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Tytuł:
Copper and iron deficiency in dairy cattle
Autorzy:
Abramowicz, B.
Kurek, L.
Chalabis-Mazurek, A.
Lutnicki, K.
Powiązania:
https://bibliotekanauki.pl/articles/1192794.pdf
Data publikacji:
2021
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
haematology
copper and iron deficiency
dairy cows
Opis:
Copper deficiency is a common homeostatic disorder in dairy cattle farms in Poland. A simultaneous decrease in blood copper and iron concentrations is very rarely diagnosed and described in dairy cows. Copper is necessary for the mobilization of iron from the liver and its transport to bone marrow, where it is used for erythropoiesis. The aim of the study was to observe changes in haematological parameters in cows, resulting from copper deficiency or simultaneous deficiency of copper and iron, in comparison with animals from the same herds in which no deficiencies of these micronutrients were found. The study was conducted on 56 cows of the HF breed, aged from 3 to 6 years, from 3 dairy farms. The animals selected for the study were divided into three groups, two deficiency groups and one control group – without deficiency. Group I comprised animals with reduced concentration of copper in the serum, while group II comprised animals with low copper and iron concentrations. Group III comprised healthy cows without clinical symptoms and mineral deficiency. In both deficiency groups, the one characterized by a low concentration of copper, as well as the one with low concentrations of copper and iron, a reduction in red blood cell parameters, which was statistically significant versus the control group, was observed. In the examined animals, normocytic normochromic anaemia was found in group I, while normocytic hypochromic anaemia was diagnosed in group II. Cows with simultaneous Cu and Fe deficiency have worse milk yield results and they are more often culled from the herd. It is not clear why only some animals in a herd develop simultaneous deficiency of these micronutrients.
Źródło:
Journal of Elementology; 2021, 26, 1; 241-248
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determinants of vitamin D status among Jordanian employees: Focus on the night shift effect
Autorzy:
Alefishat, Eman
Abu Farha, Rana
Powiązania:
https://bibliotekanauki.pl/articles/2168364.pdf
Data publikacji:
2016-07-22
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
vitamin D
vitamin D deficiency
night shift work
Jordan
working conditions
risk assessment
Opis:
Objectives To assess the association between night work and 25-hydroxy vitamin D (25OHD) levels, and to evaluate effect of potential risk factors on 25OHD levels. Material and Methods A total of 140 adult Jordanian employees were recruited. Demographic, lifestyle and working patterns data were documented through a well-structured questionnaire. Vitamin D status was assessed by measuring circulating concentrations of 25OHD. Results Mean 25OHD level was 23.8 ng/ml. No significant difference was found in 25OHD levels between the summer and winter (p = 0.46), or between males and females (p = 0.35). The female night workers had significantly lower serum 25OHD levels compared to the female day workers (p = 0.01). No significant difference in serum 25OHD levels was found between the night and day male workers (p = 0.25). The number of night shifts/month was negatively correlated with 25OHD levels in both the males and females (p = 0.01 and p = 0.007, respectively). Age was positively correlated with 25OHD levels in both the males and females (p = 0.02 and p = 0.001, respectively). Body mass index was negatively associated with 25OHD levels in the whole sample (p = 0.03), but not within each gender group (p = 0.21 for the males and p = 0.09 for the females). Smoking had no significant association with 25OHD levels (p = 0.99 for the males and p = 0.22 for the females). Conclusions Our results suggest that women working night shifts are at higher risk of 25OHD deficiency, and, consequently, of other health problems linked to 25OHD deficiency. Int J Occup Med Environ Health 2016;29(5):859–870
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 5; 859-870
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Attention to biotinidase deficiency in children! A case report
Uwaga na niedobór biotynidazy u dzieci! Opis przypadku
Autorzy:
Alkan, Cigdem
Tan, Makbule Neslişah
Mevsim, Vildan
Powiązania:
https://bibliotekanauki.pl/articles/1034818.pdf
Data publikacji:
2018
Wydawca:
Medical Communications
Tematy:
biotinidase deficiency
newborn screening
primary care
Opis:
Biotinidase deficiency is an autosomal recessive metabolic disease that causes biotin deficiency. The exact diagnosis of the lack of biotinidase is made by demonstrating the absence of enzyme activity in the serum. Biotinidase deficiency is treated with oral biotin taken for lifetime. Early diagnosis and treatment are very important and prevent a number of complications. In this case report, a newborn baby was referred for periodic healthcare assessments to a family medicine centre, where biotinidase deficiency was diagnosed. Screening performed as part of periodic health assessment in the primary care setting is important for the detection of certain diseases, as many disease-related disabilities can be prevented with early diagnosis. In family practice, “shared decision-making,” which represents one of the elements of the patient-centred clinical method, is very effective, provided that patients and their relatives adapt to preventive healthcare.
Niedobór biotynidazy jest autosomalnym recesywnym zaburzeniem metabolicznym powodującym niedobór biotyny. Rozpoznanie niedoboru biotynidazy ustala się na podstawie braku aktywności enzymatycznej w surowicy, a jego leczenie polega na doustnym przyjmowaniu biotyny przez całe życie. Wczesne rozpoznanie i leczenie mają bardzo istotne znaczenie i pozwalają zapobiec licznym powikłaniom. W opisanym przypadku niedobór biotynidazy został rozpoznany u noworodka w ośrodku medycyny rodzinnej, gdzie został on skierowany w celu przeprowadzenia okresowej oceny stanu zdrowia. Badania przesiewowe wykonywane w ramach okresowej kontroli w placówkach podstawowej opieki zdrowotnej odgrywają ważną rolę w wykrywaniu niektórych chorób. W praktyce lekarza rodzinnego „wspólne podejmowanie decyzji”, które stanowi jeden z elementów klinicznej metody zorientowanej na pacjenta, jest skuteczne o tyle, o ile pacjenci i ich krewni potrafią dostosować się do wymogów profilaktycznej opieki zdrowotnej.
