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Tytuł:
Analiza porównawcza wyników oznaczeń laboratoryjnych biomarkerów zapalenia – wskaźnika sedymentacji krwinek czerwonych (ESR) i białka C-reaktywnego (CRP) w stanach zapalnych u pacjentów hospitalizowanych
Comparative analysis of inflammatory biomarkers values - erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in hospitalized patients with inflammation
Autorzy:
Siudzińska, Agnieszka
Łobos, Marek
Sujecki, Adam
Paradowski, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1032623.pdf
Data publikacji:
2013
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
CRP
ESR
inflammation
zapalenie
esr
crp
Opis:
Introduction: Erythrocyte sedimentation rate (ESR, in Poland known as OB) and C-reactive protein (CRP) are biomarkers most often used to diagnose and monitor systemic inflammation. However, they are independent markers and have different properties. The aim of this study was to compare the values of specific markers of systemic inflammation such as ESR and CRP in patients hospitalized in the internal wards and suspected of suffering from systemic inflammation. Material and methods: The study group included 187 patients (99 women and 88 men, aged from 20 to 97 years) hospitalized in the internal medicine clinics of the Military Medical Academy University Teaching Hospital - Central Veterans' Hospital in Lodz. Each marker of inflammation, ESR and CRP, were measured in patients’ peripheral blood (ESR) and serum (CRP). Results: For the diagnosis of inflammation there was no significant correlation between CRP and ESR in groups of patients both with mild (CRP > 6.1 – 40 mg/L) and severe (CRP ≥ 40.1) inflammation. However, in persons with highly developed inflammation (ESR ≥ 31 mm/h and CRP ≥ 40.1 mg/L) there was a strong correlation between the mentioned biomarkers (r = 0.9973). Conclusions: The results indicate that CRP and ESR biomarkers are independent parameters that are clinically useful for the diagnosis and monitoring of inflammations. For the diagnosis of acute inflammation the designation of serum CRP is clinically more useful than the measurement of ESR.
Wstęp: Odczyn opadania krwinek czerwonych (ESR, w Polsce znany pod nazwą odczyn Biernackiego - OB) i stężenie białka C-reaktywnego (CRP) są najczęściej wykorzystywanymi przez lekarzy biomarkerami do rozpoznawania i monitorowania stanu zapalnego ustroju. Jednak są one wskaźnikami niezależnymi i cechują się różnymi własnościami. Celem niniejszej pracy była analiza porównawcza wyników oznaczeń dwóch laboratoryjnych biomarkerów zapalenia: ESR i CRP u pacjentów leczonych na oddziałach internistycznych, u których podejrzewano narastający lub istniejący proces zapalny. Materiał i metody: Badaniem objęto 187 chorych (99 kobiet i 88 mężczyzn, w wieku od 20 do 97 lat) hospitalizowanych w klinikach chorób wewnętrznych Uniwersyteckiego Szpitala Klinicznego im. Wojskowej Akademii Medycznej – Centralnego Szpitala Weteranów w Łodzi. U każdego pacjenta w tym samym czasie wykonano oznaczenie dwóch wskaźników stanu zapalnego: ESR i CRP. Wyniki: Dla rozpoznawania narastającego zapalenia nie wykazano istotnej korelacji między CRP i ESR w grupach pacjentów zarówno o małym (CRP > 6,1 – 40 mg/L), jak i dużym (CRP ≥ 40,1) nasileniu zapalenia. Z drugiej strony, u ludzi z silnie już rozwiniętym zapaleniem (ESR ≥ 31 mm/h i CRP ≥ 40,1 mg/L) zaznaczyła się wysoka korelacja pomiędzy tymi biomarkerami (r = 0,9973). Wnioski: Wyniki wskazują, że analizowane biomarkery CRP i ESR są parametrami niezależnymi i są klinicznie użyteczne w rozpoznawaniu i obserwacji stanów zapalnych. W rozpoznawaniu zapalenia o ostrym przebiegu bardziej użytecznym klinicznie biomarkerem jest stężenie CRP w surowicy niż wartość ESR.
Źródło:
Folia Medica Lodziensia; 2013, 40, 2; 207-233
0071-6731
Pojawia się w:
Folia Medica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Taurine-EVA copolymer-paraffin rods dosimeters for EPR high-dose radiation dosimetr
Autorzy:
Maghraby, A. M.
Mansour, A.
Abdel-Fattah, A. A.
