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Wyświetlanie 1-13 z 13
Tytuł:
Are we helping or harming our insulin-treated diabetic patients during ambulatory treatment?
Autorzy:
Szczesniak, G.
Dziemidok, P.
Paprzycki, P.
Powiązania:
https://bibliotekanauki.pl/articles/50293.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Tematy:
helping
harming
insulin-treated patient
diabetic patient
ambulatory treatment
diabetes mellitus
insulin therapy
body weight
hemoglobin
knowledge
behaviour
Opis:
Introduction. Correctness of insulin treatment depends on both the experience and skills of the doctor and knowledge and behaviour of the patient. Objective. Evaluation the adequacy of insulin doses administered to diabetes patients in ambulatory conditions. Material and methods. The treatment of 59 patients hospitalized in the Diabetology Ward was evaluated at admission, discharge and 3 months after hospitalization. Results. The mean daily doses of insulin significantly differed at times of evaluation and were: 53.90, 39.31 and 43.34 units, respectively (p≈0.000001). A significant reduction of body weight, 90.86 vs. 88.25 kg (p≈0.000001), was obtained only during hospitalization, and was maintained 3 months after discharge (87.86 kg). Significant differences were also noted in the body mass index (33.44 vs. 32.48 vs. 32.37 kg/m2, p≈0.000001). The change in waist circumference was not statistically significant (107.87 vs. 104.89 cm; p≈0.06). A decrease in the number of hypoglycaemia episodes was observed, but were statistically insignificant (25 vs. 23; p≈0.7). Three months after hospitalization an insignificant decrease of HbA1c level was noted (8.41% vs. 8.03%; p≈0.07). Conclusions. During treatment in the Diabetology Ward the procedure of choice was more frequently a reduction than an increase in insulin doses. This management led to the reduction of the patients’ body weight, improvement of glycaemia, without any significant effect on the diabetes control determined by the HbA1c level.
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association of chosen microsatellite markers on chromosomes 10, 11p and 14q with IDDM susceptibility in the population of midwestern Poland
Autorzy:
Jungerman, M
Fichna, P
Powiązania:
https://bibliotekanauki.pl/articles/2047273.pdf
Data publikacji:
1996
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
microsatellite marker
human disease
chromosome
statistical analysis
Polska
susceptibility
insulin-dependent diabetes mellitus
health control
polymerase chain reaction
Wielkopolska region
diabetic child
population
Opis:
In search for new markers of insulin-dependent diabetes (IDDM) susceptibility we studied the CATT tetranucleotide repeat in intron 1 of tyrosine hydroxylase (TH) gene on chromosome lip, the CA repeat at T-cell receptor a chain (TCRA) locus on chromosome 14q and two CA repeats at D10S211 and D10S213 loci in the chromosome 10 region containing glutamic acid decarboxylase (GAD2) gene. Alleles at these microsatellite loci were identified in a population of diabetic children and unrelated healthy controls originating from Wielkopolska, a midwestern region of Poland. We found significant association of certain alleles at TH, TCRA and D10S211 loci with diabetes in the population under study. On the contrary, none of the alleles at D10S213 locus was associated with the disease. Our findings indicate that typing of microsatellite markers may represent useful additional tool for identifying individuals at high risk of developing IDDM. Regarding loci on chromosome 10 our data and data published by other authors may suggest the extistence of two separate regions of association with IDDM susceptibility on this chromosome.
