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    Wyświetlanie 1-11 z 11
    Tytuł:
    THE INFLUENCE OF PLASTICIZER IN NAIL LACQUER FORMULATIONS ON FLUCONAZOLE PERMEABILITY THROUGH THE BOVINE HOOF MEMBRANE
    Autorzy:
    Elezovic, Alisa
    Elezović, Amar
    Hadziabdic, Jasmina
    Powiązania:
    https://bibliotekanauki.pl/articles/895713.pdf
    Data publikacji:
    2020-02-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    plasticizer
    fluconazole
    nail lacquer
    in vitro permeability
    bovine hoof membrane
    Opis:
    Medicinal nail lacquers are the most effective topical treatment of nail diseases. These formulations generally are organic solutions of the active substance as well as film-forming polymer and plasticizer, which affects the characteristics of the film formed after application and solvent evaporation. The aim of this work was to test effects of plasticizer present in nail lacquer formulations on permeation kinetics of fluconazole through the bovine hoof membrane in a novel in vitro test. The formulations contained Eudragit RS100 dissolved in acetone, and dibutyl-phthalate, PEG 400 or propylene glycol as plasticizers present in two different concentrations. Permeation studies were carried out during 7-day period, and the obtained permeability profiles analyzed using similarity and difference factors, and by model dependent permeation kinetics. When analyzed within the same strength, the highest extent of fluconazole permeation was obtained from formulation with lower concentration of propylene glycol at 0.9% fluconazole concentration, while for formulations with 1.8% and 2.7% of fluconazole, the highest permeation was achieved from formulation with the higher content of PEG400. The permeation profiles showed greater difference within one formulation of different fluconazole content, than with the same plasticizer present in different concentrations, when using dibutyl-phthalate and PEG400. Permeation profiles were similar when using propylene glycol. When comparing formulations with the same concentration of plasticizers, there were differences in formulations with the higher fluconazole concentrations. Permeation kinetics depended on fluconazole concentration as well as the path length the active substance had to pass to reach the receptor solution.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 43-56
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    DETERMINATION OF FLUCONAZOLE AND ITS OXIDATION PRODUCTS WITH KINETIC EVALUATION UNDER POTASSIUM PERMANGANATE TREATMENT IN ACIDIC SOLUTIONS BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
    Autorzy:
    Hubicka, Urszula
    Krzek, Jan
    Żmudzki, Paweł
    Żuromska-Witek, Barbara
    Motyl, Dariusz
    Kryczyk, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/895338.pdf
    Data publikacji:
    2019-02-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    stability
    fluconazole
    oxidation studies
    kinetic evaluation
    UPLC/MS
    Opis:
    For the determination of fluconazole (FLU) oxidation stability under permanganate treatment at the acidic pH, a sensitive, reproducible, and stability-indicating ultra-performance liquid chromatography–mass spectrometry (UPLC/MS) method was developed. Three additional products (tR = 5.79, 6.98, 7.54) were observed besides the FLU (tR = 6.22). The proposed method was used to study the kinetics of FLU oxidative degradation. An oxidation process followed kinetics of the second-order reaction. The degradation rate constant and the corresponding half-life obtained for the FLU oxidative degradation were 0.5626 h-1 and 16.69 h, respectively. The putative oxidation products were characterized and their fragmentation pathways, on a basis of MS/MS data, were proposed.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 19-27
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Yeasts isolated from frequently in-patients and out-patients
    Autorzy:
    Dynowska, M.
    Ejdys, E.
    Biedunkiewicz, A.
    Kubiak, D.
    Sucharzewska, E.
    Roslan, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/5588.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    yeast
    isolation
    in-patient
    out-patient
    patient
    fluconazole
    nystatin
    nosocomial infection
    Opis:
    The paper is a part of a general mycological monitoring study of nosocomial infections. Differences in the species composition and drug resistance of fungi isolated from in-patients and out-patients prompted an analysis of this topic. The studies were conducted with fungi from the collection of the Department of Mycology, University of Warmia and Mazury in Olsztyn, that were isolated from the oral cavity, sputum, bronchoscopic fluid, anus and skin from 100 in-patients and 100 out-patients. Laboratory analyses, including species categorization of fungi, were performed according to routine mycological diagnostics. Drug sensitivity to fluconazole and nystatin was tested with the disc diffusion method. In the group of in-patients, a wider taxonomic diversity of fungi (12 species) was found in comparison with the out-patients (7 species) and 31 cases of multifocal infections were recorded, while in the second group the number of the latter was only six. In all patients, C. albicans were predominant, constituting the largest proportion in focal infections in all patients and in multifocal infections in the in-patients. In the latter, over a half of the examined individuals were resistant to fluconazole (C. glabrata and C. krusei – 80%, C. tropicalis and S. capsularis – 60%, C. guilliermondii – 50%) and nystatin (T. beigelii – 80%, C. krusei and C. tropicalis – 50%). Substantially lower drug resistance of fungi was recorded in the out-patients. The hospital environment is an abundant reservoir of different fungal species with significantly greater expansiveness and aggressiveness compared to the environment outside a hospital.
