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Tytuł:
Prevalence of Cryptosporidium sp. In Patients with Colorectal Cancer
Autorzy:
Sulżyc-Bielicka, Violetta
Kołodziejczyk, Lidia
Jaczewska, Sylwia
Bielicki, Dariusz
Kładny, Józef
Safranow, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1396664.pdf
Data publikacji:
2012-07-01
Wydawca:
Index Copernicus International
Tematy:
Cryptosporidium
colorectal cancer
Opis:
Parasitic protozoans of the Cryptosporidium genus are intracellular intestinal parasites of mammals, causing cryptosporidiosis. Clinically, cryptosporidiosis manifests as chronic diarrhoea. Individuals with immune disorders, including those with neoplasms, are at risk of symptomatic invasion.The aim of the study was the evaluation of Cryptosporidium sp. prevalence in patients with diagnosed colorectal cancer.Material and methods. The studied group encompassed 87 patients with diagnosed colorectal cancer, undergoing surgery at the Department of General and Oncological Surgery, Pomeranian Medical University, in the years 2009-2010. Immunoenzymatic tests for Cryptosporidium sp. on faeces samples were performed with the use of commercial test kit, ProSpecT®Cryptosporidium Microplate Assay (Remel Inc).Results. The presence of Cryptosporidium sp. was found in 12.6% of studied patients with colorectal cancer. The performed statistical analysis did not reveal any correlation between Cryptosporidium sp. infection and gender, age, neoplasm advancement stage as per Astler-Coller scale, neoplasm differentiation grade, or neoplastic tumour localisation in relation to the splenic flexure.Conclusions. There was found high prevalence of Cryptosporidium sp. in patients with colorectal cancer. It was comparable to the prevalence reported for patients with immune deficiency.
Źródło:
Polish Journal of Surgery; 2012, 84, 7; 348-351
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Colorectal surgery in elderly population
Autorzy:
Zawadzki, Marek
Krzystek-Korpacka, Małgorzata
Rząca, Marek
Czarnecki, Roman
Obuszko, Zbigniew
Witkiewicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1392435.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
elderly
colorectal surgery
colorectal cancer
Opis:
Introduction: With the rising number of elderly patients and increasing incidence of colorectal cancer, management of geriatric patients has become the forefront of colorectal surgery. Objectives: This study aimed to investigate the short-term surgical outcomes that follow colorectal resection in elderly patients. Materials and methods: A total of 464 patients who underwent surgical resection for colorectal tumor between 2013 and 2017 were included. The patients were divided into a group of the elderly (≥75 years) and the young (<75 years). Clinicopathological data of the patients were reviewed retrospectively. Results: The elderly group constituted 30% of the study population. A greater number of patients in the elderly group underwent Hartmann’s procedure (p = 0.02) and right hemicolectomy (p = 0.029), and younger patients more often received low anterior resection (p = 0.027). The duration of the surgical procedure was shorter in the elderly group (p < 0.01) but they stayed in the hospital one day longer (p = 0.023). Postoperative complications and mortality tended to be higher in seniors (p = 0.088). The younger patients showed a tendency towards a higher rate of distant metastases (p = 0.053). Seniors received fewer preoperative chemoradiation in comparison to the young group (p = 0.014). Conclusion: Older persons constitute one-third of patients treated electively in colorectal departments. Colorectal surgery in geriatric patients is associated with a prolonged hospital stay and a higher potential for complications and mortality.
