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Wyświetlanie 1-10 z 68
Tytuł:
Differential distribution of cathepsin b in human umbilical cord tissues
Autorzy:
Gogiel, Tomasz
Galewska, Zofia
Romanowicz, Lech
Powiązania:
https://bibliotekanauki.pl/articles/1039685.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
umbilical cord
pregnancy
cathepsin B
umbilical cord artery
umbilical cord vein
Wharton's jelly
Opis:
The extracellular matrix components are differentially distributed among various structures of the umbilical cord. Wharton's jelly is especially rich in collagens and growth factors. Cathepsin B is a major cysteine protease involved in collagen degradation, as well as in the activation of precursor forms of other collagenolytic enzymes and growth factors. We assessed the activity and expression of cathepsin B in the umbilical cord arteries, veins and Wharton's jelly. Extracts of separated umbilical cord components were subjected to an activity assay with the use of specific fluorogenic substrate. The expression of cathepsin B protein was qualitatively evaluated by Western immunoblotting and quantitatively determined with an immunoenzymatic method. The total cathepsin B activity and content calculated per gram of DNA were higher in Wharton's jelly than in the umbilical cord vessels, and the latter parameter was the lowest in the umbilical cord arteries. Moreover, the expression and the activity of latent cathepsin B (following activation by pepsin digestion) calculated per gram of DNA were the highest in Wharton's jelly and the lowest in the umbilical cord arteries. High expression and activity of latent, pepsin-activatable cathepsin B related to DNA content in Wharton's jelly seem to reflect the stimulation of its cells by high amounts of collagen I and growth factors.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 679-684
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distribution of cathepsin L in human umbilical cord tissues
Autorzy:
Gogiel, Tomasz
Wolańska, Małgorzata
Galewska, Zofia
Kinalski, Piotr
Sobolewski, Krzysztof
Romanowicz, Lech
Powiązania:
https://bibliotekanauki.pl/articles/1038609.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cathepsin L
cysteine protease inhibitors
umbilical cord
umbilical cord artery
umbilical cord vein
Wharton's jelly
Opis:
The extracellular matrix components show specific distribution patterns within various structures of the umbilical cord, among which Wharton's jelly is especially collagen-rich tissue. Cathepsin L is a potent cysteine protease engaged in degradation of extracellular matrix proteins, including collagens. We evaluated the activity and expression of cathepsin L, and the inhibitory effect of cysteine protease inhibitors in the umbilical cord arteries, vein and Wharton's jelly. Cathepsin L activity and anti-papain inhibitory effect of cysteine protease inhibitors were quantified in extracts of separated umbilical cord tissues using fluorogenic substrates. The results were calculated per DNA content. The enzyme expression was assessed by Western immunoblotting. The active cathepsin L activity (without activation by pepsin digestion), its percentage in the total activity (after pepsin activation), and the expression of the mature single-chain enzyme were the lowest in the umbilical cord arteries and the highest in Wharton's jelly. The effect of cysteine protease inhibitors showed similar distribution as in the case of the active enzyme, being the highest in Wharton's jelly. Distribution of the activity and expression of mature cathepsin L within the umbilical cord probably results from distinctions in the proenzyme activation process. Differences in the action of cysteine protease inhibitors can partly restrict divergences in the enzyme activity that could reflect its expression alone. Differential enzyme action seems to contribute to tissue-specific collagen turnover within the umbilical cord cells, especially those of Wharton's jelly.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 507-512
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical and Radiological Differences in Patients Following Traumatic SCI at Different Ages
Autorzy:
Mendonça, Thalia Saraiva
de Arruda Andrade, Vitor Dias
Nogarotto Cembraneli, Pedro
de Faria Cavalcante, Julia Brasileiro
Rocha, André Salotto
Tognola, Waldir Antonio
Morais, Dionei de Freitas
de Melo-Neto, João Simão
Powiązania:
https://bibliotekanauki.pl/articles/28409361.pdf
Data publikacji:
2021-08-21
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
life cycle stages
stage
life cycle
spinal cord injuries
spinal cord trauma
Opis:
Background. Traumatic spinal cord injury (SCI) is a lesion that can affect several spinal structures, including the vertebrae, spinal cord, ligaments, and other adjacent parts of the spine. Traumatic spinal cord injury (SCI) can cause functional changes in patients of different ages. Material and methods. The study aims to determine whether there are social, clinical, and radiological differences between young, middle-aged, and elderly adults with SCI caused by a ground-level fall. This retrospective study analyzed the records of patients with a clinical diagnosis of SCI. It enrolled patients with traumatic spinal cord injury after a ground-level fall divided as follows: young aged adults 18–35 years of age (G1); middle-aged adults aged 36–60 years (G2); and elderly adults aged over 60 years (G3). Their clinical, social, and radiological variables were analyzed. Results. It is observed that low schooling level, being widowed, and being a homemaker were more frequently encountered among elderly adults, whereas being single was more common in middle-aged adults. The morphologic diagnosis of compression fracture and the associated injury of facial trauma occurred more frequently in elderly adults, with an increasing tendency with age. Conservative therapeutic management was most commonly encountered in elderly adults, compared to surgery from a posterior approach in middle-aged adults. Listhesis was better identified in middle-aged adults by computed tomography (CT). Spinal cord contusion and injury to the C1 vertebra were demonstrated in young adults by magnetic resonance imaging (MRI). Conclusions. 1. Elderly adults with low education level, widowed, and homemakers were more susceptible to SCI caused by a fall. 2. Single marital status was more frequently noted in young adults. 3. The most frequent clinical aspects were the morphological aspect of compression fracture and facial trauma as an associated injury in elderly adults, with the occurrence of facial trauma increasing with age. 4. Conservative therapeutic management was more common in elderly adults than surgery from a posterior approach in middle-aged adults. 5. Regarding the radiological aspects of CT, listhesis was better identified in middle-aged adults. Spinal cord contusions and C1 vertebra lesions were better identified in young adults by MRI.
