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Tytuł:
Increased constitutional chromosome sensitivity to bleomycin in patients with hereditary non-polyposis colorectal cancer [HNPCC]
Autorzy:
Kladny, J
Zajaczek, S
Lubinski, J
Powiązania:
https://bibliotekanauki.pl/articles/2047245.pdf
Data publikacji:
1996
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
chromosome sensitivity
lymphocyte
hereditary non-polyposis colorectal cancer
tumour
colorectal cancer
bleomycin
genotoxic effect
Opis:
It has been suggested that mutagen sensitivity is a constitutional factor which may be useful in identification of patients with an increased risk for the development of tumors. In this study, the chromosome sensitivity to bleomycin was measured according to Hsu in patients with hereditary non-polyposis colorectal cancer (HNPCC), sporadic colorectal cancer and in control persons with no tumor history in family. In vitro lymphocytes were exposed to bleomycin according to Hsu and chromosomal damage was quantified by scoring breaks of 100 cells. A significant difference (P < 0.01) in the mean number of breaks per cell (b/c) was found between HNPCC patients (0.59 ± 0.14; n = 12; mean age 55.4 yrs) and control individuals (0.35 ± 0.13: n = 12; mean age 55.8 yrs). In contrast, patients with sporadic colorectal cancer showed a mean b/c value of 0.43 ± 0.14 (n = 14; mean age 63.4 yrs) which was not significantly higher than that in control individuals for this group (0.42 ± 0.15; n = 14; mean age 63.1 yrs). Selenium protected lymphocytes of HNPCC patients against bleomycin activity in vitro.
Źródło:
Journal of Applied Genetics; 1996, 37, 4; 385-392
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Incidence of hereditary non-polyposis colorectal cancer [HNPCC] in the city of Szczecin, north-western Poland
Autorzy:
Kladny, J
Lubinski, J
Powiązania:
https://bibliotekanauki.pl/articles/2046601.pdf
Data publikacji:
1997
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
incidence
Polska
Szczecin city
hereditary non-polyposis colorectal cancer
colorectal cancer
Opis:
The study population consisted of 140 consecutive colorectal cancer patients, inhabitants of the city of Szczecin, north-west Poland, who were histopathologically diagnosed in the period of 2 years - 1991-1992. Family history was obtained in 124 (88.6%) of patients. A definitive diagnosis of HNPCC was established if requirements of the International Collaborative Group on HNPCC (ICG- HNPCC) were met. Suspected HNPCC were recognised according to criteria described by Ponz de Leon or Mecklin or Kunitomo. HNPCC as defined by International Collaborative Group on HNPCC was identified in 2 (1.6%) families. Suspected HNPCC were recognised in 16.9%, 3.2% and 4.0% of patients if Ponz de Leon or Mecklin or Kunitomo criteria were applied, respectively. In our series in 19 of 124 cases, colorectal carcinomas were diagnosed in patients under 50 years of age. Only in one of these cases, features characteristic of HNPCC other than young age were found which suggests that in our region the frequency of somatic or germ line de novo mutations in genes predisposing to colorectal cancer may be high. Our results suggest that the frequency of HNPCC inherited from ancestors in Poland and other countries is approximately similar and this syndrome is common disease everywhere.
Źródło:
Journal of Applied Genetics; 1997, 38, 1; 103-114
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prognostic significance of p53 protein accumulation in cancer cells obtained from selected group of patients with sporadic colorectal cancer
Autorzy:
Paluszkiewicz, P
Karski, J.
Berbec, H.
Pawlowska-Wakowicz, B.
Cybulski, M.
Karski, M.
Paszkowska, A.
Powiązania:
https://bibliotekanauki.pl/articles/2043897.pdf
Data publikacji:
1999
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
patient
cancer cell
monoclonal antibody
p53 protein
cancer prognosis
immunohistochemistry
sporadic colorectal cancer
accumulation
colorectal cancer
Źródło:
Journal of Applied Genetics; 1999, 40, 2; 135-144
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Age at diagnosis of cancer as predictor of mutation accurrence in families suspected of HNPCC
Autorzy:
Kurzawski, G
Debniak, T.
Kladny, J.
Lubinski, J.
Powiązania:
https://bibliotekanauki.pl/articles/2041741.pdf
Data publikacji:
2001
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
diagnosis
mutation
age
colorectal cancer
mutational analysis
cancer
Źródło:
Journal of Applied Genetics; 2001, 42, 3; 359-366
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Plasminogen activator inhibitor 1 (PAI-1) 1334G/A genetic polymorphism in colorectal cancer.