Źródło:
Journal of Applied Genetics; 1996, 37, 2; 217-228
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diabetic autonomic neuropathy of the gastrointestinal tract - etiopathogenesis, diagnosis, treatment and complications
Autorzy:
Kuzemko, Dorota
Rymarz, Ewa
Prystupa, Andrzej
Dzida, Grzegorz
Mosiewicz, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/972715.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
diabetic neuropathies
diabetes complications
diabetes mellitus
gastrointestinal autonomic neuropathy
Opis:
Introduction. Late complications of diabetes mellitus are a serious challenge for physicians treating diabetic patients. Micro- and macro-angiopathic changes are of the most severe sequels. However, it should be remembered that the effects of long-term diabetes are also associated with changes in the peripheral nervous system. One of the complications most troublesome for patients is diabetic autonomic neuropathy of the gastrointestinal (GI) tract. Objective. The review article presents the pathogenesis of diabetic neuropathy of the autonomous gastrointestinal tract, and advances in the diagnosis and treatment of this disease. The study used materials in the database which demonstrate current standards of conduct, based on the principles of EBM. Brief description of the state of knowledge. Diabetic neuropathy is one of the most common complications of diabetes mellitus. According to epidemiologists, it affects 10% to even 100% of patients with long-standing disease. Damage to the nervous fibres mainly results from hyperglycaemia, which leads to the typical symptoms of dysfunction of GI tract segments. The main additional examinations include abdominal ultrasound (US) and abdominal X-ray. In cases with oesophageal disorders accompanied by dysphagia, gastroscopy is found useful for excluding possible neoplastic lesions. The gold standard for evaluation of gastric emptying is radioisotopic scintigraphy, however it is available only in some specialistic departments. Other recommended methods include: manometry, EGG, insulin tests, NMR and expiratory tests. To date, the problem has been managed symptomatically; in special cases, surgical interventions have been required. Conclusions. At present, a wide array of treatment options is available, including new forms of drugs and less radical surgical procedures carried out in numerous centres worldwide.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2017, 11, 1; 6-9
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effectiveness of electrical stimulation and low-intensity laser therapy on diabetic neuropathy: A systematic review
Autorzy:
Adehunoluwa, Emmanuel A.
Adesina, Miracle A.
Adeulure, Taiwo G.
Akinfolarin, Yemi T.
Babatunde, Kazeem O.
Efunniyi, Adenike O.
Mamud, Olusola S.
Oyejola, Oluwatimilehin G.
Tiamiyu, Oluwaleke M.
Olajire, Tolulope I.
Powiązania:
https://bibliotekanauki.pl/articles/1077040.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Diabetes mellitus
diabetic neuropathy
electric stimulation
laser therapy
Opis:
Diabetes mellitus (DM) is a group of metabolic diseases which typically presents with frequent urination, increased thirst and increased hunger. DM be classified into three main types: type I (insulin-dependent DM), type-II (non-insulin dependent DM) and type III (gestational DM). Diabetes is a group of diseases of global health significance as 382 million people worldwide had diabetes in the year 2013 and this was projected to increase to an estimated 415 million in 2015. Damage to the nerves of the body (diabetic neuropathy) is the most common complication of diabetes. The signs and symptoms of diabetic neuropathy include numbness, diminished sensation, pain etc. Various types of electrotherapy, such as transcutaneous electrical nerve stimulation (TENS), pulsed-dose electrical stimulation, frequency-modulated electromagnetic neural stimulation, have been reported effective in managing diabetic neuropathy. This study is a systematic review of the evidence to enable the determination of the effectiveness of electrical stimulation and low-intensity laser therapy (LILT), and also aid their recommendation if proven to be effective. The outcome of this study was that TENS and other forms of electrical stimulation reviewed in this study may be effective and safe non-pharmacological treatment modalities in relieving the symptoms associated with diabetic neuropathy. The effectiveness of LILT couldn’t be determined due to the different parameters used to evaluate patients’ outcome and limited number of studies. Authors recommend that further randomized controlled trials with similar methodological parameters and studies with higher quality of evidences are needed to establish the true effectiveness of these modalities in diabetic neuropathy.
Źródło:
World News of Natural Sciences; 2019, 23; 110-127
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Geographic variability of major non-traumatic lower limb amputations in diabetic and non-diabetic patients in Poland
Autorzy:
Wierzba, W.
Krasnodębski, P.
Śliwczyński, A.
Karnafel, W.