Źródło:
Polish Journal of Surgery; 2018, 90, 4; 29-34
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Incidence of hereditary non-polyposis colorectal cancer [HNPCC] in the city of Szczecin, north-western Poland
Autorzy:
Kladny, J
Lubinski, J
Powiązania:
https://bibliotekanauki.pl/articles/2046601.pdf
Data publikacji:
1997
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
incidence
Polska
Szczecin city
hereditary non-polyposis colorectal cancer
colorectal cancer
Opis:
The study population consisted of 140 consecutive colorectal cancer patients, inhabitants of the city of Szczecin, north-west Poland, who were histopathologically diagnosed in the period of 2 years - 1991-1992. Family history was obtained in 124 (88.6%) of patients. A definitive diagnosis of HNPCC was established if requirements of the International Collaborative Group on HNPCC (ICG- HNPCC) were met. Suspected HNPCC were recognised according to criteria described by Ponz de Leon or Mecklin or Kunitomo. HNPCC as defined by International Collaborative Group on HNPCC was identified in 2 (1.6%) families. Suspected HNPCC were recognised in 16.9%, 3.2% and 4.0% of patients if Ponz de Leon or Mecklin or Kunitomo criteria were applied, respectively. In our series in 19 of 124 cases, colorectal carcinomas were diagnosed in patients under 50 years of age. Only in one of these cases, features characteristic of HNPCC other than young age were found which suggests that in our region the frequency of somatic or germ line de novo mutations in genes predisposing to colorectal cancer may be high. Our results suggest that the frequency of HNPCC inherited from ancestors in Poland and other countries is approximately similar and this syndrome is common disease everywhere.
Źródło:
Journal of Applied Genetics; 1997, 38, 1; 103-114
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Occurrence of BK Virus and Human Papilloma Virus in colorectal cancer
Autorzy:
Jarzyński, Adrian
Zając, Przemysław
Żebrowski, Remigiusz
Boguszewska, Anastazja
Polz-Dacewicz, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/990851.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
bkv
hpv
colorectal cancer.
Opis:
Introduction and objective. Colorectal cancer is one of the most common cancers worldwide. In Poland, it is the second most common cancer, regardless of gender. The aim of study was to analyze the incidence of HPV and BKV in the tissue of colorectal cancer and to determine the relationship between the presence of these viruses and the development of this cancer. Materials and method. The experiments were conducted using 50 colorectal cancer tissues collected from histological sections. The clinical material was embedded in paraffin blocks. Next, DNA extraction was performed. Isolates of colorectal cancer tissue were tested for the presence of HPV DNA. BKV DNA was detected by PCR using specific primers and then differentiated from JCV by digestion with BamHI enzyme. Results. In clinical specimens taken from patients with colorectal cancer, HPV DNA was detected in 20% of cases. In 10% of cases the presence of HPV type 18 was confirmed, in the other 90% of the samples HPV type 16 was detected, while the presence of BKV was confirmed in 30% of cases. Coinfection with HPV and BKV was shown in 12% of patients. In one case, BK virus coexisted with HPV type 18, in the remaining 5 cases with HPV type 16. Conclusions. Developing colorectal cancer can show no symptoms, even for many years. This is why it is so important to become familiar with as many etiological factors as possible. The development of many human neoplasms is often initiated by exposure to infectious agents – such as bacterial or viral infections. Similar to the human papillomavirus, the BK virus was detected in clinical specimens. It seems that HPV and BKV infections can contribute to the neoplastic process, which requires detailed studies on a larger group of patients.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of diet in primary prevention of colorectal cancer
Autorzy:
Kamińska, Daniela
Klusek, Jolanta
Klusek, Justyna
Powiązania:
https://bibliotekanauki.pl/articles/472488.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
Tematy:
colorectal cancer
prevention
diet
Źródło:
Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia; 2016, VI; 20-30
2083-7267
2450-3487
Pojawia się w:
Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characteristics and results of treatment of patients treated surgically with colorectal cancer in old and senile age
Autorzy:
Banaszkiewicz, Zbigniew
Zwoliński, Tomasz
Tojek, Krzysztof
Jarmocik, Paweł
Jawień, Arkadiusz
Powiązania:
https://bibliotekanauki.pl/articles/1392531.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
Colorectal cancer
aged patients
Opis:
Colorectal cancer (CC) in Poland is the type of cancer with the highest dynamics of disease growth and is epidemiologically related to age. The analysis involved 353 patients operated on due to CC in senile and old age and compared with younger patients. It was found that people at this age are more often diagnosed with CC They were more often women, the patients did not differ in the stage of cancer, while they were significantly more often qualified for surgery due to urgent indications. In patients with colonic cancer, the resectability and radicality of the procedures in comparison with patients with rectal cancer was significantly higher, while there were more complications and deaths in the 30-day follow-up in this group. The overall survival in senile and old age was significantly worse. In the first year of follow-up after surgical treatment of patients in this group, complications and deaths were more frequently observed. However, in patients who survived 12 months after the operation, the overall survival rate did not significantly differ.
