- Tytuł:
- New functional aliphatic polycarbonates – materials for advanced biomedical applications
- Autorzy:
-
Pastusiak, M.
Kawalec, M.
Jaworska, J.
Kurcok, P.
Janeczek, H.
Dobrzyński, P. - Powiązania:
- https://bibliotekanauki.pl/articles/284834.pdf
- Data publikacji:
- 2014
- Wydawca:
- Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
- Tematy:
-
bioresorbable polymers
cyclic carbonates (co)polymerization
1,3-trimethylene carbonate
functional polymers - Opis:
- The aim of this study is to develop a new method of synthesis of functional (co)polycarbonates by ring -opening polymerization of ethyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate (MTC-Et), benzyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate (MTC-Bz) and their copolymerization with 1,3-trimethylene carbonate (TMC) with potential application in the formation of bioresorbable scaffolds for living cells and drug delivery, systems for achieving controlled drug release. (Co)polymerizations were conducted in bulk, in the presence of low toxic lanthanum acetylacetonate - La(acac)3xH2O as catalyst. All synthesized materials were obtained at 120°C. The results are very promising. A series of (co) polymers were obtained with high conversion and relatively high molecular weights. The composition of the comonomers and their sequence lengths were determined by means 1H NMR and 13C NMR measurements. Higher reactivity during the investigated copolymerizations presented carbonates with pending ethyl or benzyl group than 1,3-trimethylene carbonate. The thermal properties obtained (co)polymers were characterized by differential scanning calorimetry.
- Źródło:
-
Engineering of Biomaterials; 2014, 17, no. 128-129; 103-106
1429-7248 - Pojawia się w:
- Engineering of Biomaterials
- Dostawca treści:
- Biblioteka Nauki
Artykuł