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    Wyświetlanie 1-7 z 7
    Tytuł:
    Accumulation of collagen in ovarian benign tumours
    Autorzy:
    Wolańska, Małgorzata
    Sobolewski, Krzysztof
    Bańkowski, Edward
    Drożdżewicz, Marek
    Powiązania:
    https://bibliotekanauki.pl/articles/1044453.pdf
    Data publikacji:
    1999
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ovarian tumours
    collagen
    glycosaminoglycan
    elastin
    Opis:
    Extracellular matrix components of benign ovarian tumours (cystadenoma, adenofibroma, cystadenofibroma) were analysed. The investigated tumours contained twice as much collagen than control ovarian tissues. Significant alterations in mutual quantitative relationships between collagens of various types were observed. The proportion of type I collagen decreased and that of type III collagen increased. The accumulation of collagen was accompanied by a reduction in sulphated glycosaminoglycan content whereas the amount of hyaluronic acid was not changed. Dermatan sulphate was the most abundant glycosaminoglycan component. It is suggested that the accumulation of collagen (natural barrier to the migration of tumour cells) and underexpression of glycosaminoglycans/proteoglycans (binding some growth factors and interleukins) may exert an inhibitory effect on tumour growth.
    Źródło:
    Acta Biochimica Polonica; 1999, 46, 4; 941-947
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Charakterystyka usieciowanych biomateriałów na bazie kolagenu i elastyny
    The characterization of cross-linked collagen and collagen/elastin based biomaterials
    Autorzy:
    Skopińska-Wiśniewska, J.
    Sionkowska, A.
    Gawron, M.
    Kozłowska, J.
    Płanecka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/286050.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    biomateriały
    kolagen
    elastyna
    biomaterials
    collagen
    elastin
    Źródło:
    Engineering of Biomaterials; 2010, 13, no. 99-101; 97-99
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of selective digestion of elastin and collagen on mechanical properties of human aortas
    Autorzy:
    Kobielarz, M.
    Chwiłkowska, A.
    Turek, A.
    Maksymowicz, K.
    Marciniak, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/306446.pdf
    Data publikacji:
    2015
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    kolagen
    elastyna
    właściwości mechaniczne
    aorta
    collagen
    elastin
    selective digestion
    mechanical properties
    Opis:
    Purpose: There are two families of fibres taking part in the process of mechanical loads transfer, i.e. elastin and collagen fibres. Their number, spatial arrangement and specific properties determine the capacity of a blood vessels to resist mechanical loads resulting from the impact of blood on vessel walls. The purpose of the present paper is to define the load-bearing capacities of elastin and collagen scaffolds equivalent to natural fibre arrangements of human aorta and produced by selective digestion. Methods: Samples of thoracic human aortas were digested by using phosphate buffer of trypsin at pH 8.0 for 22 hours in order to degrade elastin and by autoclaving followed by incubation in 90% formic acid for 22 hours. The efficacy of digestion was assessed immunohistochemically. Mechanical properties of pre-stretched native and digested samples were determined by uniaxial tensile test. Results: Samples subjected to autoclaving have been successfully deprived of both types of collagen and elastin has been intact. Treatment with trypsin caused a removal of elastin and the presence of type I and IV collagen was demonstrated. Digestion of aortic samples either by formic acid or trypsin has resulted significantly decreasing mechanical properties in comparison with native samples. Conclusions: Collagen and elastin scaffold-like stuctures have been effectively produced by selective digestion of thoracic human aorta and their contribution to the load-bearing process was evaluated. Isolated collagen network are more durable and stiffer and less deformable than elastin network, hence are responsible for load-bearing process at higher strain since the range of working of elastin is at lower strain values.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2015, 17, 2; 55-62
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Elastin and collagen fibres alterations for abdominal aortic aneurysms population with constant maximum diameter size
    Autorzy:
    Kobielarz, M.
    Maksymowicz, K.
    Będziński, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/285143.pdf
    Data publikacji:
    2011
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    abdominal aorta
    aneurysm
    elastin fibres
    collagen fibres
    maximum diameter size
    cluster analysis
    Opis:
    Development of abdominal aortic aneurysm (AAA) is a dynamic process proceeding as a result of the multi-factor pathological remodelling of elastin and collagen fibres, results an aneurysm expansion. In clinical practice, development of AAA is identified with aneurysm growth. Hence, the aim of this paper is to propose a taxonomy of load-bearing structural components alterations for AAA with relatively constant maximum diameter (average diameter 6.9±0.8 cm). Structural investigations of normal (n=47) and aneurismal (n=46) vessels were carried out on the basis of histological and ultrastructural examinations. The histological preparations were subjected to histometric evaluation; the number of collagen and elastin fibres and additionally the thickness of the particular vascular wall layers. A qualitative analysis of the abdominal aortic wall, mainly estimation of fibres arrangement, based on histological and ultrastructural (SEM) examinations were additionally performed. Using a cluster analysis, three stages of load-bearing fibres alterations for AAA population were distinguished. The clusters were systematized according to NAA results. For AAA population with relatively constant maximum diameter in the first stage of load-bearing fibres remodeling was observed a substantial loss of elastin fibres. The second stage is characterized by an increase in the number of collagen fibres. In the final stage the number of collagen is dramatically reduced. Presented results provide evidence to risk of AAA rupture is not connected with AAA size but a remodelling of extra-cellular matrix proteins. The remodelling is accompanied by changes in the AAA wall thickness, which should be taken into consideration when evaluating the degree of advancement of this disease.