Źródło:
Polish Journal of Surgery; 2018, 90, 1; 1-6
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Symptoms of colorectal cancer contributes to its localization and advancement
Autorzy:
Nizioł, M.
Kostrzewska, B.
Kamińska, D.
Domurat, M.
Zińczuk, J.
Misiura, M.
Guzińska-Ustymowicz, K.
Pryczynicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/1918846.pdf
Data publikacji:
2019-08-26
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Cancer localization
colorectal cancer
symptoms
Opis:
Introduction: Colorectal cancer is one of the most common cancers occurring in Poland. Unfortunately, this cancer is most often diagnosed at the time of great advancement. This is caused by the appearance of specific symptoms only in the late stages of cancer. Also, such low detection of early stages of adenocarcinoma may be caused by disregarding of slight symptoms. Purpose: To analyse symptoms in patients with colorectal cancer and correlate with chosen clinical-pathological parameters. Materials and methods: The study group consisted of 46 patients diagnosed with colorectal cancer. Information on symptoms associated with cancer (subjective and objective) have been selected from patients' medical history. The presence of these symptoms was correlated with the age and sex of patients, tumor location, histological type of cancer, grade of histological malignancy (G), stage of tumor (T stage), presence of lymph node metastases and distant metastases. Results: It has been shown that the presence of pain complaints described by the patient are associated with the occurrence of cancer in the colon. The painfulness and pathological resistance diagnosed by the physician are more often associated with cancer located in the colon. In the case of tumors located in the rectum, faecal admixtures appear more frequently. It has also been shown that the presence of admixtures of blood and mucus in the stool is associated with more advanced local tumors, infiltrating pericolorectal tissues (T3 + T4). Conclusions: Familiarity with clinical symptoms of colorectal cancer could make patients more sensitive to more often screening for cancer. Analysis of these symptoms could indicate to the physician the location or stage of the cancer.
Źródło:
Progress in Health Sciences; 2019, 1; 76-82
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diabetes association of polyps and colon cancer
Autorzy:
Miłek, Tomasz
Forysiński, Karol
Myrcha, Piotr
Ciostek, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1392134.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
colorectal cancer
colorectal polyps
diabetes mellitus
Opis:
Aim: The aim of the study was to retrospectively assess the relationship between the occurrence of polyps and colon cancer in patients with type 2 diabetes. Methods: In 2014–2015, 976 colonoscopies were performed in patients. We compared the number of polyps with high-grade dysplasia and colorectal cancers in patients with and without diabetes. In addition, in the diabetic group we documented the relationship between HbA1C and the occurrence of polyps with high-grade dysplasia, and colon cancer. The data were statistically analyzed. Results: 1. Patients with diabetes show a higher incidence of polyps with high-grade dysplasia/carcinoma – 32/91 (35.16%) in comparison to patients without diabetes – 136/885 (15.37%), P < 0.001; 2. Patients with diabetes show a higher incience of polyps with cancer – 9/91 (9.89%) as compared to patients without diabetes – 18/885 (2.03%), P < 0.001. 3) Colorectal cancer occurred significantly more often in uncontrolled diabetes (P = 0.022). Conclusion: The conducted study shows a significant association between type 2 diabetes and the incidence of colorectal adenomas. These findings may lead to a conclusion that diabetic patients are at a higher risk of developing colorectal cancer, thus are in higher need for controlled colonoscopy. Therefore, it may be worth considering a scheme for screening patients in the above-mentioned group with colonoscopy.
Źródło:
Polish Journal of Surgery; 2019, 91, 4; 9-12
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Risk factors in reoperations in colorectal surgery
Autorzy:
Zawadzki, Marek
Krzystek-Korpacka, Małgorzata
Rząca, Marek
Czarnecki, Roman
Obuszko, Zbigniew
Sitarska, Magdalena
Witkiewicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1392140.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
colorectal cancer
colorectal surgery
complication
reoperation
Opis:
Background: Reoperations in colorectal surgery are usually a consequence of major surgical complications. Recently, the rate of reoperation has been proposed as a marker of surgical performance. Yet, the incidence of re-intervention varies significantly in literature, ranging from 5.2% to 13%. Therefore, in this study we investigated 30-day reoperation rates and made an attempt to identify risk factors of re-intervention following colorectal resection at our institution. Methods: This is a retrospective study of patients who had undergone colorectal resection at a single institution from 2013 to 2017. Univariate and multivariate analysis of predicting factors were performed. Results: Out of 464 patients included, 51 required reoperations (11%). The most common causes of reoperations were anastomotic leakage, postoperative bleeding, and wound dehiscence. In univariate analysis the age of the patient and location of the tumor were related to an increased rate of reoperation. In multivariate analysis patients older than 75 (OR = 2.1; 95%CI = 1.1–3.9) and tumors sited in the rectum (OR = 2.66; 95%CI = 1.4–5) were associated with an increased risk of re-intervention. Patients who required postoperative re-intervention stayed in hospital longer (14 vs. 6 days, P < 0.0001) and had higher mortality (9.8% vs. 1.2%, P = 0.002). Conclusions: Our study shows that reoperation rates that follow colorectal surgery are frequently undervalued. In our series, 11% of patients required an unplanned return to the operative room. Patient’s age and rectal tumors were the two independent factors that affect the rate of reoperation. Novel aspect: Data concerning reoperation rates in colorectal surgery is varying and most reports have shown the incidence of re-intervention to be as low as 5–7%. Our study demonstrates that reoperations after curative surgery for colorectal cancer are more frequent and may occur in over a tenth of total patients operated on.
Źródło:
Polish Journal of Surgery; 2019, 91, 4; 13-18
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of 7965 screening colonoscopies and treatment results of detected colorectal cancers – experiences of one center
Autorzy:
Nowicki, Andrzej
Kula, Zbigniew
Lemanowicz, Marzena
Powiązania:
https://bibliotekanauki.pl/articles/1064862.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
National Screening Program for Early Detection of Colorectal Cancer
colorectal cancer
screening colonoscopy
Opis:
Introduction: Colorectal cancer is one of the most common cancers in both sexes and is one of the leading causes of death in Poland and the world. An effective method to prevent the development of colorectal cancer (CRC) is the detection of polyps during a screening colonoscopy and their removal. Objective: The aim of the study was to evaluate results of screening for early detection of colorectal cancer by colonoscopy. Material and methods: The study was based on analysis of medical records of 7965 patients who underwent colonoscopy as part of the National Screening Program (NSP) for Early Detection of Colorectal Cancer in the 2000–2014 period. Results: Polyps were removed in 2900 (36.4%) patients, among whom 1885 (23.6%) had adenomas, which were more frequent in men (32.9%). Tubular adenomas were observed in 1685 patients (21.1%), tubulo-villous adenomas were detected in 157 patients (2%) and villous adenomas – in 43 (0.5%) of them. Sixty-three (0.79%) colorectal cancers were detected in various clinical stages, including adenocarcinoma in situ in 3 patients. Probability of 5-year survival rate of colorectal cancer amounted to 74% while 10-years survival was reached in 63% of patients. Conclusions: The detection rate of polyps, adenomas and carcinomas thanks to screening colonoscopy was 36.4%, 23.6% and 0.79% respectively, while the probability of 5-year survival was 74%. An improvement in the quality of colonoscopy was observed in subsequent years of the NSP, which translated into better detection of adenomas.
Źródło:
OncoReview; 2016, 6, 3; A134-142
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synchronous Gastric and Rectal Cancer in a 50 Year-Old Man – Case Report
Autorzy:
Pierko, Jacek
Łukaszewicz, Jerzy
Sawicka-Pierko, Anna
Hady, Hady Razak
Dadan, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1396903.pdf
Data publikacji:
2012-12-01
Wydawca:
Index Copernicus International
Tematy:
synchronous tumor
gastric cancer
colorectal cancer
Opis:
The occurrence of synchronous tumors of the gastrointestinal tract is rarely observed in general surgery, diagnosis is frequently incidental, often intraoperatively. The aim of this study was to present a case of a 50 year-old male patient admitted to the Department of Gastroenterology, University Hospital in Białystok, due to abdominal pain, significant weakness and excretion of tarry stools. Imaging diagnostics revealed the presence of a large gastric tumor (histopathological type - adenocarcinoma), and single metastasis to the liver. The patient was qualified for total gastrectomy. Surgery was performed at the 1st Department of General and Endocrinological Surgery, University Hospital in Białystok. Rectal cancer, which was observed during the operation was removed simultaneously.
Źródło:
Polish Journal of Surgery; 2012, 84, 11; 582-584
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Variability of clinical characteristic of colorectal cancer patients – analysis of selected parameters
Autorzy:
Copija, Angelika
Głogowski, Łukasz
Walkiewicz, Katarzyna
Janion, Karolina
Nowakowska-Zajdel, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1035800.pdf
Data publikacji:
2018
Wydawca:
Medical Education
Tematy:
clinical features
colorectal cancer
epidemiology
Opis:
Introduction: A steady increase of the incidence of colorectal cancer has been observed for over 30 years, particularly in well-developed countries. Colorectal cancer is one of the lifestyle-related neoplasms and depends on environmental factors. Aim: Aim of the study was to analyse selected clinical features of colorectal cancer patients. Material and methods: The study group consisted of 577 consecutive patients with colorectal cancer treated in the Department of Clinical Oncology in Bytom in 2006–2014. The patients were included into the study prospectively. The analysis of selected clinical, pathological and anthropometrical parameters was conducted. Results: The study group included 237 women and 341 men aged 26 to 86 years (mean age 64.3 ± 9.2 years). Primary tumours were mostly located in the colon and had histological grade 2. The surgical removal of the primary tumour was performed in 540 patients. 65 patients underwent preoperative radiotherapy, 201 – postoperative chemotherapy and 91 – postoperative radio-chemotherapy. 132 of patients obtained the first-line palliative chemotherapy. 88 of patients did not received oncological treatment. KRAS/RAS mutation were determined in 73 patients and the EGFR expression status in 53 patients. Conclusions: Colorectal cancer patients are a heterogeneous group with differential clinical, pathological and molecular features. 1. Therapeutic management of patients with colorectal cancer largely depends on its location, clinical and pathological stage, patients performance status and comorbidities. 2. Understanding the clinical features of patients with colorectal cancer becomes helpful in designing of screening, which take into account clinical profile of the patient, i.e. age, gender, comorbidities and anthropometric characteristics
Źródło:
OncoReview; 2018, 8, 3; 80-85
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Selected psychosocial aspects of life of patients with a stoma
Autorzy:
Nowicki, Andrzej
Farbicka, Paulina
Powiązania:
https://bibliotekanauki.pl/articles/1064909.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
colorectal cancer
psycho-oncology
stoma
Opis:
Cancer causes huge problems, physical and mental nature mainly. In particular, we cannot forget about the functioning of these patients in the social and spiritual spheres. The increasing trend of incidence of rectal cancer makes the disease is becoming a priority for doctors, nurses and psycho-oncologists. Despite the increasing quality of medical services, patients face a number of problems associated with cancer treatment, which may result in formation of a colostomy. The procedure, which is necessary to save the patient’s life, is often perceived by them as “mutilation”. Acceptance of the disease and satisfaction of life in patients with a stoma after the operation for rectal cancer are dependent on many factors. Social support, living conditions and the time elapsed since creation of the stoma have great impact. “Stoma nurse” plays an extremely important role. Seeing the difficulties in adapting the stoma she should verify the patient’s pessimism as to his/her own self, develops a sense of responsibility from minor to major issues and strengthen a sense of independence.
Źródło:
OncoReview; 2016, 6, 2; A72-76
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surgical site infection among patients after colorectal cancer surgery
Autorzy:
Banaszkiewicz, Zbigniew
Cierzniakowska, Katarzyna
Tojek, Krzysztof
Kozłowska, Elżbieta
Jawień, Arkadiusz
Powiązania:
https://bibliotekanauki.pl/articles/1393474.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
surgical site infection
colorectal cancer
Opis:
Wstęp: Zakażenie miejsca operowanego występuje u 2,5–22,3% operowanych chorych. Jest ono wykładnikiem jakości leczenia na oddziałach zabiegowych i ma duży wpływ na jego koszt. Materiał i metodyka: Analizie poddano chorych, u których w obserwacji 30-dniowej wystąpiło zakażenie miejsca operowanego. Grupę wyjściową stanowiło 1581 chorych z rozpoznaniem raka jelita grubego poddanych zabiegowi operacyjnemu w jednym ośrodku. Kryteriami wyłączającymi z badania były: brak wiarygodnej dokumentacji leczenia (szpitalnego lub ambulatoryjnego) i zgon chorego przed 30. dniem po operacji bez rozpoznanego zakażenia miejsca operowanego. Analizę statystyczną wykonano przy użyciu programu Statistica 10. Wyniki: Powikłania pooperacyjne wystąpiły u 262 chorych (16,6%). Najczęściej występującym było zakażenie miejsca operowanego (198 pacjentów; 12,52%). Stwierdzono, że wystąpienie tego powikłania zależne było od zaawansowania klinicznego raka, wieku chorych, chorób współtowarzyszących (cukrzyca i choroby kardiologiczne). Ponadto zauważono, że powikłanie to występowało znamiennie częściej u chorych operowanych w trybie pilnym z powodu powikłań oraz u tych, u których wyłoniono stomię jelitową. Nie stwierdzono natomiast zależności wystąpienia tego powikłania od płci chorych i lokalizacji guza nowotworowego. Wniosek: U chorych po operacji raka jelita grubego największe zagrożenie wystąpienia zakażenia miejsca operowanego wystąpiło u chorych po 75. roku życia, obciążonych cukrzycą i chorobami kardiologicznymi, z dużym zaawansowaniem klinicznym raka, operowanych w trybie ostrego dyżuru, u których konieczne było wyłonienie stomii jelitowej (a szczególnie kolostomii).
Źródło:
Polish Journal of Surgery; 2017, 89, 1; 9-15
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Patients’ awareness of the prevention and treatment of colorectal cancer
Autorzy:
Dziki, Łukasz
Puła, Anna
Stawiski, Konrad
Mudza, Barbara
Włodarczyk, Marcin
Dziki, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1394394.pdf
Data publikacji:
2015
Wydawca:
Index Copernicus International
Tematy:
colorectal cancer
patients’ awareness
prevention
Opis:
The aim of the study was to assess patients’ awareness of the prevention and treatment of colorectal cancer. Material and methods. Patients diagnosed with colorectal cancer, hospitalised at the Department of General and Colorectal Surgery of the Medical University in Łódź during the period from January 2015 to April 2015, were asked to complete a questionnaire concerning their families’ medical case record, factors predisposing them to the development of colorectal cancer, the tests applied in diagnostics, and the treatment process. The questionnaire comprised 42 closed-ended questions with one correct answer. A statistical analysis of all answers was carried out. Results. The study group consisted of 30 men and 20 women aged 27–94 years old. A strong, statistically significant negative correlation between a patient’s age and his/her awareness of the prevention and treatment of colorectal cancer was noted (p<0.001; r= -0.51). The study demonstrated a statistically significant relationship between the occurrence of neoplasms in a patient’s family (p=0.009) or, more specifically, the occurrence of colorectal cancer (p=0.008), and the awareness of the prevention programme. The women’s group was characterised by statistically significantly greater awareness of colonoscopy as a screening examination (p=0.004). Conclusions. Patients need more information on colorectal cancer, its risk factors, prevention, the treatment process, and postoperative care. Lack of awareness of the colorectal cancer issue can be one of the major factors contributing to the high incidence of this disease.