    Źródło:
    Annals of Parasitology; 2014, 60, 3
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Efficacy of Lamiaceae essential oils with selected azoles against Candida albicans clinical isolates
    Autorzy:
    Proškovcová, M.
    Čonková, E.
    Váczi, P.
    Marcinčáková, D.
    Harčárová, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/16539174.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    Candida albicans
    fluconazole
    itraconazole
    Lamiaceae essential oils
    synergistic effect
    Opis:
    A current problem in candidiasis treatment is increasing resistance to azoles, which are often prescribed to patients. The study underlines the high resistance of yeasts to fluconazole, which achieved high MIC (minimal inhibitory concentration) values both alone and in combination with essential oils (EOs). Antifungal activity of Hyssopus officinalis, Thymus vulgaris, Salvia officinalis and Rosmarinus officinalis EOs was determined against 13 clinical isolates of Candida albicans and reference strain Candida albicans ATCC 10231. The synergistic effect was investigated for the combination of itraconazole and fluconazole with Hyssopus officinalis and Thymus vulgaris EOs. Based on the fractional inhibitory concentration index, the synergistic effect was achieved in all of the samples exposed to itraconazole with Hyssopus officinalis (FICI 0.3±0.06). On the other side, the additive effect was proven in use of itraconazole with Thymus vulgaris (FICI 0.75±0.35) and fluconazole with both EOs tested (FICI 0.81±0.19; 0.88±0.57) This study shows the importance of monitoring the synergistic effect of antifungals combined with EOs, because it is a possible solution for reducing the resistance and improving the disease prognosis.
    Źródło:
    Polish Journal of Veterinary Sciences; 2022, 25, 2; 279-285
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antibiotics sensitivity of Candida clinical and food-borne isolates
    Autorzy:
    Maroszyńska, Marta
    Kunicka-Styczyńska, Alina
    Rajkowska, Katarzyna
    Maroszyńska, Iwona
    Powiązania:
    https://bibliotekanauki.pl/articles/1039473.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Candida
    fluconazole
    voriconazole
    caspofungin
    nystatin
    clinical and food strains
    Opis:
    Candida is a yeast species recognized as the most frequent etiological agent of systemic and invasive thrush in humans. Invasions can affect all tissues, organs and systems of human in various stages of development. In the last 10 years Candida infections have increased 15 times. The purpose of our study was to determine the sensitivity of four antibiotics belonging to three different groups of antifungal agents against clinical and food-borne Candida strains. Our studies showed that of all tested strains, 7% was resistant to nystatin, 32% to fluconazole, 23% to voriconazole, and no strains grew in the presence of caspofungin. Despite the differences in biochemical profiles of clinical and food-borne isolates of Candida, a group of strains showing resistance to antibiotics include both types of isolates. At the same time circulating of antibiotic-resistant strains outside the hospital environment and the yeast infection via food is possible.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 4; 719-724
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Isobolographic in vitro interactions of fluconazole with citrus essential oils against Cladosporium cladosporioides
    Autorzy:
    Wroblewska-Luczka, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/2098240.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    fluconazole
    essential oil
    in vitro interaction
    isobolographic analysis
    Cladosporium cladosporioides
    Opis:
    Introduction. Cladosporium is one of the most abundant genera of environmental fungi worldwide and a very common respiratory allergen. To-date, many C. cladosporoides infections have been identified. Risk factors for C. cladosporioides infection are primarily injuries, metabolic disorders, organ transplantation and autoimmune diseases, among others. Objective. The aim of the study was to assess the type of pharmacodynamic interactions between fluconazole and some selected essential oils: orange, mandarin, lemon and grapefruit, in an in vitro study against C. cladosporioides. Materials and method. Experiments were carried out using the plate cultivation method. Fluconazole was tested against C. cladosporioides at concentrations ranging from 0.05–3.3 mg / ml, and the activity of essential oils added to PDA medium at concentrations ranging from 1–30%. The dose-effect curves for the collected results were determined with by the log- probit method. Isobolographic analysis of the results allowed determining the type of interactions between fluconazole and the tested essential oils. Results. Lemon essential oil was the most active, and in a concentration of 1% it inhibited the growth of C. cladosporioides by 21%. Isobolographic analysis showed that the combination of fluconazole with orange and grapefruit essential oil had an additive interaction, and with mandarin and lemon – an additive interaction with a tendency to synergy in the plate culture test for C. cladosporioides. Conclusions. The use of isobolographic analysis can contribute to the introduction of natural substances with the desired activities into the pharmacotherapy of many infections and diseases. The use of natural substances can also help to reduce the number of side-effects caused by conventional and standard therapies.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2021, 15, 1; 15-19