Powiązania:
https://bibliotekanauki.pl/articles/2085410.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
diabetes mellitus
diabetic patients
non-diabetic patients
non-traumatic lower limb amputations
Opis:
Introduction. High amputation of the lower limb not only causes immense physical disability but also the destruction of the patient’s mental state, and helps to shorten life of patients with diabetes. The incidence of amputations in diabetic patients is 10 times higher in comparison to non-diabetic subjects (2.8% vs. 0.29%). The purpose of the study is an analysis of the geographic variability of major non-traumatic lower limb amputation in diabetic and non-diabetic patients in Poland. Materials and method. All major non-traumatic lower limb amputations performed for the first time, in particular data between 1 January 2013 – 31 December 2013, and between 1 January 2014 – December 2014, were identified in the National Health Fund (NHF) database. In the presented study, the patients were grouped in relevant provincial departments of the NHF according to their place of residence, and not according to the hospital where lower limb amputation was performed. Results. In 2013 in Poland, 4,727 major non-traumatic lower limb amputation were performed in diabetic patients, and 4,350 in 2014. On the other hand, in non-diabetic patients, 3,469 major non-traumatic lower limb amputations were performed in 2013, and 3149 in 2014. The mean number indicator of major non-traumatic lower limb amputations in diabetic patients in Poland, compared to the average indicator of amputations in patients without diagnosed diabetes in Poland was 19.9-fold in 2013 and 19.4-fold higher in 2014. Conclusions. In populations of diabetic patients and individuals without diagnosed diabetes major non-traumatic lower limb amputations are performed over 19-fold more frequently.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 76-79
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hyperglycemia induced C2C12 myoblast cell cycle arrest and skeletal muscle atrophy by modulating sirtuins gene expression in rats
Autorzy:
Surinlert, P.
Thitiphatphuvanon, T.
Khimmaktong, W.
Pholpramool, C.
Tipbunjong, C.
Powiązania:
https://bibliotekanauki.pl/articles/2087134.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
diabetic mellitus
hyperglycemia
muscle atrophy
sirtuins
skeletal muscle
Źródło:
Polish Journal of Veterinary Sciences; 2021, 24, 4; 563-572
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Long-term complications of diabetes and the risk of diabetic foot
Przewlekłe powikłania cukrzycy i ryzyko stopy cukrzycowej
Autorzy:
Krysiak-Zielonka, I.
Powiązania:
https://bibliotekanauki.pl/articles/2052827.pdf
Data publikacji:
2018
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
diabetes mellitus
chronic complications of diabetes
diabetic foot
cukrzyca
przewlekłe powikłania cukrzycy
stopa cukrzycowa
Opis:
Background. Chronic complications of diabetes are presently the most vital problem in diabetology and the most significant challenge in the treatment of the diseases. Because of peripheral neuropathy and macroangiopathy, people with diabetes are particularly vulnerable to foot problems. The following study aims to evaluate the development of chronic complications in patients with type 2 diabetes, with a particular focus on the prevalence of limb ischemia symptoms. Material and methods. The study involved patients with type 2 diabetes mellitus and nondiabetic persons at a similar age. Diabetics were divided into 2 groups. Group 1 consisted of type 2 diabetic patients with no trophic lesions of the limbs; Group 2 included patients with diabetic foot disease; and the control group (Group 3) were the non-diabetic elderly. The study was to analyse the incidence of retinopathy, nephropathy and neuropathy in both diabetic groups. Besides, it was to evaluate changes in macroangiopathy among diabetic patients and the control group. Results. In all groups, symptoms of lower limb ischaemia were assessed, which allowed making comparisons between them. The studied material indicated that the occurrence of diabetic ulcers is mostly associated with macroangiopathy and its symptoms, polyneuropathy and particular types of neuropathy, retinopathy and horny foot skin. Conclusions. An interdisciplinary approach to the problem of the diabetic foot allows recognising its early clinical symptoms.
Wprowadzenie. Przewlekłe powikłania cukrzycy są obecnie najważniejszym problemem w diabetologii i stanowią największe wyzwanie w leczeniu cukrzycy. Z powodu obwodowej neuropatii i makroangiopatii chorzy na cukrzycę są grupą szczególnie narażoną na problemy zdrowotne stóp. Celem pracy jest ocena rozwoju przewlekłych powikłań u chorych na cukrzycę typu 2 ze szczególnym uwzględnieniem analizy częstości występowania objawów niedokrwienia kończyn. Materiał i metody. Badaniami objęto chorych z cukrzycą typu 2 oraz osoby niechorujące na cukrzycę w podobnym przedziale wiekowym. Diabetyków podzielono na 2 grupy. Grupę 1- stanowili chorzy na cukrzycę typu 2 bez zmian troficznych kończyn, grupę 2- stanowili chorzy z zespołem stopy cukrzycowej, grupę kontrolną (grupa 3)- stanowiły osoby w wieku podeszłym niechorujące na cukrzycę. Przeanalizowano występowanie retinopatii, nefropatii i neuropatii w obu grupach diabetyków. Oceny zmian o charakterze makroangiopatii dokonano wśród chorych na cukrzycę i w grupie kontrolnej. Wyniki. We wszystkich grupach oceniano objawy niedokrwienia kończyn dolnych. Dokonano porównań między grupami. W badanym materiale występowanie owrzodzeń cukrzycowych wiąże się w największym stopniu z makroangiopatią i jej objawami, polineuropatią i poszczególnymi typami neuropatii, retinopatią oraz występowaniem zrogowaciałego naskórka stóp. Wnioski. Interdyscyplinarne podejście do problemu stopy cukrzycowej umożliwia rozpoznawanie jej wczesnych objawów klinicznych.