Źródło:
Polish Journal of Surgery; 2015, 87, 9; 459-463
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of photodynamic therapy with hypericin on the secretion of selected cytokines of colorectal cancer cells tested in vitro
Autorzy:
Międzybrodzka, Anna
Kawczyk-Krupka, Aleksandra
Aebisher, David
Cieślar, Grzegorz
Czuba, Zenon Paweł
Powiązania:
https://bibliotekanauki.pl/articles/25102362.pdf
Data publikacji:
2023-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
colorectal cancer
hypericin
photodynamic therapy
Opis:
Introduction and aim. Photodynamic therapy is a complex process involving the introduction of photosensitizers into the patient’s body and irradiation of them in order to destroy the lesion, and activate the immune system. An important role in photodynamic therapy is played by photobiochemical and physical mechanisms that affect the tumor vessels and lead to the death of the damaged cell. The aim of the study is to determine the effect of photodynamic therapy with the use of Hypericin (Hyp) on the secretion of selected cytokines by colorectal cancer cells. Material and methods. Two colorectal cancer cell lines SW480 and SW620 were used in the study. Cells treated Hypericin were exposed to visible light. Then cell viability was determined by the MTT assay with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium. Assays were performed for control samples without hypericin and light exposure, with Hyp without light exposure, without Hyp and irradiated with light, and test samples with Hyp and light exposure. Results. In the experiment we reveal, that Hyp- photodynamic activity does not influence the secretion of cytokines. Conclusion. The obtaining results confirming the destructive effect of Hyp- PDT on the colon cancer cells, show a possibility of extending the indication for photodynamic therapy using Hyp, qualification of precancerous changes.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 2; 194-201
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of hypericin-mediated photodynamic therapy on GM-CSF, MIF, VCAM-1 and ICAM-1 secretion in colorectal cancer cells in vitro
Autorzy:
Międzybrodzka, Anna
Kawczyk-Krupka, Aleksandra
Aebisher, David
Cieślar, Grzegorz
Czuba, Zenon Paweł
Powiązania:
https://bibliotekanauki.pl/articles/25102366.pdf
Data publikacji:
2023-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
colorectal cancer
hypericin
photodynamic therapy
Opis:
Introduction and aim. Photodynamic therapy with hypericin (HYP-PDT) is gaining importance as a potential treatment method for malignant neoplasms. The following study investigated whether HYP-PDT influences the secretion of certain factors of colon cancer cells in vitro. Material and methods. Two colon cancer cell lines were used in this experiment: SW480 and SW620. The cells were properly prepared and then treated with photodynamic therapy with hypericin at concentrations of 0.25 µM and 0.5 µM and irradiation at the doses of 1 J/cm2 , 5 J/cm2 and 10 J/cm2 . After using HYP-PDT, changes in the concentrations of four factors: GM-CSF, MIF, VCAM-1 and ICAM-1 were analyzed in the test tubes. Results. In the case of SW480 cells: a notable decrease in GM-CSF, MIF, VCAM-1 and ICAM-1 secretion was noted after HYP-PDT. In the case of SW620 cells, after HYP-PDT: no effect on GM-CSF secretion was noted; it inhibited the secretion of VCAM-1 and MIF and increased the secretion of ICAM-1. Conclusion. Photodynamic therapy with hypericin shows immunomodulatory potential in an in vitro cell line experiments. This may indicate its possible ability to modify the course of malignant tumors and therefore requires further research.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 2; 202-216
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer
Autorzy:
Laczmanska, Izabela
Sasiadek, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1039825.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mutations
epigenetics
colorectal cancer
phosphatases
Opis:
Phosphorylation and dephosphorylation processes catalyzed by numerous kinases and phosphorylases are essential for cell homeostasis and may lead to disturbances in a variety of vital cellular pathways, such as cell proliferation and differentiation, and thus to complex diseases including cancer. As over 80 % of all oncogenes encode protein tyrosine kinases (PTKs), protein tyrosine phosphatases (PTPs), which can reverse the effects of tyrosine kinases, are very important tumor suppressors. Alterations in tyrosine kinase and phosphatase genes including point mutations, changes in epigenetic regulation, as well as chromosomal aberrations involving regions critical to these genes, are frequently observed in a variety of cancers. Colorectal cancer (CRC) is one of the most common cancers in humans. CRCs occur in a familial (about 15 % of all cases), hereditary (about 5%) and sporadic (almost 75-80 %) form. As genetic-environmental interrelations play an important role in the susceptibility to sporadic forms of CRCs, many studies are focused on genetic alterations in such tumors. Mutational analysis of the tyrosine phosphatome in CRCs has identified somatic mutations in PTPRG, PTPRT, PTPN3, PTPN13 and PTPN14. The majority of these mutations result in a loss of protein function. Also, alterations in the expression of these genes, such as decreased expression of PTPRR, PTPRO, PTPRG and PTPRD, mediated by epigenetic mechanisms have been observed in a variety of tumors. Since cancer is a social and global problem, there will be a growing number of studies on alterations in the candidate cancer genes, including protein kinases and phosphatases, to determine the origin, biology and potential pathways for targeted anticancer therapy.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 467-470
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Correlation of clinico-pathologic data with inflammatory cells infiltration in colorectal cancer
Autorzy:
Grudzińska, M.
