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Tytuł:
Effectiveness of electrical stimulation and low-intensity laser therapy on diabetic neuropathy: A systematic review
Autorzy:
Adehunoluwa, Emmanuel A.
Adesina, Miracle A.
Adeulure, Taiwo G.
Akinfolarin, Yemi T.
Babatunde, Kazeem O.
Efunniyi, Adenike O.
Mamud, Olusola S.
Oyejola, Oluwatimilehin G.
Tiamiyu, Oluwaleke M.
Olajire, Tolulope I.
Powiązania:
https://bibliotekanauki.pl/articles/1077040.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Diabetes mellitus
diabetic neuropathy
electric stimulation
laser therapy
Opis:
Diabetes mellitus (DM) is a group of metabolic diseases which typically presents with frequent urination, increased thirst and increased hunger. DM be classified into three main types: type I (insulin-dependent DM), type-II (non-insulin dependent DM) and type III (gestational DM). Diabetes is a group of diseases of global health significance as 382 million people worldwide had diabetes in the year 2013 and this was projected to increase to an estimated 415 million in 2015. Damage to the nerves of the body (diabetic neuropathy) is the most common complication of diabetes. The signs and symptoms of diabetic neuropathy include numbness, diminished sensation, pain etc. Various types of electrotherapy, such as transcutaneous electrical nerve stimulation (TENS), pulsed-dose electrical stimulation, frequency-modulated electromagnetic neural stimulation, have been reported effective in managing diabetic neuropathy. This study is a systematic review of the evidence to enable the determination of the effectiveness of electrical stimulation and low-intensity laser therapy (LILT), and also aid their recommendation if proven to be effective. The outcome of this study was that TENS and other forms of electrical stimulation reviewed in this study may be effective and safe non-pharmacological treatment modalities in relieving the symptoms associated with diabetic neuropathy. The effectiveness of LILT couldn’t be determined due to the different parameters used to evaluate patients’ outcome and limited number of studies. Authors recommend that further randomized controlled trials with similar methodological parameters and studies with higher quality of evidences are needed to establish the true effectiveness of these modalities in diabetic neuropathy.
Źródło:
World News of Natural Sciences; 2019, 23; 110-127
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of neutrophil phagocytic, complement functions, and cytokines expression among diabetic patients in Abuja, Nigeria
Autorzy:
Babandina, Musa Muhammad
Mainasara, Abdullahi Suleiman
Bakare, Mustapha
Emeribe, Anthony Uchenna
Shuwa, Halima Ali
Haruna, Shamsuddeen
Muhammad, Aminu Said
Abdullahi, Idris Nasir
Powiązania:
https://bibliotekanauki.pl/articles/454973.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
diabetes mellitus
effector molecules
pro-inflammatory markers
Opis:
Introduction. Inflammatory response in Diabetes Mellitus (DM) begins with chronic sub-clinical inflammations as a result of insulin resistance and activation of both innate and adaptive immune system as the disease progresses to complicated diabetes. Hence, the present study investigated the neutrophil phagocytic, complement function (CH50), and some cytokine profiles among diabetic and non-diabetic patients attending the National Hospital in Abuja, Nigeria. Aim. To evaluate the neutrophil phagocytic, complement function (CH50), and some cytokine profiles among post-operative septic diabetic and post-operative septic non-diabetic patients at the National Hospital in Abuja, Nigeria. Material and methods. Subjects were recruited by convenient sampling technique through interviewer-administered questionnaires. Subsequently, blood samples were collected. Fasting blood sugar (FBS) (mmol/L) was determined using glucose oxidase method. Neutrophil function test (Fmol/phag) was assayed using nitroblue tetrazolium reduction test (NBT). Hemolytic complement function (CH 50) test was conducted using serum harvested from sheep sensitized with human group (ORh D +ve) red blood cells. While serum Interleukin-4, -6, -10 and TNF- α were determined using Enzyme Linked Immunosorbent Assay (ELISA). Results. Mean ± Standard deviation (SD) of FBS concentration of 10.5 ± 1.3 (mmol/|L) among diabetic and 4.7 ± 0.9 (mmol/L) among non-diabetics was recorded. There is a decrease in neutrophil phagocytic function with a mean ± SD of 5.4 ± 2.1 (Fmol/ phag) in diabetics compared to 9.2 ± 2.1 (Fmol/phag) in non-diabetics. Similarly, complement (CH 50) function and C-reactive protein were significantly lower in diabetics when compared to non-diabetics (p<0.001). There was a significant difference in IL-6 concentration between diabetics and non-diabetics groups, but no significant difference was observed in TNF-α, IL-4 and IL-10 concentrations between study groups (p>0.05). TNF-α and IL-6 was significantly higher in diabetics with cardiovascular disorders compared to non-diabetics subjects with cardiovascular disorders (p<0.001). Conclusion. Findings from this study revealed the association of complement, neutrophil phagocytic function, CRP and IL-6 among septic diabetic patients,. In addition TNF-α and IL-6 expression was higher in DM patients with cardiovascular disorders.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 229-235
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przezskórne interwencje wieńcowe u pacjentów chorych na cukrzycę typu 2. Stenty uwalniające leki antyproliferacyjne a problem restenozy
Percutaneous coronary interventions in patients with type 2 diabetes. Drug eluting stents and restenosis problems
Autorzy:
Bachórzewska-Gajewska, H.
