- Tytuł:
- Selectivity of oxidative stress targeting in estrogen-induced experimental nephrocarcinogenesis.
- Autorzy:
-
Kobiela, Jarek
Krajewski, Jacek
Kalińska-Błach, Beata
Stefaniak, Tomasz - Powiązania:
- https://bibliotekanauki.pl/articles/1043806.pdf
- Data publikacji:
- 2002
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
estrogen-induced carcinogenesis
protein carbonyl group
renal carcinogenesis
oxidative stress - Opis:
- Specificity of targeting of the oxidative stress towards lipid and protein fractions in a model of estrogen-induced Syrian hamster nephrocarcinogenesis was evaluated. The amount of proteins modified by oxidative stress was significantly elevated as early as one month after the initial implantation of estradiol to the experimental versus the control group, while the stress did not affect lipids. Subcellular localization of the oxidative stress target was determined by the analysis of protein oxidation in subcellular fractions of kidney cells. The endoplasmic reticulum membranes were the fraction most affected by the oxidative stress.
- Źródło:
-
Acta Biochimica Polonica; 2002, 49, 1; 51-58
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł