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    Wyświetlanie 1-8 z 8
    Tytuł:
    Genotoxic effects of 60Co gamma-rays on Chinese hamster ovary (CHO) cells
    Autorzy:
    Dicu, T.
    Brie, I.
    Virag, P.
    Fischer, E.
    Perde, M.
    Foriş, V.
    Cernea, V.
    Cosma, C.
    Powiązania:
    https://bibliotekanauki.pl/articles/147740.pdf
    Data publikacji:
    2008
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    cellular radiosensitivity
    genotoxic effects
    ionizing radiation
    comet assay
    Opis:
    The aim of the present study was to evaluate the cellular radiosensitivity and radiation-induced DNA damage and repair in Chinese hamster ovary (CHO) cells. Cell survival after irradiation was assessed using the clonogenic assay. The initial, radio-induced and residual DNA damage in Chinese hamster ovary (CHO) cells exposed to 60Co gamma-rays were determined using the alkaline comet assay. A linear-quadratic (LQ) survival curve was observed in CHO line. Data obtained by comet assay demonstrated a linear dose-response correlation in the range of tested doses (0.3-4 Gy). The process of DNA repair was modeled by exponential equation. In addition, we found a good correlation (R2 = 0.995) between clonogenic cell survival and radio-induced DNA damage.
    Źródło:
    Nukleonika; 2008, 53, 4; 161-165
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immunological and genotoxic effects of occupational exposure to α-cypermethrin pesticide
    Autorzy:
    El Okda, El-Sayed
    Abdel-Hamid, Mona A.
    Hamdy, Ahmed M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2161902.pdf
    Data publikacji:
    2017-06-19
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    p53
    pyrethroids
    immunological
    genotoxic
    cypermethrin
    Oxidative stress
    Opis:
    Objectives The aim of this work has been to find out the occupational oxidative stress, immunological and genotoxic health hazards among α-cypermethrin (CYP) pesticide-exposed workers. Material and Methods A cross-sectional study was performed including 200 workers divided into 3 groups according to the level of exposure: highly exposed group (50 workers), moderately exposed group (50 workers) and unexposed group (100 workers). All workers were subjected to detailed laboratory investigation for gene P53 mutations, immunological parameters as a cluster of differentiation into 3 percentage (CD3%), CD4% and CD8% in addition to peripheral blood total leukocytic and platelet counts that were measured. Spectrophotometer technique was used for detection of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione peroxidase (GPx). Air samples were collected with a High Volume Small Surface Sampler for measurement of α-cypermethrin level. Results A highly exposed group to the α-cypermethrin had lower CD4/CD8 as compared to an unexposed group with statistically significant difference. As regards gene mutation, exons 5a and 6 were more frequent among the highly exposed group as compared to no mutation among moderately exposed and unexposed groups with significant difference. As regards antioxidants; SOD, CAT, GSH and GPx were higher among the unexposed group as compared to the highly and moderately exposed group with statistically significant difference. Significant negative correlation was found between working years and antioxidant parameters. Conclusions Repeated exposure to α-CYP may lead to gene mutations, immunological disturbances and oxidative stress. Strict safety precautions are required not only for workers but also for public users. Int J Occup Med Environ Health 2017;30(4):603–615
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2017, 30, 4; 603-615
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Usefulness of biomarkers as intermediate endpoints in health risks posed by occupational lead exposure
    Autorzy:
    Borghini, Andrea
    Gianicolo, Emilio Antonio
    Andreassi, Maria Grazia
    Powiązania:
    https://bibliotekanauki.pl/articles/2177066.pdf
    Data publikacji:
    2015-10-16
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    biomarkers
    occupational exposure
    lead
    individual susceptibility
    genotoxic effects
    health risk
    Opis:
    The article concerns potential harmful effects of exposure to lead. Although the occurrence of severe lead poisoning has receded in several countries, occupational exposure resulting in moderate and clinically symptomatic toxicity is still common. An earlier and precise characterization of an individual response is obligatory in order to assess the possible risks for human health. Biomarkers may fill important gaps in the path from exposure to a disease. Specifically speaking, emerging (DNA double strand breaks and telomeric DNA erosion) and validated (micronuclei induction and chromosomal aberrations) biomarkers of genotoxicity seem to provide evidence for the assessment of molecular and cellular damage. Moreover, identification of genetic variability with a key role in modulating genotoxic damage may help minimize risks for susceptible subjects. Further investigations are naturally needed to properly define their diagnostic and/or prognostic value as “early warning” signs of a long-term risk for a subsequent clinically overt disease.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2016, 29, 2; 167-178
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Increased constitutional chromosome sensitivity to bleomycin in patients with hereditary non-polyposis colorectal cancer [HNPCC]
    Autorzy:
    Kladny, J
    Zajaczek, S
    Lubinski, J
    Powiązania:
    https://bibliotekanauki.pl/articles/2047245.pdf
    Data publikacji:
    1996
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    chromosome sensitivity
    lymphocyte
    hereditary non-polyposis colorectal cancer
    tumour
    colorectal cancer
    bleomycin
    genotoxic effect
    Opis:
    It has been suggested that mutagen sensitivity is a constitutional factor which may be useful in identification of patients with an increased risk for the development of tumors. In this study, the chromosome sensitivity to bleomycin was measured according to Hsu in patients with hereditary non-polyposis colorectal cancer (HNPCC), sporadic colorectal cancer and in control persons with no tumor history in family. In vitro lymphocytes were exposed to bleomycin according to Hsu and chromosomal damage was quantified by scoring breaks of 100 cells. A significant difference (P < 0.01) in the mean number of breaks per cell (b/c) was found between HNPCC patients (0.59 ± 0.14; n = 12; mean age 55.4 yrs) and control individuals (0.35 ± 0.13: n = 12; mean age 55.8 yrs). In contrast, patients with sporadic colorectal cancer showed a mean b/c value of 0.43 ± 0.14 (n = 14; mean age 63.4 yrs) which was not significantly higher than that in control individuals for this group (0.42 ± 0.15; n = 14; mean age 63.1 yrs). Selenium protected lymphocytes of HNPCC patients against bleomycin activity in vitro.
