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    Tytuł:
    Serum levels of IFN-γ and IL-4 in hospitalised COVID-19 patients – evidence of reduced cytokine storm in discharged patients
    Autorzy:
    Olatunbosun Arinola, Ganiyu
    Adekunle Onifade, Abdulfattah
    Adigun, Kehinde
    Babatunde Oshingbesan, Mosunmade
    Powiązania:
    https://bibliotekanauki.pl/articles/29520462.pdf
    Data publikacji:
    2023-12-31
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cytokine storm
    re-purposed treatment
    SARS-CoV-2
    Opis:
    Introduction and aim. Coronavirus disease 2019 is characterised by cytokine storm and it was managed with repurposed drugs, however the effect of this treatment on cytokine storm is unknown. The aim of the study was to investigate the effect of repurposed management on serum Th1 pro-inflammation cytokine (IFN-γ) and Th2 anti-inflammation cytokine (IL-4) in COVID-19 patients. Material and methods. The levels of IFN-γ and IL-4 were determined in sera from 45 COVID-19 patients at admission followed-up till discharge after repurposed treatment using ELISA. The mean levels and proportions above normal reference ranges of IFN-γ and IL-4 were compared in COVID-19 at admission and discharge. Results. The mean values of IFN-γ and IL-4 were significantly higher in COVID-19 patients at admission compared with discharged COVID-19 patients whereas IFN-γ:IL-4 ratio was significantly higher in discharged COVID-19 patients compared with admitted COVID-19 patients. Significantly higher proportion of COVID-19 patients at discharge had IFN-γ within the normalreference ranges compared with COVID-19 patients at admission whereas the proportions of COVID-19 patients at discharge and COVID-19 patients at admission having IL-4 within the normal reference ranges were the same. Conclusion. Cytokine storm was evidenced in COVID-19 patients at admission and repurposed treatment suppressed pro-inflammation cytokine (IFN-γ) in most discharged COVID-19 patients.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2023, 4; 750-755
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytokiny i burza cytokinowa przyczyną zaburzeń wielonarządowych i śmierci
    Cytokines and cytokine storm - the cause of multiorgan failure and death
    Autorzy:
    Gliński, Zdzisław
    Żmuda, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/22180984.pdf
    Data publikacji:
    2021
    Wydawca:
    Krajowa Izba Lekarsko-Weterynaryjna
    Tematy:
    cytokiny
    burza cytokinowa
    stany zapalne
    infekcja bakteryjna
    infekcja wirusowa
    COVID-19
    zaburzenia wielonarządowe
    cytokines
    cytokine storm
    inflammation
    Opis:
    Cytokines are low molecular weight signaling proteins which have a complex regulatory influence on inflammation and the immune system T-cells response. In response to various stimuli, cytokines are secreted by different cells predominantly white blood cells. Regulation of immune homeostasis requires a balance between sufficient cytokine produ hey integrate functions of several cell types into a coherent immune action to eliminate the pathogen and avoidance of a hyperinflammatory response. Pyroptosis, oncosis and necroptosis are inflammatory, lytic forms of programmed cell death that protect against infections and can be triggered by pathogen and host molecules. Inflammation, complex response involving immune cells, blood vessels, and molecular mediators, is part of innate defense mechanisms and plays a role in the healing process. Beyond the innate and adaptive immunity, cytokines has a major role in cytokine storm. No single definition of cytokine storm or the cytokine release syndrome, is widely accepted. Cytokine storm is based on the elevated circulating cytokine levels, acute systemic inflammatory reactions and dysfunction. Cases can progress rapidly to disseminated intravascular coagulation with either vascular occlusion or catastrophic hemorrhages, dyspnea, hypoxia, hypotension, hemostatic imbalance, vasodilatory shock, and death. In this article, interdependence of these inflammatory mediators in a normal and a dysregulated response was presented.
    Źródło:
    Życie Weterynaryjne; 2021, 96, 07; 482-487
    0137-6810
    Pojawia się w:
    Życie Weterynaryjne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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