Źródło:
Health Problems of Civilization; 2018, 12, 1; 14-21
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Macrophages in Diabetes Mellitus: A Review on Understanding of Macrophage Function
Autorzy:
Chatterjee, Susraba
Guria, Srikanta
Powiązania:
https://bibliotekanauki.pl/articles/1059398.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Alloxan
Beta-cell Therapy
Cytokines
Diabetes mellitus
Diabetic Nephropathy
Diabetic Retinopathy
Macrophage
Macrophage Type 1
Macrophage Type 2
Streptozotocin
Opis:
Diabetes mellitus (DM) causes millions of deaths all over the world. Immune system contains macrophages that play very important role in DM. Excessive secretion of different cytokines can induce the DM development. Diabetes mellitus (DM) also affect the function of macrophage. We review the important findings regarding the role of macrophage in DM. This review may emphasize future direction towards development of novel immune-modulatory therapeutic intervention.
Źródło:
World Scientific News; 2019, 134, 2; 319-325
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neuropatia cukrzycowa u dzieci i dorosłych z cukrzycą typu I - diagnostyka, leczenie
Diabetic neuropathy in children and adult with type I diabetes – diagnosis and management
Autorzy:
Stańczyk, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1059266.pdf
Data publikacji:
2007
Wydawca:
Medical Communications
Tematy:
autonomic neuropathy
diabetic neuropathy
diagnosis of neuropathy
management of neuropathy
peripheral neuropathy
type I diabetes mellitus
neuropatia cukrzycowa
neuropatia obwodowa
neuropatia autonomiczna
rozpoznawanie neuropatii
leczenie neuropatii
cukrzyca typu I
Opis:
Diabetic neuropathy is one of the most common and serious complications of diabetes both type I and type II. In type I diabetes mellitus neuropathy usually assumes form of a distal symmetric polyneuropathy (DPN) and/or a diabetic autonomic neuropathy (DAN). Other forms as acute sensory neuropathy, cranial neuropathy, truncal radiculoneuropathy or proximal motor neuropathy are present sporadically in patients with type I diabetes. Damage to nerves in the abnormal environment of diabetes mellitus leads to diabetic neuropathy. There are three hypotheses that explain the pathogenetic mechanism of polyneuropathy: metabolic, vascular and immunological. Many diabetic patients have demonstrable abnormalities of autonomic function without any evidence of clinical disease. Tests of autonomic function and tests of conduction veloautocity in peripheral nerves are assumed to be a measure of neurological state and may be important methods of assessing therapy of diabetic complications. Control of hyperglycaemia is the basis of the adequate management. α-liponic acid is used due to some evidences suggesting the role of free radicals in pathogenesis diabetic neuropathy. Antiepileptics and antidepressants inhibiting selective norepinephrine and serotonin reuptake are administered for pain control in symptomatic management.
