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    Tytuł:
    The severity of depressive and anxiety symptoms in postmenopausal women depending on their Magnesium, Zinc, Selenium and Copper levels
    Autorzy:
    Wieder-Huszla, S.
    Zabielska, P.
    Kotwas, A.
    Owsianowska, J.
    Karakiewicz-Krawczyk, K.
    Kowalczyk, R.
    Jurczak, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1192499.pdf
    Data publikacji:
    2020
    Wydawca:
    Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
    Tematy:
    depressive disorder
    postmenopause
    micronutrients
    Opis:
    Women, especially in the peri- and postmenopausal periods, undergo many organic and functional changes. Fluctuation and ultimately a decline in the levels of female reproductive hormones is a long-lasting process, potentially leading to regulatory disorders of the autonomic nervous system. In consequence, postmenopausal women experience depressive mood disorders and more severe anxiety symptoms. The aim of this study was to assess the severity of anxiety and depressive symptoms in postmenopausal women in connection with the serum levels of zinc (Zn), magnesium (Mg), selenium (Se), and copper (Cu). The study involved 102 healthy postmenopausal women. It was divided into two parts: the first part was based on a survey performed using standardized research instruments and a questionnaire developed by the authors. The second part involved a biochemical serum analysis, whose aim was to determine the levels of selected elements. The mean level of anxiety as a state was 4.53±1.79, and the mean level of anxiety as a trait was 3.86±2.03. The mean level of depression according to the Beck Depression Inventory was 6.77±6.82. As many as 77.5% of the women had no depressive symptoms. The mean serum levels of the studied elements were as follows: magnesium (19.41±02.81 mg dm-3), zinc (0.94±0.22 mg dm-3), selenium (0.06±0.03 mg dm-3), and copper (0.40±0.57 mg dm-3). No relationship was demonstrated between the levels of selected elements and the development of depressive and anxiety disorders in the studied postmenopausal women.
    Źródło:
    Journal of Elementology; 2020, 25, 4; 1305-1317
    1644-2296
    Pojawia się w:
    Journal of Elementology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mental well-being of healthcare workers in 2 hospital districts during the first wave of the COVID-19 pandemic in Finland: a cross-sectional study
    Autorzy:
    Rantanen, Noora
    Lieslehto, Johannes
    Oksanen, Lotta-Maria A.
    Oksanen, Sampo A.
    Anttila, Veli-Jukka
    Lehtonen, Lasse
    Geneid, Ahmed
    Sanmark, Enni
    Powiązania:
    https://bibliotekanauki.pl/articles/2152977.pdf
    Data publikacji:
    2022
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    major depressive disorder
    workload
    post-traumatic stress disorder
    COVID-19
    mental health
    health personnel
    Opis:
    Objectives The COVID-19 pandemic has caused unseen pressure on healthcare systems in many countries, jeopardizing the mental well-being of healthcare workers. The authors aimed to assess the mental well-being of Finnish healthcare workers from 2 hospital districts (Helsinki University Hospital [HUS] and Social and Health Services in Kymenlaakso [Kymsote]) with differing COVID-19 incidence rates during the first wave of the COVID-19 pandemic in spring 2020. Material and Methods A total number of 996 healthcare workers (HUS N = 862, Kymsote N = 134) participated in this prospectively conducted survey study during summer 2020. Symptom criteria of self-reported mental health symptoms followed ICD-10 classification, excluding duration criteria. Participants were divided into symptom categories “often/sometimes”, and “rarely/never”. These groups were compared to sociodemographic factors and factors related to work, workload, and well-being. Results The degree of mental health symptoms did not differ between the 2 healthcare districts despite differing COVID-19 incidences (p = 1). The authors observed a significant relationship between self-reported diagnostic mental health symptoms and experiences of insufficient instructions for protection against COVID-19 (in HUS cohort p < 0.001), insufficient recovery from work (p < 0.001), and subjective increased workload (p < 0.001). Conclusions The authors’ results show the importance of well-planned and sufficient instructions for protection from SARS-CoV-2 for healthcare workers, indicating their need to feel safe and protected at work. The workload of healthcare workers should be carefully monitored to keep it moderate and ensure sufficient recovery. Sufficient control of the epidemic to keep the burden of the healthcare system low is vital for healthcare workers’ well-being.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2022, 35, 6; 707-718
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zaburzenia depresyjne wśród studentek i studentów w Polsce
    Depressive Disorders Amog Students in Poland
    Autorzy:
    Karmolińska-Jagodzik, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/916340.pdf
    Data publikacji:
    2019-12-15
    Wydawca:
    Uniwersytet im. Adama Mickiewicza w Poznaniu
    Tematy:
    depressive disorder
    students
    Beck’s test
    Opis:
    This article describes depressive disorders among contemporary students in Poland. The researchresults analyses data obtained in the national survey in 2019 on a group of 4,500 full-time and extramuralstudents2. The selection of the research sample was consistent with a random selection. Theresearch was carried out in a research team (Prof. dr hab. A. Cybal – Michalska, Prof. UAM, dr hab.S. Jaskulska, Prof. UAM, dr hab. N. Walter, Dr. M. Marciniak, Dr. E. Karmolińska – Jagodzik) underthe guidance of prof. UAM, dr hab. Jacek Pyżalski under the grant implemented for the State Agencyfor Solving Alcohol Problems. Issues related to depression were within the scope of my analysis. Thisarticle includes a description of the causes of depression and the theoretical disorder itself. In addition,it article provides an analysis of the test results using the Beck test in individual subscales for studentsin Poland. The article is a diagnostic approach to the student community in Poland in the scope of thephenomenon discussed.
    Źródło:
    Studia Edukacyjne; 2019, 55; 139-162
    1233-6688
    Pojawia się w:
    Studia Edukacyjne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of Pb and Cd levels in whole blood of postmenopausal women on the incidence of anxiety and depressive symptoms
    Autorzy:
    Jurczak, A.
    Brodowska, A.
    Szkup, M.
    Prokopowicz, A.
    Karakiewicz, B.
    Łój, B.
    Kotwas, A.
    Grochans, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/2081732.pdf
    Data publikacji:
    2018
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Pb
    Cd
    depressive disorder
    anxiety
    postmenopausal women
    Opis:
    Introduction. To-date, the influence of heavy metals such as Pb or Cd on mental functioning, and especially on the occurrence of depressive and anxiety-related disorders, has not been well understood. Objectives. 1) Assessment of Pb and Cd levels in whole blood of postmenopausal women. 2) Assessment of the severity of anxiety and depressive symptoms depending on Pb and Cd levels in whole blood of postmenopausal women. Materials and method. The survey-based study involved 198 healthy postmenopausal women from West Pomeranian province in Poland. It was performed using the Primary Care Evaluation of Mental Disorders (PRIME-MD), Beck’s Depression Inventory (BDI), and the State-Trait Anxiety Inventory (STAI). The second part of the study was based on biochemical analysis of the levels of heavy metals (Pb, Cd). Results. The mean level of Pb was 19.85 ± 8.99 μg/l and Cd 0.87±0.98 μg/l; these levels were within normal ranges. Analysis of the mean levels of Pb and Cd in whole blood of postmenopausal women in relation to the severity of depressive symptoms did not reveal statistically significant differences. Correlation analysis demonstrated a statistically significant (p<0.05) negative correlation (-0.22) between the level of Pb and the severity of anxiety as a state. Correlations between the levels of Pb and Cd and the severity of anxiety as a trait were not statistically significant. Conclusions. The mean Pb and Cd levels in whole blood of healthy postmenopausal women did not exceed acceptable limits. The study did not confirm a relationship between the levels of selected heavy metals and the severity of anxiety and depressive symptoms in healthy women. However, there was a relationship between the level of Pb and the severity of anxiety as a state.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2018, 25, 2; 219-223
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Psychosocial conditioning of depressive disorders in post-menopausal women
    Autorzy:
    Humeniuk, E.