Źródło:
Pediatria i Medycyna Rodzinna; 2018, 14, 4; 428-430
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Recycling of selected fraction of municipal solid waste as artificial soil substrate in support of the circular economy
Autorzy:
Alwaeli, Mohamed
Alshawaf, Mohammad
Klasik, Marta
Powiązania:
https://bibliotekanauki.pl/articles/2232549.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
municipal solid waste
artificial soil substrates
crop production
soil deficiency
germination rate
odpady komunalne stałe
gleba
szybkość kiełkowania
produkcja roślinna
składniki gleby
sztuczna gleba
Opis:
Regions with warm climate are poor in organic matter or have a deficit of soil. The purpose of the work was to select the optimal mix from biodegradable wastes such as cardboard (Cb), natural textiles (Tx) newspaper (Np), colored newspaper (Cp), and office paper (Op) for creating artificial soil by combining these materials with compost and sand. To select the optimum mix, 15 samples were taken (3 from each type of waste in the following proportions: 25%, 50% and 75% ). The optimum mix was analyzed for grass germination rate and root development. Tests were performed in the laboratory with conditions similar to those of regions with warm climate and soil deficiency in a specially designed testing spot (bioterm). The effects of particular mixes on plant germination rate and growth were measured. Out of all mixes, the textile compositions Tx50 and Tx25 supported best the plant propagation. During the whole experimental process, the grass showed various growth tendencies. The best results for grass height were observed for mixes with textiles and colored newspaper. Based on this data and subsequent laboratory research, the best substrate composition was selected. For the whole period of the tests, germination rate in the pot with the mix was higher than the germination rate in the control sample with compost. Considering the experimental conditions of this research, the tested substrates can be used to aid in plant propagation, especially in regions with warm climate and soil deficiencies, and for restoration of damaged land areas.
Źródło:
Archives of Environmental Protection; 2022, 48, 4; 68--77
2083-4772
2083-4810
Pojawia się w:
Archives of Environmental Protection
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena zawartosci jodku potasowego w krajowej soli spozywczej
Autorzy:
Andrzejewska, E
Gajda, J.
Rokicka, B.
Jarecka, J.
Powiązania:
https://bibliotekanauki.pl/articles/871838.pdf
Data publikacji:
1993
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
zywnosc
mikroelementy
Polska
dieta
jodek potasu
niedobor jodu
sol kuchenna
normy polskie
choroby czlowieka
tarczyca
profilaktyka
woda
sol jodowana
jod
food
microelement
Polska
diet
potassium iodide
iodine deficiency
table salt
Polish standard
human disease
thyroid
prophylaxis
water
iodinated salt
iodine
Opis:
Zbadano 3418 próbek soli spożywczej, w tym 2440 próbek soli jodowanej. Odsetek próbek, w których stwierdzono właściwą zawartość jodku potasowego wynosił od 30% do 50% w zależności od producenta soli.
The purpose of the study was to assess the correctness of salt iodination and its distribution in Poland. The subject of the study was salt for human consumption iodinated or not, according to Polish norm PN-88/C-84081/02 „Sól (chlorek sodowy). Requirements. Salt samples were taken from retail shops or stores in 36 provinces. The study was carried out in the years 1992-1993 according to PN-80/C-84081.35 „Sól (chlorek sodowy) standard. Potassium iodide was determined by photo-colorimetry. The total number of studied salt samples was 3418, including 2440 samples of iodinated salt. The per cent of samples with proper content of potassium iodide was from 30% to 50% depending on the producer. The study demonstrated that in most cases the process of salt iodination is done incorrectly.
Źródło:
Roczniki Państwowego Zakładu Higieny; 1993, 44, 4; 295-300
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of correlation between vitamin D level and prevalence of preterm births in the population of pregnant women in Poland
Autorzy:
Baczyńska-Strzecha, Marta
Kalinka, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/2161845.pdf
Data publikacji:
2017-10-06
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
pregnancy
vitamin D
preterm delivery
vitamin D deficiency
preterm birth
preterm labor
Opis:
Objectives Aim of this project is determination of the correlation between the level of vitamin D in blood serum and duration of pregnancy in population in central Poland. Material and Methods 25-Hydroxyvitamin D (25(OH)D) level was determined in blood serum, using enzyme-linked immunosorbent assay (ELISA). Standardized history of each patient was recorded. The history included: general medical history, data regarding the course of pregnancy and information about health-related behavior that could influence vitamin D concentration. Two hundred-and-one Caucasian women at childbirth were qualified into the study. The study group was divided into 2 parts: 100 patients who had a spontaneous premature birth and 101 patients who had birth at full term. Results Vitamin D deficiency (< 30 ng/ml) was very common for both groups (69.6% of patients in the premature group and 72% – in the control group). Patients who had a premature birth had severe vitamin D deficiency (less than 10 ng/ml) more often than in the control group (34% vs. 14.2%, p = 0.001). Severe vitamin D deficiency increased the risk of premature birth but the association was not statistically significant in the multivariate regression model (odds ratio (OR) = 2.47, 95% confidence interval (CI): 0.86–7.15, p = 0.094). Conclusions Severe vitamin D deficiency (< 10 ng/ml) may be the factor increasing the risk of preterm birth. Int J Occup Med Environ Health 2017;30(6):933–941
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2017, 30, 6; 933-941
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Znaczenie kwasu foliowego dla zdrowia organizmu człowieka
The importance of folic acid for the health of the human body
Autorzy:
Banyś, Karolina J.
