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Wyświetlanie 1-15 z 99
Tytuł:
Iodine supplementation activates folliculogenesis in rabbit ovary
Autorzy:
Abadjieva, D.
Petkova, M.
Grigorova, S.
Kistanova, E.
Powiązania:
https://bibliotekanauki.pl/articles/2087684.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
ovary
growing rabbits
growth-differentiation factor 9
iodine supplement
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 3; 559-566
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nitric oxide trascriptional players during seed dormancy and germination
Autorzy:
Albertos, P.
Mateos, I.
Fernandez-Arbaizar, A.
Romero-Puertas, M.
Lorenzo, O.
Powiązania:
https://bibliotekanauki.pl/articles/80484.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
nitric oxide
seed dormancy
germination
phytohormone
abscisic acid
plant growth regulator
transcription factor
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Success factors for micro and small agribusiness enterprises (MSEs) - the case of Ghana
Autorzy:
Asuming Boakye, A.
Ampadu-Ameyaw, R.
Essegbey, G.O.
Onumah, J.A.
Powiązania:
https://bibliotekanauki.pl/articles/43874.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Przyrodniczy w Poznaniu. Wydawnictwo Uczelniane
Tematy:
Ghana
micro-enterprise
small enterprise
success factor
entrepreneurship
economic growth
business success
Źródło:
Journal of Agribusiness and Rural Development; 2018, 47, 1
1899-5241
Pojawia się w:
Journal of Agribusiness and Rural Development
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of the frequency of the transforming growth factor beta-1 sequence polymorphisms in patients with alcohol dependence syndrome
Autorzy:
Augustyńska, Beata
Araszkiewicz, Aleksander
Woźniak, Marcin
Grzybowski, Tomasz
Skonieczna, Katarzyna
Woźniak, Alina
Żyła, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1039134.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
transforming growth factor TGFβ-1
alcohol dependence syndrome
TGF-β1 gene
Opis:
Alcohol abuse is one of the most significant factors in the development of liver fibrosis. The pathomechanism of liver fibrosis is the same regardless of its etiology. Fibrosis is a sign of an imbalance between the synthesis of the extracellular matrix components and their degradation. Among the many cytokines that affect hepatic stellate cell activation it seems that transforming growth factor beta (TGF-β) is the most significant, either as the direct factor stimulating polymerase chain reaction (HSC) proliferation and transformation into myofibroblasts, or as the direct factor causing an increase in the activity of genes responsible for the synthesis of extracellular matrix components. The aim of the study was to reveal possible dependencies and differences between the presence of certain alleles of the TGF-β1 gene and its blood level in the study and control group. Blood samples were obtained from 39 patients, the control group consisted of 21 patients. The results obtained in the course of this study showed no statistically significant differences between the frequencies of particular polymorphisms. In the case of haplotype frequencies, insignificant differences were found for the algorithm Excoffier-Laval-Balding predicted haplotypes while one significant difference between the study and control groups was detected in case of the TC haplotype frequency predicted using the Expectation-Maximization algorithm. However, the difference in frequency of TC haplotype predicted by both algorithms was not significant. Genetic analysis of two single nucleotide polymorphisms (SNPs) in exon I of the TGF-β1 gene did not show significant differences between the occurrence of particular polymorphisms and haplotypes in the populations under study.
Źródło:
Acta Biochimica Polonica; 2015, 62, 1; 63-67
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
IGF-I and IGF-binding proteins in synovial fluid of patients with Lyme arthritis
Autorzy:
Bączyk, J.
Guszczyn, T.
Romanowicz, L.
Pancewicz, S.
Moniuszko, A.
Popko, J.