    Bojar, I.
    Owoc, A.
    Wojtyla, A.
    Fronczak, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/52119.pdf
    Data publikacji:
    2011
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    psychosocial conditioning
    depressive disorder
    woman
    postmenopausal woman
    rural area
    depression
    human disease
    urban area
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2011, 18, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    INCREASED LEVELS OF INTERLEUKIN-10 EXPRESSION COMPARED TO INTERLEUKIN-6 IN LEUKOCYTES OF HEALTHY SUBJECTS. COULD IT BE USEFUL IN THE FUTURE OF THE DEPRESSION DIAGNOSIS?
    Autorzy:
    Grzybkowska, Agata
    Anczykowska, Katarzyna
    Pyczek, Joanna M
    Żychowska, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/2137747.pdf
    Data publikacji:
    2018-09-17
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    depressive disorder
    gene expression
    inflammation
    physical activity
    peripheral blood mononuclear cells
    Opis:
    It is a well known, that the physical activity promotes mental health. Physically active people relatively rarely suffer from psychosomatic and depressive disorders. It is possible that the differences in gene activity in peripheral blood leukocytes may be associated with depression, especially genes participating in inflammatory response. Thus, the aim of our study was to investigate the levels of IL6 and IL10 mRNA and IL10/IL6 ratio in peripheral blood leukocytes in healthy, physically active individuals. One hundred healthy young men (20-23 years old) participated in this study. All of them declared regular physical activity. Participants were non-smokers, and consumed alcohol occasionally. To access genes expression, 2 ml of venous blood was collected. RNA isolation was performed and then the relative expression of IL6 and IL10 was calculated using quantitative real-time polymerase chain reaction (Q-RT-PCR). Pro and anti-inflammatory balance was calculated as 2^relative of IL10/ 2^relative expression of IL6. Low expression of tested genes was found in healthy young men. Mean expression for IL6 was 2^0.051 (n=90) and for IL10 2^0.08 (n=98). Mean ratio IL10/IL6 was 2^1.58. Higher expression of IL10 compared to IL6 may be essential not only for the physical performance but also for the mental health. Diverse reports in the literature may be associated with choosing various control groups, i.e. sedentary or older individuals. It is possible, that measuring the expression of IL6 and IL10 (especially the ratio IL10/IL6) in peripheral blood leukocytes may be useful in the assessment of depressive disorders. Thus, molecular study of active young men can confirm the need for physical activity among people suffering from depression, but further studies are needed, particularly among people with psychosomatic disorders.
    Źródło:
    Acta Neuropsychologica; 2018, 16(3); 243-248
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Związek między pięcioma formami krzywdzenia dzieci a zaburzeniami depresyjnymi i lękowymi: przegląd systematyczny i metaanaliza
    THE A SSOCIATION BETWEEN FIVE FORMS OF CHILD MALTREATMENT AND DEPRESSIVE AND ANXIETY DISORDERS: A SYSTEMATIC REVIEW AND META-ANALYSIS
    Autorzy:
    Gardner, M. J.
    Thomas, H. J.
    Erskine, H. E.
    Powiązania:
    https://bibliotekanauki.pl/articles/499216.pdf
    Data publikacji:
    2019
    Wydawca:
    Fundacja Dajemy Dzieciom Siłę
    Tematy:
    krzywdzenie dzieci
    przemoc wobec dzieci
    zaburzenia depresyjne
    zaburzenia lękowe zespołu stresu pourazowego
    wyniki
    child maltreatment
    child abuse
    depressive disorders
    anxiety disorders posttraumatic stress disorder
    outcomes
    Opis:
    Kontekst: Krzywdzenie dzieci to globalny problem zdrowia publicznego, który obejmuje przemoc fizyczną, seksualną, emocjonalną, zaniedbanie i bycie świadkiem przemocy domowej. Niniejszy przegląd systematyczny i metaanaliza podsumowuje związek między tymi pięcioma formami krzywdzenia dzieci a zaburzeniami depresyjnymi i lękowymi. Metodologia: W analizie uwzględniono opublikowane badania kohortowe i badania kliniczno-kontrolne, w których zaobserwowano związek między jakąkolwiek formą krzywdzenia dzieci (lub ich połączenie) a zaburzeniami depresyjnymi i lękowymi. Łącznie pod względem kwalifikowalności oceniono 604 badań, z których 106 spełniło kryteria włączenia, a 96 uwzględniono w metaanalizach. Dane zebrano w metaanalizach efektów losowych, podając iloraz szans (OR) z odpowiadającymi 95% przedziałami ufności (CI) dla każdej formy krzywdzenia dziecka. Wyniki: Wszystkie formy krzywdzenia dzieci były związane z zaburzeniami depresyjnymi („jakiekolwiek krzywdzenie dziecka” [OR = 2,48, 2,14–2,87]; wykorzystywanie seksualne [OR = 2,11, 1,83–2,44]; przemoc fizyczna [OR = 1,78, 1,57–2,01]; przemoc emocjonalna [OR = 2,35; 1,74–3,18]; zaniedbanie [OR = 1,65; 1,35–2,02]; oraz bycie świadkiem przemocy domowej [OR = 1,68; 1,34–2,10]). Niektóre formy krzywdzenia dzieci były istotnie związane z zaburzeniami lękowymi („jakiekolwiek krzywdzenie dziecka” [OR = 1,68, 1,33–2,4]; wykorzystywanie seksualne [OR = 1,90, 1,6–2,25]; przemoc fizyczna [OR = 1,56, 1,39–1,76] i zaniedbanie [OR = 1,34, 1,09–1,65]). Istotne statystycznie związki stwierdzono również między kilkoma formami krzywdzenia dzieci a zespołem stresu pourazowego. Wnioski: Istnieje silny związek między pięcioma formami krzywdzenia dzieci a rozwojem zaburzeń psychicznych. Badanie Global Burden of Disease Study (GBD) obejmuje jedynie wykorzystywanie seksualne jako czynnik ryzyka zaburzeń depresyjnych i lękowych. Te ustalenia badawcze wspierają włączenie dodatkowych form krzywdzenia dzieci jako czynników ryzyka w GBD.
    Background: Child maltreatment is a global public health issue that encompasses physical abuse, sexual abuse, emotional abuse, neglect, and exposure to intimate partner violence (IPV). This systematic review and meta-analysis summarises the association between these five forms of child maltreatment and depressive and anxiety disorders. Methods: Published cohort and case-control studies were included if they reported associations between any form of child maltreatment (and/or a combination of), and depressive and anxiety disorders. A total of 604 studies were assessed for eligibility, 106 met inclusion criteria, and 96 were included in meta-analyses. The data were pooled in random effects meta-analyses, giving odds ratios (ORs) with corresponding 95% confidence intervals (CIs) for each form of child maltreatment. Results: All forms of child maltreatment were associated with depressive disorders (any child maltreatment [OR = 2.48, 2.14–2.87]; sexual abuse [OR = 2.11, 1.83– 2.44]; physical abuse [OR = 1.78, 1.57–2.01]; emotional abuse [OR = 2.35, 1.74– 3.18]; neglect [OR = 1.65, 1.35–2.02]; and exposure to IPV [OR = 1.68, 1.34–2.10]). Several forms of child maltreatment were significantly associated with anxiety disorders (‘any child maltreatment’ [OR = 1.68, 1.33–2.4]; sexual abuse [OR = 1.90, 1.6– 2.25]; physical abuse [OR = 1.56, 1.39–1.76]; and neglect [OR = 1.34, 1.09–1.65]). Significant associations were also found between several forms of child maltreatment and post-traumatic stress disorder (PTSD). Conclusions: There is a robust association between five forms of child maltreatment and the development of mental disorders. The Global Burden of Disease Study (GBD)
    Źródło:
    Dziecko krzywdzone. Teoria, badania, praktyka; 2019, 18, 3; 117-156
    1644-6526
    Pojawia się w:
    Dziecko krzywdzone. Teoria, badania, praktyka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Association of the DIO2 gene single nucleotide polymorphisms with recurrent depressive disorder
    Autorzy:
    Gałecka, Elżbieta
    Talarowska, Monika
    Orzechowska, Agata
    Górski, Paweł
    Bieńkiewicz, Małgorzata
    Szemraj, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1039107.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    depressive disorder
    iodothyronine deiodinase type II
    polymorphism
    haplotype
    Opis:
    Genetic factors may play a role in the etiology of depressive disorder. The type 2 iodothyronine deiodinase gene (DIO2) encoding the enzyme catalyzing the conversion of T4 to T3 is suggested to play a role in the recurrent depressive disorder (rDD). The current study investigates whether a specific single nucleotide polymorphism (SNP) of the DIO2 gene, Thr92Ala (T/C); rs 225014 or ORFa-Gly3Asp (C/T); rs 12885300, correlate with the risk for recurrent depression. Genotypes for these two single nucleotide polymorphisms (SNPs) were determined in 179 patients meeting the ICD-10 criteria for rDD group and in 152 healthy individuals (control group) using a polymerase chain reaction (PCR) based method. The specific variant of the DIO2 gene, namely the CC genotype of the Thr92Ala polymorphism, was more frequently found in healthy subjects than in patients with depression, what suggests that it could potentially serve as a marker of a lower risk for recurrent depressive disorder. The distribution of four haplotypes was also significantly different between the two study groups with the TC (Thr-Gly) haplotype more frequently detected in patients with depression. In conclusion, data generated from this study suggest for the first time that DIO2 gene may play a role in the etiology of the disease, and thus should be further investigated.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 2; 297-302
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zaburzenia psychiczne w stwardnieniu rozsianym
    Psychiatric disorders in multiple sclerosis
    Autorzy:
    Florkowski, Antoni
    Chmielewski, Henryk
    Gałecki, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1058494.pdf
    Data publikacji:
    2009
    Wydawca:
    Medical Communications
    Tematy:
    anxiety
    cognitive impairment
    depressive disorder
    emotional disorders
    fatigue
    multiple sclerosis
    depresja
    lęk
    zaburzenia emocjonalne
    zmęczenie
    zaburzenia funkcji poznawczych
    stwardnienie rozsiane
    Opis:
    Multiple sclerosis is chronic and progressive disorder of central nervous system, in which different psychiatric diagnosis comorbit in 75% with neurological symptoms. The reasons of depressive disorders are still not precisely known. Psychiatric disorders are often comorbid with neurological disorders and also influence diagnosis and treatment, more often than in other somatic illnesses. It is worth to emphasize that psychic disturbances are a consequence of neurological disorders but can also be primary sign of the disease. Especially emotional disorders and cognitive impairment are characteristic to patients with multiple sclerosis. Emotional, behavioural disorders and cognition dysfunction are often a result of pharmacotherapy of neurological disorders. Psychiatric disorders are often met in patients with autoimmunological disorders, what is more corticosteroid treatment may worsen the symptoms. Depressive disorders, especially serious and moderate episodes, occur twice more frequent than in general population. Following some authors patients suffering from multiple sclerosis and psychiatric disorders present deeper cognitive function impairment, poorer life quality and motor abilities as well as have worse treatment response. Although cognitive functions’ worsening occurs in half number of multiple sclerosis patients, dementia appears in few cases. Psychiatric disorders commonly comorbit with multiple sclerosis have adverse influence on everyday functioning.
