Temat: cytokine - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Central single and chronic administration of morphine stimulates corticosterone and interleukin 9(IL)-6 in adjuvant-induced arthritis
Autorzy:: Zubelewicz, B.
Muc-Wierzgon, M.
Harbuz, M.S.
Brodziak, A.
Powiązania:: https://bibliotekanauki.pl/articles/69429.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: interleukin 6
arthritis
cytokine
corticosterone
morphine
central nervous system
neuroendocrine change
rat
hypothalamic-pituitary-adrenal axis
immune response
Źródło:: Journal of Physiology and Pharmacology; 2000, 51, 4,2
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Obesity and iron metabolism
Autorzy:: Zekanowska, E.
Boinska, J.
Giemza-Kucharska, P.
Kwapisz, J.
Powiązania:: https://bibliotekanauki.pl/articles/80448.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: adipocyte
adipose tissue
body fat
body mass index
child
endocrine organ
harmful effect
hepcidin
interleukin 1
interleukin 6
iron deficiency
iron homeostasis
iron metabolism
obesity
overweight
proinflammatory cytokine
tumour necrosis factor-alpha
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Plasma membrane rafts and chaperones in cytokine/ STAT signaling.
Autorzy:: Sehgal, Pravin
Powiązania:: https://bibliotekanauki.pl/articles/1043429.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cytokine receptors
chaperones
fever
heat shock protein 90 (HSP90)
signal transducers and activators of transciption (STATs)
caveolin
lipid rafts
Opis:: We and others have recently obtained data suggesting that cytokine-STAT signaling in many different cell-types is a chaperoned pathway initiated at the level of specialized plasma membrane microdomains called "rafts" (the "raft-STAT signaling hypothesis"). These findings are of broad significance in that all cytokines and growth factors initiate signaling in target cells by interacting with respective cell-surface receptors. The new data suggest that raft microdomains represent the units of function at the cell-surface through which ligand-stimulated STAT signaling is initiated. Moreover, recent evidence shows the involvement of chaperone proteins in regulating the STAT signaling pathway. These chaperones include the human homolog of the tumorous imaginal disc 1 protein (hTid1) which associates with Janus kinase 2 (JAK2) at the level of the plasma membrane, heat shock protein 90 (HSP90) which associates with STAT3 and STAT1 proteins in caveolin-1-containing raft and cytoplasmic complexes, and glucose regulated protein 58 (GRP58/ER-60/ERp57), a thiol dependent protein-disulfide isomerase, found in association with STAT3 "statosome" complexes in the cytosol and in the raft fraction. We suggest a function of the HSP90 chaperone system in preserving IL-6/STAT3 signaling in liver cells in the context of fever. The identification and function of protein partners associated with specific STAT species in rafts and in cytosolic complexes, and in the efficient departure of cytokine-activated STATs from the cytosolic face of rafts towards the cell nucleus are now areas of active investigation.
Źródło:: Acta Biochimica Polonica; 2003, 50, 3; 583-594
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Interleukin-6 biology is coordinated by membrane bound and soluble receptors.
Autorzy:: Rose-John, Stefan
Powiązania:: https://bibliotekanauki.pl/articles/1043433.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: inflammation
cytokine
sgp130Fc fusion protein
gp130
cytokine receptor
soluble receptor
Opis:: Cytokine receptors exist in membrane bound and soluble form. Both forms bind their ligands with comparable affinity. While most soluble receptors are antagonists in that they compete for the ligands with their membrane counterparts, some soluble receptors are agonists. In this case, the complex of ligand and soluble receptor binds on target cells to a second receptor subunit and initiates signal transduction. Soluble receptors of the IL-6 family of cytokines are agonists. In vivo, the IL-6/soluble IL-6R complex stimulates several types of target cells not stimulated by IL-6 alone, since they do not express the membrane bound IL-6R. This process has been named transsignaling. We have shown that in several chronic inflammatory diseases like chronic inflammatory bowl disease, peritonitis and rheumatoid arthritis, transsignaling via the soluble IL-6R complexed to IL-6 is a crucial point in the transition from the acute to the chronic state of the disease. The mechanism by which the IL-6/ soluble IL-6R complex regulates the inflammatory state is discussed.
Źródło:: Acta Biochimica Polonica; 2003, 50, 3; 603-611
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Serum levels of IFN-γ and IL-4 in hospitalised COVID-19 patients – evidence of reduced cytokine storm in discharged patients
Autorzy:: Olatunbosun Arinola, Ganiyu
Adekunle Onifade, Abdulfattah
Adigun, Kehinde
Babatunde Oshingbesan, Mosunmade
Powiązania:: https://bibliotekanauki.pl/articles/29520462.pdf
Data publikacji:: 2023-12-31
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: cytokine storm
re-purposed treatment
SARS-CoV-2
Opis:: Introduction and aim. Coronavirus disease 2019 is characterised by cytokine storm and it was managed with repurposed drugs, however the effect of this treatment on cytokine storm is unknown. The aim of the study was to investigate the effect of repurposed management on serum Th1 pro-inflammation cytokine (IFN-γ) and Th2 anti-inflammation cytokine (IL-4) in COVID-19 patients. Material and methods. The levels of IFN-γ and IL-4 were determined in sera from 45 COVID-19 patients at admission followed-up till discharge after repurposed treatment using ELISA. The mean levels and proportions above normal reference ranges of IFN-γ and IL-4 were compared in COVID-19 at admission and discharge. Results. The mean values of IFN-γ and IL-4 were significantly higher in COVID-19 patients at admission compared with discharged COVID-19 patients whereas IFN-γ:IL-4 ratio was significantly higher in discharged COVID-19 patients compared with admitted COVID-19 patients. Significantly higher proportion of COVID-19 patients at discharge had IFN-γ within the normalreference ranges compared with COVID-19 patients at admission whereas the proportions of COVID-19 patients at discharge and COVID-19 patients at admission having IL-4 within the normal reference ranges were the same. Conclusion. Cytokine storm was evidenced in COVID-19 patients at admission and repurposed treatment suppressed pro-inflammation cytokine (IFN-γ) in most discharged COVID-19 patients.
Źródło:: European Journal of Clinical and Experimental Medicine; 2023, 4; 750-755
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Blood platelet secretory activity in the course of giardiosis
Autorzy:: Matowicka-Karna, J.
Panasiuk, A.
Powiązania:: https://bibliotekanauki.pl/articles/837701.pdf
Data publikacji:: 1998
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: Giardia lamblia
cytokine
giardiasis
blood
cytotoxic effect
platelet
Źródło:: Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:: Annals of Parasitology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
Autorzy:: Maden, M.
Yildiz, R.
Çöl, R.
Arican, M.
Ider, M.
Parlak, K.
Tras, B.
Powiązania:: https://bibliotekanauki.pl/articles/2087148.pdf
Data publikacji:: 2021
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: abomasal displacement
acute phase response
oxidative stress
cytokine response
hemostatic dysfunction
dairy cow
Źródło:: Polish Journal of Veterinary Sciences; 2021, 24, 4; 595-605
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Occupational exposure to 50 Hz magnetic fields does not alter responses of inflammatory genes and activation of splenic lymphocytes in mice
Autorzy:: Luo, Xue
Jia, Shujie
Li, Renyan
Gao, Peng
Zhang, Yanwen
Powiązania:: https://bibliotekanauki.pl/articles/2177064.pdf
Data publikacji:: 2015-09-24
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: mice
magnetic fields
inflammation
spleen
lymphocytes
cytokine
Opis:: Objectives The objective of the present study was to observe the effects of 50 Hz magnetic fields (MFs) on the immune function of splenic lymphocytes in mice. Material and Methods Twenty male Kunming mice (6 weeks old), weighing 18– 25 g, were randomly divided into sham exposure (N = 10) and 500 μT MFs (N = 10) groups. The mice in the MFs group were exposed to 500 μT MFs for 8 h daily (5 days/week) for up to 60 days. In vitro study was carried out to examine the effects of 50 Hz MFs on the expression of inflammatory factor genes and a cluster of differentiation 69 (CD69) in mouse prime splenic lymphocytes activated by para-Methoxyamphetamine (PMA) and ionomycin. In the in vitro experiments, lymphocytes were isolated from the spleen of 10 healthy Kunming mice, the cells were cultured in the Roswell Park Memorial Institute 1640 medium (RPMI-1640) and exposed to 0 μT, 250 μT, 500 μT, or 1 mT MFs in an incubator under 5% carbon dioxide (CO₂) at 37°C for 6 h. The levels of interleukin-2 (IL-2), IL-4, interferon-gamma (IFN-γ), GATA binding protein 3 (GATA-3) and T cell-specific T-box transcription factor (T-bet) were assessed by the real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR), respectively. The expression of CD69 was checked using the flow cytometry. Results Under our experimental conditions, body weight of the mice exposed to occupational, extremely low frequency- electromagnetic fields (ELF-EMFs) significantly decreased on day 20 and day 30. There were no significant changes observed in vivo in spleen weight, splenic coefficient, splenic histology profile and cytokine production in spleen tissues. Our in vitro experiments showed that 50 Hz MFs had no effect on the expression of these genes and CD69 to primary splenic cells. Conclusions In conclusion, under the applied experimental conditions, occupational exposure to 50 Hz magnetic field did not alter responses of inflammatory genes and activation of splenic lymphocytes in mice, except for body weight.