Knopczyk, Monika W.
Bobrowska-Korczak, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/762697.pdf
Data publikacji:
2020-03-15
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
kwas foliowy
MTHFR
niedobór
mutacja
aktywny kwas foliowy
folic acid
mutation
deficiency
active folic acid
Opis:
A well-balanced diet is undoubtedly a key factor to maintain your body's normal state of health. A deficiency or excess of any nutrient can cause negative effects on human health. Folic acid is one of the elements of the diet, which is often supplied in insufficient quantities. This vitamin and its derivatives participate in the metabolism of amino acids and nucleic acids. Therefore, it is necessary for the proper functioning of the body's cells and for maintaining homeostasis, especially of the nervous, circulatory and cardiovascular systems. The biological activity of folic acid and its derivatives essentially affects the metabolism of important amino acids, such as methionine, homocysteine, serine, glycine, pyrimidine and purine synthesis and DNA methylation. The synthetic form of folic acid (most oxidized), which can be found in fortified foods, dietary supplements or pharmaceuticals, does not show biological activity. It is transformed in a series of reactions with the participation of many enzymes to form folates, which differ in the number of glutamic acid residues and the degree of oxidation. The actively biological form is reduced folate (L-5-MTHF), which is transported together with the blood to cells where it undergoes biological processes important for our health. The MTHFR gene, coding for the enzyme protein of the same name - methylene tetrahydrofolate reductase, is located on chromosome 1 at the 1p36.3 locus. This protein is responsible for the catalysis of the enzymatic reaction, which is the reduction of 5,10-methylenetetrahydrofolate to L-5-methyltetrahydrofolate, i.e. the active form of folate. This form is necessary in the process of homocysteine degradation, in the aftermath remethylation to methionine. This protein is responsible for the catalysis of the enzymatic reaction, which is the reduction of 5,10-methylenetetrahydrofolate to L-5-methyltetrahydrofolate, i.e. the active form of folate. This form is necessary in the process of homocysteine degradation, in the aftermath remethylation to methionine. However, according to available literature, mutation of the MTHFR 677C> T gene occurs in even 53% of the population. Among carriers of the TT genotype, it can cause about 70% reduction of MTHFR reductase activity. It is especially dangerous for people who do not provide adequate amounts of folic acid along with their diet and for those who need a high amount of this vitamin, e.g. due to taking medications that reduce its absorption, i.e. metformin or oral contraceptives. Many people metabolize folic acid on insufficient levels. For medical reasons, not the mutation itself is a problem, but too low the folate levels. In recent years, there is more and more discussion about the active form of folic acid and the possibility of effective supplementation with metapholine, which is a combination of calcium with L-5-MTHFR. It is a natural and reduced form of folate, which hydrolized and then transforms into L-5-MTHFR. Metapholine, in comparison to folic acid, is not reduced to be incorporated into metabolic processes in the cell, which is catalyzed by DHFR and MTHFR enzymes. In addition, the absorption of the active form of folic acid is faster because some metabolic pathways are missed. This is particularly important for people who have a MTHFR gene mutation homozygous with 665C> T and / or 1298A> C polymorphism and a mutation of the DHFR gene with 458A> T polymorphism. Numerous clinical studies have confirmed the efficacy and safety of the active form of folic acid. In a study by Houghton et al., which was conducted among pregnant Canadian women, L-5-MTHFR was shown to be at least as effective in lowering homocysteine levels as folic acid supplementation. In addition, the active form of folic acid was more effective at storing folate in erythrocytes. In a study conducted by Lamers et al. on 135 women after a period of 24 weeks, L-5MTHR was shown to be a suitable alternative in reducing plasma homocysteine levels compared to folic acid and placebo. In addition, Bentley et al. analyzed the results of 112 pregnant women from the USA. Patients were assigned to two groups in which each took vitamin B12. In addition, in one of them women supplemented with L-5-MTHFR, and in the other - folic acid. The results showed that patients who supplemented the active form of folic acid not only had higher hemoglobin levels, but also less often had anemia. When analyzing clinical trials of patients with the MTHFR mutation, the same trend was observed. Metafoline increased plasma folate levels and decreased homocysteine levels. In one study on German women, there was a decrease in homocysteine levels and an increase in folate levels in both plasma and red blood cells in patients who supplemented the active form of folic acid. In another study involving Swiss patients with the current 677CC MTHFR or 677TT MTHFR mutation, it was demonstrated that using L-5-MTHFR significantly reduces homocysteine levels compared to folic acid. It is also worth mentioning that Prinz-Langenhol et al. in a study on women with the 677CC and 677TT mutations proved that the active form of folic acid has a better effect on increasing folate levels than folate. It is also worth mentioning that folic acid at high doses can mask ailments or even diseases caused by vitamin B12 deficiency. In addition, folic acid administered at high doses in patients with the MTHFR mutation is not reduced to an oxidized, inactive form and is not properly transported to plasma. Non-metabolised folic acid can be dangerous to the human body and contribute to the development of cancer. Supplementation, in particular the active form of folic acid, should be considered by patients who are carriers of the MTHFR or DHFR mutation. In addition, the use of stimulants such as alcohol or nicotine also negatively affects the absorption of this vitamin. Taking some medications weakens the absorption of folic acid - these include folic acid antagonists, anti-tuberculosis drugs, hormonal oral contraceptives, nonsteroidal anti-inflammatory drugs or metformin widely used. Folic acid is necessary for the proper functioning of the human body and its deficiency may induce various disease processes in the body, which