- Tytuł:
- Tumor Anti-Initiation and Anti-Progression Properties of Sulphated-Extract of Colocasia esculenta
- Autorzy:
-
Gamal-Eldeen, Amira M.
Amer, Hassan
Fahmy, Cinderella A.
Dahlawi, Haytham
Elesawy, Basem H.
Faizo, Nahla L.
Raafat, Bassem M. - Powiązania:
- https://bibliotekanauki.pl/articles/2015590.pdf
- Data publikacji:
- 2021-12-01
- Wydawca:
- Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
- Tematy:
-
Colocasia esculenta
CYP1A
cancer chemoprevention & tumor anti-initiating
HDAC
macrophage function
breast MCF-7 carcinoma - Opis:
- Colocasia esculenta (Taro) is an edible tuberous plant; however, corms are its most worldwide consumed part while the corm powder is widely used in food industries. In this work, a sulphated polysaccharide extract of C. esculenta corm (SCE) was prepared and its cancer chemopreventive properties was explored. The amending of carcinogen metabolism and radical scavenging affinity revealed that SCE is a strong tumor anti-initiation agent via suppressing cytochrome P450-1A and enhancing glutathione and the carcinogen detoxification enzyme; glutathione S-transferase. SCE exhibited a strong scavenging affinity towards critical radicals (hydroxyl and peroxyl). It induced lymphocyte growth and modulated the macrophage functions into an anti-inflammatory profile, via elevating macrophage proliferation and its binding affinity of fluorescein isothiocyanate-lipopolysaccharide (FITC-LPS) and inhibiting nitric oxide and tumor necrosis factor-α generation. Furthermore, SCE showed a potent cytotoxicity against human breast MCF-7 carcinoma cells (IC50 27.73 µg/mL), whereas SCE treatment inhibited the activity of histone deacetylase (HDAC IC50 37.70 µg/mL) and disturbed the pattern of cell cycle phases. An arrest in both S- and G2/M-phases was linked with shifted cell populations towards late apoptosis and necrosis, as detected by flow cytometry. SCE is a promising cancer chemopreventive agent to be used in healthy food industries and for high breast cancer-risk population.
- Źródło:
-
Polish Journal of Food and Nutrition Sciences; 2021, 71, 4; 393-401
1230-0322
2083-6007 - Pojawia się w:
- Polish Journal of Food and Nutrition Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł