Temat: ebselen - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Carboxyebselen a potent and selective inhibitor of endothelial nitric oxide synthase
Autorzy:: Hatchett, R J
Gryglewski, R.J.
Mlochowski, J.
Zembowicz, A.
Radziszewski, W.
Powiązania:: https://bibliotekanauki.pl/articles/70733.pdf
Data publikacji:: 1994
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: carboxyebselen
nitric oxide
L-arginine
endothelium
inhibitor
ebselen
Źródło:: Journal of Physiology and Pharmacology; 1994, 45, 1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 2.

Tytuł:: Free radical scavengers can modulate the DNA-damaging action of alloxan.
Autorzy:: Blasiak, Janusz
Sikora, Agnieszka
Czechowska, Agnieszka
Drzewoski, Józef
Powiązania:: https://bibliotekanauki.pl/articles/1043667.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: vitamin C
spin trapping
free radicals
alloxan
vitamin E
DNA damage
ebselen
comet assay
DNA repair
diabetes mellitus
Opis:: Alloxan can generate diabetes in experimental animals and its action can be associated with the production of free radicals. It is therefore important to check how different substances often referred to as free radical scavengers may interact with alloxan, especially that some of these substance may show both pro- and antioxidant activities. Using the alkaline comet assay we showed that alloxan at concentrations 0.01-50 μM induced DNA damage in normal human lymphocytes in a dose-dependent manner. Treated cells were able to recover within a 120-min incubation. Vitamins C and E at 10 and 50 μM diminished the extent of DNA damage induced by 50 μM alloxan. Pre-treatment of the lymphocytes with a nitrone spin trap, α-(4-pyridil-1-oxide)- N-t-butylnitrone (POBN) or ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), which mimics glutathione peroxides, reduced the alloxan-evoked DNA damage. The cells exposed to alloxan and treated with formamidopyrimidine-DNA glycosylase (Fpg) and 3-methyladenine-DNA glycosylase II (AlkA), enzymes recognizing oxidized and alkylated bases, respectively, displayed greater extent of DNA damage than those not treated with these enzymes. The results confirmed that free radicals are involved in the formation of DNA lesions induced by alloxan. The results also suggest that alloxan can generate oxidized DNA bases with a preference for purines and contribute to their alkylation.
Źródło:: Acta Biochimica Polonica; 2003, 50, 1; 205-210
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Informacja

Wyszukujesz frazę "ebselen" wg kryterium: Temat

Źródło danych

Dostawca treści

Kolekcja

Rok wydania

Wydawca

Temat

Autor

Typ dokumentu

Język