- Tytuł:
- Fibroblast biological activity on poly(l-lactide) and poly(l-lactide-co-trimethylene carbonate)
- Autorzy:
-
Ścisłowska-Czarnecka, A.
Pamuła, E.
Kołaczkowska, E. - Powiązania:
- https://bibliotekanauki.pl/articles/284073.pdf
- Data publikacji:
- 2011
- Wydawca:
- Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
- Tematy:
-
fibroblasts
biomaterials
PLLA - Opis:
- Poly-L-lactide (PLLA) is acknowledged biocompatible polyester. However, it possesses high crystallinity/brittleness/stiffness and requires long time for complete degradation. In the current study we present data on PLTMC, a copolymer of L-lactide and trimethylene carbonate (TMC). Poly(trimethylene carbonate) (PTMC) is characterised by good mechanical properties and rapid degradation rate and for this it might possess new desired features for medical applications. During the experiments, adhesion and activity of fibroblasts cultured on PLLA and PLTMC were studied and compared during two time points of 3 and 5 days. On day 3, the number of adherent fibroblasts was compromised when fibroblasts were cultured in the presence of PLTMC but the proper adherence was recovered by day 5. The same pat-tern was observed when we evaluated some activity parameters of fibroblasts. In particular, the release of proteins and nitric oxide was studied as the increased levels of the mediators might indicate unwanted inflammatory-like condition. Overall, the results suggest that the synthesized PLTMC initially shows unwanted effects on fibroblasts but with the time these effects are abolished. Therefore PLTMC seems to represent a new material that is non-cytotoxic and compatible with the living cells.
- Źródło:
-
Engineering of Biomaterials; 2011, 14, 102; 7-10
1429-7248 - Pojawia się w:
- Engineering of Biomaterials
- Dostawca treści:
- Biblioteka Nauki
Artykuł