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Tytuł:
Rozwój uzależnienia a zmiany społecznych zachowań młodocianych toksykomanów
The Progress of Dependence and Changes in the Social Behavior of Young Adult Drug Addicts
Autorzy:
Zakrzewski, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/699054.pdf
Data publikacji:
1982
Wydawca:
Polska Akademia Nauk. Instytut Nauk Prawnych PAN
Tematy:
uzależnienie
toksykomania młodzieżowa
środki narkotyczne
zależność społeczna
zależność psychiczna
młodociani
zależność fizyczna
zmiany osobowości
addiction
youth toxicomania
narcotic drugs
social dependence
psychological dependence
juvenile
physical dependence
personality changes
Opis:
In the present study the changes in behavior of young adult drug addicts are described, which occurred as their dependence has developed since the beginning of taking drugs. We regard as scientifically fruitless frequent general statements concerning young adult (as well as adult) drug addicts irrespective of their age and the stage of dependence. The research on which the present study is based was a part of multidisciplinary studies of young adult drug addicts which were conducted by the Department of Mental Health of the Polish Academy of Sciences in Łódź in the years 1974-76. It concerned all patients aged 15-23 registered in the out-patient clinics for young drug addicts and in district out-patient clinics for adults in the city of Łódź because of the repeated taking of narcotic drugs. It is important to note that the discussed population consisted of 102 young adults, of which 23% were girls. Three detailed interviews were carried on in relation to each case: one with the mother of the given boy or girl (in exceptional cases with another adult member of the family), the second one at school with the tutor and the teachers, and the third one with the drug addict himself . The questionnaires on which the interviews were based took into account, to a high degree, the family conditions of the addicts, their behavior at home , from their earliest childhood up to the latest months, their school history, ways of spending their leisure time, the outset and circumstances of taking drugs, the use of alcohol, the peer groups, living problems in the period preceding the taking of drugs and in subsequent years, delinquency etc. Data were also collected concerning the criminal records of the addicts and the history of various diseases treated in different out-patient clinics. The study was conducted by a team of several persons working under supervision of the author of the present paper. Estimation of the degree of dependence was based on medical diagnosis. Among the addicts, the following three stages of dependence were distinguished: the stage of social dependence, that of mental dependence and the stage of physical dependence. The greatest part (50%) of the addicts were in the stage of mental dependence. The addicts were noticed to move to the more advanced stages of dependence in course of time. The mean duration of the period of taking drugs was: with young adults socially dependent 5 months, with those mentally dependent 1 year 5 months, and with those physically dependent 2 years 8 months. There are, however, limitations to this regularity. Some individuals withdrew from talking drugs within the first 12 months of social dependence. Others reached the stage of mental dependence very rapidly, so to say cutting down or even skipping the first stage of dependence. There were also those who remained for a long time in the preliminary stage of the illness, that is, that of mental dependence, revealing no symptoms of physical dependence even after one or two years. It is thus apparent that the progress of dependence and its rapidity are not the derivative of the length of the period of taking drugs only. An important role is also played by the intensity of taking drugs, by their peculiarities and by the individual immunity of the central nervous system of a given person. The notion of the so-called social dependence is controversial to a certain degree and as such used only by some of the authors. However, the results of the present study speak in its favor as the term defining the first, and so to say preliminary stage of dependence, preceding the next stages of dependence in the medical sense. In the present study the notion of social dependence is of a very broad range, i.e., its criteria are not limited to the pressure of the peer  group and the boy’s or girl’s eagerness to adjust themselves to this group. On the basis of the collected material, we included in the notion social dependence also the cases in which the addicts communicated with loose society circles, e.g. in cafés, which was accompanied by the predominant trend to adjust themselves to the fashion and customs of such circles, as well as the cases of an influence of individual persons of different sex attracted to each other. The notion of social dependence is worthy of separation, particularly, as the patterns of taking drugs have now become generally accepted among the youth. Taking certain drugs several times, or even once, caused a considerable improvement of mood of the individuals inclined to experience conflicts intensely, who had a low tolerance to frustration and a poor ability to overcome obstacles, if they only happened upon the drug which changed their mental stale favourably from their point of view. Phenmetrazine was good for some of the persons examined to suppress their mental inhibitions, while others used sedatives to suppress states of tension and excitement, still others - morphine and its derivatives to experience something new and to get away from the dullness of the everyday life. The process of social dependence turning into mental dependence among the addicts consisted in the fact that - as they were experimenting with various drugs in the company of others - they soon found that not only the interpersonal ties were hereby fortified, but also their hitherto only poorly tolerated mental state could undergo a favorable change. As this belief grew stronger and proved true in all next instances of taking the drug, they experienced the more and more intense desire to take such drugs whenever the state of tension, discouragement or irritation had reached a considerable degree of intensity. However, after some time the hitherto felt desires were dominated by additional and extremely trying sensations of not only mental but also physical nature which occurred in the periods of the break in drug taking. The addicts tried at any price to get rid of withdrawal symptoms. Most frequent were the complaints about the sensation of irritation, restlessness, inability to concentrate on anything, lack of energy, anxiety, insomnia or nightmares, headache and melalgia, hand tremor and other annoying and exhausting symptoms. The examined persons with these symptoms had already found themselves in the stage of physical dependence. In the diversity and variability of drugs taken by the addicts as their dependence developed, a following essential regularity could be noticed: the comparatively greatest diversity of drugs taken was usually found at the stage of social dependence. In that of mental dependence, morphine and the specimens approximal to it more and more prevailed among the drugs taken by a given individual, thus reducing the role of other drugs. The transition to physical dependence meant further concentration on the opiates (mainly morphine), while other drugs – including alcohol- became substitutes and were taken when the individual did not possess the favorite drug and thus felt  withdrawal symptoms. The danger of conversion to morphine and other opiates, with all its consequences, thus grew as the taking of drugs continued. It is a matter of course that, as the individual gradually needed drugs more and more difficult to obtain (that, is, those from the morphine group), which were sold at a higher price, and as he needed more and more of the drug and found it more and more difficult to do without - the ways of obtaining it had to change. A phenomenon occurs which can be called escalation not only of the drugs taken, but also of the means of obtaining them. The means in question become more and more ruthless, one counts less and less both with one’s own hitherto existing line of conduct and ambitions and with the probable reactions of the environment. The means of obtaining drugs grow also more and more absorbing, they engage more and more time and efforts. Simultaneously followed the process of diminution of individual interests and of the disappearance of ambitions in the addicts. It was more and more difficult for them to acquit themselves of the hitherto performed social roles. And thus, for instance, within the range of the role of a pupil, the following symptoms could be found among the addicts beginning from the stage of mental dependence: considerable difficulties of concentration, the slowing down of the run of thought, passiveness and drowsiness during the classes, increasing absence from school, being far away with thought even if physically present at school, regular remiss in doing homework, indifference to school failures, reluctance to undertake efforts to overcome them - that is, greater and greater slackness in the school duties. School, usually quitted in the advanced stages of dependence, gave place to irregular and chance periods of working, which did not in the least lead to any professional promotion of a given individual. All the hitherto existing forms of activity which satisfied their former interests and life plans were - as the dependence developed - replaced by the efforts to obtain every now and again new doses of the longed-for drug. Parallel to this process new specific elements appeared in the life of the addicts: contacts with out-patient clinics, stays in detoxication centres and mental hospitals, which repeated from time to time, and in a considerable number of the cases – court appearances ending more than once with imprisonment. In general, it must be stated that the progress of dependence has led to intense degradation changes in the lives of the addicts. The whole of those changes were composed of the following: increasing problems and failure at school, quitting school, aggravating conflicts at home, participation in youth groups and circles out of control which were characterized by socially negative patterns of behavior, giving up one’s professional ambitions, staying for months in hospitals, undergoing detoxication treatment, gradual limitation of one’s aims and interests to obtaining and taking drugs, court appearances every now and again.
Źródło:
Archiwum Kryminologii; 1982, VIII-IX; 363-388
0066-6890
2719-4280
Pojawia się w:
Archiwum Kryminologii
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Narkomania jako zjawisko społeczne- historia problemu w Polsce
Drug addiction as a social phenomenon. the history of the problem in Poland
Autorzy:
Bielewicz, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/699292.pdf
Data publikacji:
1988
Wydawca:
Polska Akademia Nauk. Instytut Nauk Prawnych PAN
Tematy:
narkomania
problem
Polska
historia
narkotyki
zjawisko
zachowanie
pacjenci
szpital psychiatryczny
handel
uzależnienie
morfina
kokaina
drug addiction
Polska
history
drugs
phenomenon
behaviour
morphine
cocaine
patients
psychiatric hospital
trade
addiction
Opis:
The phenomenon of drug addiction has been known in Poland for at least several dozen years. In the period of the second Republic, it was not a major social problem. In 1933, the total of 295 addicts were hospitalized in Poland. According to pre-war researchers, the number of drug addicts could be estimated at over 5 thousand persons in the early 1930s. The pre-war addicts took first of all classic drugs: morphine, heroin, and cocaine. Also codeine, Somniphrene and Pantopon were rather frequently taken. Less frequent was the use of hashish, mescaline and peyotl. Headache wafers played the part of substitutes.             According to the data of the health service and the Warsaw public prosecutor's office, about three – fourth of drug addicts were men. Most addicts were in their thirties; hardly any could be found among the youth, as far as morphinism is concerned in particular. This type of addiction could be found nearly exclusively among persons aged over 30. The situation shaped ,somewhat differently as regards codeine addicts: also younger persons. could be found in this group. In the socio professional structure of addicts included in the files of the Warsaw public prosecutor's office, clerks prevailed; their percentage amounting to 30. The second most numerous group were craftsmen and tradesmen-,13 per cent, and the third on -representatives of medical professions (chemists, doctors, surgeon, assistants, nurses, midwifes) of whom there were 9 per cent. The percentage of workers was 2, of prostitutes-5, and artists-4. In the opinion of the most of the pre-war researchers, the above socio-professional structure is distorted. According to them, drug-addiction was much more widespread among officers (of the air force and navy in particular), artists, writers and journalists. As regards religion, pre-war addicts constituted as varied a mosaic as the entire society in those days. There were among them representatives of all of the most numerous religious groups then found in Poland. Roman Catholics were most, and members of the orthodox church-least :susceptible to drug addiction. The pre-war researchers of drug addiction devoted a lot of attention to the problem of etiology of this ,,social disease'' Some of them stressed above all the medical-others-the economic and political, and still others - the cultural or those related to civilization causes. There were also conceptions that laid particular emphasis on physiology and biochemistry of the human body.              The evolution of drug addiction in the post-war forty years may be divided into four stages.             The first of them lasted till about mid-1960s. The extent of the phenomenon was then limited, with the average of about 400 persons treated in out-patient clinics, and about 150 -in psychiatric hospitals. Also the police statistics point to small sizes of this phenomenon. In 1967, as few as 9 offences directly related to drug addiction were recorded in Poland. Drug addicts of those days descended from rather specific circles. They were mostly representatives of medical professions, that is persons with a relatively easy access to drugs. Over 90 per cent of all morphine addicts were employees of the health service. Drugs taken most frequently were the classical ones;(morphine, cocaine), tranquilizers (Glimid, Tardyl) and stimulants (amphetamines). In thest period, one could hardly speak of drug addiction as a subcultural phenomenon. It was mainly a medical problem. The majority of the drug taking persons were those already dependent. The addicts of those days formed no close groups sharing a given ideology, specific symbols or language. The taking of narcotic drugs was not a social but an individual behaviour in most cases.             The second stage are the late 1960s and the early 1970s. In that period, a rapid growth in the extent of drug addiction can be noticed. In the years 1969-1973, the number of patients treated because of drug addiction in out-patient psychiatric clinics was quintupled, and in psychiatric hospitals, tripled. In 1972, there were about 3,150 patients treated in psychiatric clinics, and about 600 in psychiatric hospitals.             Also the number of offences directly related to drug addiction grew rapidly. While in 1967 there was not a single instance of unauthorized giving of narcotic drug (art. 161 of the Penal Code) or of forging prescriptions (art. 265 § 1 of the Penal Code), 105 and 417 such acts respectively were recorded five years later. In 1971, over 3,000 persons "taking narcotic drugs" were registered in the police files. As found in a sociological study carried out in 1972 among students of all grammar, vocational and elementary vocational schools in Gdańsk, Sopot and Gdynia, 8.3 per cent of the respondents had contacts with narcotic drugs. In the case of about 45 per cent of this group, these contacts were occasional. According to the authors of the study, this percentage is the "minimum frequency of occurence" of drug taking "in the population of school youth in Gdansk, Gdynia and Sopot.'' In this early 1970s, the number of persons in danger of becoming addicts (i.e. those who took drugs regularly) and those already dependent was estimated at about 30 thousand.             In the discussed period, also the character of addiction underwent changes: it became a subcultural phenomenon. The base on which it developed were the youth contestation movements which emerged in Poland as well. Addiction was given a cultural dimension by the ideology of the hippie movement. Taking drugs ceased to be an individual behaviour and became a social one which expressed certain attitudes and symbolized the affiliation to a given subculture. The young who took drugs formed smaller or bigger groups with strong internal bonds and a great sense of solidarity. They used specific symbols (way of dressing, recognition signals, rich repertoire of gestures, aliases, etc.) and quite a rich language (characteristic names of drugs and activities related to their taking). The very taking of drugs was acompanied by more or less developed rituals (narcotic coctails, seances, etc.).             In that period - and later on as well -the phenomenon of drug addiction was concentrated among the youth and in highly urbanized and industrialized regions. In 1972, nearly 75 per cent of persons hospitalized for the first time were those aged under 25, and over 60 per cent-under 29. In 1970, over 90 per cent of addicts treated in hospitals lived in towns. The limited drug marked. caused the youth to resort to substitutes on the unpracedented scale. In those years, general use of such substances as trichloroethylene, Ixi (washing powder), Butaprene (glus), ether, benzene, solvents and others started. Yet the major typ of addiction still remaind that to opium and its derivates, particularly in men, and to sleeping-draught and tranquilizers in women.             The third stage in the evolution of drug addiction are the years 1973-1976. In that period, a nearly 27 per cent decrease in the total of patients of psychiatric clinics, and a 40 per cent one in the case of those treated for the first time could be noticed. The morbidity index went down from 3.5 to 2.0. A similar trend, though less dynamic one, concerned also hospital service. In an attempt at explaining this phenomenon, three factors should be mentioned. Firstly, the early 1970s are the period when youth movements started to die out. Also a relative social peace reigned in those years, which caused drug addiction lose its socio-cultural base. Secondly, the medical authorities introduced a number of limitations in the accessibility of drugs in that period. Thirdly, repressive action of the police also influenced this tendency to a high degree. The prosecution agencies not only increased their efficiency greatly, but also acquired a much better knowledge of the addicts circles. These actions however proved insufficient to fully control addiction.             The fourth stage in the evolution of addiction started in the late 1970s. In the years 1977-1984, the number of patients treated in out-patient clinics increased twice over, and that of hospitalized persons - five times over. The indicates of dissemination and morbidity grew rapidly. Beginning from mid-1970s, the number of persons registered in the police files grew nearly two and a half times over. Also the number of deaths due to over dosage went up from year to year. In 1978, 18 such cases were recorded, with the number amounting to as many as 117 in 1986. The number of offences directly related to drug addiction went up from 1,093 in 1978 to 3,014 in 1983. The number of persons taking narcotic drugs was estimated at about 500-800 thousand in 1983; that of persons in danger of becoming addicts - at 99-95 thousand, and of actual addicts - about 40 thousand. Such is the minimum spread of the discussed phenomenon.             The unprecedented dissemination of drug addiction may be attributed to the emergence of two factors of which one is technological, and the other one psycho-social. In mid-1970s, the technology of production of a strong drug from poppy was worked out in Poland, which resulted in a great amount of strong narcotics appearing on the market. on the other hand, crisis started to accumulate in Poland in mid-1970s, which resulted in a growing frustration among the youth. The concurrence of these two factors brought about the explosion of drug addiction.
Źródło:
Archiwum Kryminologii; 1988, XV; 251-286
0066-6890
2719-4280
Pojawia się w:
Archiwum Kryminologii
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prawo karne wobec środków odurzających i psychotropowych (z problematyki teorii kryminalizacji)
Illegal Drugs and Penal Law (Some Problems of the Theory of Criminalization)
Autorzy:
Krajewski, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/699088.pdf
Data publikacji:
1995
Wydawca:
Polska Akademia Nauk. Instytut Nauk Prawnych PAN
Tematy:
prawo karne
środki odurzające
teoria kryminalizacji
penal law
illegal drugs
theory of criminalization
Opis:
The present policy of all countries of the world  towards narcotic  and psychotropic drugs is in fact prohibitionIST. This means that all circulation of such drugs  ‒ their manufacture, transport, import, export, introduction into trade, giving,  and sometimes also possession – is illegal and carries most severe penal sanctions in some cases. It should be borne in mind, though, that this prohibition is ONLY about eighty years old now. Before, despite a large numer of addicts (not at all smaller than today according to some estimations), purely medical approach to such persons prevailed, and the drugs were subject only (if at all) to some administrative control and rationing at most. The drug prohibition emerged immediately after World War I, chiefly in United Stetes. As can be judged today, the criminalization of drugs and addicts introduced in those days was highly emotional. For this reason, by no means the harmfulness of narcotic and psychotropic drugs on both the individual and the social scale, one should consider the use and reasons of prohibitive policy from the viewpoint of today’s standards of rational criminalization. It is unquestionable that any social policy with respect to drugs should aim first and foremost at reduction of their consumption. The question remains, though, about the extent to which prohibition and penal law can actually serve towards this aim. Universal in the world of today as it is, the prohibitive approach to drugs assumes a variety of forms. There are different models of prohibition which base on different penal law regulations. They can be classified in two dimensions: restrictiveness vs. permissiveness, and repressiveness vs. treatment. Te first of the above dimensions pertains to the extent of criminalization; the other one – to treatment by the law of addicted offenders. Restrictive systems are those which provide for absolute prohibition with no exceptions whatever and ban all circulation of drugs, possession included. Instead, permissive systems provide for  an extent of decriminalization of that circulation, chiefly with respect to possession of drugs. Involved here is usually decriminalization, or even total depenalization of possession of specific amounts of drugs or drugs possessed for a specific purpose as e.g. own consumption. This depenalization can be introduced not only by substantive law but also by procedural provisions law. In this latter case, elements of expediency are introduced, offering the prosecutor or court the possibility to discontinue proceedings or to drop the charge. Repressive systems treat addicted offenders like all the other offenders, applying to them regular penal sanctions both for traditional criminal offenses (as e.g.. theft), and for the “prohibitive” ones (such as possession of drugs). Treatment-oriented systems, instead, reflect a belief as to futility of punishing addicts: within tchem, attempts are made at implementing a principle “tratment instead of punishment”. In most cases, this means that an addict can avoid penal sanction if he submits to withdrawal treatment. The actual application of such provisions on conditional stay of proceedings usually depends on the seriousness of the offense committed. It can be stated that most of today’s European legislations try more or less consistently to combine elements of permissiveness with the treatment orientation. Particularly useful in the analysis of the reason and sense of prohibition are specific economic notions and categories used successfully within so-called economic approach in criminology: demand and supply. Therefore, to what extent are prohibition and penal law capable of reducing the demand for narcotic and psychotropic drugs? First, the demand for those substances is created by a great variety of categories of individuals. The first such category are the consumers. This group, however, is by no means uniform as it consists of both addicted persons, occasional users, and experimenters. Another group which is of great importance in terms of the aims of prohibition are potential consumers, that is practically the whole of socjety if we take the extreme approach. Penal law can influence those groups through its instruments of special and general prevention. The possibilities of applying individual prevention to addicts or occasional users are minimal, though, which results from the very essence of addiction. It is a general opinion today that punishment cannot force an addict to give up his addiction. Only therapy can potentially be successful here; but – an extremely important issue – therapy to which a person submits voluntarily. Today’s spread of this opinion is expressed in the above-mentioned principle of “treatment instead of punishment”. It means that, the very principle of prohibition preserved, penal repression with respect to addicts is avoided. In this interpretation, the individual preventive action of punishment is reserved for the group of persons who experiment with drugs (as it would be simply impossible to criminalize a mere wish to take drugs). The question still remains, though, whether punishment as a form of shock therapy makes any sense here. The general preventive effect of penal law assumes the forms of either deterrence or so-called positive prevention. Deterrence is entirely out of the question in the case of addicted drug consumers due to the considerable rigidity of their demand. Yet deterrence is just as inefficient with respect to potential consumers. This is caused by a huge dark number of “prohibition”, resulting from their specific nature of offenses without no victims: the police encounter immense difficulties trying to disclose such acts. Most legislators try to make up for these weak points introducing severe statutory penalties. This is ineffective in the light of the long-discovered truth that it is rather inevitability than severity of punishment that determines the effectiveness of deterrence. A similar problem arises with respect to potential integrative function of penal law. The question is whether this kind of function – consisting in reinforcement of specific values with the aim to integrate a group – can really be performed by relatively seldom euforced provisions such as no doubt the penal law provisions designed to safeguard prohibition. What remains, therefore, is just the argument, classically used when discussing the problem of decriminalization, that this step might be interpreted as a consent to a specific behavior (here, the taking of drugs) which, in turn, might have disastrous consequences. In this interpretation, prohibition is the last outpost to curb completely unrestrained spread of drug addiction. Penal law's inability to exert any crucial influence on demand considered, it is assumed more and more often today that prohibition aims basically at reducing the supply of drugs. The application of penal law to this area  is justified to the extent that its addressees are not addicts but manufacturers, smugglers, dealers and other such persons most of whom are not drugs consumers themselves but only derive profit from the addiction of others. No doubt, penal law sometimes succeeds to eliminate such persons by means of incapacitation or deterrence.  Generally, though, there is a specific and important internal contradiction involved in prohibition: delegalization of drugs in a situation of continued demand makes the  provision of supply a most attractive activity since it yields immense profits. As a result, not even the most severe penalties can either deter those involved in this activity or prevent the recruitment of their successors, the less so as the risks they run are actually rather small for reasons that have been mentioned above. It might perhaps prove possible to eliminate all supply of drugs, but not without the use of universal terror. This option, however, is out of the question in a democratic state governed by the ruled by law. Therefore, are there any alternatives to prohibition? The answer seems to be yes. First and foremost, one should realize the crucial problem of today’s drug addiction is demand. Admittedly, the demand for drugs can be seen as a apecific cultural constant, something we have to put up with. One should bear in mind, however, the  attempts at influencing that phenomenon with constructive and creative rather than destructive methods. Quite obviously, this is an extremely difficult and entangled  task – as difficult and  entangled as any struggle against the couses and not just the synptoms of a social problem. It seems, however, that work on developing constructive strategies to fight the demand  for drugs is the basic challenge of modern civilization. Namely, if we manage to gain any influence over the couses that make so many young people of today reach for drugs – if we manage to cause a reduction of that demand – departure from prohibition and resumption of the purely medical  approach to drugs might perhaps become possible. For this reason, decriminalization or legalization of drugs should be seen today as a long-term strategic aim; before it can actually be achieved, prolonged preparations, experiments, small steps strategies, and chiefly efforts towards reduction of demand by methods other than  repression are necessary. I believe it would be too risky if we tried to run this operation straight away and to leave the matter to be regulated by nothing but the forces of the free market. Finally, the fact has to be borne in mind that decriminalization can only be sensible if it is done globally; this means that such decision require close international co-operation and co-ordination.
Źródło:
Archiwum Kryminologii; 1995, XXI; 41-79
0066-6890
2719-4280
Pojawia się w:
Archiwum Kryminologii
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Criminal Law Issues of the New Polish Law Counteractive of Drug Abuse
Autorzy:
Krajewski, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/43436842.pdf
Data publikacji:
1998-12-31
Wydawca:
Polska Akademia Nauk. Instytut Nauk Prawnych PAN
Tematy:
intoxicants
drug addiction
narcotics
psychotropic drugs
criminal liability
criminal law
offense
drug abuse
Źródło:
Droit Polonais Contemporain; 1998, 1-4; 101-115
0070-7325
Pojawia się w:
Droit Polonais Contemporain
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Liposomal drug delivery, a novel approach: PLARosomes.
Autorzy:
Kozubek, Arkadiusz
Gubernator, Jerzy
Przeworska, Ewa
Stasiuk, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1044303.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
drugs
liposomes
vesicles
amphiphiles
Opis:
Almost from the time of their rediscovery in the 60's and the demonstration of their entrapment potential, liposomal vesicles have drawn attention of researchers as potential carriers of various bioactive molecules that could be used for therapeutic applications in humans and animals. Several commercial liposome-based drugs have already been discovered, registered and introduced with great success on the pharmaceutical market. However, further studies, focusing on the elaboration of more efficient and stable amphiphile-based vesicular (or non-viral) drug carriers are still under investigation. In this review we present the achievements of our group in this field. We have discovered that natural amphiphilic dihydroxyphenols and their semisynthetic derivatives are promising additives to liposomal lipid compositions. The presence of these compounds in lipid composition enhances liposomal drug encapsulation, reduces the amount of the lipid carrier necessary for efficient entrapment of anthracycline drugs by a factor of two, stabilizes liposomal formulation of the drug (both in suspension and in a lyophilized powder), does not influence liposomal fate in the blood circulation system and benefits from other biological activities of their resorcinolic lipid modifiers.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 639-649
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The intercalation of imidazoacridinones into DNA induces conformational changes in their side chain.