Sudnik, U.
Dobrzycki, S.
Powiązania:
https://bibliotekanauki.pl/articles/261252.pdf
Data publikacji:
2009
Wydawca:
Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
Tematy:
stenty uwalniające leki
restenoza
cukrzyca
drug eluting stents
restenosis
diabetes mellitus
Opis:
Na świecie notuje się coraz więcej zachorowań na cukrzycę, której częstym następstwem jest choroba wieńcowo-naczyniowa. Wyniki przezskórnej interwencji wieńcowej (PCI), a także operacji pomostowania aortalno-wieńcowego (CABG) u pacjentów chorych na cukrzycę typu 2 są w tym przypadku mniej korzystne. Implementacja stentów wieńcowych uwalniających leki pozwoliła poprawić efekty kliniczne, głównie dzięki zminimalizowaniu stopnia restenozy. Celem pracy jest podsumowanie aktualnego stanu wiedzy, dotyczącego efektywności oraz bezpieczeństwa stosowania stentów uwalniających leki antyproliferacyjne u pacjentów chorych na cukrzycę typu 2.
Cardiovascular disease is a major consequence of this chronic condition. Outcomes after percutaneous coronary interventions (PCI) and coronary artery bypass grafting (CABG) are worse in patients with diabetes mellitus (DM) compared with those without DM. Drugs eluting stents implantation has improved the clinical outcomes of diabetic patients, especially the reduction of restenosis rate. The purpose of this review is to summarize the current achievements relating to the effectiveness and safety of drug eluting stents in diabetic patients.
Źródło:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2009, 15, 3; 265-272
1234-5563
Pojawia się w:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The utility of nerve conduction studies in patients with diabetic polyneuropathy
Autorzy:
Banach, Marta
Powiązania:
https://bibliotekanauki.pl/articles/552713.pdf
Data publikacji:
2015
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
type 2 diabetes mellitus
nerve conduction studies
diabetic polyneuropathy
Źródło:
Family Medicine & Primary Care Review; 2015, 3; 171-174
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Endocrine disorders in patients with hereditary hemochromatosis
Autorzy:
Banaszkiewicz, Katarzyna
Sikorska, Katarzyna
Sworczak, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/895739.pdf
Data publikacji:
2019-02-05
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
Diabetes Mellitus
Osteoporosis
endocrinology
iron overload
hemochromatosis
Opis:
Hereditary hemochromatosis (HH) is a rare genetic disorder, developing secondary to the accumulation of iron in tissues, which may lead to multiple organ failure. If untreated, it may result in liver cirrhosis or cardiomyopathy. The damage to the pancreas and the anterior pituitary, on the other hand, leads to a decreased production and secretion of hormones that are essential to life. Common symptoms of HH, that are distressing for patients, include joint pain, particularly involving hands and wrists, as well as the chronic fatigue syndrome. Iron overload affects the skeletal system, leading to osteoporosis. The pathological accumulation of iron in the anterior pituitary impairs the gonadotropin synthesis, resulting in reduced serum levels of testosterone in men and estrogens in women. This, however, contributes to lower bone mass. In vivo tests have also revealed that abnormal iron accumulation is related to an increased activity and number of osteoclasts, as well as the influence on the differentiation and activity of osteoblast-lineage cells. Based on a systematic review of literature, hereditary hemochromatosis (HH) will be presented as a chronic disease, affecting most of the endocrine glands.
Źródło:
European Journal of Translational and Clinical Medicine; 2018, 1, 2; 72-76
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Death due to rare rhinocerebral mucormycosis infection: a case report
Autorzy:
Baral, T.
Mugada, V.
Kolakota, R.K.
