Temat: endothelial cell - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Retroviral targeting of proliferating endothelial cells
Autorzy:: Gornikiewicz, Alexander
Zommer, Anna
Jakesz, Raimund
Gnant, Michael
Brostjan, Christine
Powiązania:: https://bibliotekanauki.pl/articles/1041388.pdf
Data publikacji:: 2005
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: targeting
endothelial cell
envelope glycoprotein
angiogenin
retrovirus
Opis:: Tumor growth requires the formation of new blood vessels by endothelial cells. Thus, surface molecules - such as angiogenin receptors - that are selectively expressed on growing endothelium represent an attractive target for directed delivery of compounds to tumor tissue. We attempted to obtain genetically engineered retroviral vectors targeted to the endothelium by inserting the human angiogenin sequence into Moloney murine leukemia virus envelope glycoprotein. Abundant expression of the chimeric protein could be verified. However, while being selective for proliferating human endothelial cells, the recombinant retroviral particles displayed low transduction efficiencies and thus have to be further improved.
Źródło:: Acta Biochimica Polonica; 2005, 52, 3; 731-735
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Experimental allogenic transplantation of cornea endothelial cells in cats
Autorzy:: Kielbowicz, Z.
Kuryszko, J.
Strzadala, L.
Powiązania:: https://bibliotekanauki.pl/articles/31702.pdf
Data publikacji:: 2010
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: experimental transplantation
transplantation
cornea
endothelial cell
cat
endothelium
Opis:: Background: The aim of the present study was assessing the possibility of experimental allogenic transplantation of cat cornea endothelial cells, multiplied in vitro, into the anterior chamber of the eyeball in recipient cats. The reason for undertaking the research is the need to develop a method that would help in the cornea treatment in animals with corneal opacification following cataract surgery, as well as lens dislocation, injuries and endothelium degeneration. Methods: Cats aged 10-12 months were used in the experiment. Cornea fragments consisting of the posterior limiting membrane and posterior epithelium were placed in Iscove;s medium with addition of 10% foetal calf serum. Multiplied in vitro cells were injected into the anterior chamber of recipient cats. The cornea was subject to histological, histometric and SEM examination on the 3rd, 7th, 20th and 30th day after the surgery. Results: Micromorphological examination of the cornea showed full restitution of its endothelium 30 days after transplantation. Complete regeneration of structures indispensable for normal functioning of the posterior epithelium occurred as a result of implantation. Conclusions: In this study the results show that implantation of the cells of posterior corneal epithelium of donor cats, multiplied into vitro and injected into the anterior chamber of recipient cats. The cornea regained its full function, the layer of the posterior epithelium was regenerated and the stroma stabilized, presenting the image of full and proper corneal translucency.
Źródło:: Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Isolation and characterization of rat gastric microvascular endothelial cells as a model for studying gastric angiogenesis in vitro
Autorzy:: Jones, M.K.
Wang, H.
Tomikawa, M.
Szabo, I.L.
Kawanaka, H.
Sarfeh, I.J.
Tarnawski, A.S.
Powiązania:: https://bibliotekanauki.pl/articles/71014.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: capillary microvessel
gastric endothelial cell
T lymphocyte
endothelial cell
monoclonal antibody
monocyte
angiogenesis
microvasculature
stomach
in vitro
rat
platelet
Źródło:: Journal of Physiology and Pharmacology; 2000, 51, 4,2
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Isolation of morphologically and functionally intact gastric mucosal microvessels rapid communication
Autorzy:: Tarnawski, A.
Arakawa, T.
Sekhon, S.
Ichikawa, Y.
Szabo, I.
Sarfeh, I.J.
