Temat: glucocorticoid - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: The expression of 11 beta hydroxysteroid dehydrogenase in severe allergic rhinitis
Autorzy:: Ohta, Nobuo
Noguchi, Naoya
Takahashi, Tomoko
Suzuki, Tatsutoshi
Kakuta, Risako
Suzuki, Yusuke
Awataguchi, Toshiichi
Suzuki, Takahiro
Takahashi, Yukiko
Shoji, Fumi
Wada, Kota
Kawano, Tasuku
Ono, Isao
Kusano, Yusuke
Miyasaka, Tomomitsu
Osafune, Hiroshi
Matsutani, Sachiko
Yaginuma, Yuji
Ishida, Yusuke
Saito, Yutaro
Yamazaki, Muneharu
Ikeda, Ryoukichi
Powiązania:: https://bibliotekanauki.pl/articles/1397797.pdf
Data publikacji:: 2019
Wydawca:: Index Copernicus International
Tematy:: allergic rhinitis
11 beta-hydroxysetroid dehydrogenase
glucocorticoid resistance
glucocorticoid therapy
glucocorticoid response
Opis:: Objective: To clarify the roles of 11 beta-HSD in resistance to glucocorticoid therapy for allergic rhinitis, a case series study was conducted. Methods: The patient group consisted of 20 subjects with allergic rhinitis, aged from 21 to 46 years (mean age 26.5), who showed persistent GC resistance necessitating surgical removal of the inferior turbinate after 6 months’ GC treatment. The patients with poor response to GC treatment for 6 months’ were defined as GC resistance. The control group consisted of 10 subjects aged from 16 to 39 years (mean age 24.5) who underwent maxillofacial surgery, from whom nasal tissues were taken and who did not receive GC treatment. Nasal mucosal tissues from patients and cntorol subjects were examined immunohistochemically. The sections were washed with 0.01 M phosphate-buffered saline (PBS; pH 7.2) containing 0.15 M NaCl and 0.01% Triton X-100, and incubated for 2 h with rabbit polyclonal anti-11 beta HSD1 and 11 beta-HSD2 antibody (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA), each diluted 1:200 in PBS containing 0.1% bovine serum albumin. Immunostained sections were assessed under an Olympus microscope with an eyepiece reticule at 200 X magnification. Cell counts are expressed as means per high-power field (0.202 mm2). Control group means (arithmetic mean ± SD) were compared with patient group means by Mann–Whitney U-test at P = 0.05. Results: Although 11 beta-HSD1 was expressed to a similar extent in patients and controls, 11 beta-HSD2 was expressed significantly more in patients with severe allergic rhinitis, resulting in a increased HSD-1/HSD-2 ratio. The significantly increased expression of 11 beta-HSD2 in the nasal epithelium and submucosal inflammatory cells of patients with severe nasal allergy were observed in the present study. Conclusion: Our findings suggest that 11 beta-HSD2 plays an important role in resistance to glucocorticoid therapy for allergic rhinitis, and its expression might be used as an additional parameter indicating steroid resistance in allergic rhinitis.
Źródło:: Polish Journal of Otolaryngology; 2019, 73, 2; 18-22
0030-6657
2300-8423
Pojawia się w:: Polish Journal of Otolaryngology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Identification and tissue distribution of a novel rat glucocorticoid receptor splice variant
Autorzy:: Ju, Huiming
Wang, Xia
Liu, Zongping
Liu, Ping
Zhao, Yan
Xiong, Renping
Zhou, Yuanguo
Chen, Xingyun
Powiązania:: https://bibliotekanauki.pl/articles/1040640.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: glucocorticoid
glucocorticoid receptor
receptor isoform
splice variant
Opis:: Glucocorticoid receptor (GR) is a steroid hormone receptor that has been shown to play important roles in diverse cellular and physiological processes. More and more evidence has revealed that the effects of glucocorticoids are mediated by the glucocorticoid receptor through genomic or nongenomic mechanisms. A growing number of glucocorticoid receptor splice variants have been identified in human tissues, but few are known in rat tissues. In this work, a novel rGR cDNA, called rGRβ, was cloned from Sprague Dawlay (SD) rat liver. Sequence analysis revealed that the rGRβ mRNA was 39 base pairs (bp) shorter than the rGR mRNA reported earlier. The deleted segment is located in exon 1 and encodes 13 repeated glutamine residues. Both the rGR and rGRβ mRNAs were quantitated by Northern blot hybridization using non-homologous glucocorticoid cDNA probes. Results showed that the rGR and rGRβ mRNAs were most abundant in the lung, the least abundant in the heart, and there were more rGR and rGRβ mRNAs in the kidney than in the liver. The identification of rGRβ may contribute to the understanding of the genomic or nongenomic effects of glucocorticoids.