    Stwardnienie rozsiane jest przewlekle postępującym schorzeniem ośrodkowego układu nerwowego, w którym dolegliwościom i objawom neurologicznym u około 75% pacjentów towarzyszą różne zaburzenia psychiczne. Do chwili obecnej nie ustalono jednoznacznie przyczyn depresji u chorych na stwardnienie rozsiane. Ponieważ zaburzenia psychiczne współistnieją w schorzeniach neurologicznych o wiele częściej niż w innych chorobach somatycznych, dosyć często wywierają wpływ na rozpoznanie i leczenie. Należy także pamiętać, że niektóre zaburzenia psychiczne mogą być powikłaniem schorzeń neurologicznych lub też stanowić objaw pierwotny choroby. Dotyczy to szczególnie zaburzeń emocjonalnych i funkcji poznawczych u chorych na stwardnienie rozsiane. Objawy dotyczące zaburzeń emocjonalnych i zachowania oraz zaburzeń funkcji poznawczych mogą być następstwem prowadzonego leczenia farmakologicznego schorzeń neurologicznych. Objawy psychiczne często występują u chorych na schorzenia autoimmunologiczne, dodatkowo stosowane u tych pacjentów leczenie kortykosteroidami może zaostrzać te objawy. Zaburzenia depresyjne, w tym epizody ciężkie i umiarkowane depresji, występują u chorych na stwardnienie rozsiane dwukrotnie częściej niż w populacji ogólnej. W ocenie niektórych autorów pacjenci ze stwardnieniem rozsianym i współwystępującymi zaburzeniami depresyjnymi wykazują głębsze upośledzenie funkcji poznawczych, prezentują gorszą jakość życia, mają większy stopień niepełnosprawności pod względem ruchowym oraz gorzej reagują na leczenie. Jakkolwiek zaburzenia funkcji poznawczych pojawiają się u połowy pacjentów chorujących na stwardnienie rozsiane, to jednak proces otępienny występuje u nielicznych osób z tym schorzeniem. Występujące dosyć powszechnie w przebiegu stwardnienia rozsianego objawy psychiczne wpływają niekorzystnie na codzienne funkcjonowanie tych chorych.
    Źródło:
    Aktualności Neurologiczne; 2009, 9, 4; 264-266
    1641-9227
    2451-0696
    Pojawia się w:
    Aktualności Neurologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Is there a link between TNF gene expression and cognitive deficits in depression?
    Autorzy:
    Bobińska, Kinga
    Gałecka, Elżbieta
    Szemraj, Janusz
    Gałecki, Piotr
    Talarowska, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/1038686.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    depressive disorder
    TNF-α
    TNFRSF1A
    TNFRSF1B
    cognitive impairment
    Opis:
    Neuroinflammation is a known factor in the pathogenesis of recurrent depressive disorders. Depression is accompanied by activated immune-inflammatory pathways including increased levels of TNFα, sTNFR1and sTNFR2.The purpose of this study was to analyse the TNF-α, TNFRSF1A and TNFRSF1B genes on both mRNA and protein levels in patients with rDD, and to investigate the relationship between TNF-α,TNFRSF1A and TNFRSF1B gene expression and cognitive performance. The study comprised 158 subjects: patients with recurrent depressive disorder (n=89) and healthy subjects (n=69). Cognitive function assessment was based on: Trail Making Test, The Stroop Test, Verbal Fluency Test and Auditory Verbal Learning Test. Both mRNA and protein expression levels of all genes were significantly higher in rDD subjects when compared to healthy controls. No statistically significant correlations were observed between the analysed variables in both the rDD group and the HS test group. The only exception was noticed in the HS test group, where increased expression of TNFRSF1A and TNFRSF1B gene negatively affected the performance of the AVLT test. However, statistically significant correlations between TNF, TNFRSF1A, TNFRSF1B mRNA gene expression levels and all the neuropsychological tests used in the survey for the entire group were observed. Conclusions: 1.The results of our study show increased expression of the TNF, TNFRSF1A and TNFRSF1B genes on both mRNA and protein levels in depression. 2. Elevated expression of TNF-α, TNFRSF1A and TNFRSF1B negatively correlates with cognitive efficiency: working memory, executive functions, attention, auditory-verbal memory, effectiveness of learning processes and verbal fluency.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 65-73
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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