- Tytuł:
- The basic biology of erbB-2 and its participation in colorectal cancers
- Autorzy:
-
Stawińska, Magdalena
Bryś, Magdalena
Krajewska, Wanda M - Powiązania:
- https://bibliotekanauki.pl/articles/764806.pdf
- Data publikacji:
- 2005
- Wydawca:
- Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
- Tematy:
-
ErbB-2
colorectal cancers
signal transduction
tumour growth - Opis:
- ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission of signals controlling normal cell growth and differentiation. A range of growth factors serve as ligands, but none is specific for the ErbB-2 receptor. Ligand binding to ErbB-1, ErbB-3 and ErbB-4 induces rapid receptor dimerization, with a marked preference for ErbB-2 as a dimer partner. When ErbB-2 is overexpressed multiple ErbB-2 heterodimers are formed and cell signalling is stronger, resulting in enhanced responsiveness to growth factors and malignant growth. This explains why ErbB-2 overexpression is an indicator of poor prognosis in colorectal cancers and may be predictive of response to treatment. ErbB-2 is a highly specific and promising target for new colon cancer treatments.
- Źródło:
-
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2005, 2
1730-2366
2083-8484 - Pojawia się w:
- Acta Universitatis Lodziensis. Folia Biologica et Oecologica
- Dostawca treści:
- Biblioteka Nauki
Artykuł