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    Wyświetlanie 1-9 z 9
    Tytuł:
    Effect of conglutinin on phagocytic activity of bovine granulocytes
    Autorzy:
    Dec, M.
    Wernicki, A.
    Puchalski, A.
    Urban-Chmiel, R.
    Radej, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/31860.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conglutinin
    phagocytic activity
    bovine granulocyte
    granulocyte
    chemotaxis
    leucocyte
    cattle
    Opis:
    In the present study we investigated the effect of bovine conglutinin on the phagocytic activity of leukocytes. We measured both the chemotactic activity of conglutinin and its effect on the internalization of zymosan particles and E. coli by granulocytes. We also assessed the binding of conglutinin to various microorganisms isolated from clinical cases in cattle. We showed that conglutinin binds strongly to the surface of yeast cells and to mannan-rich zymosan particles, while weak binding was observed in the case of the bacterial strains tested, including those whose O antigen is composed of mannan. Conglutinin (1-10 μg/ml) neither acts as a chemotactic factor for peripheral blood leukocytes nor affects ingestion of E. coli by granulocytes. However, as flow cytometry based assay showed, conglutinin (0.1-1 μg/ml) increased ingestion of zymosan expressed as mean fluorescence intensity (MFI) of positive cells.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 3
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of granulocyte colony-stimulating factor therapy for osteogenesis imperfecta: a case report
    Autorzy:
    Paszko-Patej, G.
    Sienkiewicz, D.
    Kułak, W.
    Okurowska-Zawada, B.
    Wojtkowski, J.
    Kalinowska, A.
    Okulczyk, K.
    Sochoń, K.
    Dmitruk, E.
    Mirska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918408.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Osteogenesis imperfecta
    granulocyte colony-stimulating factor
    muscle strength
    Opis:
    Introduction: Osteogenesis imperfecta (OI) is a genetic disorder of increased bone fragility and low bone mass. OI type IV. Materials and methods: We examined the safety and effectiveness of a low dose of analog granulocyte colony-stimulating factor (G-CSF) in a 15-year-old girl OI type IV. G-CSF 5 μg/kg was given subcutaneously, for 5 days/month for 3, 6 and 12 months. Laboratory tests, including blood, biochemical tests were performed, in addition to clinical examination.Results: Clinical examination revealed an increase of muscle strength in the upper and lower limbs between base line and day 6 and 12 months. We found no serious adverse events. Leukocyte levels remained below 38,000/μL. Low dose G-CSF was safe and well tolerated by the patient. Conclusions: A significant increase in muscle strength in this patient may indicate beneficial effects of G-CSF factor in this disorder. These results are inspiring and warrant further studies.
    Źródło:
    Progress in Health Sciences; 2017, 7(1); 205-208
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Granulocyte colony-stimulating factor potential use in the treatment of children with cerebral palsy
    Autorzy:
    Paszko-Patej, G.
    Sienkiewicz, D.
    Okurowska-Zawada, B.
    Kułak, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918437.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Granulocyte colony-stimulating factor
    neuroprotection
    studies
    cerebral palsy
    Opis:
    Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the blood. Recent studies demonstrated the presence of CSF-receptor (G-CSFR) system in the brain and spinal cord, and their roles in neuroprotection and neural tissue repair, as well as improvement in functional recovery. G-CSF exerts neuroprotective actions through the inhibition of apoptosis and inflammation, and the stimulation of neurogenesis. This review highlights recent studies on the potential use of G-CSF in cerebral palsy.
    Źródło:
    Progress in Health Sciences; 2017, 7(1); 187-192
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of granulocyte colony-stimulating factor treatment in children and patients with cerebral palsy: a preliminary report
    Autorzy:
    Paszko-Patej, G.
    Kułak, W.
    Okurowska-Zawada, B.
    Sienkiewicz, D.
    Wojtkowski, J.
    Sochoń, K.
    Kalinowska, A.
    Okulczyk, K.
    Topór, E.
    Mirska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918403.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Granulocyte colony-stimulating factor
    children
    cerebral palsy
    Opis:
    Introduction: Recent reports have revealed that neuroinflammation and apoptosis in brains affected by cerebral palsy could be therapeutic targets. Granulocyte colony-stimulating factor (G-CSF) exerts anti-inflammatory and antiapoptosis effects and stimulates the proliferation of neural stem and progenitor cells in the brain. Purpose: To assess the efficacy and safety of G-CSF treatment in children and adolescents with CP. Materials and methods: Six patients with spastic tetraplegia CP aged 3-15 years were enrolled in this study. Five patients had GMFCS (Gross Motor Function Classification System) level at V, three children had epilepsy, and three had severe mental retardation. We used the gross motor function measure-66 (GMFM-66) to assess motor function.GCSF (5μg/kg/body/day) was administered subcutaneously for five consecutive days during the four months. The parents also evaluated the physical and mental development of their children. Results: We observed improvement in motor function in patients with CP on the GMFM-66 scale. Parents reported improvement in behavior, speech development, and a decrease in spasticity in children with CP. G-CSF therapy was well-tolerated. No side effects were observed during the study. Conclusions: Our preliminary report suggests that G-CSF treatment improves motor and mental function in patients with CP. Further studies are needed to confirm these observations
    Źródło:
    Progress in Health Sciences; 2017, 7(1); 78-82
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Granulocyte colony-stimulating factor therapy for facioscapulohumeral dystrophy: a case report
    Autorzy:
    Sienkiewicz, D.
    Kułak, W.
    Okurowska-Zawada, B.
    Paszko-Patej, G.
    Wojtkowski, J.
    Dmitruk, E.
    Okulczyk, K.
    Sochoń, K.
    Kalinowska, A.
    Żak, J.
    Pogorzelski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918329.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Facioscapulohumeral dystrophy
    granulocyte colony-stimulating factor
    muscle strength
    Opis:
    We examined the safety and effectiveness of a low dose of analog granulocyte-colony stimulating factor in a 15-year-old boy with facioscapulohumeral dystrophy. The onset of disease was noted at 12 years of age. The physical examination noted general muscle atrophy more pronounced at left side of the body. He was able to walk 300 meters within 6 minute walk test. Granulocyte colony-stimulating factor 5 μg/kg was given subcutaneously daily for 5 days/month for 1, 2, 3, 6 and 12 months. Clinical examination, laboratory tests including blood, biochemical tests, and CD34+ cells were performed. A significant increase of muscle strength in the lower and upper limbs between baseline, and after 3 months of treatment, after 6, and after 12 months was found. He was able to walk 480 meters within 6 minutes after 12 months. Electromyography demonstrated increase of amplitude in the examined in upper and lower limbs after six months compared to baseline. Leukocyte levels remained below 25000/μL. CD34+ increased significantly at day 5 of granulocyte colony-stimulating factor admini-stration. It was safe and well tolerated by the patient. A significant increase in muscle strength in this patient with facioscapulohumeral dystrophy after 3 months of treatment, after 6, and after 12 months since the first treatment course was completed may indicate beneficial effects of granulocyte colony-stimulating factor in this disorder.
    Źródło:
    Progress in Health Sciences; 2016, 6(2); 175-177
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of selenium compounds of different structure on morphology, blood biochemistry and phagocytic capability of granulocytes in rats
    Autorzy:
    Musik, I.
    Kielczykowska, M.