Powiązania:
https://bibliotekanauki.pl/articles/2088062.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Opolski. Instytut Nauk o Zdrowiu
Tematy:
Mucormycosis
Diabetes mellitus
Orbital cellulitis
amphotericin B
Opis:
Background: Rhinocerebral mucormycosis is the most common form of mucormycosis in patients with diabetes mellitus; it is linked to poor prognosis, presenting most commonly in an acute setting, mimicking symptoms of sinusitis or periorbital cellulitis. The general survival rate in chronic cases is 83%, compared to 10–35% in acute. Aim of the study: To report a death due to rhinocerebral mucormycosis in a 45-year-old male patient. Case report: In this case report a 45-year-old male presented with acute rhinocerebral mucormycosis and was admitted in a state of unconsciousness with complaints of sudden onset weakness of right upper and lower limb, motor aphasia, right facial swelling, orbital swelling, and diminished distant vision. Upon primary diagnosis of stroke, treatment started immediately. However, past medical history from patient’s attendants revealed that the patient underwent a tooth extraction procedure 20 days prior, and had since developed redness of the right eye, diminished distant vision, and swelling of the right side of the face. Pus was drained, and reports revealed orbital cellulitis with an intracranial spread. By the time of admission to hospital, the patient had abnormal lab profiles (WBC, ESR, serum creatinine), acute kidney injury, with MRI revealing rhinocerebral mucormycosis. The patient developed septic shock and died during treatment. Conclusions: Acute mucormycosis carries a high mortality rate. Pleiotropic manifestations and organ dysfunction add to the further risk of mortality. Timely diagnosis and management may increase the chances of the survival rate of the patient.
Źródło:
Medical Science Pulse; 2019, 13, 4; 40-43
2544-1558
2544-1620
Pojawia się w:
Medical Science Pulse
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of dietary-induced obesity on lipid peroxidation, antioxidant enzymes and total plasma antioxidant capacity
Autorzy:
Beltowski, J.
Wojcicka, G.
Gorny, D.
Marciniak, A.
Powiązania:
https://bibliotekanauki.pl/articles/70421.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
diabetes mellitus
hyperlipidemia
oxidative stress
arterial hypertension
free radical
antioxidative enzyme
obesity
lipid peroxidation
atherosclerosis
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 4,2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Free radical scavengers can modulate the DNA-damaging action of alloxan.
Autorzy:
Blasiak, Janusz
Sikora, Agnieszka
Czechowska, Agnieszka
Drzewoski, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1043667.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
vitamin C
spin trapping
free radicals
alloxan
vitamin E
DNA damage
ebselen
comet assay
DNA repair
diabetes mellitus
Opis:
Alloxan can generate diabetes in experimental animals and its action can be associated with the production of free radicals. It is therefore important to check how different substances often referred to as free radical scavengers may interact with alloxan, especially that some of these substance may show both pro- and antioxidant activities. Using the alkaline comet assay we showed that alloxan at concentrations 0.01-50 μM induced DNA damage in normal human lymphocytes in a dose-dependent manner. Treated cells were able to recover within a 120-min incubation. Vitamins C and E at 10 and 50 μM diminished the extent of DNA damage induced by 50 μM alloxan. Pre-treatment of the lymphocytes with a nitrone spin trap, α-(4-pyridil-1-oxide)- N-t-butylnitrone (POBN) or ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), which mimics glutathione peroxides, reduced the alloxan-evoked DNA damage. The cells exposed to alloxan and treated with formamidopyrimidine-DNA glycosylase (Fpg) and 3-methyladenine-DNA glycosylase II (AlkA), enzymes recognizing oxidized and alkylated bases, respectively, displayed greater extent of DNA damage than those not treated with these enzymes. The results confirmed that free radicals are involved in the formation of DNA lesions induced by alloxan. The results also suggest that alloxan can generate oxidized DNA bases with a preference for purines and contribute to their alkylation.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 205-210
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of diabetes-related complications and the cost of diabetes in Poland. The methodology and the research sample used in Economedica DM-PL Survey
Autorzy:
Bogusławski, Stefan
Wojciechowska, Agata
Smaga, Anna
Strojek, Krzysztof
Wróbel, Katarzyna
Wojtyniak, Bogdan
Juszczyk, Grzegorz
Czech, Marcin
Zdrojewski, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/2203241.pdf
Data publikacji:
2023-06-07
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
diabetes mellitus
prevalence
cost of illness
research design
Opis:
Background: Knowledge about diabetes mellitus (DM)-related complications, the direct and indirect costs incur red by patients with DM is still insufficient in Poland. Economedica DM-PL (Economedica) survey was a cross-sectional observational study that aimed to assess these issues. Material and methods: The survey was carried out in 2016 on a representative sample of 2032 diabetic patients recruited by 195 general practioners (GP) and 48 diabetologists (D) randomly selected from the national registry of physicians. Each GP and D recruited 8 to 10 patients with DM according to the specified protocol. The study included 1938 medical questionnaires (comple ted by the GPs and Ds), 1938 questionnaires about costs (completed by the patients) and 1532 treatment adherence questionnaires. Results: The Economedica survey provided new insights into DM epidemiological and cost data. 70% of patients with type-1 DM were diagnosed with the disease before the age of 40. For 76% patients with type-2 DM, it was diagnosed aeftr the age of 50. The average monthly out-of-pocket medical costs for DM patients in 2016 reached 66.2 EUR, while their non-medical costs were 36.8 EUR. Conclusions: The methodology applied in our study proved useful for providing new dimensions of DM epidemiological and cost data in Poland.