Źródło:
Ortopedia Traumatologia Rehabilitacja; 2021, 23(4); 305-314
1509-3492
2084-4336
Pojawia się w:
Ortopedia Traumatologia Rehabilitacja
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spinal arachnoid cysts – a report of two cases and a review of the literature
Autorzy:
Mehta, S.
Dharmarajan, S.
Brzozowski, M.
Trojanowski, T.
Powiązania:
https://bibliotekanauki.pl/articles/3719.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
spinal arachnoid cyst
spinal cord tumour
spinal cord lesion
patient
neurological symptom
Źródło:
Journal of Pre-Clinical and Clinical Research; 2010, 04, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
FGF binding by extracellular matrix components of Whartons jelly
Autorzy:
Malkowski, Andrzej
Sobolewski, Krzysztof
Jaworski, Stefan
Bankowski, Edward
Powiązania:
https://bibliotekanauki.pl/articles/1041086.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
umbilical cord
fibroblast growth factor
metalloproteinases
Opis:
Our earlier paper has reported that Wharton's jelly is a reservoir of several peptide growth factors, including acidic and basic fibroblast growth factors (aFGF and bFGF, respectively). Both can be extracted by buffered salts solutions in the form of high molecular mass complexes, probably with a component(s) of the extracellular matrix. Both aFGF and bFGF from such extracts hardly penetrate 10% polyacrylamide gels during electrophoresis. Pre-treatment of Wharton's jelly with hyaluronidase slightly increased the extractability of aFGF, but did not affect the extractability of bFGF. In contrast, the pre-treatment of tissue homogenate with bacterial collagenase (2000 U/ml, 37°C, 18 h) increased the extractability of bFGF. The presence of β-mercaptoethanol in the extracting solutions increased the extractability of both FGFs, but did not release FGFs in their free form, despite reducing the molecular mass of the FGF-containing complexes. We conclude that both aFGF and bFGF are bound through disulphide bonds to a protein component of Wharton's jelly. We propose that ground substance composed mainly of collagen fibrils and hyaluronate molecules, which surrounds the cells of Wharton's jelly, prevents the access of the extracting solution to aFGF and bFGF. Although hyaluronate and collagen do not bind aFGF or bFGF directly, they may constitute a barrier which prevents the dispersion of FGFs in Wharton's jelly. Thus, the high concentration of FGFs around the cells of Wharton's jelly may facilitate the interaction of these factors with membrane receptors, thereby resulting in stimulation of cell division and differentiation, as well as of the synthesis of extracellular matrix components.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 357-363
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spontaneous intramedullary spinal cord haemorrhage due to anticoagulation therapy
Autorzy:
Szmygin, M.
Kuczynska, M.
Kuklik, E.
Niziolek, J.
Porzucek, A.
Drelich-Zbroja, A.
Powiązania:
https://bibliotekanauki.pl/articles/2099029.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
spontaneous
spinal cord
MR Imaging
intramedullary
Opis:
Background: Anticoagulants are used mainly in the prevention of venous thromboembolism. The frequency of haemorrhagic complications is correlated with patients’ age and level of International Normalized Ratio (INR). Spontaneous intramedullary spinal cord haemorrhage due to anticoagulation therapy is an extremely rare occurrence. A 62-year old male was admitted to hospital with acute abdominal pain and paraplegia. Because of persistent atrial fibrillation and previous history of ischaemic stroke, on admission the patient was treated with anticoagulant, INR – 15. MRI revealed an abnormal fusiform hyperintesity area in the spinal cord. ‘Haemo’ sequence confirmed the presence of hemosiderin deposits at the level of Th5 – Th7. Anticoagulation therapy might be a cause of spontaneous intramedullary spinal cord haemorrhage. Maintaining high levels of clinical suspicion and utilizing MRI with additional ‘haemo’ option may help in making the right diagnosis.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2019, 13, 4; 179-180
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Collagen of umbilical cord vein and its alterations in pre-eclampsia.