Autorzy:
Smolarz, Beata
Romanowicz-Makowska, Hanna
Kulig, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043627.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
PCR
1334G/A polymorphism
prognostic marker
colorectal cancer
plasminogen activator inhibitor 1 (PAI-1)
Opis:
Plasminogen activator inhibitor 1 (PAI-1) content in colorectal cancer tissue extracts may be of strong prognostic value: high levels of PAI-1 in tumours predict poor prognosis. The gene encoding PAI-1 is highly polymorphic and PAI-1 gene variability could contribute to the level of PAI-1 biosynthesis. In the present work the distribution of genotypes and frequency of alleles of the 1334G/A polymorphism in 92 subjects with colorectal cancer in samples of cancer tissue and distant mucosa samples as well as in blood were investigated. Blood samples age matched healthy individuals (n = 110) served as control. The 1334G/A polymorphism was determined by PCR amplification using allele specific primers. No differences in the genotype distributions and allele frequencies between blood, distant mucosa samples and cancer tissue were detected. However, the distribution of the genotypes of the 1334G/A polymorphism in patients differed significantly (P <0.05) from those predicted by the Hardy-Weinberg equilibrium. There were significant differences in the frequencies of alleles between the colorectal cancer subjects and controls (P <0.05). The results support the hypothesis that the 1334G/A polymorphism may be associated with the incidence of colorectal cancer.
Źródło:
Acta Biochimica Polonica; 2003, 50, 2; 489-495
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bacterial DNA repair genes and their eukaryotic homologues: 2. Role of bacterial mutator gene homologues in human disease. Overview of nucleotide pool sanitization and mismatch repair systems
Autorzy:
Arczewska, Katarzyna
Kuśmierek, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/1040920.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
MutT protein
human MutT homologue
DNA damage
mismatch repair
hereditary non-polyposis colorectal cancer
DNA repair
Opis:
Since the discovery of the first E. coli mutator gene, mutT, most of the mutations inducing elevated spontaneous mutation rates could be clearly attributed to defects in DNA repair. MutT turned out to be a pyrophosphohydrolase hydrolyzing 8-oxodGTP, thus preventing its incorporation into DNA and suppresing the occurrence of spontaneous AT→CG transversions. Most of the bacterial mutator genes appeared to be evolutionarily conserved, and scientists were continuously searching for contribution of DNA repair deficiency in human diseases, especially carcinogenesis. Yet a human MutT homologue - hMTH1 protein - was found to be overexpressed rather than inactivated in many human diseases, including cancer. The interest in DNA repair contribution to human diseases exploded with the observation that germline mutations in mismatch repair (MMR) genes predispose to hereditary non-polyposis colorectal cancer (HNPCC). Despite our continuously growing knowledge about DNA repair we still do not fully understand how the mutator phenotype contributes to specific forms of human diseases.
Źródło:
Acta Biochimica Polonica; 2007, 54, 3; 435-457
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antigen levels of urokinase-type plasminogen activator receptor and its gene polymorphism related to microvessel density in colorectal cancer
Autorzy:
Przybylowska, Karolina
Szemraj, Janusz
Kulig, Andrzej
Dziki, Adam
Ulanska, Joanna
Blasiak, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1040754.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
plasminogen activation system
urokinase type plasminogen activator receptor (uPAR)
gene polymorphism
colorectal cancer
cancer progression
angiogenesis
microvessel density
Opis:
We determined the distribution of genotypes and frequencies of alleles of the (CA)n repeat polymorphism in intron 3 of the urokinase plasminogen activator receptor (uPAR) gene, uPAR antigen levels and microvessel density (MVD) in tumour and distant mucosa samples from 52 patients with colorectal cancer. The uPAR level was higher for patients with high MVD comparing to patients with lower MVD which may suggest that uPAR can be correlated with progression of colorectal cancer. The significant relationship between the high MVD and uPAR antigen level appeared to be independent of the (CA)n repeat polymorphism because no differences in the level of uPAR antigen between carriers of alleles were found. The received results, indicate that uPAR might be considered as a target in colorectal cancer patients' therapy.
Źródło:
Acta Biochimica Polonica; 2008, 55, 2; 357-363
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Unexpected domain composition of MACC1 links MET signaling and apoptosis
Autorzy:
Kokoszyńska, Katarzyna
Kryński, Jacek
Rychlewski, Leszek
Wyrwicz, Lucjan
Powiązania:
https://bibliotekanauki.pl/articles/1040592.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
protein structure modeling
colorectal cancer
bioinformatics
death domain
Opis:
Colorectal cancer, one of the most challenging malignancies, still has a limited number of recognized prognostic and predictive markers indicating appropriate treatment. MACC1 (metastasis-associated in colon cancer-1), a novel regulator of tumor growth and metastasis has recently been identified as an important prognostic factor of metastatic disease in colorectal cancer. The mechanism of MACC1 activity remains undetermined. Here we apply a combination of fold recognition and homology modeling algorithms to draft MACC1 function. The applied methods revealed that the MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Previously a similar domain architecture (ZU5-DD) was observed in other proteins, involved mainly in signal transduction and apoptosis regulation. Based on the specific aspects of the closest homologues' biology functional hypotheses on MACC1 are proposed. A broad range of bioinformatic analyzes indicates that MACC1, besides its involvement in signal transduction from the MET receptor, links MET signaling and apoptosis.
Źródło:
Acta Biochimica Polonica; 2009, 56, 2; 317-324
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ostra niedrożność przewodu pokarmowego. Ocena zapadalności na podstawie analizy materiału własnego
Acute intestinal obstruction. Incidence estimation based on own material analysis
Autorzy:
Kostecki, Jacek
Zaniewski, Maciej
Hadasik, Dawid
Smyła, Zbigniew
Majewski, Eugeniusz
Korzeniowski, Tomasz
Piekorz, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1034684.pdf
Data publikacji:
2011
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
niedrożność przewodu pokarmowego
rak jelita grubego
zrosty otrzewnowe
intestinal obstruction
colorectal cancer
abdominal adhesions
Opis:
BACKGROUND Intestinal obstruction is cured in surgery department. Despite endoscopy, which is fast developing alternative method, classical surgery is still basic and most effective way of treatment. Except obstruction, mainly caused by cancer, incarcerated hernia and adhesions are the other main reasons of ileus. Abdominal adhesions develop mainly as an effect of previous operations. The aim of this study was to compare frequency of each type of ileus in two similar periods. MATERIAL AND METHODS Retrospective analysis was performed on 318 patients operated in two periods: 1980–1983 and 2006–2009 in Department of Surgery of District Specialist Hospital in Tychy. RESULTS Ileus caused by incancerated hernia and abdominal adhesions was found in 210 cases (66.1%). Obstruction was reason of 108 cases (33.9%). The most frequent reason of strangulation ileus was incancerated hernia (53.6%). The main reason of obstructive ileus was cancer (93%). There were significant differences between analised two periods. There were more cases of ileus in period 2006–2009 comparing to years 1980–1983 (200 vs 118). We observed significant more abdominal adhesions (67 vs 30) and obstructions as an eff ect of cancer (76 vs 25). There were no significant differences in frequency of incancerated hernias. CONCLUSIONS It’s urgent and still great problem to find effective way of preventing abdominal adhesions. Such big increase of colorectal cancer in advanced stage cannot be explained by longer mean length of live. Physician’s more effective training in oncology is urgent necessity. More effective diagnostic and prophylactic programs should be introduced.
WSTĘP Niedrożność mechaniczna przewodu pokarmowego jest chorobą leczoną w oddziałach chirurgii. Pomimo szybkiego rozwoju alternatywnych endoskopowych metod leczenia, klasyczna chirurgia jest nadal podstawowym i najskuteczniejszym sposobem postępowania w przypadku niedrożności. Poza zatkaniem, którego najczęstszą przyczyną są nowotwory, innymi głównymi powodami niedrożności są uwięźnięta przepuklina lub zrosty jelitowe (powstające głównie jako wynik poprzednich laparotomii). Celem pracy było porównanie częstości występowania poszczególnych typów ostrej niedrożności przewodu pokarmowego w dwóch odległych od siebie jednakowych okresach czasu. MATERIAŁ I METODY W latach 1980–1983 oraz 2006–2009 na Oddziale Chirurgii Ogólnej Wojewódzkiego Szpitala Specjalistycznego w Tychach z powodu ostrej niedrożności jelit leczono operacyjnie 318 chorych. Dokonano retrospektywnej analizy historii chorób. WYNIKI Niedrożność z zadzierzgnięcia stwierdzono u 210 (66,1%), a z zatkania u 108 chorych (33,9%). U chorych z niedrożnością z zadzierzgnięcia dominowała niedrożność spowodowana uwięźnięciem przepukliny (53,6%). Główną przyczyną niedrożności z zatkania była zmiana nowotworowa (93%). Stwierdzono istotne różnice w częstości występowania ostrych niedrożności w obydwu okresach czasowych. Porównując lata 2006–2009 z okresem wcześniejszym stwierdzono istotny wzrost przypadków (200 vs 118) niedrożności. Analizując poszczególne typy niedrożności, poza znacząco większą liczbą niedrożności wywołanych nowotworami (76 vs 25), uwagę zwraca częstsze występowanie niedrożności spowodowanej przez zrosty jelitowe (67 vs 30). Nie zaobserwowano istotnych różnic w liczbie niedrożności wywołanych uwięźnięciem przepukliny. WNIOSKI Poszukiwanie skutecznego zapobiegania zrostom otrzewnowym pozostaje pilnym, nadal otwartym problemem. Znaczący wzrost liczby nowotworów jelita grubego nie może być tłumaczony starzeniem się społeczeństwa. Konieczne jest zwrócenie większej uwagi na szkolenie lekarzy w zakresie onkologii i wprowadzenie skutecznych programów diagnostycznych oraz profilaktycznych.
Źródło:
Annales Academiae Medicae Silesiensis; 2011, 65, 1-2; 20-24
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer
Autorzy:
Laczmanska, Izabela
Sasiadek, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1039825.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mutations
epigenetics
colorectal cancer
phosphatases
Opis:
Phosphorylation and dephosphorylation processes catalyzed by numerous kinases and phosphorylases are essential for cell homeostasis and may lead to disturbances in a variety of vital cellular pathways, such as cell proliferation and differentiation, and thus to complex diseases including cancer. As over 80 % of all oncogenes encode protein tyrosine kinases (PTKs), protein tyrosine phosphatases (PTPs), which can reverse the effects of tyrosine kinases, are very important tumor suppressors. Alterations in tyrosine kinase and phosphatase genes including point mutations, changes in epigenetic regulation, as well as chromosomal aberrations involving regions critical to these genes, are frequently observed in a variety of cancers. Colorectal cancer (CRC) is one of the most common cancers in humans. CRCs occur in a familial (about 15 % of all cases), hereditary (about 5%) and sporadic (almost 75-80 %) form. As genetic-environmental interrelations play an important role in the susceptibility to sporadic forms of CRCs, many studies are focused on genetic alterations in such tumors. Mutational analysis of the tyrosine phosphatome in CRCs has identified somatic mutations in PTPRG, PTPRT, PTPN3, PTPN13 and PTPN14. The majority of these mutations result in a loss of protein function. Also, alterations in the expression of these genes, such as decreased expression of PTPRR, PTPRO, PTPRG and PTPRD, mediated by epigenetic mechanisms have been observed in a variety of tumors. Since cancer is a social and global problem, there will be a growing number of studies on alterations in the candidate cancer genes, including protein kinases and phosphatases, to determine the origin, biology and potential pathways for targeted anticancer therapy.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 467-470
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Współistnienie raka jelita grubego i ciąży
Colorectal cancer during pregnancy
Autorzy:
Osuch, Beata
Wyględowski, Jerzy
Mazurek-Kantor, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1031053.pdf
Data publikacji:
2011
Wydawca:
Medical Communications
Tematy:
colorectal cancer
diagnosis
digestive tract cancer
pregnancy
treatment
ciąża
leczenie
rak jelita grubego
rak przewodu pokarmowego
rozpoznanie
Opis:
According to literature data, colorectal cancer may coexist in 0.02-0.1% of all pregnancies. Pregnant women may develop any type of malignancy, usually breast cancer, cervical cancer, lymphomas, malignant melanoma, leukemias, ovarian cancer, thyroid cancer and digestive tract tumors. The commonest digestive tract malignancies are large bowel and rectal cancer. Pregnancy may alter the course of neoplastic disease. In this setting, one of the key diagnostic problems is the masking of tumor signs and symptoms by coexisting pregnancy, making correct diagnosis considerably more difficult. This results in higher clinical stages at presentation and delayed treatment. First published reports of colorectal cancer during pregnancy are usually incidental findings, discovered as a result of treatment of various complications of pregnancy. Modern oncologic science, supported by early tumor detection programs, enables timely diagnosis and effective treatment of many digestive tract tumors. Nevertheless, distortion of tumor signs by pregnancy, different dynamics of tumor growth, pregnancy-imposed limitations of diagnostic and therapeutic modalities, all contribute to delayed diagnosis and institution of correct treatment. Doctors should be vigilant and able to differentiate signs and symptoms pregnancy-related from those indicating a colorectal cancer. The scope of diagnostic and therapeutic modalities implemented when faced with a colorectal cancer coexisting or not with pregnancy is similar. Apart of clinical stage and tumor location, the key factors influencing timing and mode of treatment of a pregnant woman are gestational age and condition of the fetus.
Współistnienie ciąży i nowotworu złośliwego dotyczy, według różnych źródeł, 0,02-0,1% wszystkich ciąż. U kobiety ciężarnej może rozwinąć się każdy rodzaj nowotworu, najczęściej jednak rozpoznawane są: rak piersi, rak szyjki macicy, chłoniaki, czerniak złośliwy, białaczki, rak jajnika, rak tarczycy, nowotwory przewodu pokarmowego. Wśród nowotworów przewodu pokarmowego dominują raki jelita grubego i odbytnicy. Ciąża może zmieniać przebieg choroby nowotworowej. Jednym z podstawowych problemów diagnostycznych w tych przypadkach jest maskowanie objawów nowotworu przez współistniejącą ciążę, co znacznie utrudnia rozpoznanie, zwykle w wyższym stopniu klinicznego zaawansowania, i tym samym opóźnia leczenie. Historia pierwszych opisanych przypadków raka przewodu pokarmowego to zwykle przypadkowe „znaleziska” ujawnione podczas leczenia różnych powikłań ciąży. Współczesna wiedza onkologiczna, poparta programami wczesnego wykrywania nowotworów, pozwala na szybkie wykrycie i skuteczne leczenie wielu nowotworów przewodu pokarmowego. Niemniej jednak w dalszym ciągu maskowanie objawów guza przez ciążę, odmienna dynamika wzrostu nowotworu, ograniczone przez ciążę metody rozpoznawcze i lecznicze opóźniają ustalenie istoty choroby oraz wdrożenie odpowiedniego postępowania. Lekarze muszą zachować czujność i umiejętnie odróżniać objawy mogące towarzyszyć ciąży od symptomów wskazujących na możliwość współistnienia raka jelita grubego. Zakres metod rozpoznawczych i leczniczych stosowanych w przypadku raka jelita grubego w ciąży i poza nią jest porównywalny. Oczywiście w przypadku kobiety ciężarnej poza stopniem klinicznego zaawansowania i lokalizacją guza do najważniejszych czynników determinujących termin i sposób leczenia należą wiek ciąży i dobrostan płodu.
Źródło:
Current Gynecologic Oncology; 2011, 9, 2; 122-129
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic Variations of the CTNNA1 And The CTNNB1 Genes in Sporadic Colorectal Cancer in Polish Population
Autorzy:
Sygut, Andrzej
Przybyłowska, Karolina
Ferenc, Tomasz
Dziki, Łukasz
Spychalski, Michał
Mik, Michał
Dziki, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1396892.pdf
Data publikacji:
2012-12-01
Wydawca:
Index Copernicus International
Tematy:
sporadic colorectal cancer
muations
catenin gene
adhesion molecules
Opis:
Experimental as well as clinical observations have demonstrated that the E-cadherin/catenin complex is a powerful inhibitor of invasion. Abrogation of this pathway is implicated in the carcinogenesis of several malignancies, especially colorectal cancer. The aim of the study was to determine the CTNNA1 and the CTNNB1 mutations and its relationship to clinical and pathological features of sporadic colorectal cancer (CRC) in Polish patients. Material and methods. Paired tumor and normal tissue samples from 110 sporadic CRC patients undergoing resective surgery were prospectively studied for the alpha catenin (CTNNA1) gene and beta catenin (CTNNB1)gene mutations by PCR/single strand conformation polymorphism (SSCP). Results. The CTNNA1 gene alteration in exon 7 were detected in 4 samples and in exon 3 of CTNNB1 gene were found in 3 samples. There was a trend at the limit of statistical significance associating younger age at diagnosis (<50) with CTNNA1 and the CTNNB1 mutations. The mutation of CTNNB1 seemed to occur more frequently in the proximal colon than distal. The CRC patients with CTNNA1 mutation had a significantly increased lymph node metastasis. On the other hand, there was no correlation between mutations and the other clinical variables (e.g. sex, grade and depth of invasion). Conclusion. Although we found a low frequency of mutations in the CTNNA1 and the CTNNB1 genes, but the analysis the relationship with clinical and pathological features of CRC patients may indicated an association of these mutations with the risk and progression of CRC.