    Donica, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/877208.pdf
    Data publikacji:
    2013
    Wydawca:
    Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
    Tematy:
    selenium compound
    different structure
    blood morphology
    blood biochemistry
    phagocytosis
    granulocyte
    rat
    Opis:
    Background. Selenium belongs to important microelements. Numerous studies have revealed relationships between its deficiency and occurrence of diverse illnesses, but the question of the proper form and dose of Se-supplementation still remains unsolved. Objective. In the present study the influence of different selenium compounds on blood morphology and biochemistry as well as on phagocytic capacity of granulocytes and NBT test in rats was investigated. Material and methods. Adolescent male Wistar rats were divided into four groups (ten animals each): I – control, received saline; II – received sodium selenite Na2SeO3; III – received selenoorganic compound A of chain structure 4-(o-tolyl-)-selenosemicarbazide of 2-chlorobenzoic acid; IV – received selenoorganic compound B of cyclic structure 3-(2-chlorobenzoylamino-)- 2-(o-tolylimino-)-4-methyl-4-selenazoline. The administration was performed by stomach tube at a dose of 5 · 10-4 mg Se g-1 b.w. once a day for 10 days. Results. Selenium compounds treatment decreased haematocrit. Erythrocytes number was unchanged in all groups receiving Se vs. control, whereas leucocytes number was depressed in groups II and IV. Haemoglobin was significantly decreased in group III. White blood count was altered in groups II and III, where all parameters were markedly decreased except for lymphocytes in group III and remained unchanged in group IV. The outcomes regarding selenium effect on biochemistry parameters of blood showed that urea remained unchanged, glucose was statistically decreased in groups II and III, whereas cholesterol was significantly diminished in group II and increased in group III vs. control. Results concerning phagocytosis and NBT test displayed that % of positive cells were decreased in groups II and III, whereas remained unaltered in group IV vs. control. Conclusions. As cyclic selenoorganic compound B did not cause many significant changes of the studied parameters it may be suggested that after further researches it could be taken into account as a possible selenium supplement.
    Wprowadzenie. Selen należy do mikropierwiastków o dużym znaczeniu dla organizmu. Badania naukowe wykazały istnienie zależności pomiędzy niedoborem selenu a występowaniem wielu poważnych schorzeń, jednakże kwestia doboru odpowiedniej formy i dawki stosowanej w suplementacji nadal pozostaje nierozwiązana. Cel. W przeprowadzonym doświadczeniu badano wpływ podawania różnych związków selenu na morfologię krwi i biochemię krwi oraz zdolności fagocytarne granulocytów i test NBT u szczurów. Materiał i metody. Młode szczury samce rasy Wistar podzielono na cztery grupy (po 10 zwierząt): I – kontrola, otrzymywała sól fizjologiczną; II – otrzymywała selenian(IV) sodu Na2SeO3; III – otrzymywała organiczny związek selenu A o budowie łańcuchowej 4-(o-tolilo-)-selenosemikarbazyd kwasu 2-chlorobenzoesowego; IV - otrzymywała organiczny związek selenu B o budowie cyklicznej 3-(2-chlorobenzoiloamino-)-2-(o-toliloimino-)-4-metylo-4-selenazolinę. Związki podawane były sondą dożołądkowo w dawce 5 · 10-4 mg Se g-1 m.c. raz dziennie przez okres 10 dni. Wyniki. Podawanie związków selenu obniżyło hematokryt. Liczba erytrocytów we wszystkich grupach pozostała niezmieniona w stosunku do kontroli a liczba leukocytów była zmniejszona w grupach II i IV. Poziom hemoglobiny został obniżony statystycznie w grupie III. Obraz białych elementów morfotycznych w porównaniu do kontroli uległ zmianie w grupach II i III gdzie wszystkie wskaźniki zostały istotnie statystycznie obniżone za wyjątkiem limfocytów w grupie III, natomiast w grupie IV nie zaobserwowano żadnych zmian. Analizując wpływ podawania selenu na parametry biochemiczne krwi stwierdzono, że stężenie mocznika pozostało niezmienione. Stężenie glukozy w przypadku grup II i III uległo istotnemu statystycznie obniżeniu. Stężenie cholesterolu w II grupie było istotnie obniżone a w III podwyższone w porównaniu z kontrolą. Badania fagocytozy i wyniki testu NBT wykazały, że % pozytywnych komórek uległ obniżeniu w grupach II i III w stosunku do grupy kontrolnej i pozostał niezmieniony w grupie IV. Wnioski. Ponieważ organiczny związek cykliczny B nie spowodował istotnych statystycznie zmian wielu badanych parametrów można byłoby sugerować, że przeprowadzenie dalszych badań pozwoli rozważyć jego zastosowanie jako suplementu selenu.
    Źródło:
    Roczniki Państwowego Zakładu Higieny; 2013, 64, 2
    0035-7715
    Pojawia się w:
    Roczniki Państwowego Zakładu Higieny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of granulocyte colony-stimulating factors in the prevention of neutropenia and febrile neutropenia – the current state of knowledge
    Autorzy:
    Sobas, Marta A.
    Wróbel, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1061837.pdf
    Data publikacji:
    2017
    Wydawca:
    Medical Education
    Tematy:
    guidelines
    long- and short-acting granulocyte colony-stimulating factors
    neutropenia
    neutropenic fever
    review
    Opis:
    Granulocyte colony-stimulating factors, introduced in the 1990s to prevent neutropenic fever, improve patients’ prognosis after myelotoxic chemotherapy. G-CSFs accelerate bone marrow recovery, shortening the duration of neutropenia and reducing its intensity as well as the risk of febrile neutropenia. There are short- and long-acting G-CSFs available these days. This paper is a review of the efficacy, toxicity and indications for short- and long-acting G-CSFs as indicated in the most recent studies.
    Źródło:
    OncoReview; 2017, 7, 1; 15-21
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lymphocyte subpopulations and apoptosis of immune cells in rabbits experimentally infected with a strain of the RHD virus having a variable haemagglutination capacity
    Autorzy:
    Niedzwiedzka-Rystwej, P.
    Deptula, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/31022.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    lymphocyte subpopulation
    apoptosis
    immune cell
    rabbit
    experimental infection
    RHD virus
    hemagglutination capacity
    granulocyte
    T cell
    B cell
    Opis:
    The paper describes the immunological response in the matter of percentage of T cells (receptor CD5+) and subpopulations (Th with receptor CD4+, Tc/Ts with receptor CD8+, T with receptor CD25+) and B cells with receptor CD19+, as well as the percentage of apoptotic granulocytes and lymphocytes, in rabbits experimentally infected with the Hagenow strain of the RHD virus. The material chosen for the experiment is special, as among all strains of RHD virus, there are only two strains which carry the variable haemagglutination capacity of red cells. The results of the study show that the Hagenow strain gives an untypical picture of T and B lymphocytes, whereas the results in inducing apoptosis seems to corespond with previous data, confirming the inclusion of apoptosis from 4 h p.i. and the intensity of the phenomenon being higher in granulocytes.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of Biolex Beta-HP on phagocytic activity and oxidative metabolism of peripherial blood granulocytes and monocytes in rats intoxicated by cyclophosphamide
    Autorzy:
    Wojcik, R
    Powiązania:
    https://bibliotekanauki.pl/articles/32265.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    beta-1,3-1,6-D-glucan
    cyclophosphamide
    rat
    phagocytic activity
    oxidative metabolism
    granulocyte
    monocyte
    flow cytometry
    peripheral blood
    immunosuppression
    blood neutrophil
    Opis:
    The objective of this study was to determine the effect of ß-l,3/l,6-D-glucan (Biolex-Beta HP) on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in rats intoxicated by cyclophosphamide. The experimental material comprised 40 adult Wistar rats aged 14 weeks, divided into two equal groups, a control group and an experimental group, each of 20 adult rats, including 10 males and 10 females. In the course of 3 successive days, 20 rats from the experimental group were administered cyclophosphamide intramuscularly at a dose of 50 mg/kg body weight/day. On the 8th day of the experiment, 10 control group (K) rats and 10 experimental group (C) rats were sacrificed. Arterial blood samples were collected and diluted with heparin to determine and compare the phagocytic activity (Phatogest) and oxidative metabolism (Bursttest) of peripheral blood granulocytes and monocytes by flow cytometry. Starting on the 8lh day of the experiment, the feed of the remaining 10 rats from the experimental group (C+G) and 10 rats from the control group (G) was supplemented with Biolex-Beta HP at a dose of 50 mg/kg body weight/day for 14 consecutive days. On day 22, arterial blood samples were collected from all (C+G) and (C) group rats, diluted with heparin to determine and compare the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes by flow cytometry. The results showed that Biolex-Beta HP modulated the phagocytic activity and oxidative metabolism of blood neutrophils and monocytes suppressed by cyclophosphamide in rats. The immunorestoring activity of Biolex-Beta HP was observed in this study.
    Źródło:
    Polish Journal of Veterinary Sciences; 2010, 13, 1; 181-188
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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