Autorzy:
Mazerski, Jan
Muchewicz, Karolina
Powiązania:
https://bibliotekanauki.pl/articles/1044393.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
molecular dynamics simulations
conformational changes
structure of intercalation complex
C-1311
antitumor drugs
imidazoacridinones
Opis:
Imidazoacridinones (IAs) are a new group of highly active antitumor compounds. The intercalation of the IA molecule into DNA is the preliminary step in the mode of action of these compounds. There are no experimental data about the structure of an intercalation complex formed by imidazoacridinones. Therefore the design of new potentially better compounds of this group should employ the molecular modelling techniques. The results of molecular dynamics simulations performed for four IA analogues are presented. Each of the compounds was studied in two systems: i) in water, and ii) in the intercalation complex with dodecamer duplex d(GCGCGCGCGCGC)2. Significant differences in the conformation of the side chain in the two environments were observed for all studied IAs. These changes were induced by electrostatic as well as van der Waals interactions between the intercalator and DNA. Moreover, the results showed that the geometry of the intercalation complex depends on: i) the chemical constitution of the side chain, and ii) the substituent in position 8 of the ring system.
Źródło:
Acta Biochimica Polonica; 2000, 47, 1; 65-78
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Protective action of vitamin C against DNA damage induced by selenium-cisplatin conjugate.
Autorzy:
Błasiak, Janusz
Kowalik, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1044192.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
endonuclease III
vitamin C
Se-Pt conjugate [(NH3)2Pt(SeO3)]
genotoxic effects of anticancer drugs
DNA damage
comet assay
DNA repair
Opis:
Genotoxicity of anticancer drugs is of a special interest due to the risk of inducing secondary malignancies. Vitamin C (ascorbic acid) is a recognized antioxidant and, since human diet can be easily supplemented with vitamin C, it seems reasonable to check whether it can protect against DNA-damaging effects of antitumor drugs. In the present work the ability of vitamin C to modulate cytotoxic and genotoxic effects of a cisplatin analog, conjugate (NH3)2Pt(SeO3), in terms of cell viability, DNA damage and repair in human lymphocytes was examined using the trypan blue exclusion test and the alkaline comet assay, respectively. The conjugate evoked a concentration-dependent decrease in the cell viability, reaching nearly 50% at 250 μM. (NH3)2Pt(SeO3) at 1, 10 and 30 μM caused DNA strand breaks, measured as the increase in the comet tail moment of the lymphocytes. The treated cells were able to recover within a 30-min incubation in a drug-free medium at 37°C. Vitamin C at 10 and 50 μM diminished the extent of DNA damage evoked by (NH3)2Pt(SeO3) but had no effect on the kinetics of DNA repair. The vitamin did not directly inactivate the conjugate. Lymphocytes treated with endonuclease III, which recognises oxidised pyrimidines, displayed a greater tail moment than those untreated with the enzyme, suggesting that the damages induced by the drug have, at least in part, an oxidative origin. Vitamin C can be considered a potential protective agent against side effects of antitumor drugs, but further research with both normal and cancer cells are needed to clarify this point.
Źródło:
Acta Biochimica Polonica; 2001, 48, 1; 233-240
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Potencjał hepatotoksyczny leków przeciwpsychotycznych: retrospektywna analiza 506 kuracji
Hepatotoxic potential of antipsychotic drugs: retrospective analysis of 506 treatment courses
Autorzy:
Pawełczyk, Tomasz
Królewska-Pakuła, Katarzyna
Kwiecińska, Ewa
Kłoszewska, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1061983.pdf
Data publikacji:
2005
Wydawca:
Medical Communications
Tematy:
adverse effects
aminotransferases
antipsychotic drugs
bilirubin
hepatotoxicity
bilirubina
hepatotoksyczność
leki przeciwpsychotyczne
objawy niepożądane
aminotransferazy
Opis:
Aim of paper: Retrospective analysis of incidence of increased aminotransferase (AT) activity in patients treated with I and II generation antipsychotic drugs and of differences in AT activity in correlation with different drugs and different classes of drugs. Method: Retrospective analysis of AT activity assessed during administration of antipsychotic drugs to 506 patients treated at the Department of Psychiatry of the Elderly and Psychotic Disorders of the Medical University in £ódŸ in 2003. Data obtained were analysed using non-parametric tests. Results: Groups of patients treated with particular antipsychotic drugs (both in mono- and polytherapy) differed significantly as to the incidence of increased AT values (GOT>3x15 IU/L; GPT>3x17 IU/L). A higher level of significance was observed for GPT activity as compared with GOT. Groups of patients treated with I and II generation antipsychotic drugs did not differ as to mean values of AT activity while significant differences were observed between courses of particular drugs within a particular generation of antipsychotic medications. Drugs where mean activity of AT did not differ from that of the control group included: sulpiride, flupenthixol and zuclopenthixol for I generation antipsychotic drugs and risperidone and quetiapine for II generation drugs. Highest values of AT activity were noticed in patients using perazine, haloperidol, clozapine and olanzapine. Duration of hospital stay of patients who experienced an increase in AT activity was significantly longer and there was a significant positive correlation between AT activity and duration of hospital stay. Conclusion: An increased AT activity occurs frequently in the setting of antipsychotic treatment. Particular antipsychotic drugs possess a different hepatotoxic potential. Patients with a history of liver disease or at high risk of developing drug-related liver damage, should receive safer drugs, which include sulpiride, thioxanthenes, risperidone and quetiapine.
Cel: Ocena retrospektywna częstości występowania podwyższonych wartości aminotransferaz (AT) u pacjentów leczonych lekami przeciwpsychotycznymi (LPP) I i II generacji oraz różnic w aktywności AT w przypadku kuracji odmiennymi lekami i kategoriami LPP. Metoda: Analizie poddano wyniki aktywności AT oznaczonych w trakcie 506 kuracji LPP pochodzące z retrospektywnie analizowanej kohorty pacjentów, którzy byli leczeni w Klinice Psychiatrii Wieku Podeszłego i Zaburzeń Psychotycznych UM w Łodzi w 2003 roku. Uzyskane dane analizowano z wykorzystaniem testów nieparametrycznych. Wyniki: Grupy leczone poszczególnymi LPP (stosowanymi w mono- i politerapii) różniły się istotnie pod względem częstości występowania podwyższonych wartości AT (AST>3x15 IU/l; ALT>3x17 IU/l). Wyższy poziom istotności obserwowano dla oznaczeń aktywności ALT w porównaniu z AST. Grupy leczone LPP I i II generacji nie różniły się średnimi aktywnościami AT, natomiast istotne różnice zaobserwowano pomiędzy kuracjami poszczególnymi lekami w obrębie I i II generacji LPP. Lekami, których średnie aktywności AT nie różniły się istotnie w porównaniu z grupą nieleczoną, były: sulpiryd, flupentyksol i zuklopentyksol dla LPP I generacji oraz risperidon i kwetiapina w kategorii LPP II generacji. Najwyższe wartości AT obserwowano w przypadku kuracji perazyną, haloperidolem, klozapiną i olanzapiną. Hospitalizacje pacjentów, u których doszło do wzrostu aktywności ALT, były istotnie dłuższe, a pomiędzy aktywnością AST a długością hospitalizacji obserwowano istotną korelację o dodatnim kierunku. Wnioski: Wzrost wartości AT jest częstym zjawiskiem w trakcie kuracji LPP. Poszczególne LPP mają różny potencjał hepatotoksyczności. U pacjentów obciążonych wywiadem lub wysokim ryzykiem polekowego uszkodzenia wątroby należy stosować leki bezpieczniejsze, do których można zaliczyć sulpiryd, tioksanteny, risperidon i kwetiapinę.
Źródło:
Aktualności Neurologiczne; 2005, 5, 4; 234-241
1641-9227
2451-0696
Pojawia się w:
Aktualności Neurologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zastosowanie topiramatu w leczeniu stanu padaczkowego
Usefulness of topiramate in status epilepticus treatment
Autorzy:
Kaczorowska, Beata
Przybyła, Monika
Chudzik, Wiesław
Powiązania:
https://bibliotekanauki.pl/articles/1061301.pdf
Data publikacji:
2006
Wydawca:
Medical Communications
Tematy:
antiepileptic drugs
epilepsy
status epilepticus drug-resistant
topiramate
treatment
leczenie
leki przeciwpadaczkowe
padaczka stan padaczkowy lekooporny
topiramat
Opis:
Status epilepticus or continuous seizures occur as a result of many hard disorders and complications in epilepsy which appear in brain on different backgrounds. Most often these cases may become serious danger for the patient’s life, so they demand immediate intervention and appropriate treatment. Particularly it concerns convulsion epilepsy seizure, appearing with metabolic disorders, which lead to acidosis and brain oedema. The aim of pharmacological treatment of status epilepticus is to stop its clinical symptoms (seizures and its other forms) as quickly as possible and to normalize its bioelectric exponent EEG. Giving the classic drugs (benzodiazepines, phenytoin, phenobarbital – phenobarbiturates, sodium valproate) not always helps to take control over this state. In case of the lack of results of this treatment one may try to use the drugs of new generation. Last days there have appeared some information concerning the efficiency of topiramate treatment in status epilepticus unresponsive to traditional pharmacological therapies. The authors present a case of a 26-year-old patient with partial epileptic attack with secondary generalization, in whom there occurred status epilepticus resistant to treatment with commonly applied drugs. Only the administration of topiramate did allow to control the status epilepticus.
Stan padaczkowy lub napady gromadne są wyrazem wielu ostrych zaburzeń i komplikacji w przebiegu padaczki zachodzących w mózgu na różnym tle. Są to w większości przypadków stany zagrażające życiu pacjenta, wymagają więc pilnej interwencji i odpowiedniego leczenia. Dotyczy to szczególnie napadów padaczkowych drgawkowych, przebiegających z zaburzeniami metabolicznymi, prowadzącymi do kwasicy i obrzęku mózgu. Celem farmakologicznego leczenia stanu padaczkowego jest jak najszybsze przerwanie jego objawów klinicznych (drgawek i innych jego form) oraz doprowadzenie do normalizacji jego bioelektrycznego wykładnika w badaniu EEG. Podawanie klasycznych leków (benzodiazepin, fenytoiny, fenobarbitalu czy walproinianu sodu) nie zawsze pozwala na opanowanie tego stanu. W przypadku nieskuteczności tego leczenia można podejmować próby stosowania leków nowej generacji. W ostatnim okresie pojawiło się kilka doniesień na temat skuteczności topiramatu w stanie padaczkowym opornym na leczenie tradycyjnymi lekami. Autorzy przedstawiają przypadek 26-letniego chorego z napadami częściowymi złożonymi wtórnie uogólniającymi się, u którego wystąpił stan padaczkowy niepoddający się leczeniu lekami powszechnie stosowanymi. Dopiero zastosowanie topiramatu, podawanego przez sondę żołądkową w postaci rozkruszonych tabletek, pozwoliło na opanowanie stanu padaczkowego.
Źródło:
Aktualności Neurologiczne; 2006, 6, 3; 191-194
1641-9227
2451-0696
Pojawia się w:
Aktualności Neurologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Combined effects of doxorubicin and STI571 on growth, differentiation and apoptosis of CML cell line K562
Autorzy:
Jakubowska, Justyna
Stasiak, Marta
Szulawska, Agata
Bednarek, Andrzej
Czyz, Malgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1040880.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
STI571
doxorubicin
anticancer drugs
K562 cells
apoptosis
differentiation
Opis:
STI571 (imatinib mesylate; Gleevec®) is an inhibitor that targets the tyrosine kinase activity of Bcr-Abl present in chronic myelogenous leukemia (CML) cells. Some preclinical studies have demonstrated that the combination of STI571 with chemotherapeutic drugs results in enhanced toxicity in Bcr-Abl-positive leukemias. We investigated the potential benefit of using STI571 to down-regulate Bcr-Abl activity for the enhancement of doxorubicin anti-proliferative action in K562 cell line derived from blast crisis of CML. At low concentrations of both drugs (40 nM doxorubicin combined with STI571 in the range of 100-150 nM), the antiproliferative effects were mainly due to cellular differentiation as assessed by benzidine staining for hemoglobin synthesis level and real-time PCR for γ-globin expression. Higher concentrations of STI571 used in combinations with doxorubicin caused mainly apoptosis as shown by DNA degradation and nuclear fragmentation visualized by fluorescence microscopy after DAPI staining, changes in cell morphology observed after Giemza-May Grünwald staining and cellular membrane organization estimated by flow cytometry after Annexin V staining. As compared with either drug alone, cotreatment with STI571 and DOX induced stronger cellular responses. A low concentration of STI571 in combination with a low concentration of DOX might be tested as an alternative approach to increasing the efficacy of chemotherapy against CML.
Źródło:
Acta Biochimica Polonica; 2007, 54, 4; 839-846
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ośrodkowe antycholinergiczne objawy niepożądane leków przeciwpsychotycznych
Central anticholinergic side effects of antipsychotic drugs
Autorzy:
Urban, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/945549.pdf
Data publikacji:
2007
Wydawca:
Medical Communications
Tematy:
acetylocholina
acetylocholine
aktywność antycholinergiczna
anticholinergic activity
antipsychotic drugs
fizostygmina
leki przeciwpsychotyczne
muscarinic receptors
physostigmine
receptory muskarynowe
Opis:
The introduction of antipsychotic drugs to psychiatric treatment is connected with significant progress in psychotic disorders therapy. Despite the effectiveness of this treatment, the drugs have numerous side effects. One of them is central anticholinergic syndrome: confusion, speaking disorders, consciousness disorders (usually delirium), agitation, and sometimes – central respiratory failure. These symptoms are caused by central muscarinic receptors blockade, especially M1 subtype. Frequently central anticholinergic symptoms are accompanied by peripheral symptoms. Central cholinergic blockade is mainly caused by certain typical neuroleptics e.g. thioridazine. Clozapine and olanzapine show the highest anticholinergic activity among atypical neuroleptics. Central anticholinergic syndrome treatment is usually symptomatic. Specific antidote – physostigmine is used exceptionally in case of severe consciousness disorders or respiratory failure. The use of this drug is limited due to its side effects, especially bradycardia. Anticholinergic features of these drugs develop more often in elderly. This group of patients also intake other types, nonpsychiatric drugs, which may cause central anticholinergic syndrome.
Wprowadzenie leków przeciwpsychotycznych do lecznictwa psychiatrycznego wiąże się ze znacznym postępem w terapii zaburzeń psychotycznych. Mimo niewątpliwej skuteczności terapeutycznej leki te wykazują wiele działań niepożądanych. Jednym z nich jest ośrodkowy zespół antycholinergiczny, objawiający się m.in. zaburzeniami orientacji, zaburzeniami mowy, zaburzeniami świadomości (zwykle majaczeniem), pobudzeniem, a czasem także ośrodkową niewydolnością oddechową. Objawy te spowodowane są blokadą ośrodkowych receptorów muskarynowych, przede wszystkim podtypu M1. Często do objawów ośrodkowych dołączają także te związane z obwodowym działaniem antycholinergicznym. Ośrodkowa blokada antycholinergiczna wiąże się przede wszystkim z terapią słabymi neuroleptykami klasycznymi, głównie tiorydazyną. Spośród leków przeciwpsychotycznych II generacji największą aktywność antycholinergiczną wykazują klozapina i olanzapina. Leczenie ośrodkowego zespołu antycholinergicznego jest w większości przypadków objawowe. Swoista odtrutka – fizostygmina – jest stosowana wyjątkowo w przypadku ciężkich zaburzeń świadomości i niewydolności oddechowej. Lek ten ma ograniczone zastosowanie z powodu swoich działań ubocznych, przede wszystkim zagrażającej życiu bradykardii. Właściwości antycholinergiczne leków przeciwpsychotycznych ujawniają się częściej u osób starszych. Ta grupa pacjentów zwykle zażywa także wiele innych, niepsychiatrycznych leków, które również działają antycholinergicznie. Z tego powodu należy, o ile to możliwe, unikać stosowania u starszych pacjentów leków przeciwpsychotycznych mogących wywołać ośrodkowy zespół antycholinergiczny.
Źródło:
Psychiatria i Psychologia Kliniczna; 2007, 7, 4; 233-237
1644-6313
2451-0645
Pojawia się w:
Psychiatria i Psychologia Kliniczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Redukcja objawów klinicznych hiperprolaktynemii oraz zmiana stężeń prolaktyny w trakcie jednoczesnego przyjmowania leków psychotropowych, w tym leków przeciwpsychotycznych, i bromokryptyny
Co-medication with psychotropic drugs, including antipsychotic drugs, and bromocriptine: changes in clinical signs of hyperprolactinaemia and prolactin level
Autorzy:
Barszcz, Zbigniew
Mucha, Sławomir
Rabe-Jabłońska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/945557.pdf
Data publikacji:
2007
Wydawca:
Medical Communications
Tematy:
bromocriptine
dysmenorrhoea
galactorrhoea
hiperprolaktynemia
hyperprolactinaemia
leczenie bromokryptyną
leki psychotropowe
mlekotok
psychotropic drugs
zaburzenia miesiączkowania
Opis:
The aim of this study was to assess changes in clinical symptoms of hyperprolactinaemia and serum prolactin level in female patients treated concomitantly with psychotropic drugs (including antipsychotics) and bromocriptine. Method: Twenty-five patients under antipsychotic medication were included, thereof 13 receiving also other psychotropic drugs. The patients’ mean age was 25.56 years. Prior to inclusion in the study, all patients were mentally stable for at least one month and presented clinical signs of hyperprolactinaemia (dysmenorrhoea, galactorrhoea) confirmed by laboratory tests (elevated serum prolactin level, abnormal result of metoclopramide test). The patients were treated with bromocriptine for 3 months (1.25-8.75 mg/d). Clinical signs of hyperprolactinaemia, prolactin level and mental state were assessed after 2 weeks, 1 month, 2 and 3 months of treatment. Results: The study revealed significant decrease of prolactin level at every time-point (p<0.001 after 3 months). There was also a significant reduction of severity of dysmenorrhoea (p<0.05 after 2 months and p<0.01 after 3 months). In the entire group a trend towards lower incidence of galactorrhoea was noticed, although no clinically meaningful reduction in severity of galactorrhoea was seen at the end of the study (p=0.063). Conclusion: Concomitant administration of psychotropic drugs (including antipsychotics) and bromocriptine results in a significant decrease of serum prolactin level and reduced severity of dysmenorrhoea.
Celem pracy była ocena zmian w częstości występowania objawów klinicznych hiperprolaktynemii (HPRL) oraz zmian stężeń prolaktyny (PRL) u pacjentek przyjmujących jednocześnie leki psychotropowe (LPT), w tym leki przeciwpsychotyczne (LPP), oraz bromokryptynę (BRK). Metoda: W badaniu wzięło udział 25 pacjentek (średnia wieku 25,56 roku) leczonych LPP (13 pacjentek przyjmowało także inne LPT) od co najmniej miesiąca, w okresie stabilizacji stanu psychicznego, z objawami klinicznymi HPRL (zaburzenia miesiączki lub mlekotok) potwierdzonej badaniami laboratoryjnymi (podwyższone stężenie PRL, nieprawidłowy wynik testu z metoklopramidem). Pacjentki przyjmowały przez 3 miesiące preparat BRK (w dawce 1,25-8,75 mg/dobę). Po 2 tygodniach, po miesiącu, po 2 i 3 miesiącach badania oznaczano stężenie PRL, oceniano występowanie objawów klinicznych HPRL oraz oceniano stan psychiczny. Wyniki: W badaniu stwierdzono istotne zmiany stężeń PRL wkażdym punkcie czasowym, wktórym dokonywano pomiaru (po 3 miesiącach p<0,001). Obserwowano istotną redukcję występowania zaburzeń miesiączkowania po 2 (p<0,05) i 3 (p<0,01) miesiącach. W całej badanej grupie obserwowano tendencję do zmniejszania się częstości występowania mleko-toku, ale nie stwierdzono istotnej redukcji występowania mlekotoku na końcu badania (p=0,063). Wnioski: W trakcie jednoczesnego stosowania LPT, w tym LPP, oraz BRK dochodzi do istotnego zmniejszenia stężeń PRL oraz istotnej redukcji w zakresie zaburzeń miesiączkowania.
Źródło:
Psychiatria i Psychologia Kliniczna; 2007, 7, 3; 154-164
1644-6313
2451-0645
Pojawia się w:
Psychiatria i Psychologia Kliniczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zaburzenia wydzielania prolaktyny w trakcie stosowania leków psychotropowych innych niż leki przeciwpsychotyczne
Disturbances of prolactin secreting during treatment with psychotropic drugs other than antipsychotics
Autorzy:
Barszcz, Zbigniew
Rabe-Jabłońska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/945566.pdf
Data publikacji:
2007
Wydawca:
Medical Communications
Tematy:
antidepressant drugs
benzodiazepins
benzodiazepiny
hiperprolaktynemia
hyperprolactinaemia
leki normotymiczne
leki przeciwdepresyjne
normothymic drugs
prolactin
prolaktyna
Opis:
The aim of this paper is to present current views on disorders of pituitary prolactin secretion during treatment with psychotropic drugs other than antipsychotic preparations. This issue was hitherto only rarely addressed to in the literature. While association between prolactin secretion and use of antipsychotic drugs was the subject of several methodologically correct studies, our knowledge on correlations of prolactin secretion disorders and administration of antidepressants, normothymics or sedatives stems mainly from studies encompassing small groups of patients or from anecdotal case reports. Modest number of publications concerning this issue may indicate that this problem either rarely occurs in everyday clinical practice or is inadequately diagnosed by clinicians and investigators. It appears, that psychotropic drugs other than antipsychotics rarely cause significant disorders of prolactin secretion and rarely lead to clinically significant hyperprolactinaemia. However, administration of many antidepressants (both tricyclic antidepressant and selective inhibitors of reuptake of serotonin) and some benzodiazepins, may induce increased pituitary prolactin secretion, which may result in clinical signs of hyperprolactinaemia. Few published studies indicate that normothymic drugs not only do not cause hyperprolactinaemia, but may even decrease its secretion.
Celem pracy jest przedstawienie wiedzy na temat zaburzeń wydzielania prolaktyny przez przysadkę w trakcie stosowania leków psychotropowych innych niż leki przeciwpsychotyczne. Kwestia ta była dotychczas bardzo rzadko opisywana w literaturze. O ile związki między wydzielaniem prolaktyny a stosowaniem leków przeciwpsychotycznych były przedmiotem licznych metodologicznie poprawnych badań, o tyle wiedza na temat związków między zaburzeniami wydzielania prolaktyny a stosowaniem leków przeciwdepresyjnych, normotymicznych czy uspokajających pochodzi przede wszystkim z badań prowadzonych na niewielkich grupach pacjentów lub z opisów pojedynczych przypadków. Niewielka liczba publikacji na ten temat może świadczyć o tym, że jest to problem rzadko spotykany w codziennej praktyce lekarskiej lub niedostatecznie rozpoznawany przez lekarzy i badaczy. Wydaje się, że leki psychotropowe inne niż leki przeciwpsychotyczne rzadko są przyczyną istotnych zaburzeń wydzielania prolaktyny, rzadko też powodują istotną klinicznie hiperprolaktynemię. Jednak w trakcie stosowania wielu leków przeciwdepresyjnych (zarówno z grupy trójpierścieniowych leków przeciwdepresyjnych, jak i z grupy selektywnych inhibitorów wychwytu zwrotnego serotoniny) oraz niektórych benzodiazepin może dochodzić do zwiększania wydzielania PRL przez przysadkę, co może manifestować się objawami klinicznymi hiperprolaktynemii. Z opublikowanych, choć nielicznych badań wynika, że leki normotymiczne nie powodują hiperprolaktynemii, przeciwnie – w trakcie ich stosowania może dochodzić do zmniejszania wydzielania prolaktyny.
Źródło:
Psychiatria i Psychologia Kliniczna; 2007, 7, 2; 103-107
1644-6313
2451-0645
Pojawia się w:
Psychiatria i Psychologia Kliniczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analiza układu centrów paramagnetycznych w termicznie sterylizowanym diklofenaku
Free radicals system analysis in thermally sterilized diclofenac
Autorzy:
Pilawa, B.
Ramos, P.
Wilczyński, S.
Czyż, K.
Powiązania:
https://bibliotekanauki.pl/articles/286239.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
diklofenak
wolne rodniki
leki przeciwzapalne
diclofenac
free radicals
anti-inflammatory drugs
Opis:
Wolne rodniki mogą powstawać m.in. w procesie fotolizy, radiolizy, termolizy i sonolizy oraz w wybranych reakcjach chemicznych [1-3]. Termoliza jest procesem polegającym na hemolitycznym rozpadzie wiązania kowalencyjnego w cząsteczce w wyniku zaabsorbowanej energii cieplnej [2,3]. Zjawisko takie może zachodzić podczas termicznej sterylizacji leków, a produkty rozpadu cząsteczki, w tym szczególnie niebezpieczne wolne rodniki, mogą zanieczyszczać sterylizowaną substancję leczniczą. Wolne rodniki zawarte w substancji leczniczej mogą powodować w organizmie efekty toksyczne. Nie znane są właściwości wolnych rodników w większości sterylizowanych substancji leczniczych. W niniejszej pracy wykonano analizę układu wolnych rodników w sterylizowanym termicznie diklofenaku. Diklofenak należy do grupy niesteroidowych leków przeciwzapalnych - NLPZ [4]. Wykazuje silne działanie przeciwzapalne, przeciwbólowe, przeciwgorączkowe. Diklofenak wiąże się z dwoma izoformami cyklooksygenazy (COX1 i COX 2) poprzez co blokuję syntezę prozapalnych prostaglandyn z kwasu arachidono- wego. Techniką pozwalającą na ocenę koncentracji wolnych rodników zanieczyszczających termicznie sterylizowane substancje lecznicze jest spektroskopia elektronowego rezonansu paramagnetycznego EPR. Pomiary EPR wykonano za pomocą spektrometru elektronowego rezonansu paramagnetycznego na pasmo X (9.3GHz) produkcji RADIOPAN-Poznań. Zastosowano modulację pola magnetycznego wynoszącą 100kHz. Częstotliwość promieniowania mikrofalowego rejestrowano miernikiem MCM 101 produkcji RADIOPAN-Poznań. Widma EPR rejestrowano w postaci pierwszej pochodnej absorpcji przy wysokim tłumieniu 15B, aby uniknąć nasycenia mikrofalowego linii. W pracy wykonano badania wolnych rodników w diklofenaku sterylizowanym termicznie. Sterylizację termiczną leku prowadzono w sterylizatorze z wymuszonym obiegiem powietrza w temperaturze180oC. Próbkę ogrzewano w czasie 30 minut. Dla diklofenaku wyjściowego nie poddanego obróbce termicznej nie rejestrowano widm EPR. Oznacza to, że w badanej substancji leczniczej nie występują wolne rodniki. Widma EPR diklofenaku ogrzewanego w temperaturze 180°C charakteryzowała wysoka asymetria. W pracy zbadano zmiany tej asymetrii w zależności od stosowanej mocy mikrofalowej. Zdefiniowano następujące parametry asymetrii poddane analizie: A1/A2, A1-A2, B1/B2, B1-B2. Zasady wyznaczania parametrów asymetrii pokazano na RYSUNKU 1. Na RYSUNKU 1 a i b przedstawiono zależność parametrów A1/A2 i B1/B2, od mocy mikrofalowej wyrażonej w jednostkach względnych (M/M0). Widać wyraźnie, że parametry te zależą w znacznym stopniu od mocy mikrofalowej. Wszystkie zbadane parametry maleją ze wzrostem mocy mikrofalowej. Zmiana parametrów asymetrii kształtu linii EPR wskazuje na występowanie więcej niż jednej grupy wolnych rodników w sterylizowanym termicznie diklofenaku. Średni współczynnik rozszczepienia spektroskopowe¬go g wynoszący 2,0027 świadczy, że niesparowane elektrony zlokalizowane są na atomach tlenu. Zarejestrowano również wpływ mocy mikrofalowej na podstawowe parametry linii EPR termicznie sterylizowanego diklofenaku. Amplituda linii EPR rośnie ze wzrostem mocy mikrofalowej, osiąga wartość maksymalną, a następnie maleje ze wzrostem mocy mikrofalowej. Szerokość linii EPR diklofenaku rośnie ze wzrostem mocy mikrofalowej. Zależności te są charakterystyczne dla wolnych rodników rozmieszczo¬nych jednorodnie w próbce. Oznacza to, że wykonany proces sterylizacji termicznej powoduje generowanie wolnych rodników w całej objętości próbki. Otrzymane wyniki badań spektroskopowych z wykorzystaniem metody elektronowego rezonansu paramagnetycznego wskazują na silne oddziaływania magnetyczne spin-spin w sterylizowanym diklofenaku. Oddziaływania te poszerzają linie EPR (ABpp=0,80mT) i są charakterystyczne dla wolnych rodników położo¬nych blisko siebie w strukturze molekularnej leku. Przeprowadzone analizy pozwalają wyciągnąć następujące wnioski: sterylizacja termiczna diklofenaku w temperaturze 180°C powoduje powstawanie wolnych rodników w leku. Wolne rodniki nie występują w diklofenaku nie poddanym sterylizacji. Zmian asymetrii linii EPR wraz ze wzrostem mocy mikrofalowej jest charakterystyczna dla złożonego układu wolnych rodników w próbce. Wolne rodniki w sterylizowanym termicznie diklofenaku są rozmieszczone jednorodnie, na co wskazuje charakter zmian parametrów linii EPR wraz ze wzrostem mocy mikrofalowej. Wolne rodniki w sterylizowanym termicznie diklofenaku są rozmieszczone blisko siebie, na co wskazuje poszerzenie dipolowe linii EPR. W diklofenaku sterylizowanym termicznie zachodzą wolne procesy relaksacji spin- sieć. Spektroskopia EPR jest metodą przydatną do oceny właściwości wolnordnikowych sterylizowanego termicznie diklofenaku.
Free radicals can be generated in photolysis, radiolysis, thermolysis and sonolysis processes and during some chemical reactions [1-3]. Thermolysis is defined as homolytic dissociation of covalent bond as result of thermal energy absorption [2,3]. This phenomenon can proceed during thermal drag sterilization, and degradation products, especially dangerous free radicals, can decontaminate of medicinal substance. Free radicals in remedial substance can cause toxic effects in human body. Properties of free radicals in the most of sterilized medicinal substances are unknown. In the present study free radicals system of thermally sterilized diclofenac was performed. Diclofenac belongs to non-steroidal anti-inflammatory drug (NSAID) [4]. Diclofenac has analgesic, antipyretic and anti-inflammatory activities. Diclofenac binds to and chelates both isoforms of cyclooxygenase (COX-1 and COX-2), thereby blocking the conversion of arachidonic acid (AA) to pro-inflammatory prostaglandins. Electron paramagnetic resonance spectroscopy (EPR) was applied as the experimental technique to evaluate concentration of free radicals decontaminating thermally sterilized medicinal substance. Measurements of EPR spectra were done by the use of EPR spectrometer at X-band (9.3GHz) produced by RADIOPAN Firm (Poznań). Modulation of magnetic field of 100kHz was applied. Microwave frequency was evaluated using MCM 101 frequency recorder produced by RADIOPAN - Poznań. The first-derivative EPR spectra were recorded with high microwave power attenuation 15dB to avoid the microwave saturation. In the present study free radicals in thermally sterilized diclofenac were studied. Thermal sterilization of the drug was performed in hot air oven with air circulating at 180°C. Sample was heated during 30 minutes. Samples of diclofenac not heated with high temperature gave no EPR signals. It indicates that stabile free radicals do not exist in initial medicinal substance. The EPR spectra of high temperature operated diclofenac are characterize by high asymmetry. In present study dependence of asymmetry on microwave power was investigated. Following parameters of asymmetry were analyzed: A1/A2, A1-A2, B1/B2, B1-B2. Principles of asymmetry parameters determination were performed on FIGURE 1. On FIGURE 1 dependence of EPR lines A1/A2 (a) and B1/B2 parameters on microwave power M/M0 in relative units stated were performed. It was shown that these parameters strongly depend on microwave power. Changes of asymmetry line parameters indicates presence of a few types of free radicals in thermally sterilized diclofenac. Mean g-factor with 2.0027 value indicates that unpaired electrons are located on oxygen atoms. Influence of microwave power on basis EPR parameters for thermally sterilized diclofenac was recorded. Amplitude rises with microwave power increase, reaches maximum value and than decreases with microwave power increase. This kind of relationship indicates that free radicals are homogenously spread in whole sample. It means that thermal sterilization processes generate free radicals in whole volume of the sample. Received spectroscopic results obtained by electron paramagnetic spectroscopy application indicates on strong spin-spin magnetic interactions in sterilized diclofenac. This interactions causing broadening EPR lines (ABpp= 0,80 m T) are characteristic for close located free radicals in molecular structure of the drug. The results of the conducted studies allow the statement that: thermal sterilization at 180°C produce free radicals in diclofenac. Free radicals do not exist in non-sterilized diclofenac. Changes of line asymmetry are characteristic for complex free radicals system in the sample. Changes of EPR line parameters indicate on homogenous spread of free radicals in thermally sterilized diclofenac. Broadening EPR lines inform that free radicals are close located to each other. Slowly spin-lattice relaxation processes proceed in thermally sterilized diclofenac. EPR spectroscopy is useful technique to evaluation free radicals properties in thermally sterilized diclofenac.
Źródło:
Engineering of Biomaterials; 2008, 11, no. 81-84; 57-58
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena koncentracji, trwałości i typu wolnych rodników powstających w tramadolu pod wpływem wysokiej temperatury
Evaluation of concentration, stability and types of free radicals generated in tramadole exposed to high temperature
Autorzy:
Pilawa, B.
Wilczyński, S.
Ramos, P.
Tomasik, A.
Powiązania:
https://bibliotekanauki.pl/articles/283751.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
wolne rodniki
tramadol
leki
free radicals
tramadole
drugs
Opis:
Wpływ wysokiej temperatury na substancje biologicznie czynne jest szczególnie istotny w kontekście termicznej sterylizacji leków. Wysoka temperatura, zabójcza dla mikroorganizmów, może powodować zrywanie się wiązań chemicznych a co za tym idzie powstawanie produktów rozpadu. Wśród produktów rozpadu powstających pod wpływem działania wysokiej temperatury w substancjach leczniczych szczególne miejsce zajmują wolne rodniki. Ich wyjątkowa pozycja wynika z faktu, iż nawet niewielkie koncentracje wolnych rodników mogą powodować niebezpieczne następstwa podczas farmakoterapii zanieczyszczonymi substancjami leczniczymi. Ważny jest fakt, że wolne rodniki mogą negatywnie wpływać na pacjenta nawet w bardzo niewielkich stężeniach. Dotyczy to zwłaszcza leków podawanych parenteralnie, między innymi tramadolu. Tramadol jest syntetycznym lekiem przeciwbólowym o opioidowym i nieopioidowym mechanizmie działaniu [1-2]. Metodą, która pozwala na ilościowe oraz jakościowe pomiary wolnych rodników w termicznie sterylizowanych lekach jest spektroskopia elektronowego rezonansu paramagnetycznego EPR. Sterylizację termiczną tramadolu wykonano w suszarce z wymuszonym obiegiem powietrza w temperaturze 180°C. Czas sterylizacji wynosił 30 minut. Próbki miały postać sproszkowaną. Pomiary EPR wykonano za pomocą spektrometru elektronowego rezonansu paramagnetycznego na pasmo X (9.3GHz) produkcji RADIOPAN - Poznań. Zastosowano modulację pola magnetycznego wynoszącą 100kHz. Częstotliwość promieniowania mikrofalowego rejestrowano miernikiem MCM 101 produkcji RADIOPAN - Poznań. Widma EPR rejestrowano w postaci pierwszej pochodnej absorpcji przy wysokim tłumieniu 15dB, aby uniknąć nasycenia mikrofalowego linii. Całkowita moc mikrofalowa wytwarzana przez klistron wynosiła około 2.2mW. Wyznaczono następujące parametry widm EPR: amplitudę linii, szerokość linii oraz współczynnik rozszczepienia spektroskopowego g. Określono również koncentrację wolnych rodników oraz ich stabilność. Wzorcem zewnętrznym służącym wyznaczeniu koncentracji wolnych rodników w termicznie sterylizowanym tramadolu była ultramaryna. Natomiast wzorcem pomocniczym na trwale umieszczonym we wnęce rezonansowej był kryształ rubinu. Określono także wpływ mocy mikrofalowej na podstawowe parametry widm EPE - amplitudę i szerokość linii EPR. Dla tramadolu nie poddanego obróbce termicznej, nie obserwowano widm EPR. Oznacza to, że w badanej substancji leczniczej nie występują trwałe centra paramagnetyczne. Widma EPR badanego leku sterylizowanego w temperaturze 180°C stanowią asymetryczne szerokie linie (RYS. 1), co wskazuje na silne oddziaływania magnetyczne spin-spin w sterylizowanym termicznie tramadolu. Oddziaływania te poszerzają linie EPR i są charakterystyczne dla wolnych rodników położonych blisko siebie w strukturze molekularnej leku. Zarejestrowano wpływ mocy mikrofalowej na amplitudę i szerokość linii EPR. Taki charakter zmian (RYS. 2) wskazuje, że wolne rodniki w termicznie sterylizowanym tramadolu są rozmieszczone jednorodnie w całej objętości próbki. Zaobserwowano wpływ czasu przechowywania na koncentracje wolnych wodników (proporcjonalną do wartości amplitudy linii EPR) w termicznie sterylizowanym tramadolu (RYS. 3). Ilość wolnych rodników maleje w kolejnych dniach pomiarowych. Zjawisko to może być związane z procesami rekombinacji pomiędzy blisko siebie położonymi wolnymi rodnikami oraz interakcji z paramagnetycznym tlenem atmosferycznym. Nie zaobserwowano wpływu czasu przechowywania na szerokość linii EPR tramadolu. Wyznaczono współczynnik rozszczepienie spektroskopowego g świadczący o typie wolnych rodników znajdujących się w próbce. Otrzymany wynik g=0,0027 sugeruje, że niesparowane elektrony zlokalizowane są na atomach tlenu. Nie zaobserwowano wpływu czasu przechowywania na średni współczynnik rozszczepienia spektroskopowego g. Wszystkie przedstawione dane wskazują, że wysoka temperatura (180°C) powoduje generowanie się dużej ilości wolnych rodników. Asymetryczne, złożone linie EPR wskazują na istnienie kilku typów wolnych rodników w tramadolu poddanemu obróbce termicznej. Poszerzenie dipolowe linii EPR sugerują niewielkie odległości pomiędzy wolnymi rodnikami. Nasycenie mikrofalowe widm EPR wskazuje na jednorodne rozmieszczenie wolnych rodników w sterylizowanym termicznie tramadolu. Wraz z czasem przechowywania koncentracja wolnych rodników maleje.
Influence of high temperature on biologic active substances is particularly important in context of thermally sterilized drugs. High temperature, lethal for microorganisms, can cause cleavage of chemical bonds and consequent degradation products forming. Among degradation products formed under the influence of high temperature, free radicals are particularly important. Its special status result from fact that even very few free radicals concentrations can cause dangerous sequences during contaminated substances pharmacotherapy. It is important that free radicals even in very few concentrations can have negative influence on patients. It concerns especially parenterally administrated drugs, inter alia tramadole. Tramadole is a synthetic drug that acts analgesic with opioid and non-opioid effect [1,2]. EPR spectroscopy brings information about types and amount of free radicals in thermally sterilized drugs. Thermal sterilization of tramadole was performed in hot air oven with air circulating at 180°C. Sterilization was performed during 30 minutes. Powdered samples were analyzed. Measurements of EPR spectra were done by the use of EPR spectrometer produced by RADIOPAN Firm (Poznań). Modulation of magnetic field of 100kHz was applied. Microwave frequency was evaluated using MCM 101 frequency recorder produced by RADIOPAN - Poznań. The first-derivative EPR spectra were recorded with high microwave power attenuation 15dB to avoid the microwave saturation. Total microwave power produced by klystron was about 2.2mW. The following EPR parameters were determined: amplitude, linewidth and g-factor. Free radicals concentration and stability were also evaluated. Ultramarine was used as reference of paramagnetic centers concentration. A ruby crystal, permanently placed in resonance cavity, was the second reference. Influence of microwave power on basic EPR parameters: amplitude and linewidth of EPR lines were tested. For not heated tramadole EPR spectra were not observed. It indicates absence of stabile paramagnetic centers in initial substance. EPR spectra of the studied drug sterilized at 180°C have asymmetric, broad lines what indicates strong spin-spin magnetic interactions in thermally sterilized tramadole. These interactions causing broadening EPR lines and are characteristic for close located free radicals in molecular structure of the drug. Influence of microwave power on EPR line amplitude was observed. This kind of relationship indicates that free radicals in thermally sterilized tramadole are homogenously located in whole sample volume. Influence of sample storage on free radicals concentration (proportionally to amplitude value) was observed. This phenomenon can be related with recombination processes between close located to each other free radicals and interactions with paramagnetic oxygen molecules. Influence of time of storage on EPR linewidths was not observed. g-factor, free radical type determining, was evaluate. Determined result g=2.0027, suggest that unpaired electrons are located on oxygen atoms. Influence of time of storage on average g - factor value was not observed. All presented data point that high temperature (180°C) cause big amount of free radicals creating. Asymmetric, complex EPR lines indicate on few types of free radicals existing in tra- madole expose to high temperature. Dipole boarded EPR lines suggest little distance between free radicals. Microwave saturation of EPR lines indicates homogeneous distribution of free radicals in thermally sterilized tramadole. Free radicals concentration decrease with increasing time of storage.
Źródło:
Engineering of Biomaterials; 2008, 11, no. 81-84; 63-64
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł

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