Neuropatia cukrzycowa jest jednym z najczęściej występujących poważnych powikłań w cukrzycy zarówno typu I, jak i typu II. W cukrzycy typu I zwykle występują obwodowa symetryczna polineuropatia (DPN) i/lub cukrzycowa neuropatia autonomiczna (DAN). Inne formy, takie jak ostra czuciowa neuropatia, neuropatia czaszkowa, radikulopatia tułowia, neuropatia ruchowa proksymalna, u pacjentów z cukrzycą typu I występują rzadziej. Uszkodzenie włókien w przebiegu cukrzycy prowadzi do wystąpienia neuropatii. Wysuwane są trzy hipotezy dotyczące mechanizmów prowadzących do neuropatii cukrzycowej: metaboliczna, naczyniowa i immunologiczna. U wielu chorych występują nieprawidłowości w funkcjonowaniu układu autonomicznego bez wyraźnych klinicznych objawów choroby. Wykonywanie testów czynności układu autonomicznego i testów oceniających przewodnictwo w nerwach obwodowych jest ważne dla oceny stanu neurologicznego i dla decyzji terapeutycznych w przypadku powikłań cukrzycowych. Kontrola hiperglikemii jest podstawą adekwatnego leczenia neuropatii cukrzycowej. Kwas α-liponowy jest stosowany w związku z uzasadnionymi sugestiami udziału wolnych rodników tlenowych w patogenezie neuropatii cukrzycowej. Leki przeciw-drgawkowe i antydepresyjne hamujące zwrotny wychwyt noradrenaliny lub serotoniny są stosowane dla łagodzenia dolegliwości bólowych.
Źródło:
Aktualności Neurologiczne; 2007, 7, 3; 202-209
1641-9227
2451-0696
Pojawia się w:
Aktualności Neurologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prevention of diabetes in primary healthcare based on the health policy program for early detection and prevention of diabetes and its complications in working individuals in the Lubusz province
Autorzy:
Bonikowska, Iwona
Jasik-Pyzdrowska, Justyna
Towpik, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/552077.pdf
Data publikacji:
2018
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
primary health care
diabetes mellitus
pre-diabetic state
primary prevention.
Źródło:
Family Medicine & Primary Care Review; 2018, 4; 313-319
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The association between ALR2 -106C > T gene polymorphisms and diabetic retinopathy susceptibility in diabetes mellitus patient: a systematic review and meta-analysis
Autorzy:
Putri, Indah Sagitaisna
Rezkita, Bastomy Eka
Irving, Steven
Azmiardi, Akhmad
Powiązania:
https://bibliotekanauki.pl/articles/4175390.pdf
Data publikacji:
2023-03-27
Wydawca:
Medical Education
Tematy:
ALR2 gene
diabetic retinopathy
diabetes mellitus
gene polymorphism
polyol pathway
Opis:
Aldose reductase gene polymorphisms has been indicated to be associated with diabetic retinopathy (DR). The research data were from PubMed and EMBASE. We identified -106C > T single nucleotide polymorphism (SNP). Pool odds ratio (OR) with 95% CI were calculated. Nine studies were included. ALR2 106C > T gene polymorphisms was associated with the increased risk of DR in T1DM (C vs. T, OR = 2.07, p = 0.001; CC vs. CT + TT, OR = 2.56, p = 0.005). T allele and TT genotype were associated with decreased risk of DR in T1DM (OR = 0.48, p = 0.0001 and OR = 0.12, p = 0.0005). In conclusion, C allele and CC genotype may be a risk factor, while T allele and TT genotype may serve as protective factor for DR in T1DM patient.
Źródło:
OphthaTherapy; 2023, 10, 1; 12-21
2353-7175
2543-9987
Pojawia się w:
OphthaTherapy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of diabetes on the connective tissue and the bone-joint system
Autorzy:
Chwalba, Artur
Otto-Buczkowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454871.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
diabetes mellitus
diabetic osteopathy
limited joint mobility
joint disorders
Opis:
Introduction. Diabetes is associated with a number of complications, including renal disease, peripheral neuropathy, retinopathy, and vascular events. Aim. Article presents the research results reported in the scientific literature about the influence of diabetes on connective tissue and the bone-joint system. Material and methods. Analysis of literature. Conclusion. Due to its multi-systemic nature, the development of additional manifestations, such as musculoskeletal complications, is possible including, for example diabetic osteopathy, limited joint mobility, joint disorders, and other, many of which are subclinical and correlated with the disease duration and its inadequate control. They should be recognized and treated properly, because their management improves the patients’ quality of life.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 3; 233-238
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The utility of nerve conduction studies in patients with diabetic polyneuropathy
Autorzy:
Banach, Marta
Powiązania:
https://bibliotekanauki.pl/articles/552713.pdf
Data publikacji:
2015
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
type 2 diabetes mellitus
nerve conduction studies
diabetic polyneuropathy
Źródło:
Family Medicine & Primary Care Review; 2015, 3; 171-174
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-13 z 13

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