Powiązania:
https://bibliotekanauki.pl/articles/1917714.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Insulin-like Growth Factor-I
Insulinlike Growth Factor-Binding Protein
metalloproteinase
synovial fluid
Lyme arthritis
post-traumatic damage
Opis:
Purpose: Multiple cellular functions are stimulated by a Insulin-like Growth Factor-I (IGF-I). The biological activity of IGF-I is modulated by IGFbinding proteins (IGF-BPs) and at the same time, the availability of IGF-BPs may be regulated by the proteolytic activity of some metalloproteinases (MMPs). The aim of the present study was to compare the amounts of IGF-I and IGF-BPs in relation to the activity of MMP-9 in serum and knee synovial fluid from patients with Lyme arthritis (LA) and post-traumatic damage (PTD). Material and methods: Serum and synovial fluids were taken from knee joints of patients with PTD and LA. ELISA (for IGF-I assay), polyacrylamine gel electrophoresis following Western immuneblotting (for IGF-I and IGF-BPs expression), and zymography (for metalloproteinases detection), were used. Results: The concentration of IGF-I in serum and synovial fluid from LA patients were significantly lowered in comparison to PTD patients. Interesting, the synovial fluid /serum ratio of IGF-I concentrations was also lower in LA patients. Low expression IGF-BP3 and high activity of MMP-9 were detected in the LA synovial fluid. Conclusions: The high proteolytic activity of MMP- 9 results in a cleavage of both IGF-I and IGF-BP3 causing a decrease in content of these substances in LA synovial fluid. In addition, the reduction in IGF and IGF-BP amounts may affect the repair processes in joint tissues of LA patients. The low concentration of IGF-I and IGF-BP3 slows down the repair processes in the joint tissues of LA patients.
Źródło:
Progress in Health Sciences; 2016, 6(1); 49-56
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sustainable growth rate, corporate value of US firms within capital and labor market distortions: The moderating effect of institutional quality
Autorzy:
Bagh, Tanveer
Naseer, Mirza Muhammad
Khan, Muhammad Asif
Pypłacz, Paula
Oláh, Judit
Powiązania:
https://bibliotekanauki.pl/articles/39827486.pdf
Data publikacji:
2023
Wydawca:
Instytut Badań Gospodarczych
Tematy:
factor market distortion
capital and labor market distortions
corporate value
institutional quality
corporate sustainable growth rate
micro-level analysis
Opis:
Research background: Understanding how distortions in capital and labor markets affect corporate value and sustainable growth is crucial in today's economy. These distortions can disrupt resource allocation and economic sustainability. Additionally, the role of institutional quality in shaping these dynamics requires thorough exploration. Purpose of the article: We quantify the effect of capital and labor market distortions on corporate value and sustainable growth rate (SGR) and how this association is moderated by institutional quality. Methods: Stemming from the sample criteria, we calibrated a final sample of 1971 United States-listed manufacturing firms for 2012–2022. This research offers insights into market inefficiencies and institutional effects. Progressing towards objectives, we use advanced techniques like feasible generalized least squares and generalized methods of moments. These methods help us rigorously analyze complex relationships among study variables. Findings & value added: Three key findings emerge: first, capital and labor market distortions have a negative and significant influence on corporate value and sustainable growth. Our primary finding implies that increasing distortions significantly reduce sustainable growth's value and potential. Second, we find institutional quality has a positive significant effect on corporate value and sustainable growth. Third, institutional quality positively moderates the association between capital and labor market distortions, corporate value, and sustainable growth. Findings suggest that institutional quality, as a potential mechanism, improves the efficiency of resource allocation and optimizes the sustainable economic system to lessen the negative effect of factor market distortions on corporate value and SGR. Besides, we conduct robustness checks to validate our findings. Finally, we offer policymakers and stakeholders actionable insights.
Źródło:
Oeconomia Copernicana; 2023, 14, 4; 1211-1255
2083-1277
Pojawia się w:
Oeconomia Copernicana
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mathematical model of endothelial cell proliferation and maturation
Autorzy:
Bajger, Piotr
Bodzioch, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/747425.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Matematyczne
Tematy:
Angiogenesis, mathematical modelling, tumour growth, vascular endothelial growth factor
Angiogeneza, modelowanie matematyczne, wzrost guza, czynnik wzrostu sródbłonka naczyniowego.
Opis:
Angiogeneza jest jedna z cech charakterystycznych raka. Lepsze ilosciowe zrozumienie tego procesu pozwoliłoby na opracowanie skuteczniejszych terapii antyangiogennych. Postawiono hipoteze, ze nie tylko liczba komórek sródbłonka, ale takze jakosc układu naczyniowego, odgrywa wazna role w sposobie, w jaki chemio- iradioterapie sa dostarczane do guza. W zwiazku z tym rozwazamy minimalnie sparametryzowany matematyczny model proliferacji i dojrzewania komórek sródbłonka. Komórki sródbłonka dziela sie na dwa rodzaje - dojrzałe i niedojrzałe (lub proliferujace). Zakłada sie, ze komórki ulegaja samoistnemu dojrzewaniu, podczas gdy utracie jakosci naczyn krwionosnych posredniczy zewnetrzny czynnik wzrostu (tutaj VEGF). Rozwazany model został dopasowany do danych eksperymentalnych. Pokazuje on, w jaki sposób hamowanie VEGF prowadzi do lepszej jakosci układu naczyniowego i wolniejszej proliferacji.
Blood vessel sprouting (angiogenesis) is one of the hallmarks of cancer. Better quantitative understanding of this process would allow more effective antiangiogenic therapies to be developed. It has been hypothesised that not only the number of endothelial cells, but also the quality of the vasculature play an important role in how chemo- and radiotherapies are delivered to tumour site. Hence in this study a minimally-parametrised mathematical model of endothelial cell proliferation and maturation is developed. Endothelial cells are subdivided into two compartments -- mature and immature (or proliferating). The cells are assumed to undergo a self-mediated maturation, while loss of blood vessel quality is mediated by an external growth factor (here VEGF). The model is fitted to experimental data. The model shows how inhibition of VEGF results in better quality vasculature and slower proliferation.
Źródło:
Mathematica Applicanda; 2018, 46, 1
1730-2668
2299-4009
Pojawia się w:
Mathematica Applicanda
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fem analysis of pressure vessel with an investigation of crack growth on cylindrical surface
Analiza mes zbiornika ciśnieniowego z badaniem rozwoju pęknięć na powłoce walcowej
Autorzy:
Balac, M.
Grbovic, A.
Petrovic, A.
Popovic, V.
Powiązania:
https://bibliotekanauki.pl/articles/301614.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
XFEM
pressure vessel
3D digital image correlation
stress intensity factor
crack growth
rozszerzona metoda elementów skończonych (XFEM)
zbiornik ciśnieniowy
cyfrowa korelacja obrazu 3D
współczynnik intensyfikacji naprężeń
rozwój pęknięć
Opis:
To ensure reliability of pressure vessels during service it is necessary to (1) know properties of materials used in their design and (2) evaluate vessels’ behaviour under different working conditions with satisfying accuracy. Due to various technical and/or technological requirements, nozzles are usually welded on vessel’s shell producing geometrical discontinuities that reduce the safety factor. To evaluate their influence, vessels with two different nozzles were experimentally studied and critical areas for crack initiation have been identified by 3D Digital Image Correlation (DIC) method. After that, the numerical analysis of equivalent 3D finite element model was performed and obtained results were compared with experimental values. In the most critical area, next to the one of the nozzles, crack was initiated and then growth of the damage was simulated using extended finite element method (XFEM). In this paper evaluation of stress intensity factors (SIFs) along crack path is presented, as well as the most probable direction of the crack propagation on the shell. Based on SIFs values, critical length of the crack and number of pressure cycles to the final failure were estimated.
Aby zapewnić niezawodność zbiorników ciśnieniowych podczas pracy, konieczna jest (1) znajomość właściwości materiałów zastosowanych do ich konstrukcji oraz (2) wystarczająco dokładna ocena zachowania zbiornika w różnych warunkach pracy. Ze względu na różne wymagania techniczne i/lub technologiczne, króćce zwykle spawa się do płaszcza zbiornika, w wyniku czego powstają geometryczne nieciągłości, które zmniejszają współczynnik bezpieczeństwa. Aby ocenić ich wpływ, przeprowadzono eksperymentalne badania zbiorników z dwoma różnymi króćcami i określono obszary krytyczne dla inicjacji pęknięć wykorzystując metodę trójwymiarowej cyfrowej korelacji obrazu (DIC). Następnie przeprowadzono analizę numeryczną równoważnego modelu elementów skończonych 3D, a uzyskane wyniki porównano z wartościami eksperymentalnymi. W najbardziej krytycznym obszarze, w pobliżu jednego z króćców, inicjowano pęknięcie, a następnie symulowano rozwój uszkodzenia przy użyciu rozszerzonej metody elementów skończonych (XFEM). W artykule przedstawiono ocenę współczynników intensyfikacji naprężeń (SIF) wzdłuż ścieżki pękania oraz najbardziej prawdopodobnego kierunku propagacji pęknięć na płaszczu zbiornika. Na podstawie wartości SIF, oszacowano krytyczną długość pęknięcia i liczbę cykli ciśnieniowych do ostatecznego uszkodzenia.
Źródło:
Eksploatacja i Niezawodność; 2018, 20, 3; 378-386
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Latent factor growth models for forecasting Polish GDP growth, inflation and unemployment using survey data
Autorzy:
Białowolski, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/500358.pdf
Data publikacji:
2015
Wydawca:
Szkoła Główna Handlowa w Warszawie
Tematy:
latent factor growth modelling
forecasting
GDP growth
inflation
unemployment
Opis:
In this paper a novel application of latent factor growth models is applied to responses to the manufacturing industry tendency survey conducted by the Research Institute for Economic Development, Warsaw School of Economics. An approach based on a common factor was assumed to explain variation in time response to specific questions drawn from the survey questionnaire. It was demonstrated that responses to questions relating to general economic situation in Poland, inflation and employment were explained by a latent growth factor, which was confirmed by RMSEA. Using cross-correlation and an ARIMAX model, it was shown that slopes obtained from latent factor growth models could be applied to forecasting or at least nowcasting of GDP growth and unemployment rate. Survey data of the type described clearly offer potential for refinement of economic projections and it is hoped that this work might stimulate further discussion of the methodology based on latent factor growth modeling for forecasting main macroeconomic time series.
Źródło:
Prace i Materiały Instytutu Rozwoju Gospodarczego SGH; 2015, 96: Analyzing and forecasting economic fluctuations; 69-93
0866-9503
Pojawia się w:
Prace i Materiały Instytutu Rozwoju Gospodarczego SGH
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Control of Aedes aegypti larvae with Aea-TMOF mimics: aromatic derivatives of enoic acid
Autorzy:
Borovsky, D.
Powiązania:
https://bibliotekanauki.pl/articles/55331.pdf
Data publikacji:
2008
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
insecticide
insect growth inhibition
enoic acid
Aedes aegypti
bioorganic insecticide
trypsin biosynthesis
trypsin modulating oostatic factor
mosquito
insect
organic mimics
larva
gut receptor
Opis:
Based on the 3D conformation of the N-terminus of TMOF in solution, six aromatic derivatives of enoic acid: 7-biphenyl-4-yl-hept-4-enoic acid (BPHE), 7-(4-butyl-phenyl)-hept-4-enoic acid (BuPHE), 7-cyclohexyl-hept-4-enoic acid (CyHE), 10-phenyl-dec-7-enoic acid (PDE), 7-p-tolyl-hept-2-enoic acid ethyl ester (THEEE) and 7-(4-methoxy-phenyl)-hept-2-enoic acid ethyl ester (MPEEE) were computer-modeled and synthesized. Treating first instar Aedes aegypti larvae with different concentrations of the TMOF mimics showed that addition of butyl to the benzyl ring, use of p-tolyl or converting the benzyl ring into cyclohexane increased the biological activity of the mimics by 5.2, 5.0 and 3.8-fold, respectively. Esterifying the carboxyl terminus into ethyl ester and addition of a methoxy group to the benzyl ring also increased, by 2-fold, the biological activity of the derivative. The position of the double bond in the aliphatic chain is important for enhanced biological activity. Aea-TMOF and CyHE fed to mosquito larvae equally inhibited trypsin biosynthesis in larvae for the first 24 h. The biological activity of CyHE, however, rapidly declined 2-3 days later, whereas TMOF activity stayed stable. These results indicate that TMOF organic mimics, although potent, need to be formulated in order to be more stable for future field applications.