Powiązania:
https://bibliotekanauki.pl/articles/147366.pdf
Data publikacji:
2014
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
EPR
ESR
radiation dosimetry
taurine
alanine
Opis:
Taurine/EPR rods (3 × 10 mm) have been prepared by a simple technique in the laboratory where taurine powder was mixed with a molten mixture of paraffin wax and an ethylene vinyl acetate (EVA) copolymer. The binding mixture EVA/Paraffin does not present interference or noise in the EPR signal before or after irradiation. The rods show good mechanical properties for safe and multi-use handling. An EPR investigation of radiation induced radicals in taurine rods revealed that there are two types of radicals produced after exposure to gamma radiation (60Co). EPR spectra were recorded and analyzed – also the microwave power saturation and modulation amplitude were studied and optimized. Response of taurine to different radiation doses (1.5–100 kGy) was studied and found to follow a linear relationship up to 100 kGy. Radiation induced radicals in taurine persists and showed a noticeable stability over 94 days following irradiation. Uncertainities associated with the evaluation of radiation doses using taurine dosimeters were discussed and tabulated. It was found that taurine possesses good dosimetric properties using EPR spectroscopy in high doses in addition to its simple spectrum.
Źródło:
Nukleonika; 2014, 59, 1; 9-13
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of humic substances on the liposome structures : ESR method
Autorzy:
Man, D.
Pisarek, I.
Braczkowski, M.
Powiązania:
https://bibliotekanauki.pl/articles/147392.pdf
Data publikacji:
2013
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
EYL liposome
ESR method
humic substances
Opis:
In this paper the changes of membrane fluidity of liposome with additions of humic substances (humic and fulvic acids) were examined. Liposome were done by the sonication of lecithin EYL. Concentrations of humic substances in attitude to EYL varied between 0–10% of weight. The technique of electron spin resonance (ESR) were used for the examination followed by three spin probes with a variety placement of the membrane located. TEMPO probe melted in the hydrophobic membrane and in the aquatic solution which allowed to determine the spectroscopic partition parameter (F), indicating the changes that occur in water-lipid interphase. Probe 5-DOXYL placed directly under the heads of polar lipids and the order parameter measuring by the TII showed the changing of membrane fluidity at surface area. 16-DOXYL probe penetrated the middle of the lipid bilayer membrane and allowed to determine the rotational correlation time τ parameter, which gives us information about changing of the liquidity lipid bilayer. Studies showed that the tested humic substances significantly changed the membrane fluidity of liposome. The dynamics of this process depends on both: the fraction of humic substances and its quality and quantity as well as the placement area of the membrane.
Źródło:
Nukleonika; 2013, 58, 3; 439-442
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of Capacitor & Diode Aging effects on Output Ripple in Voltage Regulators and Prognostic Detection of Failure
Autorzy:
K, Preethi Sharma
Vijayakumar, T
Powiązania:
https://bibliotekanauki.pl/articles/2055277.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Buck
MOSFET
ESR
SMPS
voltage ripple
Opis:
Objectives: To design and simulate a buck converter and detector circuit which can prognostically indicate the power supply failure. Failure of Aluminium Electrolytic Capacitor (AEC) is considered as the parameter causing the power supply failure. To analyse variation of output ripple voltage due to possible changes in the Equivalent Series Resistance (ESR) and effective capacitance of the capacitor and design a detector to detect the failure of power supply prognostically. Methods: A DC-DC buck converter in SMPS topology is designed by assuming an input voltage of 12V with 3 volts possible fluctuations and an output voltage of 3.3 volts is desired. Simulation is carried out to measure the variation in output ripple voltage caused due to aging of electrolytic capacitor using TINA by Texas Instruments. A detector is also designed to compare the ripple voltage and a predefined threshold voltage so as to indicate the possible failure of Switched Mode Power Supply (SMPS) well in advance by monitoring the output ripple increase. Novelty: Having a fault tolerant power supply is very important in safety critical applications. Here by monitoring the output ripple variation, the degradation of AEC is predicted by calculating the ESR and capacitance variation. This simple yet effective prognostic detection will support in the design of fault tolerant power supplies. Highlight: It is found that, the ripple at the output increases with aging of the electrolytic capacitor, as with time the equivalent capacitance decreases and Equivalent Series Resistance (ESR) of the capacitor increases. The designed detector output is found to prognostically indicate the failure of SMPS.
Źródło:
International Journal of Electronics and Telecommunications; 2022, 68, 2; 281--286
2300-1933
Pojawia się w:
International Journal of Electronics and Telecommunications
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impact of humic acids on EYL liposome membranes : ESR method
Autorzy:
Pytel, B.
Filipiak, A.
Pisarek, I.
Olchawa, R.
Man, D.
