- Tytuł:
- Evolutionary Algorithm that Designs the DNA Synthesis Procedure
- Autorzy:
-
Michalak, M.
Nowak, R. - Powiązania:
- https://bibliotekanauki.pl/articles/308431.pdf
- Data publikacji:
- 2011
- Wydawca:
- Instytut Łączności - Państwowy Instytut Badawczy
- Tematy:
-
bioinformatics
gene synthesis
optimum searching - Opis:
- Chemical synthesis of nucleotide chains is very erroneous for long sequences. Often a gene is constructed from short fragments joined with the use of complementary helper chains. The number of possible potential solutions for a long gene synthesis is very large, therefore a fast automated search is required. In the presented approach a modified method of long DNA construction is proposed. A computer program that searches for an optimal solution in the space of potential synthesis methods has been developed. This software uses an evolutionary algorithm for global optimization and a hillclimbing algorithm for local optimization. The long DNA construction method was tested on random sequences. The results are very promising. The next step is to perform experiments in a biotechnological wet laboratory involving DNA strand synthesis using the method designed by the presented software.
- Źródło:
-
Journal of Telecommunications and Information Technology; 2011, 4; 50-54
1509-4553
1899-8852 - Pojawia się w:
- Journal of Telecommunications and Information Technology
- Dostawca treści:
- Biblioteka Nauki
Artykuł