Źródło:
Pestycydy; 2008, 1-2; 27-34
0208-8703
Pojawia się w:
Pestycydy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor
Autorzy:
Brzozowski, T.
Konturek, P.C.
Konturek, S.J.
Pajdo, R.
Schuppan, D.
Drozdowicz, D.
Ptak, A.
Pawlik, M.
Nakamura, T.
Hahn, E.G.
Powiązania:
https://bibliotekanauki.pl/articles/69750.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
gastric ulcer
gastric blood flow
prostaglandin
ulcer healing
hepatocyte
cyclooxygenase-2
cyclooxygenase-1
growth factor
gastrin
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 4,1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of integrins and vascular endothelial growth factor isoforms mRNA expression in the canine uterus during perimplantation period
Autorzy:
Bukowska, D.
Kempisty, B.
Jackowska, M.
Wozna, M.
Antosik, P.
Piotrowska, H.
Jaskowski, J.M.
Powiązania:
https://bibliotekanauki.pl/articles/31799.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
integrin
vascular endothelial growth factor
isoform
mRNA expression
dog
uterus
pregnancy
bitch
Opis:
Integrins are the major receptors within the extracellular matrix (ECM) that mediate several functions connected with cell life and metabolism, such as cell adhesion, migration, cytoskeletal organization, proliferation, survival, and differentiation. A vascular endothelial growth factor (VEGF) is one of the most important angiogenic factors. It has been suggested that the expression of this gene may play crucial physiological roles in reproductive organs. All investigated endometrial tissues were isolated on day 10-12 after mating. Control bitches, used in this study, were in metestrus, which was determined according to the vaginal cytology and progesterone level in blood. Early pregnancy was verified by flushing the uterine horns with PBS. Total RNA was isolated from the bitches endometrium by means of the Chomczyński and Sacchi method, treated by DNase I, and reverse-transcribed into cDNA. A quantitative analysis of integrins α2b, β2 and β3, VEGF 164, 182 and 188 cDNA was performed by RT-PCR. In results we have shown an increased expression of all investigated genes (integrins α2b, β2 and β3, VEGF 164, 182, and 188) in pregnant bitches uterus as compared to non-pregnant females (P<0.001). Our results indicated that the expression of genes encoding integrins and vascular endothelial growth factors is different in relation to the time of the embryo implantation and it is increased in the first period of this process. This may be associated with the induction of specific mechanisms responsible for receptivity of uterus following the embryo attachment. In addition, all of investigated genes are up-regulated in a pregnancy-specific manner and the increased expression of these genes may regulate the uterus function during the implantation of canine embryos.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Differential expression of epidermal growth factor and transforming growth factor beta isoforms in dog endometrium during different periods of the estrus cycle
Autorzy:
Bukowska, D.
Kempisty, B.
Jackowska, M.
Wozna, M.
Antosik, P.
Piotrowska, H.
Jaskowski, J.M.
Powiązania:
https://bibliotekanauki.pl/articles/30107.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
expression
epidermal growth factor
transforming growth factor-beta
isoform
dog
endometrium
different period
oestrous cycle
Opis:
Both epidermal growth factor (EGF) and transforming growth factor (TGF) play an important physiological role in the processes of proliferation and differentiation of several different cell types. However, the expression profiles of these factors in domestic bitches endometrium are still poorly recognized. The aim of the present study was to identify and analyze the differential expression of these factors in various stages of the estrus cycle. Endometrial tissue from proestrus (n=17), estrus (n=10), day 10 diestrus (n=15), day 35 diestrus (n=18) and anestrus (n=25) was collected soon after ovariohysterectomy. Total RNA was isolated from the endometrium by means of Chomczyński and Sacchi method, treated by DNase I, and reverse- transcribed into cDNA. Quantitative analysis of EGF, TGFβ1, TGFβ2, and TGFβ3 cDNA was performed by real-time quantitative polymerase chain reaction (RT-PCR). EGF expression in canine endometrium was increased in the estrus stage as compared to proestrus (P<0.05), day 10 diestrus (P<0.05), day 35 diestrus (P<0.01) and anestrus (P<0.001). We also found the differences in EGF expression between day 10 and day 35 of estrus as well as between day 35 of estrus with anestrus (P<0.05, P<0.01, respectively). The TGFf1 transcript contents were also higher in estrus as compared to other stages (P<0.01). The TGFβ2 and TGFβ3 in the estrus stage was increased compared to proestrus, day 10 diestrus, day 35 diestrus and anestrus (P<0.05). We proved that expression of EGF and TGFβ transcript isoforms is related to the phase of estrus in bitches and therefore may be regulated by specific hormone concentrations during these periods. Our results confirm the hypothesis that these growth factors play a role in the regulation of biochemical changes in the endometrial tissues during the estrus cycle.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vascular Endothelial Growth Factor and Survivin Immunostaining in Gastric Adenocarcinoma
Autorzy:
Bury, Jarosław
Szumiło, Justyna
Dąbrowski, Andrzej
Ciechański, Aleksander
Śliwińska, Justyna
Wallner, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1396680.pdf
Data publikacji:
2012-07-01
Wydawca:
Index Copernicus International
Tematy:
vascular endothelial growth factor
VEGF
survivin
adenocarcinoma
stomach
survival
Opis:
Two molecules - vascular endothelial growth factor involved in new vessels formation and survivin - antiapoptotic protein, reported to be associated with worse prognosis in various malignancies have been chosen for the study. Both are potential target for novel therapiesThe aim of the study was to determine the immunostaining of VEGF and survivin in gastric carcinoma and to analyse their relationship to the selected clinicopathological features and survival.Material and methods. Formalin-fixed, paraffin-embedded sections from 41 gastric adenocarcinomas were used for immunohistochemical reaction with monoclonal antibodies against vascular endothelial growth factor and survivin. The results were compared with selected clinicopathological features and survival.Results. Positive immunohistochemical reaction for vascular endothelial growth factor and survivin was revealed in 24 (58,53%) and 30 (73,17%), gastric carcinomas respectively. Vascular endothelial growth factor-negative gastric carcinomas were significantly more common in cases without metastases to regional lymph nodes and distant organs and in less advanced cases. Similar, distant metastases were also statistically less common in survivin-negative carcinomas. The differences in immunohistochemical reactions for survivin between less and more advanced cases almost reach statistical significance. The only factors significantly influenced 1, 2 and 3-year survival were vascular endothelial growth factor and survivin status. Statistically significant higher percentage of survival was noted in patients with vascular endothelial growth factor- and survivin-negative tumors.Conclusions. It seems that vascular endothelial growth factor and survivin play role in local invasion and spread of gastric adenocarcinoma and negatively influences survival. However, further studies are required to assess their true usefulness in the clinical practice.
Źródło:
Polish Journal of Surgery; 2012, 84, 7; 341-347
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dolny Śląsk jako najdynamiczniejszy region w kraju - efekt statystyczny czy rzeczywisty wszechstronny rozwój?
Lower Silesia - the Most Dynamic Region in Poland. Statistical Effect or Real Versatile Development?
Autorzy:
Cybulski, Leszek
Powiązania:
https://bibliotekanauki.pl/articles/585599.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Ekonomiczny w Katowicach
Tematy:
Analiza czynnikowa
Analiza statystyczna
Innowacyjność regionu
Rozwój regionalny
Wzrost gospodarczy regionu
Economic growth of the region
Factor analysis
Regional development
Regional innovation
Statistical analysis
Opis:
Regional development analyses are often affected by simplifications coming from heuristic reasoning. It is assumed that the Lower Silesia region has the highest growth rate since 2005 due to proper configuration of growth factors. But this hypothesis is false when one takes into account persistent high unemployment rate and low employment, average innovativeness, increase in interregional disproportions and low domestic demand due to slow increase of households' disposable incomes. Author tries to identify real sources of the Lower Silesias economic growth.
Źródło:
Studia Ekonomiczne; 2015, 209; 42-53
2083-8611
Pojawia się w:
Studia Ekonomiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 99

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