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2016, 29, 2; 277-291
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Inflammatory mediators of hypertrophic adenoids in children with otitis media with effusion
Mediatory zapalne przyrosłych migdałkach gardłowych u dzieci chorych na wysiękowe zapaleniem ucha
Autorzy:: Leszko, Katarzyna
Latoch, Eryk
Żelazowska-Rutkowska, Beata
Powiązania:: https://bibliotekanauki.pl/articles/2215723.pdf
Data publikacji:: 2023-01-01
Wydawca:: Oficyna Wydawnicza Mediton
Tematy:: lymphocytes T and B
adenoid
cytokine
VEGF
MMP
apoptosis
limfocyty T i B
migdałek
cytokiny
apoptoza
Opis:: Adenoid is lymphoid tissues in the pharynx that play an important role in host defense against invading antigens. The structures of adenoid consist of well-defined microcompartments which all participate in the immune response: the lymphoepithelium, the follicular germinal center, the mantle zone, the interfollicular area. Otitis media with effusion (OME) is a common middle ear disease in children, but etiology of this disease is not clearly understood. Immunologic reaction within adenoid, pro-inflammatory cytokines (Th1 and Th2), decrease of lymphocytes T and B, metaloproteinase may lead to chronic infection.
Migdałek gardłowy wchodząc w skład obwodowych narządów limfatycznych jest miejscem pierwszego kontaktu z antygenami, docierającymi drogą oddechową i pokarmową. Migdałek gardłowy zawiera komórki aktywne immunologiczne niezbędne do odpowiedzi immunologicznej komórkowej oraz humoralnej. Komórki te zajmują trzy główne przedziały limfoidalne: limfonabłonek, grudkowe ośrodki rozmnażania wraz ze strefą osłonową tych ośrodków oraz przestrzeń międzygrudkowa. Wysiękowe zapalenie ucha środkowego (OME) jest częstą chorobą ucha środkowego występującą u dzieci. Jednak etiologia tej choroby nie jest do końca poznana. Reakcje immunologiczna toczące się w obrębie migdałka gardłowego, udział cytokin prozapalnych typu Th1 i Th2, limfocytów T i B oraz metaloproteinaz może prowadzić do przewlekłego zakażenia w obrębie ucha środkowego u dzieci.
Źródło:: Alergia Astma Immunologia - przegląd kliniczny; 2023, 28, 1; 31-34
1427-3101
Pojawia się w:: Alergia Astma Immunologia - przegląd kliniczny
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Origin of circulating acute phase cytokines: modified proteins may trigger il-6 production by macrophages. Preliminary report
Autorzy:: Koj, A
Guzdek, A.
Potempa, J.
Korzus, E.
Travis, J.
Powiązania:: https://bibliotekanauki.pl/articles/68989.pdf
Data publikacji:: 1994
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: interleukin 6
macrophage
acute phase cytokine
cytokine
modified protein
glycated albumin
fibrinogen degradation product
modified serpin
Źródło:: Journal of Physiology and Pharmacology; 1994, 45, 1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Role of p38 mitogen-activated protein kinase in the healing of gastric ulcers in rats
Autorzy:: Kabayashi, N.
Kataoka, T.
Ono, A.
Tsukimi, Y.
Okabe, S.