include: the formation of neural tube defects, disorders in the nervous system, megaloblastic anemia, a negative effect on the functioning of the cardiovascular system and the development of atherosclerosis and cancer. More and more people have anemia, including megaloblastic anemia, which is characterized by abnormal nucleic acid synthesis. The consequence of too low folate levels is impaired red blood cell production, an increase in their volume, and premature death. Extremely dangerous is megaloblastic anemia, the so-called malignant anemia in pregnant women, as it can lead to serious complications such as hemorrhage, infection, and even intrauterine fetal death. A significant influence of folic acid on the functioning of the nervous system has been proven in many clinical studies. This vitamin is involved in the formation of important neurotransmitters such as: adrenaline, dopamine and noradrenaline, therefore its deficiency may lead to the development of neuropsychiatric disorders (dementia, epilepsy, depression and psychosis). These disorders are often caused by high levels of homocysteine, which is not properly metabolized to methionine due to folate deficiency. An excess of homocysteine, as a consequence, leads to atherosclerosis in the cerebral arteries and, as a result of insufficient blood supply, transient ischaemic attack occur, which can contribute to the development of dementia or Alzheimer's disease. Nutritional observations indicate that eating fresh vegetables rich in folic acid protects against the formation of some cancers, e.g. large intestine, breast, ovary, uterus, lungs, pancreas. Deficiency of folic acid promotes the activation of protooncogenes to oncogenes, which in consequence results in a decrease in the stability of cellular DNA. A study carried out by Giovannicci et al. showed that excessive alcohol consumption and folic acid deficiency associated with it increased the risk of developing colorectal cancer by almost four times. However, what cannot be overlooked, the results of clinical trials show us that very high doses and folic acid accumulation favor the development of some cancers. It is thought that excess of folic acid may lead to hypermethylation of DNA and, consequently, to inactivation of the suppressor genes responsible for controlling cell division. Women in the pre-contraceptive period, during pregnancy and breastfeeding are included in the group of people with a special need for folic acid, in whom deficiency can cause many negative effects. The presence of folic acid is necessary in the process of cell formation and growth in the developing fetus, especially when the neural tube is forming. Moreover adequate folic acid concentration decreases risk of fetal heart and urinary tract defects, and also reduces the occurrence of thrombosis and miscarriage in pregnant women. Steeweg-de Graaff J. et al. conducted evaluation of emotional and behavioral development at the age of 3 depending on the concentration of folates and homocysteine in the mother's blood plasma at an early stage of the pregnancy. It was noted that with insufficient folate supply, associated with a lack of or its late supplementation increases the risk of emotional problems in children. In addition, defects of the nervous system may occur as a result of dysfunction of folate metabolism. In its transformation pathway MTHFR reductase takes a particular role. Its reduced activity contributes to the impairment of folic acid metabolism, and the MTHFR gene - type 677CC is considered a risk factor for the development of neural tube defects. Randomized study compared pharmacokinetic parameters of [6S]-5-MTHF and folic acid in healthy women of childbearing age with different MTHFR genotypes (677TT n = 6, 677CC n = 8). Higher peak folate concentrations in plasma with [6S]-5-MTHF supplementation was found, in comparison with folic acid and not depending in the MTHFR genotype, as well as a shorter time needed to reach maximum concentration. In a different randomized, double-blind trial significantly higher folate levels in red blood cells were obtained in women receiving [6S]-5-MTHF. Studies confirm the hypothesis that nutritional deficiencies are of great importance in terms of fetal development. The results testify the need of folic acid supplementation, in which it is worth to consider the use of biologically active form, 12 weeks before planned pregnancy. In the second and third trimesters, the supplementation of folic acid is an important element in prevention of anemia caused by vitamin B12 and folic acid deficiency, i.e. megaloblastic anemia. Moreover, it was found that folic acid at a daily dose of 400 - 800 μg reduce the risk of fetal neural tube defects. In its guidelines, Polish Society of Gynecologists and Obstetricians (PTGiP) recommends supplementation of 400 μg / day of folic acid in women in low risk group in the pre-contraceptive period, pregnancy and during breastfeeding and supplementation of 800 μg/ day of folic acid in women in intermediate risk group and also high risk group in II and III trimester and during breastfeeding. It is worth emphasising that in most recent guidelines, PTGiP pays attention to the problem of folic acid metabolism and emphasizes the appropriateness of supplementation with its active form, especially at high doses. In folic acid metabolism, MTHFR catalyzes the synthesis to the active form of folate (L-5-MTHFR). It is necessary in the process of homocysteine degradation following remethylation to methionine. Unfortunately, as a result of inappropriate methylation, e.g. as a result of active form of folic acid deficiency, the concentration of homocysteine in the blood serum increases, which is responsible for various pathogenic processes in the body. Insufficient supply and improper metabolism of folic acid, as well as vitamins B6, B12 deficiency may be factors favorable for development of atherosclerosis and other diseases related to the cardiovascular system (e.g. heart attack, stroke, coronary artery disease). Excessively high concentration of homocysteine in the blood plasma, caused by disorders of its metabolic pathway in the body, is one of the reasons for the formation of atherosclerotic changes in blood vessels. Excess of homocysteine, with a simultaneous deficiency of folate and vitamin B12, damages the endothelium of blood vessels and increases oxidation processes, which are associated with the development of inflammation, oxidation of LDL cholesterol and change in the structure of the walls of blood vessels. In addition, the risk of developing peripheral thrombosis and hypertension increases. In the meta-analysis of Linda L. et al. it was found that high concentration of homocysteine is an independent factor of developing coronary heart disease. In the majority of studies, the risk of this disease is increased by 20% to 50% with every increase of concentration of homocysteine by 5 μmol /L in the blood of the examined persons. To ensure proper functioning of blood vessels and to reduce the risk of cardiovascular disease, one needs to provide adequate concentration of homocysteine in the body. Folates and their adequate supply with diet or supplementation play a key role in this process. Looking at the numerous clinical studies, available literature and the function of folic acid, it can be stated that it is an essential compound with multidirectional biological action, which is involved in the synthesis of amino acids and nucleic acids important for health. It plays an important role in tissues, such as: the fetus, hematopoietic system and gastrointestinal epithelium, in which cell divisions occur. For this reason, the presence of folic acid in the right amounts, ensures the proper functioning of our body. A deficiency of folic acid in the diet leads to a reduced concentration of folate in plasma and red blood cells. It is a condition that contributes to the formation of many serious diseases in our body and congenital neural tube defects in the fetus. As clinical studies have shown, the optimal concentration of folates in the blood reduces the risk of cardiovascular, circulatory, central nervous system diseases and certain types of cancer. To reduce the risk of diet-related diseases caused by folic acid deficiency, daily diet should be optimally balanced and contain products rich in natural folates. If diet is an insufficient source of folic acid, its supplementation should be considered, with the possible inclusion of its active form. Supplementation is recommended, in particular, for people with: megaloblastic anemia, diabetes mellitus, malabsorptions (e.g. Crohn's disease), alcoholism, malnutrition, neurodegenerative diseases (e.g. Alzheimer's disease), cardiovascular diseases, elevated homocysteine levels and using certain medications (e.g. oral contraceptives, metformin, methotrexate). It is also worth mentioning that metapholine supplementation bypasses the multistage metabolic process before incorporating folates into the cell cycle, as opposed to the inactive form of folic acid. This is particularly important for patients with the DHFR and MTHFR mutation, which depending on the polymorphism, may occur in up to 53% of the Caucasian population. Consequently, MTHFR reductase activity is reduced by up to 70%.
Kwas foliowy jest niezbędny do właściwego funkcjonowania organizmu i zachowania homeostazy. Uczestniczy w metabolizmie kwasów nukleinowych, aminokwasów, syntezie pirymidyn i puryn. Syntetyczna postać kwasu foliowego nie wykazuje aktywności biologicznej. Przekształcana jest w szeregu reakcji do postaci folianów (L-5-MTHF) które, są transportowane do komórek, gdzie bierze udział w ważnych procesach biologicznych. Gen MTHFR odpowiedzialny jest za katalizę reakcji enzymatycznej: redukcję 5,10-metylenotetrahydrofolianu do aktywnej formy. Mutacja genu MTHFR 677C>T występuje nawet u 53% populacji czego konsekwencją jest zmniejszenie aktywności reduktazy – MTHFR nawet o 70%. Metafolina (aktywna forma) w przeciwieństwie do kwasu foliowego, aby zostać włączona do procesów metabolicznych w komórce, nie ulega redukcji, katalizowanej przez DHFR oraz MTHFR. Jest to istotne w szczególności dla osób, które mają mutację genu MTHFR oraz DHFR. Przyjmowanie niektórych leków osłabia wchłanialność kwasu foliowego. Kwas foliowy jest niezbędny do prawidłowego funkcjonowania organizmu człowieka a jego niedobór może indukować różne procesy chorobowe w organizmie, do których zaliczamy: powstawanie wad cewy nerwowej, zaburzenia w układzie nerwowym, niedokrwistość megaloblastyczną, negatywny wpływ na funkcjonowanie układu sercowo – naczyniowego oraz rozwój miażdżycy i nowotworów. Witamina ta bierze udział w powstawaniu ważnych neuroprzekaźników, takich jak: adrenalina, dopamina i noradrenalina, dlatego jej niedobór może prowadzić do powstania zaburzeń neuropsychiatrycznych. Niedobór kwasu foliowego sprzyja aktywacji protoonkogenów do onkogenów. Liczne badania kliniczne i dostępna literatura potwierdzają funkcję kwasu foliowego, że jest to niezbędny związek o wielokierunkowym działaniu biologicznym, który pełni istotną rolę w tkankach. Suplementacja metafoliną omija wieloetapowy proces metaboliczny w przeciwieństwie do nieaktywnej postaci kwasu foliowego.
Źródło:
Farmacja Polska; 2020, 76, 2; 79-87
0014-8261
2544-8552
Pojawia się w:
Farmacja Polska
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Demand deficiency, money velocity and heterogeneity
Autorzy:
Basci, Sidika
Gherbi, Tahar
Powiązania:
https://bibliotekanauki.pl/articles/14154840.pdf
Data publikacji:
2020-06-21
Wydawca:
Wyższa Szkoła Bankowa we Wrocławiu
Tematy:
Demand Deficiency
Money Velocity
Heterogeneity
Wealth Distribution
Agent Based Modelling
Opis:
Aim: Money velocity data for the United States show that there is a decline in all of the broad money aggregates in recent decades. This points to a sustained demand deficiency element. Can consumer heterogeneity be the cause of this declining trend? The aim of this paper is to find an answer for this question.   Design / Research Methods: To achieve our aim we use Agent Based Modelling (ABM). In our model, the agents are heterogeneous consumers with different spending propensities.   Conclusions / findings: We show that heterogeneous consumers with different spending propensities alone puts a downward pressure on money velocity. This pressure is coupled with a sustained worsening in the wealth distribution. We observe that as money accumulates in the hands of agents with the lowest propensity to spend, money velocity keeps declining. This also puts a downward pressure on nominal aggregate demand and hence a deflationary bias on the general price level.   Originality / value of the article: This paper shows that heterogeneity of economic agents should not be ignored and that ABM is a very powerful tool to analyse heterogeneity.   Implications of the research: The implication for policy makers is that the demand deficiency associated with the fall in money velocity will persist until the worsening of wealth dispersion comes to a halt.
Źródło:
Central European Review of Economics and Management; 2020, 4, 2; 137-153
2543-9472
Pojawia się w:
Central European Review of Economics and Management
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fizjologiczne procesy starzenia się kobiety i mężczyzny a płodność
Physiological processes of aging women and men and fertility
Autorzy:
Bassa, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1289782.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Kardynała Stefana Wyszyńskiego w Warszawie
Tematy:
starzenie się gonad
niedobór hormonów
menopauza
andropauza
niepłodność
gonadal aging
hormone deficiency
menopause
andropause
infertility
Opis:
Starzenie się jest naturalnym procesem fizjologicznym, postępującym i nieodwracalnym. Wskutek starzenia zmniejsza się zdolność adaptacyjna organizmu oraz osłabieniu ulegają jego mechanizmy obronne. Procesom starzenia ulegają wszystkie gruczoły hormonalne, jednak najbardziej wyraźne zmiany zachodzą w jajnikach. Wraz z wiekiem stopniowo wygasa ich czynność, aż do menopauzy. Wygasaniu aktywności jajników, na skutek niedoborów hormonów jajnikowych towarzyszy zespół objawów klimakterycznych. U mężczyzn wraz z wiekiem stopniowo obniża się produkcja testosteronu oraz zmniejsza się liczba plemników – jednak płodność mężczyzny może być zachowana nawet do starości. Procesom starzenia się układu rozrodczego towarzyszy szereg dolegliwości związanych z niedoborem hormonów płciowych – m.in. osteoporoza.
Aging is a natural, progressive and irreversible process. As a result of aging, the body's adaptive capacity is reduced and its defense mechanisms weakened. All hormonal glands are aging, but the most obvious changes occur in the ovaries. Their activity gradually decreases with age until the menopause. Ovarian function, due to deficiency of ovarian hormones, is accompanied by a syndrome of climacteric symptoms. As men age, testosterone production is gradually decreasing and sperm counts are reduced - but men's fertility can be preserved even in old age. The aging process of the reproductive system is accompanied by a number of problems associated with deficiency of sex hormones - among others osteoporosis.
Źródło:
Studia nad Rodziną; 2018, 22, 3(48); 99-108
1429-2416
Pojawia się w:
Studia nad Rodziną
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Medico-social effectiveness of biological monitoring of iodine deficiency status (IDS) among women of reproductive age in Kazakhstan
Autorzy:
Beisbekova, A.
Raushanova, A.
Juszkiewicz, K.
Kainarbayeva, M.
Chuyenbekova, A.
Khassenova, G.
Kozhakhmetova, A.
Kenessary, D.
Powiązania:
https://bibliotekanauki.pl/articles/2082012.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
iodine
iodine deficiency diseases
women of reproductive age
Opis:
Introduction. Iodine deficiency is one of the most important public health problems in the world. It mostly affects pregnant women and children. The lack of iodine leads to an increase in the numbers of perinatal mortality and mental retardation. Materials and method. In 2012–2014, a survey was carried out of 2,342 women, of whom 2284 were analyzed for salt to measure the content of iodine, and 2,242 women of reproductive age had their urine samples analyzed by the ceriumarsenite method based on the Sandell-Kolthoff reaction. Determination of the medical and social effectiveness of biological monitoring of IDS was carried out in 3 stages. Results. The study revealed that in the eastern Kazakhstan region the relative risk (RR) of overall prevalence of iodine deficiency among women was 1.1 times higher (95% ID: 0.35–3.61; Z statistic = 0.192) among household respondents (≤15mkg/kg). In the Pavlodar region, the RR of the prevalence of total iodine deficiency is 0.5 times higher in households where the salt was not sufficiently iodized. In the Zhambyl region the RR of the iodine deficiency prevalence was about twice as high due to insufficient iodized salt. Conclusions. The introduction of biological monitoring of IDS among women, especially pregnant women, may positively affect the detection of the risk limits for the birth of infants with reduced mental abilities or other diseases during pregnancy, using timely targeted preventive measures to exclude factors that affect the spread of IDS.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 73-77
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Excess or Deficiency of Regulations of the Commercial Activities Law in the Civil Code?
Autorzy:
Bielski, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/2082832.pdf
Data publikacji:
2019
Wydawca:
Akademia Leona Koźmińskiego w Warszawie
Tematy:
commercial contracts law
deficiency of legal regulations
commercial activities law
Opis:
The author of the paper understands the term of “excess of legal regulations” as the situation of imposition of regulations governing a specific institution of the com-mercial activities law under the Civil Code, which are fully or partially obsolete from the point of view of the needs of contemporary business trading. The term of “deficiency of legal regulations”, in turn, is to denote a complete lack of a regula-tion of a specific institution of the commercial activities law as may be desired in the domain of contemporary business trading, or the existence of such a regulation but in a form that is limited, incapable of addressing the needs and challenges of the said domain. When it comes to the legal regulations of the commercial activi-ties law, the author argues that it is hard to regard the current legal situation in Poland as successfully fulfilling the requirements of a coherent legal system and of the legislative technique principles that are applied therein. In the text, the author provides a detailed explanation of why commercial activities governed by the Civil Code suffer from a substantial deficiency of legal regulations in the scope in question.