Autorzy:
Romanowicz, Lech
Jaworski, Stefan
Powiązania:
https://bibliotekanauki.pl/articles/1043784.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
collagen
umbilical cord vein
pre-eclampsia
Opis:
The state of the vascular system of the mother and of placenta is known to exert a great influence on intrauterinal development of the fetus. Pre-eclampsia is the most common pathological syndrome connected with pregnancy. Since collagen is one of the main constituents of the vessel wall a comparison was made with collagen content and its molecular polymorphism in umbilical cord veins of newborns from healthy and pre-eclamptic mothers. It was found that umbilical cord veins of newborns from mothers with pre-eclampsia contained 18% less collagen than those of the newborns from normal pregnancies. This decrease was accompanied by a slight decrease of collagen solubility, but all its types (I, III, IV, V and VI) were present. However, the umbilical vein wall of newborns from mothers with pre-eclampsia contained relatively less of type I and more of type III collagen than the normal umbilical cord. These differences may be connected with a disturbance of blood flow in fetus of a woman with pre-eclampsia.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 451-458
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Proteoglycans of human umbilical cord arteries.
Autorzy:
Gogiel1, Tomasz
Jaworski, Stefan
Powiązania:
https://bibliotekanauki.pl/articles/1044232.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
pregnancy
umbilical cord
proteoglycans
artery
glycosaminoglycans
Opis:
Proteoglycans (PGs) were dissociatively extracted from human umbilical cord arteries (UCAs) with 4 M guanidine hydrochloride containing Triton X-100 and protease inhibitors, purified by Q-Sepharose anion exchange chromatography and lyophilized. They were analysed by gel filtration, SDS/PAGE and agarose gel electrophoresis before and after treatment with chondroitinase ABC. It was found that the PG preparation was especially enriched in chondroitin/dermatan sulphate PGs. The predominant PG fraction included small PGs that emerged from Sepharose CL-2B with Kav = 0.74. Their molecular mass, estimated by SDS/PAGE, was 160-200 kDa and 90-150 kDa, i.e. it was typical for biglycan and decorin, respectively. Treatment with chondroitinase ABC yielded the core proteins of 45 and 47 kDa, characteristic for both small PGs. Remarkable amounts of the 45 kDa protein were detected in non-treated PG samples, suggesting the presence of free core proteins of biglycan and decorin. Large PGs were present in lower amounts. In intact form they were eluted from Sepharose CL-2B with Kav = 0.17 and 0.43. Digestion with chondroitinase ABC yielded the core proteins with a molecular mass within the range of 180-360 kDa but predominant were the bands of 200, 250 and 360 kDa. The large PGs probably represent various forms of versican or perlecan bearing chondroitin sulphate chains.
Źródło:
Acta Biochimica Polonica; 2000, 47, 4; 1081-1091
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Safety and efficacy of granulocyte colony stimulating factor in a patient with tetraplegia caused by cervical hyperextension injury: a case report
Autorzy:
Okurowska-Zawada, B
Kułak, W
Sienkiewicz, D
Paszko-Patej, G
Dmitruk, E
Kalinowska, A
Wojtkowski, J
Korzeniecka–Kozerska, A
Powiązania:
https://bibliotekanauki.pl/articles/1916580.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Cervical hyperextesniosn
spinal cord injury
tetraplegia
male
Opis:
he authors present the case of a 17-year-old boy who suffered a cervical spinal injury as a result of the sharp bending of the head after slipping (without falling). After about 30 minutes, he began to feel tingling in the limbs and he developed tetraparesis. He went through physical rehabili-tation, psychological rehabilitation, occupational therapy, and periodic catheterization. Additionally, we introduced to him a low dose of analog granulocyte colony-stimulating factor (G-CSF). G-CSF 5 μg/kg was given subcutaneously daily for 5 days per month for 3 months, again after 6 months, and again after 10 months. The boy could sit indecently and walk with assistance. A significant increase in muscle strength in this patient with tetraplegia after 10 months of treatment may indicate beneficial effects of G-CSF in this disorder.