Powiązania:: https://bibliotekanauki.pl/articles/69658.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: ulcer
gastric ulcer
p38 kinase
cytokine
nitric oxide
angiogenesis
p38 mitogen-activated protein kinase
acetic acid
healing
rat
Źródło:: Journal of Physiology and Pharmacology; 2001, 52, 2
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Vacuum-assisted closure (VAC) for postoperative secondary peritonitis: Effect on bacterial load as well as local and systemic cytokine response (initial results)
Autorzy:: Jannasch, Olof
Meyer, Frank
Fuellert, Angela
König, Brigitte
Eder, Frank
Tautenhahn, Jörg
Powiązania:: https://bibliotekanauki.pl/articles/1392893.pdf
Data publikacji:: 2018
Wydawca:: Index Copernicus International
Tematy:: Vacuum-therapy
Postoperative secondary peritonitis
Bacterial load
Local and systemic cytokine response
Opis:: Aim: To investigate the effects of vacuum-assisted closure (VAC) vs. relaparotomy on demand (ROD) onto the i) severity and course of disease, ii) surgical outcome, iii) intraperitoneal bacterial load as well as iv) local/systemic inflammatory and immune response in postoperative secondary peritonitis. Methods: Over a defined time period, all consecutive patients of the reporting surgical department with a secondary peritonitis (assessed by Mannheim’s Peritonitis Index [MPI] and APPACHE II score) were enrolled in this systematic unicenter clinical prospective observational pilot study. Patients were subclassified into VAC or ROD group according to surgeon’s individual decision at the time point of primary surgical intervention with the intent to sanitize the source of infection. Early postoperative result was assessed by 30-d and in-hospital mortality. Bacterial load was characterized by microbiological culture of intraperitoneal fluid collection obtained on postoperative days (POD) 0 (primary surgical intervention), 1,4,7,10,13 and following description of the microbial spectrum including semiquantitative assessment of bacterial load. Local/systemic inflammatory and immune response was determined by ELISA-based analysis of CrP, PCT and the representative cytokines such as TNF-α/IL-1α/IL-6/IL-8/IL-10 of serum and peritoneal fluid samples. Results: Over a 26-month investigation period, 18 patients (male:female=9:9) were eligible for study criteria: n=8 were enrolled in the VAC and n=10 in the ROD group. With regard to early postoperative results represented by mortality, there is no significant difference between both patient groups. Despite the relatively low number of cases enrolled, a tendency for more severe findings associated with the VAC group could be detected based on the MPI score. There was also a tendency for higher APACHE II scores in the VAC group from the 7th POD on and, in addition, patients of this group had a longer hospital stay. For patients with persisting infection, there were no relevant differences comparing VAC therapy and ROD. Cytokines released in particular at the beginning of the inflammation cascade with proinflammatory characteristics showed higher values within the peritoneal fluid whereas CrP and PCT were found to be higher within the serum samples. Conclusion: Comparing data of various local/systemic inflammatory and immune parameters, there were only a few correlations. This may indicate compartmentation of the inflammatory process within the abdominal cavity. Based on the observed inter-individual variation of this pilot study data, the clinically applicable benefit appears questionable. In this context, reliable effects of VAC therapy on the reduction of bacterial burden within the abdominal cavity could not clearly be detected.
Źródło:: Polish Journal of Surgery; 2018, 90, 5; 27-35
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: The growth differentiation factor-15 (GDF-15) can be useful in the detection of distant metastases in sera of colorectal cancer patients
Autorzy:: Jakubowska, K.
Pryczynicz, A.
Dymicka-Piekarska, V.
Cepowicz, D.
Jagodzińska, D.
Lewczuk, Ł.
Lebelt, A.
Ozimkiewicz, M.
Kiszło, P.
Guzińska-Ustymowicz, K.
Powiązania:: https://bibliotekanauki.pl/articles/1917712.pdf
Data publikacji:: 2016
Wydawca:: Uniwersytet Medyczny w Białymstoku
Tematy:: Colorectal cancer
Growth differentiation factor-15
macrophage inhibitory cytokine-1
serum.
Opis:: Purpose: Growth differentiation factor-15 (GDF- 15) protein belongs to a transforming growth factor-β family which determines the growth and differentiation of cells. In cancers, GDF-15 influences on the proliferation, differentiation, viability, migration and invasiveness of cancer cells. The aim of our study was to evaluate the expression of GDF-15 in the tissue and its levels in sera of patients with colorectal cancer. Materials and methods: The level of GDF-15 in the sera of 55 patients diagnosed with colorectal cancer was determined using the ELISA method whereas expression of this protein was performed by immunohistochemical method. Results: The mean value of GDF-15 levels in the sera of patients with colorectal cancer was significantly higher than in healthy control group (p<0.001). The expression of GDF-15 in the tissue was weak, moderate and strong in 23.6%, 15.7% and 60.7% cases, respectively. Statistical analysis showed that the expression of GDF-15 correlated with patients’ age (p<0.005) and non-mucinous type of cancer (p<0.001). The high GDF-15 levels in the serum was associated with tumor size (p<0.01) and distant metastases (p<0.05). Conclusions: According to our results, we postulate that the level of GDF-15 in serum can be use to assess the metastatic behavior of colorectal cancer
Źródło:: Progress in Health Sciences; 2016, 6(1); 40-48
2083-1617
Pojawia się w:: Progress in Health Sciences
Dostawca treści:: Biblioteka Nauki