Temat: deltorphin I analogues - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Synthesis and binding properties of deltorphin I analogues containing (R) and (S)-α-hydroxymethylnaphtylalanine.
Autorzy:: Olma, Aleksandra
Gniadzik, Agnieszka
Lipkowski, Andrzej
Łachwa, Magdalena
Powiązania:: https://bibliotekanauki.pl/articles/1044072.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: deltorphin I analogues
amphiphilic amino acids
α,α-disubstituted amino acids
opioid peptides
opioid receptor binding
α-hydroksymethylamino acids
Opis:: New analogues of deltorphin I (DT I), in which the phenylalanine residue in position 3 is substituted with amphiphilic α,α-disubstituted amino acid enantiomers, (R) and (S)-α-hydroxymethylnaphtylalanine, were synthesized and tested for μ and δ opioid receptor affinity and selectivity. Although both analogues have lower affinity to δ receptors than DT I, they both expressed specificity to δreceptors.
Źródło:: Acta Biochimica Polonica; 2001, 48, 4; 1165-1168
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Effect of tetrazole moiety on coordinating efficiency of deltorphin.
Autorzy:: Łodyga-Chruścińska, Elżbieta
Ołdziej, Stanisław
Micera, Giovanni
Sanna, Daniele
Chruściński, Longin
Olczak, Jacek
Zabrocki, Janusz
Powiązania:: https://bibliotekanauki.pl/articles/1043323.pdf
Data publikacji:: 2004
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Cu(II) complexes
opiod peptides
tetrazole analogues of deltorphin I
Opis:: A study of the effect of the tetrazole moiety, a cis-amide bond surrogate, on the Cu(II) coordinating properties of oligopeptides is reported. Insertion of the tetrazole moiety Ψ[CN4] into the peptide sequence of [D-Ala2]deltorphin I changes considerably the coordination ability of the peptide. Potentiometric and spectroscopic results show that if the tetrazole moiety is in a suitable position in the peptide chain, i.e. it follows the second residue, a stable CuL species involving 3N coordination is formed in the physiological pH range. The tetrazole Ψ[CN4] ring provides one of these nitrogens. The data indicate that Cu(II) ions are strongly trapped inside a bent peptide backbone. The peptide conformation changes achieved by Cu(II) coordination may be essential for the binding of tetrazole deltorphins at opiate receptors.
Źródło:: Acta Biochimica Polonica; 2004, 51, 1; 93-106
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

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