Źródło:
Progress in Health Sciences; 2014, 4, 2; 181-184
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-Anisakis antibodies in human umbilical cord blood
Przeciwciała anty-Anisakis w ludzkiej krwi pępowinowej
Autorzy:
Figueiredo Jr, Israel
Vericimo, Mauricio Afonso
São Clemente, Sergio Carmona
Brasil Teixeira, Gerlinde Platais
Powiązania:
https://bibliotekanauki.pl/articles/1030876.pdf
Data publikacji:
2018
Wydawca:
Medical Communications
Tematy:
Anisakis spp.
ELISA
cord blood
fish
newborn
Opis:
Introduction: Little is known about the influence of seroreactivity to fish nematode antigens on the unborn child. Aim: The objective of this study was to ascertain whether infants born to women with Anisakis spp. seroreactivity had problems with growth at birth, or during neonatal care. Methods: We conducted a retrospective database search of puerperal women interviewed at two perinatal facilities in Niterói, Brazil. Neonates were selected by the presence of anti-Anisakis IgG antibodies in cord blood and categorised, by analysis of maternal blood results, as reactive or nonreactive. The Mann–Whitney U test was used for hypothesis testing in continuous variables. A generalised linear model was used for binary logistic regression. Results: Of the 147 neonates studied, 121 were labelled as nonreactive and 26, as reactive. There were no significant betweengroup differences in maternal age (p = 0.193), number of prenatal visits (p = 0.362), presence of prenatal conditions (p = 0.980), mode of delivery (p = 0.193), gestational age (p = 0.266), birth weight (p = 0.294), need for resuscitation (p = 0.675), development of conditions during hospital stay (p = 0.201), or length of hospital stay (p = 0.528). There was also no significant association between IgG positivity in cord blood in raw fish intake (p = 1.000) or intake >2 times/week (p = 0.729). Conclusions: The presence of anti-Anisakis IgG in cord blood of infants born to women seroreactive to Anisakis did not pose a hazard to this neonatal population and did not influence growth, conditions at birth, or development of any clinical conditions before hospital discharge.
Wstęp: Niewiele wiemy na temat wpływu seroreaktywności w kierunku antygenów nicieni pasożytujących na rybach na płód. Cel pracy: Niniejsze badanie miało na celu stwierdzenie, czy seroreaktywność matki w kierunku Anisakis spp. wpływa na rozwój dziecka w trakcie ciąży lub bezpośrednio po urodzeniu. Metody: W powyższym celu przeprowadzono retrospektywne badanie analizujące dane pacjentek objętych opieką dwóch placówek położniczych w Niterói w Brazylii. Uwzględnione w badaniu noworodki zostały wyłonione na podstawie obecności przeciwciał IgG anty-Anisakis w krwi pępowinowej i podzielone na dwie grupy, jako charakteryzujące się seroreaktywnością bądź jej brakiem, na podstawie wyników badania krwi matki. W celu sprawdzenia hipotezy dotyczącej zmiennych ciągłych posłużono się testem U Manna–Whitneya. W celu przeprowadzenia binarnej regresji logistycznej zastosowano uogólniony model liniowy. Wyniki: Spośród 147 noworodków objętych badaniem 121 dzieci zaklasyfikowano jako niereaktywne, a 26 – jako reaktywne w kierunku anisakiozy. Nie stwierdzono występowania statystycznie istotnych różnic pomiędzy grupami pod względem wieku matki (p = 0,193), liczby wizyt w okresie ciąży (p = 0,362), występowania u płodu jednostek klinicznych w okresie prenatalnym (p = 0,980), sposobu rozwiązania (p = 0,193), wieku ciąży w momencie rozwiązania (p = 0,266), masy urodzeniowej (p = 0,294), konieczności resuscytacji po urodzeniu (p = 0,675), pojawienia się problemów zdrowotnych u dziecka w trackie pobytu w szpitalu (p = 0,201) ani też długości pobytu w szpitalu (p = 0,528). Nie stwierdzono również statystycznie istotnej korelacji pomiędzy obecnością przeciwciał klasy IgG w krwi pępowinowej a obecnością surowych ryb w diecie matki (p = 1,000) ani też spożyciem surowych ryb częstszym niż dwa razy w tygodniu (p = 0,729). Wnioski: W badanej przez nas populacji noworodków obecność przeciwciał anty-Anisakis klasy IgG w krwi pępowinowej noworodków urodzonych przez matki charakteryzujące się seroreaktywnością w kierunku nicieni z rodziny Anisakis nie stwarzała zagrożenia i nie miała wpływu na rozwój fizyczny płodu, występowanie u niego jednostek chorobowych w momencie urodzenia ani ich pojawienie się w okresie pobytu w szpitalu po urodzeniu.
Źródło:
Pediatria i Medycyna Rodzinna; 2018, 14, 3; 310-313
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 68

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