless, tasteless and colorless gas which is generated by heme oxygenase enzymes (HOs). HOs degrade heme releasing equimolar amounts of CO, iron and biliverdin, which is subsequently reduced to bilirubin. CO shares many properties with nitric oxide (NO), an established cellular messenger. Both CO and NO are involved in neural transmission and modulation of blood vessel function, including their relaxation and inhibition of platelet aggregation. CO, like NO, binds to heme proteins, although CO binds only ferrous (FeII) heme, whereas NO binds both ferrous and ferric (FeIII). CO enhances the activity of guanylate cyclase although it is less potent than NO. In contrast, CO inhibits other heme proteins, such as catalase or cytochrome P450. The effects of CO on gene expression can be thus varied, depending on the cellular microenvironment and the metabolic pathway being influenced. In this review the regulation of gene expression by HO/CO in the cardiovascular system is discussed. Recent data, derived also from our studies, indicate that HO/CO are significant modulators of inflammatory reactions, influencing the underlying processes such as cell proliferation and production of cytokines and growth factors.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 31-47
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of protoporphyrins on production of nitric oxide and expression of vascular endothelial growth factor in vascular smooth muscle cells and macrophages.
Autorzy:
Józkowicz, Alicja
Dulak, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1043649.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cell viability
metalloporphyrins
vascular endothelial growth factor
nitric oxide
heme oxygenase
Opis:
Heme oxygenase-1 (HO-1), an inducible enzyme degrading heme to biliverdin, iron and carbon monoxide, is involved in regulation of inflammation and angiogenesis. Tin protoporphyrin (SnPPIX) and zinc protoporphyrin (ZnPPIX) are commonly used as competitive inhibitors of HO-1. We aimed to compare the effects of SnPPIX and ZnPPIX on the production of vascular endothelial growth factor (VEGF), activity of inducible nitric oxide synthase (iNOS) and cell viability. All experiments were performed on rat vascular smooth muscle cells and murine RAW264.7 macrophages treated with 3-10 μM protoporphyrins. Some cells were additionally stimulated with IL-1β or with lipopolysaccharide. After a 24 h incubation period SnPPIX and ZnPPIX significantly reduced the generation of VEGF in vascular smooth muscle cells and RAW264.7, both in resting and stimulated cells. The inhibitory potentials of both protoporphyrins on VEGF synthesis were very similar. In contrast, analysis of iNOS activity revealed that results obtained with different HO-1 inhibitors are discrepant. Generation of nitric oxide by iNOS was significantly increased by SnPPIX but strongly decreased by ZnPPIX. Similar differences were observed when cell viability was compared. SnPPIX improved the cell survival rate, whereas the same doses of ZnPPIX exerted some cytotoxic effects. In summary, SnPPIX and ZnPPIX can be used as HO-1 inhibitors in some experimental models. However, these compounds produce also HO-independent effects, which can make the interpretation of experiments very uncertain. Thus the involvement of the HO-1 pathway should be always confirmed by more specific methods.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 69-79
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mikologiczne skazenia zywnosci
Autorzy:
Wieczorek, C
Powiązania:
https://bibliotekanauki.pl/articles/825985.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Technologów Żywności
Tematy:
plesnie
przemysl spozywczy
zywnosc
zanieczyszczenia mikrobiologiczne
mikotoksyny
czynniki wzrostu
skazenie zywnosci
mould
food industry
food
microbiological contamination
mycotoxin
growth factor
food contamination
Opis:
W artykule opisano zanieczyszczenie żywności pleśniami i omówiono warunki sprzyjające wytwarzaniu mikotoksyn. Wzrost pleśni powoduje pogorszenie jakości lub zepsucie produktów spożywczych, co może prowadzić do zmiany wyglądu, nieprzyjemnego zapachu, obniżonej zdolności kiełkowania nasion, skażenia mikotoksynami i/lub alergii i infekcji u ludzi. Wysoka toksyczność metabolitów pleśni jest dużym zagrożeniem dla konsumentów. Tworzenie mikotoksyn następuje wyłącznie w wyniku wzrostu pleśni toksynotwórczych. Szczególny wpływ na rodzaj występujących pleśni ma skład żywności. Natomiast rozwój i wzrost pleśni w znaczącym stopniu uwarunkowane są: aktywnością wody (aw), temperaturą, wartością pH, zawartością O2 i CO2, rodzajem substratu i składem mikoflory.
The article describes results of food contamination by molds and conditions fostering mycotoxin contamination of foods. The molds growth leads to quality deterioration or spoiling of different kind of foodstuffs. It may result in an unpleasant odour and appearance of the product, reduced seed germination, mycotoxin pollution and/or human allergy and infection. The highly toxic fungal metabolites are particulary dangerous for consumers. Mycotoxins formation in foodstuffs takes place only as a result of growth of toxin-creating molds. Substrates composition influences specially the mold spectrum in foods. Whereas the mold growth and expansion are considerably determined by aw, temperature, pH, atmosphere and microbial competition.
Źródło:
Żywność Nauka Technologia Jakość; 2003, 10, 3; 119-129
1425-6959
Pojawia się w:
Żywność Nauka Technologia Jakość
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On constant-weight TSP-tours
Autorzy:
Jones, Scott
Kayll, P.
Mohar, Bojan
Wallis, Walter
Powiązania:
https://bibliotekanauki.pl/articles/743167.pdf
Data publikacji:
2003
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
graph labelling
complete graph
travelling salesman problem
Hamilton cycle
one-factor
two-factor
k-factor
constant-weight
local matching conditions
edge label growth-rate
Sidon sequence
well-spread sequence
Opis:
Is it possible to label the edges of Kₙ with distinct integer weights so that every Hamilton cycle has the same total weight? We give a local condition characterizing the labellings that witness this question's perhaps surprising affirmative answer. More generally, we address the question that arises when "Hamilton cycle" is replaced by "k-factor" for nonnegative integers k. Such edge-labellings are in correspondence with certain vertex-labellings, and the link allows us to determine (up to a constant factor) the growth rate of the maximum edge-label in a "most efficient" injective metric trivial-TSP labelling.
Źródło:
Discussiones Mathematicae Graph Theory; 2003, 23, 2; 287-307
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Potential role of transforming growth factor β1 in drug resistance of tumor cells.
Autorzy:
Stoika, Rostyslav
Yakymovych, Mariya
Souchelnytskyi, Serhiy
Yakymovych, Ihor
Powiązania:
https://bibliotekanauki.pl/articles/1043628.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
tumor cells
drug resistance
transforming growth factor b1
Opis:
Acquired drug resistance of tumor cells is frequently observed in cancer patients undergoing chemotherapy. We studied murine leukemia L1210 cells sensitive and resistant to the cytotoxic action of cisplatin and showed that cisplatin-resistant leukemia cells were also refractory to TGF β1-dependent growth inhibition and apoptosis. Addressing the question about the mechanisms responsible for the cross-resistance to cisplatin and TGF β1, we found that cisplatin- and TGF β1-resistant L1210 cells possessed a decreased expression of type I TGF β1 receptor, while the expression of type II TGF β1 receptor was not affected. Western blot analysis of Smad proteins 2, 3, 4, 6, and 7, which participate in signal transduction pathway down-stream of the TGF b1 receptors, revealed an increased expression of Smad 6, inhibiting TGF b1 action, only in cisplatin- and TGF β1-resistant L1210 cells. TGF β1 and especially the cytotoxic mistletoe agglutinin increased Smad 6 expression in TGF β1-sensitive but not in TGF β1-resistant L1210 cells. TGF β1-resistant L1210 cells also differed from TGF β1-sensitive cells by the lack of expression of the pro-apoptotic p53 protein and higher level of expression of the anti-apoptotic Bcl-2 protein. Thus, the described co-expression of tumor cell refractoriness to an anti-cancer drug and to the inhibitory cytokine TGF β1 is accompanied by multiple changes in the TGF β1 signal transduction pathway and in other regulatory systems of the target cells. Besides, we found that various anti-tumor drugs and cytotoxic plant lectins increased the level of TGF b1 expression in both TGF β1-sensitive and -resistant L1210 cells. A hypothesis is proposed that TGF β1 can at least partly mediate the effect of cell-stressing agents and, thus, the development of TGF β1 resistance may be responsible for the appearance of tumor cell refractoriness to the action of some anti-cancer drugs.
Źródło:
Acta Biochimica Polonica; 2003, 50, 2; 497-508
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis.
Autorzy:
Kimura, Hideo
Esumi, Hiroyasu
Powiązania:
https://bibliotekanauki.pl/articles/1043646.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
angiogenesis
vascular endothelial growth factor
hypoxia inducible factor 1
hypoxia
reciprocal regulation
nitric oxide
Opis:
Physiologically, angiogenesis is tightly regulated, or otherwise it leads to pathological processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1) plays as a key transcription factor in hypoxia-mediated VEGF gene upregulation. Nitric oxide (NO) as well as hypoxia is reported to upregulate the VEGF gene by enhancing HIF-1 activity. The Akt/protein kinase B (PKB) pathway may be involved in NO-mediated HIF-1 activation in limited cell lines. There are some reports of negative effects of NO on HIF-1 and VEGF activity. These conflicting data of NO effects may be attributed mainly to the amount of released NO. Indeed, NO can be a positive or negative modulator of the VEGF gene under the same conditions simply by changing its amounts. The VEGF-mediated angiogenesis requires NO production from activated endothelial NO synthase (eNOS). Activation of eNOS by VEGF involves several pathways including Akt/PKB, Ca2+/calmodulin, and protein kinase C. The NO-mediated VEGF expression can be regulated by HIF-1 and heme oxygenase 1 (HO-1) activity, and the VEGF-mediated NO production by eNOS can be also modulated by HIF-1 and HO-1 activity, depending upon the amount of produced NO. These reciprocal relations between NO and VEGF may contribute to regulated angiogenesis in normal tissues.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 49-59
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 99

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