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Tytuł:
Bradykinin-related peptides up-regulate the expression of kinin B1 and B2 receptor genes in human promonocytic cell line U937
Autorzy:
Guevara-Lora, Ibeth
Florkowska, Magdalena
Kozik, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1040550.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
inflammation
cytokine
kinin receptors
macrophage
kinins
Opis:
Kinins, universal mediators of inflammation, are recognized by two kinds of receptors, B1 and B2, which have been found to be expressed in numerous cell types of several species. However, the knowledge of the regulation of these receptors in leukocytes is still not satisfactory. In the current work, we have demonstrated a constitutive production of B2 receptor mRNA in the human promonocyte U937 cells and its two-fold augmentation after cell differentiation with retinoic acid and phorbol ester. Bradykinin and des-Arg10-kallidin induced the expression of both B2 and B1 receptors in cells before and after differentiation. Generally, the undifferentiated cells were more susceptible to bradykinin-dependent induction of kinin receptors (increases by approximately 250% and 200% for B2 and B1 receptors, respectively). The induction, by approx. 200%, of B1 receptor by des-Arg10-kallidin was detected on both mRNA and protein levels. In addition, an unexpected strong induction of B2 receptor by this compound was observed in the retinoic acid- and phorbol ester-differentiated cells (by 150% and 200%, respectively) that suggests a possible autoregulation of kinin receptors by own agonists during the inflammatory state. On the other hand, a strong enhancement of the expression of both receptors by interleukin 1β, especially in the phorbol ester-differentiated cells, indicates the involvement of kinin receptors in the propagation of the inflammatory processes.
Źródło:
Acta Biochimica Polonica; 2009, 56, 3; 515-522
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Origin of circulating acute phase cytokines: modified proteins may trigger il-6 production by macrophages. Preliminary report
Autorzy:
Koj, A
Guzdek, A.
Potempa, J.
Korzus, E.
Travis, J.
Powiązania:
https://bibliotekanauki.pl/articles/68989.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
interleukin 6
macrophage
acute phase cytokine
cytokine
modified protein
glycated albumin
fibrinogen degradation product
modified serpin
Źródło:
Journal of Physiology and Pharmacology; 1994, 45, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Interleukin-6 biology is coordinated by membrane bound and soluble receptors.
Autorzy:
Rose-John, Stefan
Powiązania:
https://bibliotekanauki.pl/articles/1043433.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
inflammation
cytokine
sgp130Fc fusion protein
gp130
cytokine receptor
soluble receptor
Opis:
Cytokine receptors exist in membrane bound and soluble form. Both forms bind their ligands with comparable affinity. While most soluble receptors are antagonists in that they compete for the ligands with their membrane counterparts, some soluble receptors are agonists. In this case, the complex of ligand and soluble receptor binds on target cells to a second receptor subunit and initiates signal transduction. Soluble receptors of the IL-6 family of cytokines are agonists. In vivo, the IL-6/soluble IL-6R complex stimulates several types of target cells not stimulated by IL-6 alone, since they do not express the membrane bound IL-6R. This process has been named transsignaling. We have shown that in several chronic inflammatory diseases like chronic inflammatory bowl disease, peritonitis and rheumatoid arthritis, transsignaling via the soluble IL-6R complexed to IL-6 is a crucial point in the transition from the acute to the chronic state of the disease. The mechanism by which the IL-6/ soluble IL-6R complex regulates the inflammatory state is discussed.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 603-611
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Occupational exposure to 50 Hz magnetic fields does not alter responses of inflammatory genes and activation of splenic lymphocytes in mice
Autorzy:
Luo, Xue
Jia, Shujie
Li, Renyan
Gao, Peng
Zhang, Yanwen
Powiązania:
https://bibliotekanauki.pl/articles/2177064.pdf
Data publikacji:
2015-09-24
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