Powiązania:
https://bibliotekanauki.pl/articles/146924.pdf
Data publikacji:
2015
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
EYL liposomes
ESR method
humic substances
Opis:
In this paper, the effects of model (commercial) and natural (extracted from peat) humic substances on the membrane of liposomes formed with egg yolk lecithin (EYL) are presented. In our research, mass concentrations of fulvic and humic acids were used, which in relation to lecithin varied from 0% to 13%. To study membrane fluidity, electron spin resonance (EPR) was used with two spin probes, penetrating various regions of the lipid bilayer. The effects of model and natural humic substances (humic acids – HAs and fulvic acids – FAs) on the lipid membrane in different regions were researched: the lipid-water interphase, and in the middle of the lipid bilayer. It was shown that FA and HA impact the fluidity of liposome membranes in different ways. Increased mass concentrations of HAs decreased membrane fluidity in both acids: extracted from peat and the model. However, increased mass concentration of FAs extracted from peat, decreased membrane fluidity in the surface region, at the same time stiffening the central part of the bilayer. Increasing the concentration of FAs extracted from peat had the opposite effect when compared to model FA. This effect may be related to the complexation of xenobiotics present in the soil environment and their impact on biological membranes.
Źródło:
Nukleonika; 2015, 60, No. 3, part 1; 455-459
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Paramagnetic properties of Cuban red mud at low temperatures
Autorzy:
Shvets, V.
Powiązania:
https://bibliotekanauki.pl/articles/184300.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
iron ores
metals oxides
ESR
low temperatures
Opis:
The electron spin resonance (ESR) spectra of Cuban red mud have been measured at three different temperatures: 295 K, 150 K and 77 K. The broad absorption line with resonance fields ∼(1.7–1.8) kOe was observed at all temperatures with values of g-factor from 3.602 to 4.020. The temperature decrease resulted in an absorption line appearance with resonance fields of 3.252 kOe (g = 2.067) at 150 K and 3.339 kOe (g = 2.086) at 77 K. The ESR-signal amplitude with resonance fields ∼(1.7–1.8) kOe decreases and the ESR-signal amplitude in the field ∼3.3 kОе increases with reduction in temperature.
Źródło:
Geology, Geophysics and Environment; 2018, 44, 4; 373-378
2299-8004
2353-0790
Pojawia się w:
Geology, Geophysics and Environment
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spin trapping studies of essential oils in lipid systems
Autorzy:
Makarova, K.
Drązikowska, K.
Suska, B.
Zawada, K.
Wawer, I.
Powiązania:
https://bibliotekanauki.pl/articles/147786.pdf
Data publikacji:
2015
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
spin trapping ESR
essential oils
DFT calculations
lipids
Opis:
In the present work, we report the results of a spin trapping ESR study of four essential oils widely used for skin care products such as creams and bath salts. The studied essential oils are Rosmarini aetheroleum (rosemary), Menthae piperitae aetheroleum (mint), Lavandulae aetheroleum (lavender), and Thymi aetheroleum (thyme). Fenton reaction in the presence of ethanol was used to generate free radicals. The N-tert- -butyl-α-phenylnitrone (PBN) was used as a spin trap. In the Fenton reaction, the rosemary oil had the lowest effect on radical adduct formation as compared to the reference Fenton system. Since essential oils are known to be lipid soluble, we also conducted studies of essential oils in Fenton reaction in the presence of lipids. Two model lipids were used, namely 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dipalmitoyl-sn- -glycero-3-phosphocholine (DPPC). The obtained results suggested that in the presence of DOPC lipids, the •OH and PBN/•CHCH3(OH) radicals are formed in both phases, that is, water and lipids, and all the studied essential oils affected the Fenton reaction in a similar way. Whereas, in the DPPC system, the additional type of PBN/X (aN = 16.1 G, aH = 2.9 G) radical adduct was generated. DFT calculations of hyperfi ne splittings were performed at B3LYP/6-311+G(d,p)/EPR-II level of theory for the set of c-centered PBN adducts in order to identify PBN/X radical.
Źródło:
Nukleonika; 2015, 60, No. 3, part 1; 461-468
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and spectroscopic interpretations of Co(II), Ni(II) and Cu(II) decxycholate complexes with molecular docking of COVId-19 protease
Autorzy:
Refat, Moamen S.
Bakare, Safyah B.
Altalhi, Tariq A.
Alam, Kehkashan
Al-Hazmi, Ghaferah H.
Powiązania:
https://bibliotekanauki.pl/articles/1849269.pdf
Data publikacji:
2021
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
deoxycholic acid
complexes
ESR
TGA/DSC
molecular docking
Opis:
Co(II), Ni(II) and Cu(II) decxycholate complexes are interesting due to their biologically active and deliberate interest in the research due to their coordination properties. The microanalytical ‘elemental analysis’, molar conductivity, (infrared and Raman) spectroscopy, thermal analyses (TGA/DSC), UV-vis spectra, and ESR for copper(II) decxycholate complex investigations were performed in the structural assignments of Co(II), Ni(II) and Cu(II) decxycholate complexes. Reaction of the sodium deoxycholate ligand (C24H39O4Na) with three transition metal ions form the complexes of formulae, [M(C24H39O4)2(H2O)2] . xH2O where M = Co(II), Ni(II) and Cu(II) where x = 2 for Cu(II) and x = 4 in case of M = Co(II) or Ni(II) metal ions. The FTIR spectra of the complexes show that decxycholate molecule is present as bidentate ligand. Molecular docking utilizing to additionally examine the interaction of COVID-19 (6LU7) with different complexes of deoxycholic acid with Co(II), Ni(II) and Cu(II). Furthermore, in the case of Co(II) deoxycholate complex, the probe is surrounded by amino residues Met235, Pro241, Glu240, Pro108, Gln110, Phe294, and Ile152. The probe molecule of Ni(II) deoxycholate complex is sited close to amino acids Tyr126, Tyr239, Leu287, Leu272, and Lys137. For, Cu(II) deoxycholate complex, the residues of amino acids comprise of Pro132, Pro108, Gln110, Gly109, Ile200, Asn203, Val202, His246, Pro293 and Tyr154. The binding energy was determined from the docking reads for Co(II)–6LU7, Ni(II)–6LU7 and Cu(II)–6LU7 deoxycholate compounds were found to be −446.99, −500.52, −398.13 kcal mol−1 individually.
Źródło:
Polish Journal of Chemical Technology; 2021, 23, 2; 54-59
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and spectroscopic interpretations of Co(II), Ni(II) and Cu(II) decxycholate complexes with molecular docking of COVId-19 protease
Autorzy:
Refat, Moamen S.
Bakare, Safyah B.
Altalhi, Tariq A.
Alam, Kehkashan
Al-Hazmi, Ghaferah H.
Powiązania:
https://bibliotekanauki.pl/articles/1849271.pdf
Data publikacji:
2021
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
deoxycholic acid
complexes
ESR
TGA/DSC
molecular docking
Opis:
Co(II), Ni(II) and Cu(II) decxycholate complexes are interesting due to their biologically active and deliberate interest in the research due to their coordination properties. The microanalytical ‘elemental analysis’, molar conductivity, (infrared and Raman) spectroscopy, thermal analyses (TGA/DSC), UV-vis spectra, and ESR for copper(II) decxycholate complex investigations were performed in the structural assignments of Co(II), Ni(II) and Cu(II) decxycholate complexes. Reaction of the sodium deoxycholate ligand (C24H39O4Na) with three transition metal ions form the complexes of formulae, [M(C24H39O4)2(H2O)2] . xH2O where M = Co(II), Ni(II) and Cu(II) where x = 2 for Cu(II) and x = 4 in case of M = Co(II) or Ni(II) metal ions. The FTIR spectra of the complexes show that decxycholate molecule is present as bidentate ligand. Molecular docking utilizing to additionally examine the interaction of COVID-19 (6LU7) with different complexes of deoxycholic acid with Co(II), Ni(II) and Cu(II). Furthermore, in the case of Co(II) deoxycholate complex, the probe is surrounded by amino residues Met235, Pro241, Glu240, Pro108, Gln110, Phe294, and Ile152. The probe molecule of Ni(II) deoxycholate complex is sited close to amino acids Tyr126, Tyr239, Leu287, Leu272, and Lys137. For, Cu(II) deoxycholate complex, the residues of amino acids comprise of Pro132, Pro108, Gln110, Gly109, Ile200, Asn203, Val202, His246, Pro293 and Tyr154. The binding energy was determined from the docking reads for Co(II)–6LU7, Ni(II)–6LU7 and Cu(II)–6LU7 deoxycholate compounds were found to be −446.99, −500.52, −398.13 kcal mol−1 individually.
Źródło:
Polish Journal of Chemical Technology; 2021, 23, 2; 54-59
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Uranium - Doping Effects on Structural and Spectral Features of Vanadate Ceramics
Autorzy:
Elsabawy, Khaled M.
Powiązania:
https://bibliotekanauki.pl/articles/1192708.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
212 Vanadate
Ceramic
ESR
IR
Uranium Doping
X- ray
Opis:
212-Vanadate ceramics with formula Bi2SrV2-xUxO9, where (0 ≤ x ≤ 0.6 mole ) were carefully synthesized by solution routes with sintering temperature at 880oC for 24 hrs. Structural analysis with XRD proved that uranium (IV)-dopant can substitute successfully until x = 0.55 mole on the Bi-layered perovskite crystal structure without damaging the original structure . It was observed that U – doping have slight to moderate effects on both ESR-signals and conduction mechanism of U-doped Bi-Sr-V-O regime. Electrical measurements indicated that the energy gap Eg and number of electrons in conduction band Ncb increase as the ratio of U doping increases from x = 0.05 till x = 0.6 mole respectively due to the increasing of paramagnetic character of uranium than vanadium.
Źródło:
World Scientific News; 2016, 30; 103-116
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł

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