Źródło:
European Journal of Translational and Clinical Medicine; 2023, 6, 1; 31-40
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative analysis of socioeconomic, behavioral and biological factors between healthy patients and patients with newly diagnosed diabetes in the Lubuskie Voivodeship
Autorzy:
Bonikowska, I.
Jasik-Pyzdrowska, J.
Szwamel, K.
Powiązania:
https://bibliotekanauki.pl/articles/2087637.pdf
Data publikacji:
2020
Wydawca:
Uniwersytet Opolski. Instytut Nauk o Zdrowiu
Tematy:
patients
type 2 diabetes mellitus
prediabetic state
Opis:
Background: The most effective way to prevent an increasing diabetic population lies in early detection of risk factors and diagnosis of carbohydrate metabolism disorders. Aim of the study: The study aimed at determining socio-economic variables, lifestyle behaviours and biological factors differentiating patients with newly diagnosed diabetes from diabetes-free individuals. Material and methods: Assessment of diabetic vs. non-diabetic individuals was performed according to the American criteria issued by the Commission on Social Determinants of Health as well as the FINDRISC form, which helps identify patients who are at risk of developing type 2 diabetes on the basis of multi-factorial determinants of its development. The research was conducted in 2018 among 1167 primary health care patients from Lubuskie Voivodeship using a diagnostic survey method which interviewed the respondents according to the FINDRISC standard questionnaire. Results: The group of healthy patients was similar to the group of patients with newly diagnosed diabetes with respect to variables such as age (p=0.713), sex (p=1), place of residence (p=1), level of education (p=0.076), professional activity (p=0.758), BMI (p=0.133), waist measurement (p=0.665), frequency of fruit and vegetables intake (p=0.572), frequency of taking hypotensive medications (p=0.176), frequency of diabetes occurrence in the family history (p=0.227) and physical activity (p=0.321). Conclusions: Early detection of carbohydrate metabolism disorders, with the use of standardised tools that assess diabetes development, appears to be essential in the prevention of this disorder. Therefore, there is a strong need to create a tool adjusted to socio-demographic factors such as geographical location, economic conditions and lifestyle. Additionally, active and massive screening for carbohydrate metabolism disorders in patients with a low risk of diabetes seems to be crucial in its prevention.
Źródło:
Medical Science Pulse; 2020, 14, 3; 55-63
2544-1558
2544-1620
Pojawia się w:
Medical Science Pulse
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prevention of diabetes in primary healthcare based on the health policy program for early detection and prevention of diabetes and its complications in working individuals in the Lubusz province
Autorzy:
Bonikowska, Iwona
Jasik-Pyzdrowska, Justyna
Towpik, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/552077.pdf
Data publikacji:
2018
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
primary health care
diabetes mellitus
pre-diabetic state
primary prevention.
Źródło:
Family Medicine & Primary Care Review; 2018, 4; 313-319
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coexistence of type 1 diabetes mellitus and spinal muscular atrophy in an 8-year-old girl: a case report
Autorzy:
Borkowska, Anna
Jankowska, Agnieszka
Szlagatys-Sidorkiewicz, Agnieszka
Sztangierska, Beata
Liberek, Anna
Plata-Nazar, Katarzyna
Kamińska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1039156.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Spinal muscular atrophy
diabetes mellitus
children
Opis:
The spinal muscular atrophy is a rare autosomal recessive genetic disease characterized by the progressive loss of muscular strength. In its natural course the disease leads to death. Diabetes mellitus type 1 is an autoimmune metabolic disorder characterized by the disturbed insulin synthesis. This is a case report of an 8-year-old girl suffering from Werdnig Hoffman disease in whom DM1 was diagnosed. The unspecific clinical manifestation and diagnostic difficulties are presented in this paper. To the authors' knowledge, this is the first publication concerning the co-existence of these two medical conditions.