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A brief review of fluconazole as an antifungal agent and the need for research into its nanoformulation
    Autorzy:
    Nagaraj, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/2201067.pdf
    Data publikacji:
    2022
    Wydawca:
    Stowarzyszenie Komputerowej Nauki o Materiałach i Inżynierii Powierzchni w Gliwicach
    Tematy:
    fluconazole
    antibiotic
    structure
    toxicity
    nanoformulations
    flukonazol
    antybiotyk
    struktura
    toksyczność
    nanopreparaty
    Opis:
    Purpose Antifungals compounds have gained significant attention, and in this context, fluconazole as an antifungal is used predominantly, and the use of a nanoformulated form of this is discussed. Design/methodology/approach Fluconazole, an FDA-approved antibiotic, is an effective antimicrobial especially used to treat fungal infections. Its uniqueness lies in the fact that it contains fluoride with triazole functionality. Its efficacy against various types of fungus is demonstrated. Findings Although it is one of the effective antibiotics, its side effects are well documented, and due to this, many techniques are tried to improve its efficacy with lesser side effects. Research limitations/implications In this respect, nanoparticles play a crucial role, and many studies worldwide are carried out on this aspect. Among many nano techniques use of chitosan as well as lipid carriers of fluconazole are being considered. However, systematic studies are warranted to take this aspect into clinical trials. Practical implications Nano-based platforms seem to be an alternating hope to combat resistance and side effect. Originality/value A thorough study is the need of the hour to devise a proper nano-based strategy of fluconazole.
    Źródło:
    Journal of Achievements in Materials and Manufacturing Engineering; 2022, 114, 2; 81--85
    1734-8412
    Pojawia się w:
    Journal of Achievements in Materials and Manufacturing Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synergistyczne działanie flukonazolu i laktonów ftalidowych jako czynnik ograniczający stosowanie leków azolowych w leczeniu kandidoz
    Synergistic effect of fluconazole and phtalide lactones as a factor limiting the use of azole drugs against candidiasis
    Autorzy:
    Olejniczak, Teresa
    Powiązania:
    https://bibliotekanauki.pl/articles/27310047.pdf
    Data publikacji:
    2023
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    efekt synergii
    Candida albicans
    laktony ftalidowe
    flukonazol
    synergistic effect
    phthalide lactones
    fluconazole
    Opis:
    The resistance of Candida albicans and other pathogenic yeasts to azole antifungal drugs has increased rapidly in recent years and is a significant problem in clinical therapy. The current state of pharmacological knowledge precludes the withdrawal of azole drugs, as no other active substances have yet been developed that could effectively replace them. Therefore, one of the anti-yeast strategies may be therapies that can rely on the synergistic action of natural compounds and azoles, limiting the use of azole drugs against candidiasis. Synergy assays perperformed in vitro were used to assess drug interactions Fractional Inhibitory Concentration Index. The synergistic effect of fluconazole (1) and three synthetic lactones identical to those naturally occurring in celery plants—3-n-butylphthalide (2), 3-n-butylidenephthalide (3), 3-n-butyl-4,5,6,7-tetrahydrophthalide (4)—against Candida albicans ATCC 10231, C. albicans ATCC 2091, and C. guilliermondii KKP 3390 was compared with the performance of the individual compounds separately. MIC90 (the amount of fungistatic substance (in µg/mL) inhibiting yeast growth by 90%) was determined as 5.96–6.25 µg/mL for fluconazole (1) and 92–150 µg/mL for lactones 2–4. With the simultaneous administration of fluconazole (1) and one of the lactones 2–4, it was found that they act synergistically, and to achieve the same effect it is sufficient to use 0.58–6.73 µg/mL fluconazole (1) and 1.26–20.18 µg/mL of lactones 2–4. Based on biological research, the influence of the structure on the fungistatic activity and the synergistic effect were determined.
    Źródło:
    Wiadomości Chemiczne; 2023, 77, 5-6; 555-567
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Detection of cross-resistance between methotrexate and azoles in Candida albicans and Meyerozyma guilliermondii: an in vitro study
    Autorzy:
    Karuga, Filip Franciszek
    Góralska, Katarzyna
    Brzeziańska-Lasota, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/11543398.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Botaniczne
    Tematy:
    cross resistance
    detection
    methotrexate
    azole
    Candida albicans
    Meyerozyma guilliermondii
    drug resistance
    fluconazole
    Opis:
    In recent years, there has been a rapid increase in the incidence of Candida infections. The different species of the genus Candida vary in their virulence abilities and susceptibility to antifungal agents, depending on several external factors. The result of such modifications may be cross-resistance, which is understood as an acquired resistance to a certain antimicrobial agent after exposure to another drug. The aim of this study was to determine the possibility of cross-resistance between fluconazole, voriconazole, itraconazole, and methotrexate in Candida albicans and Meyerozyma guilliermondii (syn. Candida guilliermondii). Fifteen strains of M. guilliermondii and eight strains of C. albicans, including the standard strains, were tested. For all strains, the minimum inhibitory concentrations (MICs) for fluconazole, voriconazole, and itraconazole were determined before and after stimulation with methotrexate. The median MICs in M. guilliermondii before and after stimulation were 9.333 and 64 mg/L (p = 0.005) for fluconazole; 0.917 and 1.667 mg/L (p = 0.001) for itraconazole, respectively. No significant change in MIC was observed for voriconazole. For C. albicans strains, the median MICs before and after stimulation were 0.917 and 64 mg/L (p = 0.012) for fluconazole; 0.344 and 1.135 mg/L (p = 0.018) for voriconazole, respectively. There was no significant change in MIC values for itraconazole. Thus, this study demonstrates the presence of cross-resistance between voriconazole, itraconazole, fluconazole, and methotrexate for the selected strains. Methotrexate exposure induces different responses when certain drugs are used for various species. Therefore, if a patient was previously exposed to methotrexate, there may be a higher risk of treatment failure with fluconazole than with other azoles such as voriconazole for fungemia caused by M. guilliermondii or itraconazole for C. albicans infection.
    Źródło:
    Acta Mycologica; 2021, 56, 1; 566
    0001-625X
    2353-074X
    Pojawia się w:
    Acta Mycologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cutaneous leishmaniasis mimicking granulomatous cheilitis and treated successfully with oral fluconazole in a boy
    Autorzy:
    Serarslan, G.
    Aksakal, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/6313.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    cutaneous leishmaniasis
    leishmaniasis
    protozoan parasite
    parasitic disease
    human disease
    mimicking granulomatous cheilitis
    oral dose
    fluconazole
    boy
    Opis:
    Cutaneous leishmaniasis is a protozoan infectious disease and widespread in Mediterranean basin including Turkey. Lesions usually start with erythematous papules, gradually enlarges and afterwards it ulcerates. We present a 12-year-old boy with diffuse persistent lip swelling mimicking granulomatous cheilitis. Systemic glucantime was started. However, severe hypotension and bradycardia was developed after injection. Oral fluconazole was started and the lesion resolved completely. Cutaneous leishmaniasis can have varied clinical manifestations and should be suspected especially in endemic areas. Oral fluconazole seems to be safe and effective treatment modality in paediatric cases.
    Źródło:
    Annals of Parasitology; 2015, 61, 3
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Additivity interactions between fluconazole and citrus essential oils to Aspergillus fumigatus
    Autorzy:
    Wroblewska-Luczka, P.
    Luszczki, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2098525.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Aspergillus fumigatus
    mycosis
    mould
    interaction
    fluconazole
    essential oil
    antifungal property
    antibacterial property
    antiinflammatory property
    isobolographic analysis
    Opis:
    Introduction. Aspergillus fumigatus is the most common pathogen causing allergic bronchopulmonary mycosis. The pathogenic capacity of Aspergillus fumigatus is related to its thermal tolerance and the small size of the spores which enables transfer to the respiratory tract. In the case of fungal diseases, their treatment is based on fungicidal antibiotics, such as fluconazole. Due to the growing problem of drug resistance, new therapeutic solutions are sought, especially of natural origin. Essential oils, due to their anti-bacterial, anti-fungal, anti-inflammatory and immunostimulatory properties, constitute interesting research material in the fight against mould. Objective. The aim of the study was to assess the type of pharmacodynamic interactions between fluconazole and selected essential oils: lemon, orange, tangerine, and grapefruit in an in vitro study against Aspergillus fumigatus. Isobolographic analysis of the results allowed determining the type of interactions between fluconazole and the tested essential oils. Results. According to the research results, a IC50 dose of fluconazole versus Aspergillus fumigatus IC50 = 1.87±0.88mg/ml. The most active essential oil was lemon oil, which at the concentration of 4% in medium completely inhibited the growth of Aspergillus fumigatus. Tangerine essential oil is the least active against A. fumigatus. Isobolographic analysis of the interactions between fluconazole and essential oils showed additive interactions for the combination of fluconazole with lemon, orange and grapefruit ols, and an additive interaction with a tendency to synergism for the combination of fluconazole with tangerine oil. Conclusions. Isobographic analysis can contribute to the introduction of natural substances into the therapy of many diseases.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2021, 15, 3; 116-120
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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