Temat: drug-drug interaction - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: New insight into organic anion transporters from the perspective of potentially important interactions and drugs toxicity
Autorzy:: Mor, A.L.
Kaminski, T.W.
Karbowska, M.
Pawlak, D.
Powiązania:: https://bibliotekanauki.pl/articles/70038.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: organic anion transporter
transmembrane transporter
drug-drug interaction
central nervous system
glycosylation
herbal preparation
dietary supplement
pharmacokinetic interaction
Źródło:: Journal of Physiology and Pharmacology; 2018, 69, 3
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Interactions of levetiracetam with ethosuximide in the mouse 6 Hz psychomotor seizure model - a type II isobolographic analysis
Autorzy:: Luszczki, J.J.
Wlaz, A.
Kondrat-Wrobel, M.W.
Pyrka, D.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3145.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: 6 Hz psychomotor seizure model
antiepileptic drug
drug interaction
ethosuximide
levetiracetam
isobolographic analysis
Opis:: The aim of the present study was to characterize the anticonvulsant effects of levetiracetam in combination with ethosuximide in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. With type II isobolographic analysis, the combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05 and P<0.01, respectively) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. The combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 appear to be particularly favorable combinations exerting supra-additive interaction in the mouse 6 Hz psychomotor seizure model. Finally, it may be concluded that because of the synergistic interactions between levetiracetam and ethosuximide, the combination might be useful in clinical practice.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Interactions of retigabine with topiramate in the mouse tonic-clonic seizure model and chimney test - an isobolographic analysis
Autorzy:: Zagaja, Mirosław
Miziak, Barbara
Kondrat-Wróbel, Maria W.
Andres-Mach, Marta
Wróblewska-Łuczka, Paula
Adamczuk, Piotr
Chmura, Robert
Czuczwar, Stanisław Jerzy
Łuszczki, Jarogniew J.
Powiązania:: https://bibliotekanauki.pl/articles/972722.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: maximal electro-shock
drug interaction
isobolographic analysis
Retigabine
Topiramate
Opis:: Introduction and objectives. Nowadays, one of the treatment options for patients with refractory epilepsy is polytherapy with two or more antiepileptic drugs (AEDs). Retigabine (RTG) is a novel third-generation AED with unique molecular mechanisms of action that has recently been approved as an add-on drug for the treatment of tonic-clonic seizures. To characterize types of interactions between RTG and topiramate (TPM – a second-generation AED), the maximal electroshock- induced seizure model (MES) and chimney test in mice were used. Materials and method. In the MES model, the anticonvulsant effects of the drugs in terms of suppression of tonic-clonic seizures in male albino Swiss mice were assessed. In the chimney test, the acute neurotoxic effects of the drugs with respect to impairment of motor coordination were determined. Type I isobolographic analysis for the combination of RTG and TPM was applied to assess the anticonvulsant and neurotoxic effects in both the MES and chimney tests. Total brain concentrations of RTG and TPM were measured to exclude any pharmacokinetic interaction between drugs. Results. The type I isobolographic analysis of interaction revealed that the combination of RTG with TPM produced additive interaction in the MES test and additivity, with a slight tendency towards antagonism in terms of acute neurotoxic effects in the chimney test. Neither RTG nor TPM mutually affected total brain concentrations in the experimental animals. Conclusions. The isobolographically analyzed combination of RTG with TPM is favourable and may be recommended to some patients with refractory epilepsy.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 1; 61-65
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Impact of hydrochlorothiazide on the stability of two perindopril salts. Evaluation of the interaction with HPLC and ESI LC/MS methods
Autorzy:: Juszczak, Anna
Stanisz, Beata J.
Szczołko, Wojciech
Pieszak, Martyna
Cielecka-Piontek, Judyta
Powiązania:: https://bibliotekanauki.pl/articles/895593.pdf
Data publikacji:: 2018-10-31
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: perindopril tert-butyloamine
perindopril arginine
hydrochlorothiazide
drug stability
interaction
Opis:: Perindopril (PER) belongs to the group of the angiotensin converting enzyme inhibitors and is widely prescribed antihypertensive drug. It can be used in monotherapy or in combination therapy for example with hydrochlorothiazide (HTH). As on the market there is no pharmaceutical formulation containing both drugs and in literature has not been reported any work about effect of HTH on PER degradation process, the primary objective of this study was the assessment of stability of two salts of perindopril - tert-butylamine (PERt) and arginine (PERa) in a mixtures model with HTH in different relative humidities and constant temperature. Objective of the study was establishing the mechanisms of drug decomposition in the presence of HTH. Results were achieved using the high performance liquid chromatography (RP-HPLC). The degradation rate constants for mixtures and pure substances were calculated. Decomposition products have been analyzed by ESI LC/MS and the decomposition mechanism for each salt has been proposed. The degradation of PERt in the presence of HTH took place according to autocatalytic reaction kinetic mechanism, described mathematically by Prout-Tompkins equation, and the decomposition process leads to hydrolysis. HTH in the model mixture with PERa generates a first-order kinetic model of the decomposition reaction, and there are two main products of decomposition: product of hydrolysis and diketopiperazine. Our study showed that HTH has statistically significant positive impact on both salts. It can be suggested that PERt or PERa and HTH can be formulated together, hence there is no negative interaction between the drugs.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1117-1125
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Estimation of dietary supplements intake in a selected group of women over 50 and the risk assessment of interactions between the ingredients of dietary supplements and drugs
Autorzy:: Sadowska, J.
Bruszkowska, M.
Powiązania:: https://bibliotekanauki.pl/articles/873493.pdf
Data publikacji:: 2016
Wydawca:: Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:: estimation
dietary supplement
intake
woman
human nutrition
risk assessment
interaction
ingredient
drug
Opis:: Background. Concurrent use of dietary supplements and drugs may result in complications of pharmacotherapy due to possible interactions between their ingredients. Objectives. The aim of the survey was to estimate the intake of dietary supplements in a group of women over 50 and to analyse the risk of interactions between the ingredients of dietary supplements and drugs taken by the women. Material and Methods. The study was carried out among 146 women over 50 years of age. Questionnaire included detailed questions on the type of prescription drugs, OTC (over-the-counter) drugs, and dietary supplements taken. The risk of interactions was determined on the basis of chemical composition of the drugs and supplements specified by the manufacturer, by comparing the obtained data with literature reports on known interactions. Results. The analysis has shown that 88.4% of respondents constantly took prescription drugs, 44.5% of them took OTC drugs, and 66.4% of respondents took dietary supplements throughout the survey period. It has been found that 71.3% of surveyed women taking prescription drugs, took dietary supplements as well. Among women taking supplements and drugs, 36.9% of respondents were taking them concurrently, 60.9% kept such an interval, but only 21.8% of them waited for at least two hours. It has been found that the drug-supplement interactions might occur in 35.8% women under the survey. Conclusions. The analysis of the obtained results has revealed that taking dietary supplements by the group under survey was frequent, and the risk of interactions between dietary supplements and drugs was significant. It is recommended that doctors ask their patients about taken supplements during regular check-ups, and inform them about possible interactions between dietary supplements and drugs. Moreover, appropriate would be to change the labelling of dietary supplements, so that the packaging provides information on possible interactions between their ingredients and drugs.
Wprowadzenie. Jednoczesne spożywanie suplementów diety i leków może być przyczyną powikłań farmakoterapii, ze względu na możliwość wystąpienia interakcji pomiędzy ich składnikami. Cel. Celem przeprowadzonych badań była ocena spożycia suplementów diety w wybranej grupie kobiet po 50 roku życia oraz analiza ryzyka wystąpienia interakcji pomiędzy składnikami suplementów diety a przyjmowanymi przez te kobiety lekami. Materiał i metody. Badania przeprowadzono wśród 146 kobiet po 50 roku życia. W ankietach zawarto szczegółowe pytania dotyczące rodzaju zażywanych leków przepisanych przez lekarza, przyjmowanych leków bez recepty oraz spożywanych suplementów diety. Ryzyko wystąpienia interakcji określono na podstawie składu stosowanych przez badane leków oraz suplementów, odnosząc uzyskane dane do informacji o interakcjach podanych w literaturze. Wyniki. Analizując uzyskane wyniki stwierdzono, że 88,4% badanych przyjmowało na stałe leki przepisane przez lekarza 44,5% stosowało leki bez recepty, a 66,4% badanych w okresie badania zażywało suplementy diety. Stwierdzono, że 71,3% badanych kobiet, przyjmujących leki przepisane przez lekarza, stosowało także suplementy diety. Spośród kobiet stosujących suplementy i leki 36,9% przyjmowało je w jednym czasie, przerwę stosowało 60,9% badanych, jednak tylko u 21,8% badanych była ona co najmniej 2 godzinna. Stwierdzono, że interakcja lek - suplement mogła zachodzić u 35,8% badanych kobiet. Wnioski. Analizując uzyskane wyniki stwierdzono, że przyjmowanie suplementów diety w badanej grupie osób było częste, a ryzyko wystąpienia interakcji pomiędzy przyjmowanymi suplementami diety a lekami było znaczne. Wskazane byłoby wprowadzenie rutynowych pytań podczas wizyty lekarskiej o stosowaniu suplementacji i informowanie pacjenta o możliwości interakcji pomiędzy składnikami suplementów diety a lekami. Celowa wydaje się także zmiana oznakowania na opakowaniach suplementów diety, uwzględniająca informacje o możliwości zajścia interakcji pomiędzy składnikami suplementów i przyjmowanymi lekami.
Źródło:: Roczniki Państwowego Zakładu Higieny; 2016, 67, 4
0035-7715
Pojawia się w:: Roczniki Państwowego Zakładu Higieny
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Diltiazem enhances the protective activity of oxcarbazepine against maximal electroshock-induced seizures in mice
Autorzy:: Zadrozniak, A.
Trojnar, M.K.
Trojnar, M.P.
Kimber-Trojnar, Z.
Dudra-Jastrzebska, M.
Andres-Mach, M.M.
Luszczki, J.J.
Powiązania:: https://bibliotekanauki.pl/articles/3526.pdf
Data publikacji:: 2008
Wydawca:: Instytut Medycyny Wsi
Tematy:: calcium channel antagonist
diltiazem
protective activity
oxcarbazepine
maximal electroshock-induced seizure
mice
mouse
drug interaction
pharmacodynamic interaction
Źródło:: Journal of Pre-Clinical and Clinical Research; 2008, 02, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Influence of irbesartan on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits
Autorzy:: Murthy, T.E.G.K.
Mayuren, C.
Powiązania:: https://bibliotekanauki.pl/articles/3672.pdf
Data publikacji:: 2008
Wydawca:: Instytut Medycyny Wsi
Tematy:: irbesartan
drug interaction
hypoglycemia
gliclazide
pharmacodynamics
pharmacokinetics
rat
rabbit
diabetes mellitus
chronic disease
metabolic disease
Źródło:: Journal of Pre-Clinical and Clinical Research; 2008, 02, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Electrostatics in computer-aided drug design
Autorzy:: Naray-Szabo, G.
Matyus, P.
Powiązania:: https://bibliotekanauki.pl/articles/1953955.pdf
Data publikacji:: 1998
Wydawca:: Politechnika Gdańska
Tematy:: electrostatics
drug design
molecular electrostatic potential
molecular electrostatic field
similarity
pharmacophore
ComFa method
protein-ligand interaction
Opis:: Hydrogen bonds and charge-charge interactions, determined by molecular electrostatics, play essential role in biopolymer-ligand associations. Accordingly, electrostatics is crucial in the qualitative and quantitative characterisation of the binding of drugs to their target molecules. In the following, we will give an account on the role of molecular electrostatics in a drug design, laying emphasis on our own work. We will survey the most important computation methods of molecular electrostatic potentials, then outline basic aspects of molecular recognition: steric, electrostatic and hydrophobic complementarity. On the basis of the complementarity, we will also define molecular similarity and discuss various applications of these concepts to the treatment of protein-ligand interactions and a rational drug design. Special attention will be paid to a receptor mapping and to a comparative molecular field analysis, with some our recent applications. A further important point will be the molecular electrostatic field (potential gradient) as a hydrophobicity measure. We will argue that the hydrophobic complementarity and similarity can be treated on the basis of matching regions of the interacting molecules that are characterised by a similar magnitude of the electrostatic field. The concept of the electrostatic complementarity will be extended to enzyme-substrate interactions, providing a firm basis for the quantitative estimation of catalytic rate enhancement.
Źródło:: TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 1998, 2, 4; 551-562
1428-6394
Pojawia się w:: TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Docking for drug interface residues of modelled VPS33B of human with PtpA of Mycobacterium tuberculosis CDC1551
Autorzy:: Reddy, K.M.
Pattathil, M.D.
Jayachandra, S.Y.
Parameshwar, A.
Sulochana, M.B.
Powiązania:: https://bibliotekanauki.pl/articles/11443.pdf
Data publikacji:: 2014
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: antigenicity
protein-protein interaction
network
homology modelling
drug design
interface residue
Mycobacterium tuberculosis
man
protein
biological function
Opis:: VPS33B, a human Vacuolar Protein Sorting (VPS) protein which mediates the phagolysosomal fusion in macrophage of the eukaryotic organisms. This protein has a great role during the mycobacterial infections, which binds with the Mycobacterium protein tyrosine phosphatase A (PtpA). A single functional domain of PtpA has been identified using SMART domain databases, followed by finding the antigenicity of PtpA using CLC main workbench tool. The protein-protein interaction network predicts the interface of biological functions of proteins, built by using Cytoscape 2.8.3 version tool for manual literature survey of protein sets. According to the literature the specific interactivity of PtpA with VPS33B of human lead to pathogenesis, and provided a good platform to find the structure of VPS33B as it lacks the 3 dimensional structure in PDB. Homology Modelling of VPS33B provides a significant properties to design a specific drug through screening the drug databases (eDrug3D). The modelled protein has been validated through SAVES server maintained by NIH and UCLA with the standard Ramachandran plot with accuracy of 90.7 %. From our findings the interface residues are very crucial points which has been found through docking the modelled protein and Mycobacterium protein and interface residues were selected manually using PyMol software.
Źródło:: International Letters of Natural Sciences; 2014, 11, 2
2300-9675
Pojawia się w:: International Letters of Natural Sciences
Dostawca treści:: Biblioteka Nauki