Źródło:
Polish Journal of Surgery; 2012, 84, 11; 560-564
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hereditary mixed polyposis syndrome –- own experience
Autorzy:
Kamocki, Zbigniew
Piłaszewicz, Agata
Zaręba, Konrad
Powiązania:
https://bibliotekanauki.pl/articles/1394430.pdf
Data publikacji:
2012
Wydawca:
Index Copernicus International
Tematy:
hereditary mixed polyposis syndrome
HMPS
colorectal cancer
surgical treatment
Opis:
Hereditary mixed polyposis syndrome (HMPS) is a rare condition of unknown genetic origin. The paper presents 25-year clinical follow up in a female patient with multiple gastrointestinal tract polyps of varied histology. They most likely served as sites of multiple colorectal cancers development. The clinical course is interesting in terms of diagnostics and therapy. The patient required extended genetic testing, intensive conservative treatment and numerous surgical procedures. This is the first case of HMPS presented in Polish publications.
Źródło:
Polish Journal of Surgery; 2012, 84, 5; 262-266
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lack of Association Between the 135G/C Rad51 Gene Polymorphism and the Risk of Colorectal Cancer Among Polish Population
Autorzy:
Mucha, Bartosz
Przybyłowska-Sygut, Karolina
Dziki, Łukasz
Dziki, Adam
Sygut, Andrzej
Majsterek, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/1396683.pdf
Data publikacji:
2012-07-01
Wydawca:
Index Copernicus International
Tematy:
polymorphism
135G/C RAD51 gene
colorectal cancer
Opis:
One of the major causes of carcinogenesis is loss of genome stability. RAD51 in process of homologous recombination (HR) played crucial role in maintenance integrity of genome through initiate of DNA double strand breaks repair. Presence of single nucleotide polymorphism (SNP) in RAD51 gene could change the capacity of DNA repair and altered the response to damaging agents. Research on potential impact of genetic variability on development and progression CRC may contribute to setting new genetic markers or/and determined individual susceptibility to CRC.The aim of the study. This study was designed to evaluate the effect of 135 G/C (rs1801320) RAD51 polymorphism located in the 5' untraslated region on the risk and progression of CRC.Material and methods. The subjects consisted of histologically confirmed colorectal cancer (n = 200) and controls (n = 200) with lack of previous history of cancer. The distribution of genotypes was determined by restriction fragment length polymorphism PCR (RFLP - PCR). Statistical analysis was based on multivariate regression model.Results and conclusion. Our study reveal no significance association of 135 G/C RAD51 polymorphism with occurrence and progression of colorectal cancer.
Źródło:
Polish Journal of Surgery; 2012, 84, 7; 358-362
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prevalence of Cryptosporidium sp. In Patients with Colorectal Cancer
Autorzy:
Sulżyc-Bielicka, Violetta
Kołodziejczyk, Lidia
Jaczewska, Sylwia
Bielicki, Dariusz
Kładny, Józef
Safranow, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1396664.pdf
Data publikacji:
2012-07-01
Wydawca:
Index Copernicus International
Tematy:
Cryptosporidium
colorectal cancer
Opis:
Parasitic protozoans of the Cryptosporidium genus are intracellular intestinal parasites of mammals, causing cryptosporidiosis. Clinically, cryptosporidiosis manifests as chronic diarrhoea. Individuals with immune disorders, including those with neoplasms, are at risk of symptomatic invasion.The aim of the study was the evaluation of Cryptosporidium sp. prevalence in patients with diagnosed colorectal cancer.Material and methods. The studied group encompassed 87 patients with diagnosed colorectal cancer, undergoing surgery at the Department of General and Oncological Surgery, Pomeranian Medical University, in the years 2009-2010. Immunoenzymatic tests for Cryptosporidium sp. on faeces samples were performed with the use of commercial test kit, ProSpecT®Cryptosporidium Microplate Assay (Remel Inc).Results. The presence of Cryptosporidium sp. was found in 12.6% of studied patients with colorectal cancer. The performed statistical analysis did not reveal any correlation between Cryptosporidium sp. infection and gender, age, neoplasm advancement stage as per Astler-Coller scale, neoplasm differentiation grade, or neoplastic tumour localisation in relation to the splenic flexure.Conclusions. There was found high prevalence of Cryptosporidium sp. in patients with colorectal cancer. It was comparable to the prevalence reported for patients with immune deficiency.
Źródło:
Polish Journal of Surgery; 2012, 84, 7; 348-351
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
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