mice
magnetic fields
inflammation
spleen
lymphocytes
cytokine
Opis:
Objectives The objective of the present study was to observe the effects of 50 Hz magnetic fields (MFs) on the immune function of splenic lymphocytes in mice. Material and Methods Twenty male Kunming mice (6 weeks old), weighing 18– 25 g, were randomly divided into sham exposure (N = 10) and 500 μT MFs (N = 10) groups. The mice in the MFs group were exposed to 500 μT MFs for 8 h daily (5 days/week) for up to 60 days. In vitro study was carried out to examine the effects of 50 Hz MFs on the expression of inflammatory factor genes and a cluster of differentiation 69 (CD69) in mouse prime splenic lymphocytes activated by para-Methoxyamphetamine (PMA) and ionomycin. In the in vitro experiments, lymphocytes were isolated from the spleen of 10 healthy Kunming mice, the cells were cultured in the Roswell Park Memorial Institute 1640 medium (RPMI-1640) and exposed to 0 μT, 250 μT, 500 μT, or 1 mT MFs in an incubator under 5% carbon dioxide (CO₂) at 37°C for 6 h. The levels of interleukin-2 (IL-2), IL-4, interferon-gamma (IFN-γ), GATA binding protein 3 (GATA-3) and T cell-specific T-box transcription factor (T-bet) were assessed by the real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR), respectively. The expression of CD69 was checked using the flow cytometry. Results Under our experimental conditions, body weight of the mice exposed to occupational, extremely low frequency- electromagnetic fields (ELF-EMFs) significantly decreased on day 20 and day 30. There were no significant changes observed in vivo in spleen weight, splenic coefficient, splenic histology profile and cytokine production in spleen tissues. Our in vitro experiments showed that 50 Hz MFs had no effect on the expression of these genes and CD69 to primary splenic cells. Conclusions In conclusion, under the applied experimental conditions, occupational exposure to 50 Hz magnetic field did not alter responses of inflammatory genes and activation of splenic lymphocytes in mice, except for body weight.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 2; 277-291
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum levels of IFN-γ and IL-4 in hospitalised COVID-19 patients – evidence of reduced cytokine storm in discharged patients
Autorzy:
Olatunbosun Arinola, Ganiyu
Adekunle Onifade, Abdulfattah
Adigun, Kehinde
Babatunde Oshingbesan, Mosunmade
Powiązania:
https://bibliotekanauki.pl/articles/29520462.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cytokine storm
re-purposed treatment
SARS-CoV-2
Opis:
Introduction and aim. Coronavirus disease 2019 is characterised by cytokine storm and it was managed with repurposed drugs, however the effect of this treatment on cytokine storm is unknown. The aim of the study was to investigate the effect of repurposed management on serum Th1 pro-inflammation cytokine (IFN-γ) and Th2 anti-inflammation cytokine (IL-4) in COVID-19 patients. Material and methods. The levels of IFN-γ and IL-4 were determined in sera from 45 COVID-19 patients at admission followed-up till discharge after repurposed treatment using ELISA. The mean levels and proportions above normal reference ranges of IFN-γ and IL-4 were compared in COVID-19 at admission and discharge. Results. The mean values of IFN-γ and IL-4 were significantly higher in COVID-19 patients at admission compared with discharged COVID-19 patients whereas IFN-γ:IL-4 ratio was significantly higher in discharged COVID-19 patients compared with admitted COVID-19 patients. Significantly higher proportion of COVID-19 patients at discharge had IFN-γ within the normalreference ranges compared with COVID-19 patients at admission whereas the proportions of COVID-19 patients at discharge and COVID-19 patients at admission having IL-4 within the normal reference ranges were the same. Conclusion. Cytokine storm was evidenced in COVID-19 patients at admission and repurposed treatment suppressed pro-inflammation cytokine (IFN-γ) in most discharged COVID-19 patients.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 750-755
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The characterization of tumor necrosis factor alpha (TNF-α), its role in cancerogenesis and cardiovascular system diseases and possibilities of using this cytokine as a molecular marker
Autorzy:
Grabarek, Beniamin
Bednarczyk, Martyna
Mazurek, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/764842.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
cytokine
inflammatory process
cancerogenesis
cardiovascular diseases
marker
Opis:
Proces zapalny jest bezpośrednio związany z sekrecją cytokin, np. czynnika martwicy nowotworu alfa (ang. Tumor Necrosis Factor alpha; TNF-α). Ta cząsteczka jest 1 z 22 białek należących do rodziny TNF i wydzielana jest głównie przez: makrofagi, monocyty, limfocyty T oraz komórki tuczne. Biologiczne efekty działania TNF-α zachodzą dzięki wiązaniu się tej cytokiny ze specyficznymi dla niej receptorami – TNFR1 i TNFR2. Duża liczba prac potwierdza kluczową rolę TNF-α w nowotworzeniu i chorobach układu sercowo-naczyniowego, będących chorobami o podłożu prozapalnym. Niestety, mimo postępu medycyny i wzrostu świadomości społeczeństwa, wymienione choroby stanowią główne przyczyny śmierci na świecie. Lepsze zrozumienie roli tej cytokiny w kancerogenezie i chorobach zapalnych może spowodować wykorzystanie TNF-α jako markera tych chorób oraz do monitorowania przeciwzapalnych efektów terapii.
The inflammatory process is directly associated with secretion of cytokines, e.g. tumor necrosis factor alpha (TNF-α). This molecule is one of the 22 proteins which belong to TNF family and is secreted mainly by: macrophages, monocytes, T lymphocyte and mast cells. The biological effects of TNF-α is possible through binding this cytokine to specific receptors – TNFR1 and TNFR2. The large number of reports provides that this cytokine plays extremely important role in cancers and cardiovascular disease – two groups of inflammatory diseases. Unfortunately, these diseases are the main cause of death in spite of advances in medicine and increasing public awareness of prevention. It is believed that better understanding both molecular potential of this cytokine and the impact in cancerogenesis and others inflammatory diseases may cause using TNF-α as a molecular marker in these diseases and will make it possible to observe the effects of anti-inflammatory therapy. It will be able to cause a drop in the incidence of these diseases and better monitoring of them.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2017, 13; 1-8
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The growth differentiation factor-15 (GDF-15) can be useful in the detection of distant metastases in sera of colorectal cancer patients
Autorzy:
Jakubowska, K.
Pryczynicz, A.
Dymicka-Piekarska, V.
Cepowicz, D.
Jagodzińska, D.
Lewczuk, Ł.
Lebelt, A.
Ozimkiewicz, M.
Kiszło, P.
Guzińska-Ustymowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/1917712.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Colorectal cancer
Growth differentiation factor-15
macrophage inhibitory cytokine-1
serum.
Opis:
Purpose: Growth differentiation factor-15 (GDF- 15) protein belongs to a transforming growth factor-β family which determines the growth and differentiation of cells. In cancers, GDF-15 influences on the proliferation, differentiation, viability, migration and invasiveness of cancer cells. The aim of our study was to evaluate the expression of GDF-15 in the tissue and its levels in sera of patients with colorectal cancer. Materials and methods: The level of GDF-15 in the sera of 55 patients diagnosed with colorectal cancer was determined using the ELISA method whereas expression of this protein was performed by immunohistochemical method. Results: The mean value of GDF-15 levels in the sera of patients with colorectal cancer was significantly higher than in healthy control group (p<0.001). The expression of GDF-15 in the tissue was weak, moderate and strong in 23.6%, 15.7% and 60.7% cases, respectively. Statistical analysis showed that the expression of GDF-15 correlated with patients’ age (p<0.005) and non-mucinous type of cancer (p<0.001). The high GDF-15 levels in the serum was associated with tumor size (p<0.01) and distant metastases (p<0.05). Conclusions: According to our results, we postulate that the level of GDF-15 in serum can be use to assess the metastatic behavior of colorectal cancer
Źródło:
Progress in Health Sciences; 2016, 6(1); 40-48
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Differential responses of hematopoietic and non-hematopoietic cells to anti-inflammatory cytokines: IL-4, IL-13 and IL-10
Autorzy:
Guzdek, A.
Stalinska, K.
Guzik, K.
Koj, A.
Powiązania:
https://bibliotekanauki.pl/articles/69534.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
non-hematopoietic cell
macrophage
interleukin 10
blood
hepatoma
antiinflammatory cytokine
in vitro
hematopoietic cell
interleukin 4
man
tumour necrosis factor-alpha
cytokine
interleukin 13
monocyte
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
Autorzy:
Maden, M.
Yildiz, R.
Çöl, R.
Arican, M.
Ider, M.
Parlak, K.
Tras, B.
Powiązania:
https://bibliotekanauki.pl/articles/2087148.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
abomasal displacement
acute phase response
oxidative stress
cytokine response
hemostatic dysfunction
dairy cow
Źródło:
Polish Journal of Veterinary Sciences; 2021, 24, 4; 595-605
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hookworm infections in human and laboratory animals - differences and similarities in immune responses
Autorzy:
Długosz, E.
Powiązania:
https://bibliotekanauki.pl/articles/2146399.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
laboratory animal
infection
man
cytokine
eosinophil
similarity
difference
hookworm
inflammation
antibody
immune response
Źródło:
Wiadomości Parazytologiczne; 2005, 51, 3; 219-225
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vacuum-assisted closure (VAC) for postoperative secondary peritonitis: Effect on bacterial load as well as local and systemic cytokine response (initial results)
Autorzy:
Jannasch, Olof
Meyer, Frank
Fuellert, Angela
König, Brigitte
Eder, Frank
Tautenhahn, Jörg
Powiązania:
https://bibliotekanauki.pl/articles/1392893.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
Vacuum-therapy
Postoperative secondary peritonitis
Bacterial load
Local and systemic cytokine response
Opis:
Aim: To investigate the effects of vacuum-assisted closure (VAC) vs. relaparotomy on demand (ROD) onto the i) severity and course of disease, ii) surgical outcome, iii) intraperitoneal bacterial load as well as iv) local/systemic inflammatory and immune response in postoperative secondary peritonitis. Methods: Over a defined time period, all consecutive patients of the reporting surgical department with a secondary peritonitis (assessed by Mannheim’s Peritonitis Index [MPI] and APPACHE II score) were enrolled in this systematic unicenter clinical prospective observational pilot study. Patients were subclassified into VAC or ROD group according to surgeon’s individual decision at the time point of primary surgical intervention with the intent to sanitize the source of infection. Early postoperative result was assessed by 30-d and in-hospital mortality. Bacterial load was characterized by microbiological culture of intraperitoneal fluid collection obtained on postoperative days (POD) 0 (primary surgical intervention), 1,4,7,10,13 and following description of the microbial spectrum including semiquantitative assessment of bacterial load. Local/systemic inflammatory and immune response was determined by ELISA-based analysis of CrP, PCT and the representative cytokines such as TNF-α/IL-1α/IL-6/IL-8/IL-10 of serum and peritoneal fluid samples. Results: Over a 26-month investigation period, 18 patients (male:female=9:9) were eligible for study criteria: n=8 were enrolled in the VAC and n=10 in the ROD group. With regard to early postoperative results represented by mortality, there is no significant difference between both patient groups. Despite the relatively low number of cases enrolled, a tendency for more severe findings associated with the VAC group could be detected based on the MPI score. There was also a tendency for higher APACHE II scores in the VAC group from the 7th POD on and, in addition, patients of this group had a longer hospital stay. For patients with persisting infection, there were no relevant differences comparing VAC therapy and ROD. Cytokines released in particular at the beginning of the inflammation cascade with proinflammatory characteristics showed higher values within the peritoneal fluid whereas CrP and PCT were found to be higher within the serum samples. Conclusion: Comparing data of various local/systemic inflammatory and immune parameters, there were only a few correlations. This may indicate compartmentation of the inflammatory process within the abdominal cavity. Based on the observed inter-individual variation of this pilot study data, the clinically applicable benefit appears questionable. In this context, reliable effects of VAC therapy on the reduction of bacterial burden within the abdominal cavity could not clearly be detected.
Źródło:
Polish Journal of Surgery; 2018, 90, 5; 27-35
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Selected cytokines and morphological parameters of blood in patients with Giardia intestinalis or Toxoplasma gondii
Autorzy:
Czyzewska, J.
Matowicka-Karna, J.
Kemona, H.
Powiązania:
https://bibliotekanauki.pl/articles/5611.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
cytokine
morphological parameter
blood
patient
Giardia intestinalis
Toxoplasma gondii
human disease
giardiasis
toxoplasmosis
Źródło:
Annals of Parasitology; 2016, 62, Suppl.
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hookworm infections in human and laboratory animals - differences and similarities in immune responses
Autorzy:
Dlugosz, E
Powiązania:
https://bibliotekanauki.pl/articles/837842.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
laboratory animal
infection
man
cytokine
eosinophil
similarity
difference
hookworm
inflammation
antibody
immune response
Źródło:
Annals of Parasitology; 2005, 51, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inflammatory mediators of hypertrophic adenoids in children with otitis media with effusion
Mediatory zapalne przyrosłych migdałkach gardłowych u dzieci chorych na wysiękowe zapaleniem ucha
Autorzy:
Leszko, Katarzyna
Latoch, Eryk
Żelazowska-Rutkowska, Beata
Powiązania:
https://bibliotekanauki.pl/articles/2215723.pdf
Data publikacji:
2023-01-01
Wydawca:
Oficyna Wydawnicza Mediton
Tematy:
lymphocytes T and B
adenoid
cytokine
VEGF
MMP
apoptosis
limfocyty T i B
migdałek
cytokiny
apoptoza
Opis:
Adenoid is lymphoid tissues in the pharynx that play an important role in host defense against invading antigens. The structures of adenoid consist of well-defined microcompartments which all participate in the immune response: the lymphoepithelium, the follicular germinal center, the mantle zone, the interfollicular area. Otitis media with effusion (OME) is a common middle ear disease in children, but etiology of this disease is not clearly understood. Immunologic reaction within adenoid, pro-inflammatory cytokines (Th1 and Th2), decrease of lymphocytes T and B, metaloproteinase may lead to chronic infection.
Migdałek gardłowy wchodząc w skład obwodowych narządów limfatycznych jest miejscem pierwszego kontaktu z antygenami, docierającymi drogą oddechową i pokarmową. Migdałek gardłowy zawiera komórki aktywne immunologiczne niezbędne do odpowiedzi immunologicznej komórkowej oraz humoralnej. Komórki te zajmują trzy główne przedziały limfoidalne: limfonabłonek, grudkowe ośrodki rozmnażania wraz ze strefą osłonową tych ośrodków oraz przestrzeń międzygrudkowa. Wysiękowe zapalenie ucha środkowego (OME) jest częstą chorobą ucha środkowego występującą u dzieci. Jednak etiologia tej choroby nie jest do końca poznana. Reakcje immunologiczna toczące się w obrębie migdałka gardłowego, udział cytokin prozapalnych typu Th1 i Th2, limfocytów T i B oraz metaloproteinaz może prowadzić do przewlekłego zakażenia w obrębie ucha środkowego u dzieci.
Źródło:
Alergia Astma Immunologia - przegląd kliniczny; 2023, 28, 1; 31-34
1427-3101
Pojawia się w:
Alergia Astma Immunologia - przegląd kliniczny
Dostawca treści:
Biblioteka Nauki
Artykuł
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