Źródło:
Krytyka Prawa. Niezależne Studia nad Prawem; 2019, 11, 4; 21-32
2080-1084
2450-7938
Pojawia się w:
Krytyka Prawa. Niezależne Studia nad Prawem
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nadmiar czy niedobór regulacji prawa czynności handlowych w kodeksie cywilnym?
Autorzy:
Bielski, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1991243.pdf
Data publikacji:
2019
Wydawca:
Akademia Leona Koźmińskiego w Warszawie
Tematy:
prawo handlowe
czynności handlowe
umowy handlowe
commercial contracts law
deficiency of legal regulations
commercial activities law
Opis:
Jedną z konsekwencji znaczącej aktywności legislacyjnej Sejmu Rzeczypospolitej Polskiej po 1989 r. jest między innymi to, że licznym nowelizacjom podlegają również akty prawne pełniące w systemie prawa szczególną funkcję (kodeksy). Czy nowelizacje te wpływają na spójność i przejrzystość zawartych w kodeksach regulacji prawnych? Czy np. zasadniczym motywem podejmowania wielu zmian legislacyjnych, którym podlegał kodeks cywilny w odniesieniu do regulacji prawnych obrotu gospodarczego - w tym zwłaszcza w odniesieniu do regulacji prawa czynności handlowych - po zmianie ustroju społeczno-gospodarczego w latach 1989-1990, był zamiar realizacji zasługującego bez wątpienia na aprobatę postulatu uwzględniania potrzeb współczesnego obrotu gospodarczego, poprzez modernizację istniejących, wprowadzanie nowych i ewentualnie rezygnację z tych istniejących regulacji prawnych w omawianej materii, których praktyczne znaczenie i zastosowanie jest obecnie znikome? Czy wobec tego w odniesieniu do aktualnego kształtu regulacji prawa czynności handlowych w kodeksie cywilnym można mówić o jej optymalnym stanie, czy też może o nadmiarze albo niedoborze regulacji prawnych w tej materii? Czy istnieją projekty zmian wymienionego obszaru regulacji prawnych i w którym kierunku zmierzają? Przedmiotem niniejszego opracowania jest poszukiwanie odpowiedzi na powyższe pytania.
The author of the paper understands the term of “excess of legal regulations” as the situation of imposition of regulations governing a specific institution of the com-mercial activities law under the Civil Code, which are fully or partially obsolete from the point of view of the needs of contemporary business trading. The term of “deficiency of legal regulations”, in turn, is to denote a complete lack of a regula-tion of a specific institution of the commercial activities law as may be desired in the domain of contemporary business trading, or the existence of such a regulation but in a form that is limited, incapable of addressing the needs and challenges of the said domain. When it comes to the legal regulations of the commercial activi-ties law, the author argues that it is hard to regard the current legal situation in Poland as successfully fulfilling the requirements of a coherent legal system and of the legis-lative technique principles that are applied therein. In the text, the author provides a detailed explanation of why commercial activities governed by the Civil Code suffer from a substantial deficiency of legal regulations in the scope in question.
Źródło:
Krytyka Prawa. Niezależne Studia nad Prawem; 2019, 11, 4; 8-20
2080-1084
2450-7938
Pojawia się w:
Krytyka Prawa. Niezależne Studia nad Prawem
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Magnesium: its role in nutrition and carcinogenesis
Autorzy:
Blaszczyk, U.
Duda-Chodak, A.
Powiązania:
https://bibliotekanauki.pl/articles/877044.pdf
Data publikacji:
2013
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
magnesium
human nutrition
carcinogenesis
tumour
magnesium deficiency
cellular process
human metabolism
dietary factor
human health
human disease
mortality
cancer
Opis:
Magnesium (Mg2+) plays a key role in many essential cellular processes such as intermediary metabolism, DNA replication and repair, transporting potassium and calcium ions, cell proliferation together with signalling transduction. Dietary sources rich in magnesium are whole and unrefined grains, seeds, cocoa, nuts, almonds and green leafy vegetables. Hard water is also considered to be an important source of magnesium beneficial to human health. The daily dietary intake of magnesium is however frequently found to be below that recommended in Western countries. Indeed, it is recognised that magnesium deficiency may lead to many disorders of the human body, where for instance magnesium depletion is believed to play an important role in the aetiology of the following; cardiovascular disease (including thrombosis, atherosclerosis, ishaemic heart disease, myocardial infarction, hypertension, arrhythmias and congestive heart failure in human), as well as diabetes mellitus, gastrointestinal (GI) tract disease, liver cirrhosis and diseases of the thyroid and parathyroid glands. Insufficient dietary intake of magnesium may also significantly affect the development and exacerbation of ADHD (Attention Deficit- Hyperactivity Disorder) symptoms in children. The known links between magnesium and carcinogenesis still remain unclear and complex, with conflicting results being reported from many experimental, epidemiological and clinical studies; further knowledge is thus required. Mg2+ ions are enzyme cofactors involved in DNA repair mechanisms that maintain genomic stability and fidelity. Any magnesium deficiencies could thereby cause a dysfunction of these systems to occur leading to DNA mutations. Magnesium deficiency may also be associated with inflammation and increased levels of free radicals where both inflammatory mediators and free radicals so arising could cause oxidative DNA damage and therefore tumour formation. The presented review article now provides a summary discussion of the various research performed concerning the impact that low magnesium intake has on tumour incidence; this includes impairment of magnesium homeostasis frequently observed in tumour cells, the influence of magnesium depletion on the progression of existing tumours and the occurrence of hypo-magnesaemia when patients are treated with certain anticancer drugs.
Magnez odgrywa kluczową rolę w wielu procesach komórkowych, takich jak metabolizm energii, replikacja i naprawa DNA, transport jonów potasu i wapnia, proliferacja komórek, a także transdukcja sygnału. Pełne ziarna zbóż, kakao, orzechy, migdały, zielone warzywa liściaste są dobrym źródłem magnezu. Twarda woda jest również uważana za ważne źródło magnezu, które pozytywnie wpływa na zdrowie człowieka. Dzienne spożycie magnezu w krajach zachodnich często jest poniżej zalecanej dawki. Niedobór magnezu może prowadzić do wielu zaburzeń w organizmie człowieka. Uważa się, że deficytjonów Mg2+ może odgrywać ważną rolę w etiologii wielu chorób, takich jak choroby sercowo-naczyniowe (zakrzepica, miażdżyca tętnic, choroba niedokrwienna serca, zawał mięśnia sercowego, nadciśnienie, zaburzenia rytmu serca, zastoinowa niewydolność serca), cukrzyca, choroby układu pokarmowego, marskość wątroby, choroby tarczycy i przytarczyc. Niewystarczające spożycie magnezu może mieć znaczący wpływ na rozwój i pogłębienie objawów ADHD u dzieci. Rola magnezu w procesie kancerogenezy jest skomplikowana. Mimo stosunkowo dużej liczby badań aktualny stan wiedzy na temat zależności pomiędzy poziomem magnezu, a kancerogenezą jest ciągle niewystarczający i niespójny. Jony magnezu pełnią funkcję kofaktorów enzymów zaangażowanych w mechanizmy naprawcze DNA, które odpowiedzialne są za utrzymywanie stabilności genomu i wierności replikacji. W związku z tym niedobór magnezu może przyczyniać się do wadliwego działania tych systemów i występowania mutacji DNA. Ponadto, w badaniach na zwierzętach obserwowano korelację pomiędzy obniżonym stężeniem magnezu, a stanem zapalnym i wzrostem poziomu wolnych rodników. Zarówno mediatory zapalne jak i wolne rodniki przyczyniają się do generowania uszkodzeń oksydacyjnych DNA, których następstwem może być powstawanie nowotworów. W artykule omówiono niektóre aspekty badań dotyczących wpływu niskiego spożycia magnezu na częstość występowania nowotworów, zaburzonej homeostazy magnezu obserwowanej w komórkach nowotworowych, wpływu niedoboru magnezu na progresję istniejących nowotworów oraz występowania hipomagnezemii w trakcie leczenia pacjentów niektórymi lekami przeciwnowotworowymi.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2013, 64, 3
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Forbidden Structures for Planar Perfect Consecutively Colourable Graphs
Autorzy:
Borowiecka-Olszewska, Marta
Drgas-Burchardt, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/31341980.pdf
Data publikacji:
2017-05-01
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
edge colouring
consecutive (interval) colouring
deficiency
Sevastjanov graph
forbidden graph
Opis:
A consecutive colouring of a graph is a proper edge colouring with posi- tive integers in which the colours of edges incident with each vertex form an interval of integers. The idea of this colouring was introduced in 1987 by Asratian and Kamalian under the name of interval colouring. Sevast- janov showed that the corresponding decision problem is NP-complete even restricted to the class of bipartite graphs. We focus our attention on the class of consecutively colourable graphs whose all induced subgraphs are consecutively colourable, too. We call elements of this class perfect consecutively colourable to emphasise the conceptual similarity to perfect graphs. Obviously, the class of perfect consecutively colourable graphs is induced hereditary, so it can be characterized by the family of induced forbidden graphs. In this work we give a necessary and sufficient conditions that must be satisfied by the generalized Sevastjanov rosette to be an induced forbid- den graph for the class of perfect consecutively colourable graphs. Along the way, we show the exact values of the deficiency of all generalized Sevastjanov rosettes, which improves the earlier known estimating result. It should be mentioned that the deficiency of a graph measures its closeness to the class of consecutively colourable graphs. We motivate the investigation of graphs considered here by showing their connection to the class of planar perfect consecutively colourable graphs.
Źródło:
Discussiones Mathematicae Graph Theory; 2017, 37, 2; 315-336
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Limit-point criteria for the matrix Sturm-Liouville operator and its powers
Autorzy:
Braeutigam, I. N.
Powiązania:
https://bibliotekanauki.pl/articles/255833.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
quasi-derivative
quasi-differential operator
matrix Sturm-Liouville operator
deficiency numbers
distributions
Opis:
We consider matrix Sturm-Liouville operators generated by the formal expression [formula] in the space [formula]. Let the matrix functions P := P(x), Q := Q(x) and R := R(x) of order n (n ∈ N) be defined on I, P is a nondegenerate matrix, P and Q are Hermitian matrices for x ∈ I and the entries of the matrix functions[formula], Q and R are measurable on I and integrable on each of its closed finite subintervals. The main purpose of this paper is to find conditions on the matrices P, Q and R that ensure the realization of the limit-point case for the minimal closed symmetric operator generated by [formula]. In particular, we obtain limit-point conditions for Sturm-Liouville operators with matrix-valued distributional coefficients.
Źródło:
Opuscula Mathematica; 2017, 37, 1; 5-19
1232-9274
2300-6919
Pojawia się w:
Opuscula Mathematica
Dostawca treści:
Biblioteka Nauki
Artykuł
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