Temat: gastric acid - Katalog OPAC zbiorów

Tytuł:: Helicobacter pylori antigens, acetylsalicylic acid, LDL and 7-ketocholesterol - their potential role in destabilizing the gastric epithelial cell barrier. An in vitro model of Kato III cells
Autorzy:: Gajewski, Adrian
Mnich, Eliza
Szymański, Karol
Hinc, Krzysztof
Obuchowski, Michał
Moran, Anthony
Chmiela, Magdalena
Powiązania:: https://bibliotekanauki.pl/articles/1038856.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Helicobacter pylori
acetylsalicylic acid
7-ketocholesterol
gastric barrier
Opis:: Colonization of gastric tissue in humans by H. pylori Gram-negative bacteria initiates gastric and duodenal ulcers and even gastric cancers. Infections promote inflammation and damage to gastric epithelium which might be followed by the impairment of its barrier function. The role of H. pylori components in these processes has not been specified. H. pylori cytotoxicity may potentially increase in the milieu of anti-inflammatory drugs including acetylsalicylic acid (ASA). The lipid transport-associated molecule such as low density lipoprotein (LDL), which is a classic risk factor of coronary heart disease (CHD) and 7-ketocholesterol (7-kCh) a product of cholesterol oxidation, which may occur during the oxidative stress in LDL could also be considered as pro-inflammatory. The aim of this study was to evaluate the cytotoxicity of H. pylori antigens, ASA, LDL and 7-kCh towards Kato III gastric epithelial cells, on the basis of the cell ability to reduce tetrazolium salt (MTT) and morphology of cell nuclei assessed by 4',6-diamidino-2-phenylindole (DAPI) staining. Kato III cells were stimulated for 24 h, at 37°C and 5% CO2, with H. pylori antigens: cytotoxin associated gene A (CagA) protein, the urease A subunit (UreA), lipopolysaccharide (LPS) and ASA, LDL or 7-kCh. H. pylori LPS, ASA, LDL and 7-kCh, but not H. pylori glycine acid extract (GE), demonstrated cytotoxicity against Kato III cells, which was related to a diminished percentage of MTT reducing cells and to an increased cell population with the signs of DNA damage. The results suggest that damage to gastric epithelial cells can be induced independently by H. pylori antigens, ASA and endogenous lipid transport-associated molecules. During H. pylori infection in vivo, especially in CHD patients, synergistic or antagonistic interactions between these factors might possibly influence the disease course. Further study is necessary to explain these potential effects.
Źródło:: Acta Biochimica Polonica; 2016, 63, 1; 145-152
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 14.

Tytuł:: The effect of nitric oxide donors and L-arginine on the gastric electrolyte barrier
Autorzy:: Szlachcic, A.
Bilski, R.
Dziadus-Sokolowska, A.
Michalski, J.
Mroczka, J.
Powiązania:: https://bibliotekanauki.pl/articles/70620.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: donor
ethanol
gastric juice
stomach wall
nitric oxide
L-arginine
aspirin
gastric electrolyte barrier
bile acid
Źródło:: Journal of Physiology and Pharmacology; 2001, 52, 2
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 15.

Tytuł:: Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats
Autorzy:: Tsukimi, Y.
Nakai, H.
Itoh, S.
Amagase, K.
Okabe, S.
Powiązania:: https://bibliotekanauki.pl/articles/70068.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: omeprazole
ulcer
gastric ulcer
indomethacin
heat shock
protein
acetic acid
healing
rat
Źródło:: Journal of Physiology and Pharmacology; 2001, 52, 3
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Informacja

Wyszukujesz frazę "gastric acid" wg kryterium: Temat

Źródło danych

Dostawca treści

Kolekcja

Rok wydania

Wydawca

Temat

Autor

Typ dokumentu

Język