Źródło:: Acta Biochimica Polonica; 2009, 56, 1; 109-113
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Prenatal glucocorticoids can programme postnatal development
Autorzy:: Tomaszewska, E.
Dobrowolski, P.
Powiązania:: https://bibliotekanauki.pl/articles/3123.pdf
Data publikacji:: 2011
Wydawca:: Instytut Medycyny Wsi
Tematy:: prenatal glucocorticoid
glucocorticoid
postnatal development
bone
dexamethasone
steroid hormone
Źródło:: Journal of Pre-Clinical and Clinical Research; 2011, 05, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Molecular basis of mechanisms of steroid resistance in children with nephrotic syndrome
Autorzy:: Świerczewska, Monika
Ostalska-Nowicka, Danuta
Kempisty, Bartosz
Nowicki, Michał
Zabel, Maciej
Powiązania:: https://bibliotekanauki.pl/articles/1039528.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: nephrotic syndrome
glucocorticoid receptor
steroid resistance
polymorphisms
Opis:: Steroid therapy, due to a wide range of anti-inflammatory properties of steroids, is a basic field of treatment in many human diseases including the nephrotic syndrome in children. However, not all patients respond positively to therapy which divides them into steroid sensitive (SS) and steroid resistance (SR) individuals. Many potential factors associated with steroid resistance have been identified so far. It seems that genetic factors associated with glucocorticoid receptor α (GRα), the structure of heterocomplex of GR as well as glycoprotein P or cytochrome P450 may play a role in the induction of glucocorticoid resistance. Here we described several of the molecular mechanisms, which can regulate glucocorticoid sensitivity and resistance. Moreover, we presented genetic defects, which can lead to various effects of treatment and, in a longer perspective, enable clinicians to individualize therapies.
Źródło:: Acta Biochimica Polonica; 2013, 60, 3; 339-344
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Consensus Committee of experts on Kawasaki Disease and Chinese Journal of Contemporary Pediatrics – the expert consensuses on intravenous immunoglobulin, aspirin, and glucocorticoid
Autorzy:: Shuying, Ren
Fangming, Deng
Zhongdong, Du
Xiaodong, Yang
Lijian, Xie
Hong, Wang
Fuyong, Jiao
Powiązania:: https://bibliotekanauki.pl/articles/40519598.pdf
Data publikacji:: 2024-03-30
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: aspirin
children
glucocorticoid
intravenous immunoglobulin
Kawasaki disease
Opis:: Introduction and aim. Kawasaki disease (KD) is an acute vasculitis with unknown etiology, usually occurring in children under 5 years old. This article will summarize the three consensuses formulated in China about KD. Material and methods. English databases for consensus search include UpToDate, BMJ Clinical Evidence, National Guideline Clearinghouse, Joanna Briggs Institute Library, Cochrane Library, and PubMed, etc.; Chinese databases include China Biomedical Literature Service, China Knowledge Network, Wanfang database, etc. All literature searches ended on February 28, 2022. Analysis of the literature. KD is a common acquired heart disease in children and can lead to severe complications such as coronary injury. However, intravenous immunoglobulin (IVIG) combined with oral aspirin (Asp) is currently recognized as the most effective treatment in KD acute stage and the first-line treatment to prevent cardiovascular complications. Glucocorticoid (GC) is mainly used for KD patients with a high risk of coronary artery aneurysm (CAA), no immunoglobulin response, and confirmed CAA. There are already consensus guidelines on diagnosing and treating KD in different countries. This article summarizes the relevant expert consensus on aspirin, glucocorticoids and IVIG for the treatment of Kawasaki disease in China. Conclusion. Still, there are inconsistent opinions in the literature on the mechanism, optimal timing, and dosage of medication for KD.
Źródło:: European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 179-187
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Factors affecting the course of Graves orbitopathy and poor response to glucocorticoid treatment followed by orbital radiotherapy
Autorzy:: Jagiełło-Korzeniowska, Agnieszka
Sokołowski, Andrzej
Hubalewska-Dydejczyk, Alicja
Romanowska-Dixon, Bożena
Bałdys-Waligórska, Agata
Powiązania:: https://bibliotekanauki.pl/articles/2159024.pdf
Data publikacji:: 2022-05-19
Wydawca:: Medical Education
Tematy:: Graves' orbitopathy
Graves' disease
TRAb
NOSPECS
glucocorticoid treatment
orbital radiotherapy
Opis:: Graves’ orbitopathy is a rare autoimmune disorder characterized by the inflammation of orbital tissues. The course of disease can be described in terms of its activity and severity. Aim: The aim of our study was to determine the factors affecting the activity and severity of Graves’ orbitopathy, as well as to identify the predictive factors of poor response to glucocorticoid treatment followed by orbital irradiation. Methods: We performed a prospective observational study of 214 patients with Graves’ orbitopathy who were divided into two groups depending on the treatment they had previously obtained for their Graves’ disease. They received i.v. methylprednisolone pulses followed by orbital radiotherapy. They were examined and had their TSH, TRAb and FT4 levels evaluated prior to treatment and after 1, 6 and 12 months. Results: A pre-treatment TRAb concentration higher by one unit (U/L) implied a mean increase in the relative risk of active orbitopathy by 4.7% (p = 0.0362). A TRAb concentration higher by one U/L 1 month after treatment implied a mean increase in the relative risk of moderate-to-severe and severe GO by 8.7% (p = 0.0167) 6 months after treatment. As regards poor response to treatment, patients with moderate-to-severe and severe Graves’ orbitopathy on admission carried a higher risk of being non-responders. Each point scored on the NOSPECS scale prior to treatment increased the relative risk of the patient being a non-responder by 30%. Conclusions: Patients with higher TRAb levels have a higher risk of active Graves’ orbitopathy and moderate-to-severe and severe Graves’ orbitopathy. Monitoring TRAb serum concentration in those patients is of great importance. Patients with more severe Graves’ orbitopathy carry a higher risk of being poor responders to immunosuppressive treatment. Therefore, careful monitoring of patients with Graves’ orbitopathy and their early referral to specialized centers is essential.
Źródło:: OphthaTherapy; 2022, 9, 2; 98-105
2353-7175
2543-9987
Pojawia się w:: OphthaTherapy
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Cross-resistance to five glucocorticoids in childhood acute lymphoblastic and non-lymphoblastic leukemia samples tested by the MTT assay: Preliminary report.
Autorzy:: Styczyński, Jan
Wysocki, Mariusz
Dębski, Robert
Balwierz, Walentyna
Rokicka-Milewska, Roma
Matysiak, Michał
Balcerska, Anna
Kowalczyk, Jerzy
Wachowiak, Jacek
Sońta-Jakimczyk, Danuta
Chybicka, Alicja
Powiązania:: https://bibliotekanauki.pl/articles/1043813.pdf
Data publikacji:: 2002
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cross-resistance
ALL
sensitivity
acute leukemia
MTT assay
AML
glucocorticoid resistance
Opis:: In vitro antileukemic activity of five glucocorticoids and their cross-resistance pattern in childhood acute lymphoblastic and non-lymphoblastic leukemia were determined by means of the MTT assay in 25 leukemia cell samples of childhood acute leukemias. The equivalent antileukemic concentrations of the drugs tested were: 34 μM hydrocortisone (HC), 8 μM prednisolone (PRE), 1.5 μM methylprednisolone (MPR), 0.44 μM dexamethasone (DX) and 0.22 μM betamethasone (BET). In comparison with initial ALL cell samples, the relapsed ALL group was more resistant to PRE (38-fold, p = 0.044), DX (> 34-fold, p = 0.04), MPR (38-fold), BET (45-fold) and HC (33-fold). The AML cell samples were even more resistant to: PRE (>85-fold, p=0.001), DX (> 34-fold, p = 0.004), MPR (> 69-fold, p = 0.036), BET (> 69-fold, p = 0.038) and HC (54-fold, p = 0.059) when compared with ALL on initial diagnosis. A significant cross-resistance among all the glucocorticoids used was found. Only in some individual cases the cross-resistance was less pronounced.
Źródło:: Acta Biochimica Polonica; 2002, 49, 1; 93-98
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki