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Tytuł:
Monitoring risk behaviour in adolescent pupils regarding consumption of psychoactive substances
Autorzy:
Wojtyła-Buciora, Paulina
Klimberg, Aneta
Kapka-Skrzypczak, Lucyna Kapka-Skrzypczak
Diatczyk, Jarosław
Urbaniak, Monika
Ulatowska-Szostak, Ewa
Bołdowski, Tomasz
Wojtyła, Andrzej
Marcinkowski, Jerzy T.
Powiązania:
https://bibliotekanauki.pl/articles/989849.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
drugs/narcotics
designer drugs (dds)/legal highs
adolescents/youth
Opis:
Introduction. Taking psychoactive substances constitutes a significant problem for Public Health, particularly in preventing drug abuse and addiction. Objectives. To estimate the amount and incidence of drug consumption in middle and high school pupils, including the circumstances in which drug taking first started, and to determine pupils’ knowledge about the consequences of taking psychoactive substances and designer drugs (DDs). Materials and methods. A randomised study was conducted throughout Poland on 9,360 pupils attending middle school (junior high school) in 2009 and 7,971 pupils from middle and high school pupils in 2011. The survey consisted of a questionnaire devised by the Chief Sanitary Inspectorate (GIS) and the replies obtained were subject to the relevant statistical analyses. Results. Drug taking was found to have increased between 2009–2011, especially among those attending high school; proportionally rising from 4% – 11%. The numbers who had ever taken designer drugs were 3% for middle school pupils and 4% from high school. Conclusions. 1) Adolescent drug consumption has increased, particularly in those of older age and in boys. 2) Despite the only brief interval for which designer drugs were legal, they have gained high popularity among the young. 3) Adolescents have insufficient knowledge about the dangers of using DDs. 4) Faced with the growing threat of a dynamic designer drug market, appropriate counter-measures in education and prevention are therefore necessary.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New applications of FeMOF as drug delivery system for theophylline
Autorzy:
Strzempek, W.
Gil, B.
Menaszek, E.
Powiązania:
https://bibliotekanauki.pl/articles/285613.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
theophylline
drugs
MOF
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 106
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Potential of electrospinning technique to drug delivery system
Autorzy:
Dzierzkowska, E.
Stodolak-Zych, E.
Powiązania:
https://bibliotekanauki.pl/articles/284071.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
electrospinning
drugs
fibers
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 119
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Halloysite nanotubes as potential carrier for gentamicin
Autorzy:
Stodolak-Zych, E.
Skóra, K.
Rapacz-Kmita, A.
Mikołajczyk, M.
Gajek, M.
Bućko, M. M.
Powiązania:
https://bibliotekanauki.pl/articles/284115.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanotubes
gentamicin
drugs
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 93
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multi-parametric SPR – in vitro characterization method for biopharmaceuticals and drug delivery systems
Autorzy:
Sadowski, J. W.
Granqvist, N.
Jokinen, A.
Powiązania:
https://bibliotekanauki.pl/articles/285101.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
drugs
SPR
biopharmaceuticals
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 120
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Selenium containing hydroxyapatite granules as drug carriers for risedronate
Autorzy:
Kolmas, J.
Pajor, K.
Pajchel, Ł.
Olędzka, E.
Sobczak, M.
Powiązania:
https://bibliotekanauki.pl/articles/285367.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydroxyapatite
drugs
biomaterials
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 70
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chitosan based drug delivery systems
Autorzy:
Piegat, A
Goszczyńska, A.
Niemczyk, A.
Powiązania:
https://bibliotekanauki.pl/articles/285591.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
drugs
polymeric materials
chitosan
Opis:
One of the research area in which polymeric materials are intensively explored, deals with the controlled drug delivery systems (DDSs), allowing for drugs distribution directly to the desired site of biological activity. The morphology of polymeric colloidal drug carriers can be described as a construction of a core-shell type. Depending on the chemical or physical bonds providing stability of those systems and the type of interactions between the drug and the polymer, among polymeric DDSs the following morphological structures can be distinguished: micelles, dendrimers, liposomes, niosomes, polymerosomes and micro- and nanocapsules [1]. The main advantages of those systems are the preparation of particles with desired size (diameter from nano to micrometers) during their synthesis / formation and high specific surface area, which can be modified by the appropriate chemical composition of the surface improving the efficiency of a drug delivery. Chitosan is biopolymer derived from chitin, that is characterised by biodegradability, biocompatibility, mucoadhesion and antimicrobial activity [2,3]. Taking into account the overall advantages of this polymer and the possibility of modification due to the accessible functional groups i.e. hydroxyl and amine, chemically modified chitosan is one of the most promising biomaterials for DDS. In order to obtain micelle structures by selfassemby in aqueous environment several hydrophobically modified chitosan derivatives, such as – stearic acid-modified chitosan [4], palmitic anhydridemodified chitosan [5], linolenic acid-modified chitosan [6], have been synthesized. The micelles prepared by these derivatives in the aqueous medium contain internal hydrophobic moieties as drug reservoir and external hydrophilic chitosan chains as surrounding shell. The above mentioned micellar systems allow encapsulation of hydrophobic antitumor drugs e.g. doxorubicin or paclitaxel due to the compatibility between the hydrophobic core and hydrophobic drug affecting the drug loading and regulate drug release. Another important group of chitosan based micro- and nanoparticles are those dedicated for gastric infection treatment. The use of chitosan in this specific application is mainly related with the mucoadhesive properties of chitosan resulted from the electrostatic interactions between its positively charged free amine groups and the negatively charged gastric mucins at the acidic stomach pH. Several problems such as high solubility of chitosan under stomach acidic conditions, low retention time and difficulty in crossing the mucus barrier have been observed in those systems [7]. Therefore various crosslinking methods e.g. with glutaraldehyde [8], genipin [9] or sodium triphosphate pentabasic (TPP) solution [10] were investigated in order to minimize these problems. The nanotechnological production of the polymeric drug carriers, as well as the disadvantages of already developed chitosan based drug delivery systems induce the NANOENCAP project concept on the development and characterization of new dendrimeric micelles polymeric systems, with rigidly defined chemical structure, allowing the encapsulation of several drugs and their controlled release, and thus forming the so-called multidrug therapy systems. To provide the biocompatibility of new polymeric materials the monomer / reactant with proven biocompatibility or naturally occurring in the human body are chosen. According to the assumptions of the project the amphiphilic character of the proposed multi-functional polymeric drug delivery systems is going to enable the encapsulation of at least two drugs, matching latest trends in the research on DDS models in multi-therapy. As an exemplary multi-drug therapy in this project, the combine therapy of peptic ulcer disease was chosen. In this work we would like to present the short review of chitosan based drug delivery systems and the concept of the project as well as preliminary studies on new chitosan derivatives and the possibility of synthesis new micellar structures.
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 27
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carbon nanopowders in technology drug form
Autorzy:
Skibska, B.
Bodek, K. H.
Powiązania:
https://bibliotekanauki.pl/articles/285643.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
carbon nanopowders
drugs
biotechnology
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 81
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sonochemical synthesis of drug molecules nanoparticles: towards controlled drug release
Autorzy:
Chytrosz, P.
Golda-Cepa, M.
Kotarba, A.
Powiązania:
https://bibliotekanauki.pl/articles/286014.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanoparticles
drugs
sonochemical synthesis
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 69
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Charakterystyka wpływu narkotyków na ośrodkowy układ nerwowy
Autorzy:
Panas, Krystyna Teresa
Powiązania:
https://bibliotekanauki.pl/articles/2140999.pdf
Data publikacji:
2011
Wydawca:
Instytut Studiów Międzynarodowych i Edukacji Humanum
Tematy:
drugs addiction
nervous system
Opis:
Article covers the issues: Substances opóźniająco the central nervous system Substances stimulating the central nervous system Substances that cause disturbances in the central nervous system Escape from the daily concerns and environmental impact
Źródło:
Humanum. Międzynarodowe Studia Społeczno-Humanistyczne; 2011, 2(7); 253-263
1898-8431
Pojawia się w:
Humanum. Międzynarodowe Studia Społeczno-Humanistyczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Opinia prawna stanowiąca uzupełnienie opinii na temat obowiązku wprowadzenia przez Polskę do sprzedaży aptecznej bez recepty produktu leczniczego ellaOne
Legal opinion complementing the opinion on Poland’s obligation to allow sale in pharmacies of a medicinal product ellaOne without prescription
Autorzy:
Kondrat, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/2223418.pdf
Data publikacji:
2015
Wydawca:
Kancelaria Sejmu. Biuro Analiz Sejmowych
Tematy:
contraception
drugs
European Union
Opis:
The author provides an analysis of Poland’s obligations as a Member State of the European Union, relating to the implementation of Community law in so far as it concerns Ellaone contraceptive. He points out that Regulation 726/2004 does not regulate issues related to the marketing of medicinal products in a comprehensive manner. Directive 2001/83/EC of the European Parliament and of the Council, according to its Article 4 para. 4, does not affect the application of national legislation prohibiting or restricting the sale or use of medicinal products as contraceptives or abortifacients. In Poland, there is no legislation expressly establishing a ban or restrictions on marketing or application of this particular type of agents, and any possible national legislation introduced to implement the restrictions permitted under the Directive should not only aim at eliminating the effect of the decision of the European Commission amending marketing authorisation issued by a decision (2009) 4049 for “ellaOne – ulipristal acetate”, a medicinal product for human use, but should relate to this category of products.
Źródło:
Zeszyty Prawnicze BAS; 2015, 1(45); 100-106
1896-9852
2082-064X
Pojawia się w:
Zeszyty Prawnicze BAS
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Problem legalizacji narkotyków miękkich w Polsce na tle regulacji prawnych przyjętych w Republice Czeskiej oraz w Królestwie Niderlandów
The issue of legalizing soft drugs in Poland against the legal regulations adopted in the Czech Republic and in the Netherlands
Autorzy:
Fiedukowicz, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/964942.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
drugs
criminalization
decriminalization
drugs possession
soft drugs
legalization
prohibition
narkotyki
kryminalizacja
dekryminalizacja
posiadanie narkotyków
narkotyki miękkie
legalizacja
prohibicja
Opis:
Celem niniejszej publikacji jest przybliżenie unormowań prawnych odnoszących się do problematyki legalizacji oraz dostępności narkotyków miękkich w Polsce. W oparciu o regulacje prawa międzynarodowego, a także najważniejsze akty prawa wewnątrzwspólnotowego wskazuje się na zasadnicze przyczyny, dla których depenalizacja zachowań polegających na posiadaniu bądź też wytwarzaniu tzw. soft drugs nie jest obecnie możliwa. Zestawienie przepisów karnych polskiej ustawy narkotykowej pozwala wytyczać pożądane kierunki zmian w polskim modelu prohibicyjnym. W tym kontekście autor prezentuje podstawowe założenia polityk antynarkotykowych przyjętych w Republice Czeskiej oraz w Królestwie Niderlandów, jako państw o mniej restrykcyjnym (radykalnym) podejściu do kwestii posiadania narkotyków. Podjęte rozważania pozwalają ostatecznie na sformułowanie odpowiedzi na pytanie: Czy zasadne jest zalegalizowanie chociażby tzw. „narkotyków miękkich”, czy też należy pozostawić obowiązujące unormowania prawne bez zmian, karząc zawsze i za każdy przejaw posiadania narkotyków i to bez względu na ich rodzaj?
The aim of this publication is to bring closer legal regulations referring to issues of legalization and availability of soft drugs in Poland. Basing on regulations of the international law as well as on the most important acts of the intra-Community law fundamental reasons are indicated for which depenalization of behaviours such as the possession or production of the so-called soft drugs is not at present possible. Comparing regulations of penalties of the Polish drug act allows setting necessary guidelines for changes to the Polish prohibition model. In this context the author is presenting fundamental assumptions of the anti-drug policies adopted in the Netherlands and Czech Republic as the states with a less restrictive (radical) approach to the issue of drug possession. The considerations undertaken allow finally formulating an answer to a question: Is it reasonable to legalize at least the so-called ‘soft drugs’ or should the binding legal regulations be maintained without changes, punishing always and for every manifestation of drug possession and irrespectively of a type of drugs?
Źródło:
Acta Universitatis Lodziensis. Folia Iuridica; 2016, 76
0208-6069
2450-2782
Pojawia się w:
Acta Universitatis Lodziensis. Folia Iuridica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Correlation between relative rates of hospital treatment or death due to ischaemic heart disease (IHD) and of IHD-related medication among socio-occupational and economic activities groups in Denmark, 1996–2005
Autorzy:
Hannerz, Harald
Dalhoff, Kim
Burr, Hermann
Latza, Ute
Powiązania:
https://bibliotekanauki.pl/articles/2178871.pdf
Data publikacji:
2014-08-06
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
pccupational epidemiology
heart therapeutic drugs
anti-hypertensive drugs
lipid modifying agents
Opis:
Objective: The aim of the present work was to establish whether or not prescribed medication is a usable risk indicator for work‑related ischaemic heart disease (IHD), in Denmark. Material and Methods: Weighted Spearman rank correlation coefficients (rho) were used to evaluate the agreement between Standardised Hazard Ratios (SHR) for hospital treatment or death due to IHD and SHR for purchase of prescriptions for medicine that may prevent IHD from (re)occurring, among socio-occupational and economic activities groups in Denmark. The SHR were based on a 10-year prospective follow-up of 2 million people in Danish national registers 1996–2005. Results: We found approximately 7 times more cases of medicine usage (N = 411 651) than we did for hospital treatment or death (N = 55 684). The correlations between the 2 types of SHR were strong (rho = 0.94 for the socio-occupational groups; rho = 0.74 for the economic activities groups). We observed, however, one markedly contradictive result; the industrial group entitled ‘general practitioner, dentists etc.’ was associated both with significantly high rates of medicine usage (SHR = 1.15, 95% CI: 1.12–1.19) and significantly low rates of hospital treatment or death due to IHD (SHR = 0.80, 95% CI: 0.71–0.91). Conclusion: Apart from a few caveats, the strong correlations obtained in the present study signify that purchase of a prescription for IHD-related medication is a usable risk indicator for IHD in the working population of Denmark. The usage of medicine data in addition to or instead of the use of death or hospital data in epidemiological studies on work-related IHD risk will bring about a tremendous increase in statistical power.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2014, 27, 4; 536-546
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Liposomal drug delivery, a novel approach: PLARosomes.
Autorzy:
Kozubek, Arkadiusz
Gubernator, Jerzy
Przeworska, Ewa
Stasiuk, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1044303.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
drugs
liposomes
vesicles
amphiphiles
Opis:
Almost from the time of their rediscovery in the 60's and the demonstration of their entrapment potential, liposomal vesicles have drawn attention of researchers as potential carriers of various bioactive molecules that could be used for therapeutic applications in humans and animals. Several commercial liposome-based drugs have already been discovered, registered and introduced with great success on the pharmaceutical market. However, further studies, focusing on the elaboration of more efficient and stable amphiphile-based vesicular (or non-viral) drug carriers are still under investigation. In this review we present the achievements of our group in this field. We have discovered that natural amphiphilic dihydroxyphenols and their semisynthetic derivatives are promising additives to liposomal lipid compositions. The presence of these compounds in lipid composition enhances liposomal drug encapsulation, reduces the amount of the lipid carrier necessary for efficient entrapment of anthracycline drugs by a factor of two, stabilizes liposomal formulation of the drug (both in suspension and in a lyophilized powder), does not influence liposomal fate in the blood circulation system and benefits from other biological activities of their resorcinolic lipid modifiers.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 639-649
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Alginate/chitosan hybrid materials loaded with ciprofloxacin
Autorzy:
Kyzioł, A.
Mazgała, A.
Michna, J.
Regiel-Futyra, A.
Moreno, I.
Sebastian, V.
Irusta, S.
Powiązania:
https://bibliotekanauki.pl/articles/284972.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
drugs
hybrid materials
biopolymers
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 106
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Porous hybrid materials as potential drug delivery systems
Autorzy:
Pajchel, Ł.
Szulkowska, A.
Kolmas, J.
Powiązania:
https://bibliotekanauki.pl/articles/283765.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hybrid materials
drugs
composites
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 43
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A comprehensive review on Primary gallbladder tuberculosis
Autorzy:
Gupta, Ashish
Gupta, Amit
Anjum, Rohik
Agrawal, Saumya
Mallik, Dhiraj
Powiązania:
https://bibliotekanauki.pl/articles/1392736.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
gallbladder
Tuberculosis
Antitubercular drugs
Opis:
Tuberculosis (TB) is an infectious disease that can affect any organ system of the body. Abdominal TB can be gastrointestinal, lymph nodal, visceral or peritoneal. The gallbladder (GB) is rarely involved in abdominal TB as a primary organ. Extensive research literature on gallbladder TB is limited to case reports. There has been no review on this rare abdominal pathology. GB tuberculosis is a difficult diagnosis preoperatively. It is a rare differential among the more common gallbladder pathologies such as cholelithiasis, or a gallbladder malignancy. Typical histopathology of the resected specimen helps to establish this rare diagnosis. Subjecting every specimen to histopathological examination followed by medical treatment offers the chance of cure. Through this review, the authors attempt to provide an insight into this disease entity.
Źródło:
Polish Journal of Surgery; 2018, 90, 2; 10-12
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Opinia na temat obowiązku wprowadzenia przez Polskę do sprzedaży aptecznej bez recepty produktu leczniczego ellaOne
Opinion on Poland’s obligation to allow sale in pharmacies of a medicinal product ellaOne without prescription
Autorzy:
Olejniczak, Dorota
Kuszel, Konrad
Powiązania:
https://bibliotekanauki.pl/articles/2223417.pdf
Data publikacji:
2015
Wydawca:
Kancelaria Sejmu. Biuro Analiz Sejmowych
Tematy:
contraception
drugs
European Union
Opis:
The opinion deals with the effects of the European Commission Implementing Decision whereby ellaOne is commercially available in all Member States without a prescription. The analysis leads to the conclusion that under the existing law, Poland is obliged to implement the decision of the Executive Committee and the medicinal product ellaOne should be available over-the-counter. Nevertheless, Polish legislature may decide to exclude or restrict the sale or use of medicinal products as contraceptives or abortifacients. Therefore, it is permissible to adopt a regulation to prohibit the sale of ellaOne or adopt provisions specifying that it will be available in Poland only on prescription.
Źródło:
Zeszyty Prawnicze BAS; 2015, 1(45); 93-99
1896-9852
2082-064X
Pojawia się w:
Zeszyty Prawnicze BAS
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Utilisation of peptides against microbial infections – a review
Autorzy:
Mirski, T.
Niemcewicz, M.
Bartoszcze, M.
Gryko, R.
Michalski, A.
Powiązania:
https://bibliotekanauki.pl/articles/2081601.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
antimicrobial peptides
infections
drugs
therapy
Opis:
The emergence of resistance in microorganisms on a global scale has made it necessary to search for new antimicrobial factors. Antimicrobial peptides (AMPs) seem to meet these expectations. AMPs are produced by bacteria, viruses, plants, and animals, and may be considered as a new class of drugs intended for the prophylaxis and treatment of both systemic and topical infections. The aim of this study is to review the results of studies on the use of peptides to combat infections in vivo. Antimicrobial peptides may be applied topically and systemically. Among the peptides used topically, a very important area for their application is ophthalmology. AMPs in ophthalmology may be used mainly for the protection of contact lenses from ocular pathogens. Many AMPs are in clinical trials for application in the therapy of local infections. There may be mentioned such preparations as: pexiganan (magainin analogue), MX-226 (based on indolicidin), NEUPREX (isolated from human BPI (bactericidal/permeability-increasing) protein), IB-367 (variant of porcine protegrin), P113 (based on histatin), daptomycin, polymyxins, as well as peptidomimetics. In the combat against systemic infections are used such peptides as: P113D (modified P113 peptide containing D-amino acids), colistin, peptoids, and peptides containing non-typical amino acids or non-peptide elements. AMPs are also used as antiprotozoal, antifungal, antitoxic and immunostimulatory agents. The limitations in the use of peptides in the treatment of infections, such as susceptibility to proteolysis, and resistance of microorganisms to the peptides, are also discussed. AMPs are a promising strategy in the fight against microbial infections.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 2; 205-210
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Self-Declaration of Religiousness and This Variable’s Connections with Indications of Psychoactive Substance Use: Data from Empirical Studies (N=2273)
Autorzy:
Jedynak, Witold
Motyka, Marek A.
Powiązania:
https://bibliotekanauki.pl/articles/2036275.pdf
Data publikacji:
2018
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
Tematy:
religiousness
morality
youth
drugs
addiction
Opis:
A steady increase in the use of intoxicants is being confirmed by empirical studies. One of the factors conducive to drug initiation is the rejection of moral norms associated with religious beliefs. The article presents the relations established between the youth’s declared religiousness and their statements on psychoactive drugs and using them. The data were collected through questionnaire surveys carried out on a randomly selected sample of high school students from the Podkarpackie region (n = 2273). The research results suggest that the process of secularisation and relativisation observed among the youth, particularly in the sphere of morality, may weaken critical attitudes towards psychoactive substances, both those legally allowed and those prohibited by law. Moreover, the links between the declared religiousness and such variables as: time spent on the Internet, acquaintances who are drug users, being raised by a single parent or both parents as well as the frequency of conversations between respondents and their parents were established. The connections between these variables are statistically significant, so it can be concluded that these distinguished variables influence the diversity in religiousness stated by participants and consequently the liberalisation of the youth’s attitudes towards drugs.
Źródło:
Roczniki Teologiczne; 2018, 65, 10 English Online Version; 141-163
2353-7272
Pojawia się w:
Roczniki Teologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative analysis of porous polymeric membranes as drug carriers
Autorzy:
Stodolak-Zych, E.
Mikołajczyk, M.
Rapacz-Kmita, A.
Powiązania:
https://bibliotekanauki.pl/articles/285554.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polymeric membranes
drugs carriers
polymers
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 53
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Drug - eluting bioresorbable vascular stents manufactured by microinjection moulding
Autorzy:
Dobrzyński, P.
Sobota, M.
Włodarczyk, J.
Stoiko, M.
Pastusiak, M.
Kasperczyk, J.
Milewski, K.
Krauze, A.
Powiązania:
https://bibliotekanauki.pl/articles/284470.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
vascular stents
bioresorbable stent
drugs
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 33
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Boosters – a Phenomenon and Threats
Autorzy:
Jędrzejko, Mariusz
Netczuk-Gwoździewicz, Marzena
Powiązania:
https://bibliotekanauki.pl/articles/1861554.pdf
Data publikacji:
2016
Wydawca:
Wyższa Szkoła Bezpieczeństwa Publicznego i Indywidualnego Apeiron w Krakowie
Tematy:
boosters
drugs
psychoactive substances
poisoning
Opis:
the article is an analysis of the issue of drugs consumption, in the historical context, and concentrates on the synthetic drugs production that lasts for the last decades. authors mainly focus on the most present topic – the boosters: their impact on health (intoxication), distribution and production. they consider measures taken by authorities to fight this phenomenon, as well as show its partial efficiency due to changes in boosters production (flexible changes of consistence) and distribution (foreign platforms use).
Źródło:
Security Dimensions; 2016, 17(17); 99-113
2353-7000
Pojawia się w:
Security Dimensions
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metody przemycania narkotyków oraz sposoby ich rozpoznawania
Drug smuggling techniques and methods of detection
Autorzy:
Lewkowicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/348215.pdf
Data publikacji:
2011
Wydawca:
Akademia Wojsk Lądowych imienia generała Tadeusza Kościuszki
Tematy:
narkotyki
przemytnictwo
transport
drugs
smuggling
Opis:
Narkotyki to współcześnie jedno z najpoważniejszych zagrożeń bezpieczeństwa wewnętrznego państw jak i światowym problemem zdrowotnym w walce od uniezależnienia od narkotyków oraz przestępczości narkotykowej. Polska ze względu na centralne położenie w Europie stała się krajem tranzytowym dla narkotyków przerzucanych z Bliskiego i Dalekiego Wschodu. Współczesne dochody z przemytu narkotyków przeznaczane są na pomnażanie zasobów finansowych organizacji przestępczych. Pieniądze te stanowią źródło do dalszego jeszcze większego pomnażania ich do innych zabronionych celów niezgodnych z prawem.
Organised crime in the form of drug smuggling and trafficking poses a serious threat to public safety. Drug addiction also constitutes a global health hazard.
Źródło:
Zeszyty Naukowe / Wyższa Szkoła Oficerska Wojsk Lądowych im. gen. T. Kościuszki; 2011, 4; 99-108
1731-8157
Pojawia się w:
Zeszyty Naukowe / Wyższa Szkoła Oficerska Wojsk Lądowych im. gen. T. Kościuszki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE COMPREHENSIBILITY OF LEAFLETS ATTACHED TO OTC ANALGESICS – PILOT SURVEY OF OPINIONS IN POLAND
Autorzy:
Bułaś, Lucyna
Hansel, Justyna
Wajda, Anna
Dolińska, Barbara
Drozd, Mariola
Powiązania:
https://bibliotekanauki.pl/articles/895603.pdf
Data publikacji:
2019-12-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
OTC analgesics
leaflet attached to the drugs
source of information about OTC drugs
Opis:
The aim of the study was to present the opinions on the leaflets attached to the packages of Over-the-counter (OTC) analgesics, taking into account the place of purchase and the usefulness of the information contained in the leaflet. The survey was conducted in Poland at the turn of February/March 2016 and June/July 2017. The authors constructed an original questionnaire consisting of 24 questions, both open and closed type. The survey was addressed to adults. In total 303 respondents were surveyed. Student t-test and Pearson’s chi-squared test were applied to determine differences between statistics, p < 0.05 was assumed as statistically significant. The respondents indicated a pharmacy as the main place of purchasing OTC analgesics. Most of the respondents declared that they read the leaflet attached to the package, and the font size used is large enough and legible. However, if it is difficult to read the information contained in it, and the majority of patients do not turn to the doctor or pharmacist for advice. The obtained results confirm that patients purchase and use drugs with increasing awareness. The study found that patients do not always understand drug information leaflets, and they do not always turn to professionals for counseling. The information contained in leaflets should be presented in a way that is clear, concise, and easily understandable to patients. It appears that the implementation of pharmaceutical care would greatly improve the safety of pharmacotherapy, including OTC non-steroidal anti-inflammatory drugs (NSAIDs).
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 1099-1106
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-25 z 319

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