Źródło:
Acta Biochimica Polonica; 2015, 62, 1; 167-168
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physical activity in type 2 diabetes mellitus: a review
Autorzy:
Burooj, Ahmed
Powiązania:
https://bibliotekanauki.pl/articles/33777868.pdf
Data publikacji:
2024-04-10
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
T2DM
Exercise
Diabetes
Diabetes Mellitus
Physical Activity
Opis:
Introduction This literature review explores the role of physical activity (PA) in managing and preventing type 2 diabetes mellitus (T2DM), synthesizing the latest guidelines for all T2DM patients. Following PRISMA guidelines, it identifies specific areas for further research. Material and Methods Indexing services (PubMed and Scopus) were used to identify relevant studies, emphasizing original research, review articles, and updated institutional guidelines spanning 2017-2023. The following keywords were used: diabetes, physical activity, type 2 diabetes mellitus, PA, and exercise. Proposal and opinion articles, non-English papers (or those lacking full-text translation), studies involving non-human subjects, pediatric populations or with skewed gender distribution were excluded. Results PA improves quality of life, BMI, glycemic control and well-being. Effects vary by activity domain, such as work or leisure time. Recommendations suggest 60 daily minutes of exercise for children, 150 weekly minutes of moderate intensity exercise for adults, and screening for adverse events. A “sit-less” approach is proposed for those unable to maintain regular activity, with glycemic monitoring for those with variability. Conclusions PA is crucial in T2DM management. Conflicting findings regarding glycemic control warrant further investigation to ascertain causes, whether related to bias or other factors.
Źródło:
European Journal of Translational and Clinical Medicine; 2024, 7, 1; 97-105
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of acetylsalicylic acid and circulating microRNAs in primary prevention of cardiovascular events in patients with Diabetes Mellitus Type 2 - a review
Autorzy:
Chabior, A.
Pordzik, J.
Mirowska-Guzel, D.
Postuła, M.
Powiązania:
https://bibliotekanauki.pl/articles/2085138.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
diabetes mellitus
primary prevention
platelets
acetylsalicylic acid
microRNA
Opis:
Introduction. Type 2 diabetes mellitus (T2DM) is a common metabolic disorder, which carries a risk for atherosclerosis and cardiovascular impairment. The purpose of this review is to demonstrate the role of acetylsalicylic acid (ASA) in primary cardiovascular prevention in T2DM patients, as well as present an outline of microRNAs (miRNA) relevant to ASA therapy and should be evaluated as targets to improve treatment. Brief description of state of knowledge. Although the etiology of hypercoagulable state in T2DM is considered multifactorial, attention mainly focuses on platelet disturbances. Platelets in T2DM not only demonstrate intensified adhesion, activation, aggregation, and thrombin generation, but are likely to deliver miRNAs at specific sites of action in the cardiovascular system, hence contributing to the pathogenesis of cardiovascular events. Objective. Since cardiovascular disease (CVD) is currently the leading cause of mortality among T2DM patients, appropriate risk stratification and management is necessary to reduce morbidity and mortality in this group. A large number of T2DM patients show inadequate response to antiplatelet therapy, which currently revolves around ASA, despite compliance with treatment regimens proposed by the guidelines. Conclusions. The review shows that the use of ASA for primary prevention is beneficial in patients at high cardiovascular risk. However, it is important to select patients in whom ASA therapy will bring the most beneficial outcome with minimal risk for adverse effects. This can be potentially achieved with the use of unique biomarkers. The biologically diverse characteristics of miRNA make them a promising novel biomarker and potential tool for better risk stratification, as well as antiplatelet therapy optimization.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 4; 515-522
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Macrophages in Diabetes Mellitus: A Review on Understanding of Macrophage Function
Autorzy:
Chatterjee, Susraba
Guria, Srikanta
Powiązania:
https://bibliotekanauki.pl/articles/1059398.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Alloxan
Beta-cell Therapy
Cytokines
Diabetes mellitus
Diabetic Nephropathy
Diabetic Retinopathy
Macrophage
Macrophage Type 1
Macrophage Type 2
Streptozotocin
Opis:
Diabetes mellitus (DM) causes millions of deaths all over the world. Immune system contains macrophages that play very important role in DM. Excessive secretion of different cytokines can induce the DM development. Diabetes mellitus (DM) also affect the function of macrophage. We review the important findings regarding the role of macrophage in DM. This review may emphasize future direction towards development of novel immune-modulatory therapeutic intervention.
Źródło:
World Scientific News; 2019, 134, 2; 319-325
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
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