Powiązania:: https://bibliotekanauki.pl/articles/70609.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: endothelial cell
prostacyclin
isolation
blood flow
gastric microvessel
ultrastructure
Źródło:: Journal of Physiology and Pharmacology; 2000, 51, 1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: The influence of selective COX-2 inhibitor on phase of healing surgical wounds: proliferation and secretion of bFGF by endothelial cells
Autorzy:: Jasiak, Łukasz
Kowalczyk, Mateusz
Mazan, Paula
Kowalczyk, Edward
Sienkiewicz, Monika
Jóźwiak-Bębnista, Marta
Wiktorowska-Owczarek, Anna
Powiązania:: https://bibliotekanauki.pl/articles/763865.pdf
Data publikacji:: 2017
Wydawca:: Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Tematy:: angiogenesis, selective COX-2 inhibitor, fibroblast growth factor, vascular endothelial cell
Opis:: The process of wound healing consists of the following phases: inflammation, proliferation, remodeling. Non-steroidal antiinflammatory drugs may be important in this process, especially in a stage called angiogenesis. For this reason, it was decided to investigate the effect of selective COX-2 (cyclooxygenase 2) inhibitor (NS-398) on the proliferation of endothelial cells and their ability to secrete bFGF (fibroblast growth factor) for vascular endothelial cells (HMEC-1). For determination of the secretion of bFGF in a cell line HMEC-1 immunosorbent ELISA assays were used. In turn, the cell proliferation assay was performed using the MTT method. Using MTT method, it was found that NS-398 at 10 μM did not affect cell viability. Whereas selective COX-2 inhibitor at 100 μM decreased cell viability in a statistically significant manner and inhibited the proliferative effect of 100 μg/mL LPS at concentrations of 10 and 100 μM. In the further step, application of NS-398 (10 and 100 μM) with LPS (100 μg/mL; inflammatory environment) reduced the secretion of bFGF in a statistically significant manner. The investigations showed that NS-398 has an antiangiogenic effect which is based on reducing the proliferation of vascular endothelial cells and inhibiting the secretion of bFGF- factor responsible for angiogenesis during wound healing.
Źródło:: Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia; 2017, 72, 1
2083-3563
0066-2232
Pojawia się w:: Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Bidirectional action of extracellular ATP on intracapillary volume of isolated rat renal glomeruli
Autorzy:: Jankowski, M.
Szczepanska-Konkel, M.
Kalinowski, L.
Angielski, S.
Powiązania:: https://bibliotekanauki.pl/articles/69343.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: relaxation
endothelial cell
renal artery
nucleotide
contraction
rat
glomerulus
renal glomerulus
Źródło:: Journal of Physiology and Pharmacology; 2000, 51, 3
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: ATP-induced Ca2plus-signalling enhances rat gastric microvascular endothelial cell migration
Autorzy:: Ehring, G.R.
Szabo, I.L.
Jones, M.K.
Sarfeh, I.J.
Tarnawski, A.S.
Powiązania:: https://bibliotekanauki.pl/articles/70926.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: gastric endothelial cell
migration
ulcer healing
angiogenesis
microvasculature
calcium signalling
rat
Źródło:: Journal of Physiology and Pharmacology; 2000, 51, 4,2
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: The shRNA-mediated silencing of VEGF-C illustrates its role in proliferation, chemosensitization, tumour colonization, and anchorage independence
Autorzy:: Tambe, P.
Purohit, I.
Suneja, D.
More, S.
Desai, P.
Shrivastava, N.
Powiązania:: https://bibliotekanauki.pl/articles/80325.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: vascular endothelial growth factor
gene expression
endothelial cell
breast cancer
lymphangiogenesis
metastasis
proliferation
chemosensitivity
tumour cell
RNAi
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 3
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: In vitro reoxygenation following hypoxia increases MMP-2 and TIMP-2 secretion by human umbilical vein endothelial cells
Autorzy:: Cavdar, Zahide
Oktay, Gulgun
Egrilmez, Mehtap
Genc, Sermin
Genc, Kursad
Altun, Zekiye
Islekel, Huray
Guner, Gul
Powiązania:: https://bibliotekanauki.pl/articles/1040424.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: hypoxia
reoxygenation
matrix metalloproteinase-2
tissue inhibitor of metalloproteinase-2
membrane type-1 matrix metalloproteinase
endothelial cell
Opis:: Endothelial cells lining the inner blood vessel walls play a key role in the response to hypoxia, which is frequently encountered in clinical conditions such as myocardial infarction, renal ischemia and cerebral ischemia. In the present study we investigated the effects of hypoxia and hypoxia/reoxygenation on gelatinases (matrix metalloproteinase-2 and -9), their inhibitor (TIMP-2) and activator (MT1-MMP), in human umbilical vein endothelial (HUVE) cells. HUVE cells were subjected to 4 h of hypoxia or hypoxia followed by 4 and 24 h of reoxygenation. The pro- and active forms of MMP-2 and MMP-9 were analyzed by gelatin zymography; TIMP-2 protein level was assayed using ELISA, while MT1-MMP activity was measured using an activity assay. The secretion of MMP-2 proform increased significantly in cells subjected to 4 h of hypoxia followed by 4 or 24 h of reoxygenation, compared with the normoxic group. TIMP-2 protein level also increased significantly in the hypoxia/reoxygenation groups, compared with the normoxic group. There were no statistically significant differences in the levels of active MT1-MMP in all groups. This study indicates that MMP-2 and TIMP-2 could be regarded as important components of a mechanism in the pathophysiology of ischemic injury following reperfusion.
Źródło:: Acta Biochimica Polonica; 2010, 57, 1; 69-73
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: The effect of Tropaeolum majus L. on bacterial infections and in vitro efficacy on apoptosis and DNA lesions in hyperosmotic stress
Autorzy:: Jurca, T.
Baldea, I.
Filip, G.A.
Olteanu, D.
Clichici, S.
Pallag, A.
Vicas, L.
Marian, E.
Micle, O.
Muresan, M.
Powiązania:: https://bibliotekanauki.pl/articles/70272.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: Tropaeolum majus
nasturtium
medicinal plant
bacterial infection
temperate climate
antioxidant
antimicrobial activity
endothelial cell
hyperosmotic stress
apoptosis
DNA lesion
Źródło:: Journal of Physiology and Pharmacology; 2018, 69, 3
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Therapeutic potential of heme oxygenase-1 in cardiovascular disease
Autorzy:: Jazwa, A.
Florczyk, U.
Stepniewski, J.
Jozkowicz, A.
Dulak, J.
Powiązania:: https://bibliotekanauki.pl/articles/80176.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: angiogenesis
angiogenic factor
antiapoptotic effect
antiinflammatory effect
antioxidant effect
carbon monoxide
cardiovascular disease
cytoprotection
endothelial cell
ferrous iron
heme oxygenase-1
hypoxia
iron
stem cell
stromal cell
therapeutic potential
vascular endothelial growth factor-A
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Helicobacter pylori from duodenal ulcer patients expresses inducible nitric oxide synthase immunoreactivity in vivo and in vitro
Autorzy:: Stachura, J
Konturek, J.W.
Karczewska, A.
Domschke, W.
Popiela, T.
Konturek, S.J.
Powiązania:: https://bibliotekanauki.pl/articles/70998.pdf
Data publikacji:: 1996
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: gastritis
gastric cancer
macrophage
gastric wall vessel
epithelial cell
duodenal ulcer
in vivo
gastric mucosa
muscle cell
in vitro
immunoreactivity
Helicobacter pylori
antibody
endothelial cell
nitric oxide
nerve fibre
ulcer disease
Źródło:: Journal of Physiology and Pharmacology; 1996, 47, 1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Selected aspects of corneal endothelial segmentation quality
Autorzy:: Piorkowski, A.
Nurzynska, K.
Boldak, C.
Reska, D.
Gronkowska-Serafin, J.
Powiązania:: https://bibliotekanauki.pl/articles/333738.pdf
Data publikacji:: 2015
Wydawca:: Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:: corneal endothelial
cell segmentation
binarization
śródbłonek rogówki
segmentacja komórki
binaryzacja
Opis:: The number and shape of cells in endothelium layer is highly correlated with the quality of vision. Therefore, its precise and automatic description plays an important role in medicine. This work presents several aspects of image processing of endothelium layer acquired by specular microscope. The comparison of cell selection accuracy is discussed using two different approaches to solve this problem: convolution filtering methods, and snake-based method. Moreover, for verification results generated by dedicated software, supplied with the microscope, were utilized. Next, the precise segmentation method is applied to improve the segmentation. The results are inspected visually, but also CV, H, and CVSL parameters, used in medicine, are calculated. The research concludes that general visual outcomes achieved by all segmentation approaches give similar results, however deep insight into cell outline position reveals some differences, which were partially removed after precise segmentation application. The analysis of parameter values show high stability of CV and CVSL parameters.
Źródło:: Journal of Medical Informatics & Technologies; 2015, 24; 155-163
1642-6037
Pojawia się w:: Journal of Medical Informatics & Technologies
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Effects of protoporphyrins on production of nitric oxide and expression of vascular endothelial growth factor in vascular smooth muscle cells and macrophages.
Autorzy:: Józkowicz, Alicja
Dulak, Józef
Powiązania:: https://bibliotekanauki.pl/articles/1043649.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cell viability
metalloporphyrins
vascular endothelial growth factor
nitric oxide
heme oxygenase
Opis:: Heme oxygenase-1 (HO-1), an inducible enzyme degrading heme to biliverdin, iron and carbon monoxide, is involved in regulation of inflammation and angiogenesis. Tin protoporphyrin (SnPPIX) and zinc protoporphyrin (ZnPPIX) are commonly used as competitive inhibitors of HO-1. We aimed to compare the effects of SnPPIX and ZnPPIX on the production of vascular endothelial growth factor (VEGF), activity of inducible nitric oxide synthase (iNOS) and cell viability. All experiments were performed on rat vascular smooth muscle cells and murine RAW264.7 macrophages treated with 3-10 μM protoporphyrins. Some cells were additionally stimulated with IL-1β or with lipopolysaccharide. After a 24 h incubation period SnPPIX and ZnPPIX significantly reduced the generation of VEGF in vascular smooth muscle cells and RAW264.7, both in resting and stimulated cells. The inhibitory potentials of both protoporphyrins on VEGF synthesis were very similar. In contrast, analysis of iNOS activity revealed that results obtained with different HO-1 inhibitors are discrepant. Generation of nitric oxide by iNOS was significantly increased by SnPPIX but strongly decreased by ZnPPIX. Similar differences were observed when cell viability was compared. SnPPIX improved the cell survival rate, whereas the same doses of ZnPPIX exerted some cytotoxic effects. In summary, SnPPIX and ZnPPIX can be used as HO-1 inhibitors in some experimental models. However, these compounds produce also HO-independent effects, which can make the interpretation of experiments very uncertain. Thus the involvement of the HO-1 pathway should be always confirmed by more specific methods.
Źródło:: Acta Biochimica Polonica; 2003, 50, 1; 69-79
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Cardiac endothelial cells isolated from mouse heart - a novel model for radiobiology
Autorzy:: Jelonek, Karol
Walaszczyk, Anna
Gabryś, Dorota
Pietrowska, Monika
Kanthou, Chryso
Widłak, Piotr
Powiązania:: https://bibliotekanauki.pl/articles/1039895.pdf
Data publikacji:: 2011
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cardiac endothelial cells
radiation
cardiotoxicity
primary cell culture
stress response
Opis:: Cardiovascular disease is recognized as an important clinical problem in radiotherapy and radiation protection. However, only few radiobiological models relevant for assessment of cardiotoxic effects of ionizing radiation are available. Here we describe the isolation of mouse primary cardiac endothelial cells, a possible target for cardiotoxic effects of radiation. Cells isolated from hearts of juvenile mice were cultured and irradiated in vitro. In addition, cells isolated from hearts of locally irradiated adult animals (up to 6 days after irradiation) were tested. A dose-dependent formation of histone γH2A.X foci was observed after in vitro irradiation of cultured cells. However, such cells were resistant to radiation-induced apoptosis. Increased levels of actin stress fibres were observed in the cytoplasm of cardiac endothelial cells irradiated in vitro or isolated from irradiated animals. A high dose of 16 Gy did not increase permeability to Dextran in monolayers formed by endothelial cells. Up-regulated expression of Vcam1, Sele and Hsp70i genes was detected after irradiation in vitro and in cells isolated few days after irradiation in vivo. The increased level of actin stress fibres and enhanced expression of stress-response genes in irradiated endothelial cells are potentially involved in cardiotoxic effects of ionizing radiation.
Źródło:: Acta Biochimica Polonica; 2011, 58, 3; 397-404
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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