    Źródło:
    Journal of Applied Genetics; 1996, 37, 4; 385-392
    1234-1983
    Pojawia się w:
    Journal of Applied Genetics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of aging and oxidative/genotoxic stress on poly(ADP-ribose) polymerase-1 activity in rat brain
    Autorzy:
    Strosznajder, Robert
    Jesko, Henryk
    Adamczyk, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1041342.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    aging
    poly(ADP-ribosyl)ation
    brain
    p53 protein
    PARP-1
    genotoxic stress
    oxidative stress
    Opis:
    Poly(ADP-ribose) polymerase-1 (PARP-1, EC 2.4.2.30), a DNA-bound enzyme, plays a key role in genome stability, but after overactivation can also be responsible for cell death. The aim of the present study was to investigate PARP-1 activity in the hippocampus, brain cortex, striatum and cerebellum in adult (4 months) and aged (24 months) specific pathogen free Wistar rats and to correlate it with PARP-1 protein level and p53 expression. Moreover, the response of PARP-1 in adult and aged hippocampus to oxidative/genotoxic stress was evaluated. Our data indicated a statistically significant enhancement of PARP-1 activity in aged hippocampus and cerebral cortex comparing to adults without statistically significant changes in PARP-1 protein level. The expression of p53 mRNA was elevated in all aged brain parts with the exception of the cerebral cortex. Our data suggest that enhancement of PARP-1 activity and p53 expression in aged brain may indicate higher DNA damage. Our data also indicate that during excessive oxidative/genotoxic stress there is no response of PARP-1 activity in aged hippocampus in contrast to a significant enhancement of PARP-1 activity in adults which may have important consequences for the physiology and pathology of the brain.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 4; 909-914
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Level of DNA damage in lead-exposed workers
    Autorzy:
    Olewinska, E
    Kasperczyk, A.
    Kapka, L.
    Kozlowska, A.
    Pawlas, N.
    Dobrakowski, M.
    Birkner, E.
    Kasperczyk, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/51218.pdf
    Data publikacji:
    2010
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    occupational exposure
    occupational disease
    human disease
    lead
    DNA damage
    comet assay
    worker
    genotoxic effect
    Polska
    industry
    heavy metal
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2010, 17, 2; 231-236
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ograniczanie ekspozycji człowieka na ksenobiotyki środowiskowe: teoria i praktyka
    Autorzy:
    Krzystyniak, Krzysztof
    Obiedziński, Mieczysław
    Kalota, Hanna
    Marszałek, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/2097585.pdf
    Data publikacji:
    2017-06-30
    Wydawca:
    Państwowa Wyższa Szkoła Zawodowa w Tarnowie
    Tematy:
    ksenobiotyki
    biomonitorowanie człowieka (HBM)
    biomarkery chemiczne
    endokrynomimetyki (ECDs)
    kancerogeny genotoksyczne
    xenobiotics
    human biomonitoring (HBM)
    chemical biomarkers
    endocrine disruptor chemicals (EDCs)
    genotoxic carcinogens
    Opis:
    Ekspozycja na ksenobiotyki środowiskowe, jakiej doświadczają wszyscy ludzie żyjący w naszych czasach, stała się przedmiotem wzmożonej uwagi naukowców, specjalistów z urzędu monitorujących zagrożenia, władz administracyjnych i twórców opracowań legislacyjnych. Wypracowane zostały podstawowe definicje i określone „jednostki szkodliwości” w toksykologicznej ocenie bezpośrednich skutków zdrowotnych chemicznych zanieczyszczeń żywności, wody i powietrza. Podjęcie na szeroką skalę bezpośredniego biomonitorowania człowieka HBM (human biomonitoring) na chemikalia środowiskowe pozwala na analizę powiązań ekspozycji na chemikalia z otyłością, upośledzoną rozrodczością, cukrzycą typu 1 (T1D), autyzmem, nowotworami i innymi schorzeniami w skali społecznej. Nadzieje na eliminację ze środowiska człowieka chemicznych endokrynomimetyków EDCs (endocrine disruptor chemicals) uszkatoksykologicznych i regulacji legislacyjnych. Kategorią ksenobiotyków o wyjątkowo istotnym wpływie na zdrowie człowieka, których monitorowanie jest traktowane priorytetowo na obszarze Unii Europejskiej, są kancerogeny genotoksyczne. Według aktualnych ocen obywatele krajów Zachodu mogą zawierać w sobie około setki niewielkich, lecz wykrywalnych ksenobiotyków chemicznych i ich metabolitów. Wszystkie ksenobiotyki jakie znajdują się w człowieku w zasadzie są pochodzenia antropogennego. Mimo trwałej obecności ksenobiotyków w bezpośrednim środowisku człowieka, warto zastanowić się nad praktycznymi możliwościami ograniczania i unikania kontaktu z chemikaliami środowiskowymi. Dotyczy to zarówno stosowania filtrów wody i powietrza, właściwej termicznej obróbki żywności, doboru produktów żywnościowych, jak i innych aspektów życia codziennego. Uwaga: Fragmenty artykułu pochodzą z nowej książki Biomonitorowanie człowieka w profilaktyce zatruć środowiskowych, autorzy: K.L. Krzystyniak, M. Obiedziński, H. Kalota, A. Marszałek, Wyd. Medyk, Warszawa 2017 r. (w druku).
    Exposure to environmental xenobiotics, which influence the everyday life of all humans in our times, has become a subject of intensive analysis by scientists, authorities of environmental hazards, state authorities and authors of legislation. Toxicological risk assessment of chemicals in contaminated food and water as well as polluted air is expressed in basic ‘toxic units’. A broad-scale human biomonitoring (HBM) for environmental toxicants is the strategy of a cause-effect analysis of chemical exposure to environmental xenobiotics. HBM demonstrates the relationships between exposure to xenobiotics and the following health disorders: obesity, impaired reproduction, type 1 diabetes (T1D), autism, cancers and other diseases in the society. Developing effective toxicological tools and legislative standards is expected to help in eliminating endocrine disruptor chemicals (EDCs), which cause infertility. The exceptional category of xenobiotics, which highly influences human health, and is treated as a priority problem to be controlled in the European Union, form genotoxic carcinogens. According to a current assessment, hundreds of chemical xenobiotics and their metabolites, in the minimum detectable quantity, mostly all of anthropogenic origin, can be found in the organisms of inhabitants in western countries. Despite the permanent presence of xenobiotics in human environment, it is worth taking into consideration practical methods to limit and avoid contacts with environmental chemicals. It concerns the provision of water and air filters, the thermal processing of food, the selection of food products, and other aspects of everyday life.
    Źródło:
    Health Promotion & Physical Activity; 2017, 2, 3; 55-68
    2544-9117
    Pojawia się w:
    Health Promotion & Physical Activity
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Protective action of vitamin C against DNA damage induced by selenium-cisplatin conjugate.
    Autorzy:
    Błasiak, Janusz
    Kowalik, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1044192.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    endonuclease III
    vitamin C
    Se-Pt conjugate [(NH3)2Pt(SeO3)]
    genotoxic effects of anticancer drugs
    DNA damage
    comet assay
    DNA repair
    Opis:
    Genotoxicity of anticancer drugs is of a special interest due to the risk of inducing secondary malignancies. Vitamin C (ascorbic acid) is a recognized antioxidant and, since human diet can be easily supplemented with vitamin C, it seems reasonable to check whether it can protect against DNA-damaging effects of antitumor drugs. In the present work the ability of vitamin C to modulate cytotoxic and genotoxic effects of a cisplatin analog, conjugate (NH3)2Pt(SeO3), in terms of cell viability, DNA damage and repair in human lymphocytes was examined using the trypan blue exclusion test and the alkaline comet assay, respectively. The conjugate evoked a concentration-dependent decrease in the cell viability, reaching nearly 50% at 250 μM. (NH3)2Pt(SeO3) at 1, 10 and 30 μM caused DNA strand breaks, measured as the increase in the comet tail moment of the lymphocytes. The treated cells were able to recover within a 30-min incubation in a drug-free medium at 37°C. Vitamin C at 10 and 50 μM diminished the extent of DNA damage evoked by (NH3)2Pt(SeO3) but had no effect on the kinetics of DNA repair. The vitamin did not directly inactivate the conjugate. Lymphocytes treated with endonuclease III, which recognises oxidised pyrimidines, displayed a greater tail moment than those untreated with the enzyme, suggesting that the damages induced by the drug have, at least in part, an oxidative origin. Vitamin C can be considered a potential protective agent against side effects of antitumor drugs, but further research with both normal and cancer cells are needed to clarify this point.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 1; 233-240
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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