    Źródło:
    Engineering of Biomaterials; 2011, 14, 102; 2-6
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ocena histologiczna i ultrastrukturalna ścian tętniaków aorty brzusznej
    Histological and ultrastructural evaluation of the walls of abdominal aortic aneurysms
    Autorzy:
    Kobielarz, M.
    Maksymowicz, K.
    Kaleta, K.
    Kuropka, P.
    Marycz, K.
    Będziński, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/286096.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    aorta brzuszna
    tętniak
    włókna elastynowe
    włókna kolagenowe
    abdominal aorta
    aneurysm
    elastin fibres
    collagen fibres
    Opis:
    Rozwój tętniaków, w tym aorty brzusznej (AAA) jest dynamicznym procesem, który zachodzi w wyniku wieloczynnikowego, patologicznego remodelingu tkanki łącznej ściany aorty. Badania strukturalne ścian naczyń tętniczych (zdrowych i z tętniakiem) przeprowadzono w oparciu o analizę histologiczną i ultrastrukturalną. Analiza porównawcza wyników wykazała, że w przypadku preparatów ścian tętniaków aorty brzusznej odnotowano cały szereg zmian, które są charakterystyczne dla rozważanego schorzenia, w tym: wzmożony proces neowaskularyzacji oraz obecność nacieku zapalnego. Ponadto, odnotowano zatarcie granic między warstwami oraz redukcję ich grubości, co szczególnie zaznaczyło się w przypadku błony wewnętrznej. Zaobserwowano istotny ubytek włókien elastynowych oraz zmienny co do intensywności w poszczególnych przypadkach ubytek włókien kolagenowych. Wykazano także, że zmiany w liczbie włókien tkanki łącznej odgrywają kluczową rolę w procesie rozwoju AAA.
    The development of abdominal aortic aneurysm (AAA) is a dynamic process proceeding as a result of the multi-factor pathological remodelling of the connective tissue. Structural investigations of normal and aneurismal vessels were carried out on the basis of histological and ultrastructural examinations. A comparative analysis of the experimental results revealed a whole series of changes characteristic of the AAA walls (intensified neovascularisation and inflammatory infiltrations). In addition, the boundaries between the layers were found to be blurred and the thickness of the layers was reduced. A substantial loss of elastin fibres and a case-specific loss of collagen fibres were observed. The number of connective tissue fibres play a key role in the AAA development.
    Źródło:
    Engineering of Biomaterials; 2010, 13, no. 99-101; 83-87
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of elastin-derived peptides, glucose, LDL and oxLDL on nitric oxide synthase expression in human umbilical artery endothelial cells
    Autorzy:
    Garczorz, Wojciech
    Francuz, Tomasz
    Gmiński, Jan
    Likus, Wirginia
    Siemianowicz, Krzysztof
    Jurczak, Teresa
    Strzałka-Mrozik, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1039891.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    nitric oxide synthase
    oxidized LDL
    LDL
    EDP
    atherosclerosis
    hyperglycemia
    endothelium
    elastin-derived peptides
    eNOS
    Opis:
    Endothelial dysfunction plays an important role in the development of atherosclerosis. Elastin-derived peptides (EDP), hyperglycemia, hypercholesterolemia and oxidized LDL have a proven proatherosclerotic potential. Nitric oxide generated by endothelial nitric oxide synthase (eNOS; EC 1.14.13.39) is an important vasorelaxant. Here we studied the influence of those proatherosclerotic factors on eNOS gene and protein expression in artery-derived endothelial cells. Human umbilical artery endothelial cells (HUAEC) were incubated with or without: glucose (270 mg/dl), LDL (200 mg/dl), oxidized LDL (oxLDL 25 mg/dl) or κ-elastin (0.5 and 2.5 µg/ml). Gene expression was assessed by real time RT-PCR, whilst the eNOS protein by ELISA. In cells incubated with 2.5 µg/ml of κ-elastin, a 31 % increase of eNOS mRNA expression was observed, but the protein level remained unchanged. OxLDL, LDL and glucose decreased the eNOS protein level by 74 %, 37 % and 29 %, respectively. OxLDL decreased eNOS mRNA by 42 %. LDL non-significantly decreased eNOS mRNA expression. An elevated glucose level did not affect the eNOS mRNA expression. Hyperglycemia and an elevated level of LDL, particularly oxLDL, decreased the level of eNOS protein in endothelial cells. As κ-elastin did not decrease the expression of eNOS gene in HUAEC, the proatherogenic properties of elastin-derived peptides are unlikely to be due to their influence on eNOS.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 3; 375-379
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Elastin-like polypeptides-alternative way of recombinant protein purification
    Autorzy:
    Kowalczyk, T.
    Hnatuszko-Konka, K.
    Gerszberg, A.
    Kononowicz, A.K.
    Powiązania:
    https://bibliotekanauki.pl/articles/81055.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    molecular biology
    biotechnology
    protein expression
    protein extraction
    purification
    elastin-like polypeptide
    biopolymer
    recombinant protein purification
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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