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    Wyświetlanie 1-6 z 6
    Tytuł:
    Prospects for the use of the achievements of regenerative medicine in otorhinolaryngology
    Autorzy:
    Ciechanowicz, Andrzej K
    Powiązania:
    https://bibliotekanauki.pl/articles/1400044.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    regenerative medicine
    pluripotent stem cells
    embryonic stem cells
    very small embryonic-like stem cells
    tissue engineering
    Opis:
    Regenerative medicine is focusing on searching for stem cells, which can be efficiently and safely used for regeneration of damaged tissues and organs. Pluripotent stem cells would be ideal for this purpose. It is because they have the ability to differentiate into cells of all three germ layers (ecto-, meso- and endoderm). One of the sources of their isolation are embryos. For many years, they are made unsuccessful attempts to use of very controversial embryonic stem cells that are isolated from embryos. So strong ethical controversy forced scientists to look for other, undoubted ethically, sources of pluripotent stem cells. Induced pluripotent stem cells are proposed, as a more promising alternative to cells isolated from embryos. Unfortunately, both embryonic stem cells and induced pluripotent stem cells tend to genetic instability leading to the formation of teratomas. In parallel studies scientists try to use of stem cells isolated from adult tissues (e.g. bone marrow cells or adipose tissue) in the regeneration of parenchymal organs. Unfortunately, there is no convincing evidence for most of these cells that can regenerate damaged parenchymal organs. Regenerative medicine more frequently is employed in the otorhinolaryngological therapies. More and more researchers’ efforts are put into the development of an effective method of stimulation (in vitro) of pluripotent stem cells isolated from adult tissue for differentiation of the renewable progenitor stem cells which can keep their potential after transplantation into the recipient (e.g. in the treatment of imbalances or hearing loss). Moreover, there are promising methods for employing of the stem cells potential in tissue engineering as they are more effectively introduced as a clinical therapies.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2017, 6, 1; 1-7
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Adult stem cells: hopes and hypes of regenerative medicine
    Autorzy:
    Dulak, Józef
    Szade, Krzysztof
    Szade, Agata
    Nowak, Witold
    Józkowicz, Alicja
    Powiązania:
    https://bibliotekanauki.pl/articles/1038957.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    embryonic stem cells
    induced pluripotent stem cells
    myocardial infarction
    very small embryonic-like stem cells
    heme oxygenase-1
    Opis:
    Stem cells are self-renewing cells that can differentiate into specialized cell type(s). Pluripotent stem cells, i.e. embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) differentiate into cells of all three embryonic lineages. Multipotent stem cells, like hematopoietic stem cells (HSC), can develop into multiple specialized cells in a specific tissue. Unipotent cells differentiate only into one cell type, like e.g. satellite cells of skeletal muscle. There are many examples of successful clinical applications of stem cells. Over million patients worldwide have benefited from bone marrow transplantations performed for treatment of leukemias, anemias or immunodeficiencies. Skin stem cells are used to heal severe burns, while limbal stem cells can regenerate the damaged cornea. Pluripotent stem cells, especially the patient-specific iPSC, have a tremendous therapeutic potential, but their clinical application will require overcoming numerous drawbacks. Therefore, the use of adult stem cells, which are multipotent or unipotent, can be at present a more achievable strategy. Noteworthy, some studies ascribed particular adult stem cells as pluripotent. However, despite efforts, the postulated pluripotency of such events like "spore-like cells", "very small embryonic-like stem cells" or "multipotent adult progenitor cells" have not been confirmed in stringent independent studies. Also plasticity of the bone marrow-derived cells which were suggested to differentiate e.g. into cardiomyocytes, has not been positively verified, and their therapeutic effect, if observed, results rather from the paracrine activity. Here we discuss the examples of recent studies on adult stem cells in the light of current understanding of stem cell biology.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 329-337
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stem cells: applications, perspectives, misunderstandings
    Autorzy:
    Dulak, Józef
    Powiązania:
    https://bibliotekanauki.pl/articles/704245.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    stem cells
    cellular therapies
    gene therapy
    embryonic stem cells
    induced pluripotent stem cells
    Opis:
    Stem cells exist and can do a lot. For several decades, bone marrow and umbilical cord blood transplants containing haematopoietic stem cells have been used in the treatment of blood diseases. Genetic modifications (gene therapy) of such cells help to cure complex immunodeficiencies and severe anaemias. The limbal stem cells taken from the eye and properly multiplied can regenerate the damaged cornea, and the epidermal stem cells help in the treatment of severe burns and some hereditary, severe skin diseases. Promising experimental research is under way on other uses of stem cells. However, these cells are appropriately selected, having real ability to differentiate into specialized cells whose malfunction is the cause of the disease. Therapeutic applications of stem cells are apparently limited to date. Meanwhile, the Internet is full of advertisements for supposedly miraculous treatments for almost any disease. Stem cells have become a modern synonym of the Holy Grail. A wonderful dish, transforming every drink into elixir of health, youth and long life. Stem cells from a single source, e.g., umbilical cord blood, or so-called cells, although without proven properties of stem cells, are offered in commercial private clinics as a panacea for autism, cerebral palsy, spina bifida, eye diseases, amyotrophic lateral sclerosis and dozens other disorders. Without justification for their action in these diseases, without convincing evidence of safety, but for a high fee. This article discusses stem cells and misunderstandings about including any cells among them. It draws attention to the real possibilities and confirmed uses of stem cells and presents the problems, doubts and dangers for patients associated with commercial offers of treatments using “stem” cells. The author cites the positions of scientific institutions and societies warning against premature commercialization of unjustified and potentially dangerous therapies
    Źródło:
    Nauka; 2020, 1
    1231-8515
    Pojawia się w:
    Nauka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Krótki przegląd na temat komórek macierzystych
    A short overview of stem cells
    Autorzy:
    Kmiecik, B.
    Skotny-Krakowian, A.
    Rybak, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/261099.pdf
    Data publikacji:
    2015
    Wydawca:
    Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
    Tematy:
    embrionalne komórki macierzyste
    indukowane pluripotencjalne komórki macierzyste
    mezenchymalne komórki macierzyste
    embryonic stem cells
    induced pluripotent stem cells
    mesenchymal stem cells
    Opis:
    Wykorzystanie komórek macierzystych może mieć duży potencjał w medycynie. Stale jednak toczą się debaty, jakie rodzaje komórek macierzystych powinny być w przyszłości wykorzystywane w celach regeneracyjnych. W poniższej pracy dokonano porównania embrionalnych, indukowanych pluripotencjalnych i somatycznych komórek macierzystych. Jednak, by bezpiecznie wykorzystywać komórki macierzyste do regeneracji ciała ludzkiego, należy jeszcze dokładniej poznać mechanizmy ich działania. Z tego powodu Amerykańska Agencja ds. Żywności i Leków (FDA) już w 2006 roku zdecydowała się na opracowanie procedur, które mają zapewnić bezpieczeństwo pacjentom korzystającym z terapii opartych na komórkach macierzystych.
    Applications of stem cells has a huge medical potential. However, among scientists there is an ongoing debate, concerning which stem cells should be used in the future for regeneration purposes. This paper presents a comparison of embryonic, induced pluripotent, and somatic stem cells. Gaining a better understanding of the molecular functioning of stem cells will probably lead to more efficient treatment methods for many incurable diseases. For this reason, American agency for Food and Drug Administration (FDA) established some general procedures, which, to some degree, should ensure the safety of experimental stem cell therapies.
    Źródło:
    Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2015, 21, 1; 40-45
    1234-5563
    Pojawia się w:
    Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Problematyka pobierania zarodkowych komórek macierzystych w oficjalnych stanowiskach Kościołów ewangelicko-luterańskich Szwecji i Norwegii
    The Issue of Obtaining Embryonic Stem Cells in the Official Standpoints of the Old Lutheran Churches of Norway and Sweden
    Autorzy:
    Aleksiejuk, Artur
    Powiązania:
    https://bibliotekanauki.pl/articles/425342.pdf
    Data publikacji:
    2016
    Wydawca:
    Parafia Ewangelicko-Augsburska w Gdańsku z siedzibą w Sopocie
    Tematy:
    bioethics
    embryo
    embryonic stem cells
    Old Lutheran Church
    Church of Sweden
    Church of Norway
    Opis:
    This article is an attempt to present the opinions expressed by two Scandinavian Old Lutheran Churches: the Church of Sweden (Svenska kyrkan) and the Church of Norway (Den norske kirke), on obtaining embry-onic stem cells from human embryos. Both ecclesiastical organisms men-tioned above belong to the Lutheran World Federation and have already elaborated important positions on bioethics. The points of view and ethical evaluation expressed by them significantly differ from each other in their points of emphasis and applied argumentation. Norwegian Lutherans, in this matter, are more conservative than their Swedish brethren and simultaneously are more critical of ethical legalization of searching for and using human embryonic stem cells. What is more, the Swedes are quite liberal in this question and perhaps more open to the fruits of biomedical progress. The documents and recommendations, which have been formed in the mentioned churches, are relatively unknown in Poland. Their publication is intended to fill in this gap. In addition, they also constituteinteresting research material and deserve attention within the context of the general scope of ecumenical dialogue.
    Źródło:
    Gdański Rocznik Ewangelicki; 2016, 10; 102-121
    1898-1127
    Pojawia się w:
    Gdański Rocznik Ewangelicki
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Klonowanie człowieka w świetle nauki Kościoła katolickiego i prawa polskiego
    Human cloning in the right of the teaching of the Catholic Church and the Polish law
    Autorzy:
    Tacikowska, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/460467.pdf
    Data publikacji:
    2013
    Wydawca:
    Warszawska Prowincja Redemptorystów
    Tematy:
    Embrion
    komórki macierzyste
    embrionalne komórki
    macierzyste
    klonowanie
    klonowanie reprodukcyjne
    klonowanie terapeutyczne
    Embryo
    stem cells
    embryonic stem cells
    cloning
    reproductive cloning
    therapeutic cloning
    Stammzellen
    embryonale Stammzellen
    Klonen
    Reproduktives Klonen
    Therapeutisches Klonen
    Opis:
    In the first part of the paper, the author discusses the moral status of a human embryo in the light of the teaching of the Catholic Church. The author argues that the human life starts as early as at conception, in the embryo stage. The author’s statement is that the human embryo is a human being, a being who has dignity and whose bodily and spiritual integrity must be respected. The author sets the requirements for operations performed on the human embryo, including experiments. Finally, the author touches upon the question of using so-called biological material from illegal sources. In the second part, the author presents the position of the Catholic Church on cloning, including both reproductive and therapeutic cloning, as well as discusses hybrid cloning, focusing on the medical and the moral aspects of this procedure. The author also handles the subject of embryonic stem cells and adult stem cells. The author devotes the third and final part of the paper to discuss Polish regulations on cloning and embryo research.
    Źródło:
    Studia Redemptorystowskie; 2013, 11; 400-409
    1731-710X
    Pojawia się w:
    Studia Redemptorystowskie
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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