Jakubowska, K.
Kańczuga-Koda, L.
Kisielewski, W.
Famulski, W.
Smereczański, N.M.
Lomperta, K.
Płoński, M.A.
Rogoz-Jezierska, N.
Koda, M.
Powiązania:
https://bibliotekanauki.pl/articles/1918914.pdf
Data publikacji:
2020-06-10
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Colorectal cancer
inflammatory cells
fibrosis
Opis:
Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At every phase of cancer development, the inflammatory process has an important impact. Accurate assessment inflammatory cells in the tumour environment in conjunction with clinico-pathologic features can be a relevant prognostic or predictive parameter. Purpose: To analyse inflammatory cell infiltration in CRC tumour mass and correlate with chosen clinico-pathologic parameters. Materials and methods: The study group consisted of 160 patients (64 women, 96 men) diagnosed with colorectal cancer who underwent surgery. Tissue material obtained from routine histopathological diagnosis was stained with H&E and used to assess the type of inflammatory cells in the invasive front and centre of the tumour. Results were subjected to statistical analysis with the age and gender of patients, tumour localization, tumour growth and size, TNM stage, adenocarcinoma type, fibrosis, necrosis, metastasis and tumour invasion (by the Spearman’s correlation coefficient test). Results: The presence of neutrophils in the invasive front of tumour mass was associated with fibrosis and inflammatory cell infiltration in the invasive front of tumour. Macrophages in the invasive front of tumour were found to correlate with tumour growth (expanding and infiltrate). Macrophages and eosinophils were associated with inflammatory cell infiltration in the invasive front and in the centre of tumour. Conclusions: The type of inflammatory cells in the invasive front or centre of the tumour may be useful to prognoses clinical features of colorectal cancer
Źródło:
Progress in Health Sciences; 2020, 10(1); 69-76
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Risk analysis for the surgical treatment of colorectal cancer in elderly patients undergoing scheduled and urgent interventions
Autorzy:
Pelzer, Oskar
Kielan, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1395714.pdf
Data publikacji:
2014-02-01
Wydawca:
Index Copernicus International
Tematy:
colorectal cancer
elderly
surgical treatment
Opis:
Due to recorded growth both in living standards and latest researches in medicine, proportion of people in old age has significantly improved all over the world. Although old age people are several percent of the entire society, number of surgeries within the group does not exceed 40%. Also risk of malignant neoplasms among old age people, significantly grows. Malignant neoplasm of colon appears to be most visible problem in group of people in age over 75 years old. The aim of the study was a retrospective analysis of results in treatment of the sick over 75 years old, suffering from Malignant neoplasm of colon. Therapy was performed in the I Unit of General Surgery and Surgical Oncology in Provinical Hospital in Jelenia Góra. Material and methods. Subject to analysis were 63 patients that went under operations in years from 2006 to 2010 due to the colorectal cancer, who have been divided now into two groups. First group included 49 patients treated as per schedule, and the second stood for 14, who required urgent treatment. Reference group has involved 20 younger patients, treated in urgent and scheduled courses, due to the colon cancer. There are no contradictions to emergencies and scheduled surgeries for patients in advanced years, suffering from colon cancer. Complications after colon cancer emergencies are far more frequent than in case of scheduled surgeries. Death rates among patients over 75 years old are far more frequent after emergencies than after scheduled surgeries. Concomitant diseases occur the same frequent during emergenices as during scheduled operations. During emergencies, it was left side of the colon that occured to be infected with cancer more frequent. Conclusions. There is no significant diversity in hospitalization time frames after emergencies and scheduled surgeries. Dangerous surgical complications within group of older patients, those after emergencies and scheduled surgeries too, are far more frequent in comparison to the reference group.
Źródło:
Polish Journal of Surgery; 2014, 86, 2; 61-67
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Increased constitutional chromosome sensitivity to bleomycin in patients with hereditary non-polyposis colorectal cancer [HNPCC]
Autorzy:
Kladny, J
Zajaczek, S
Lubinski, J
Powiązania:
https://bibliotekanauki.pl/articles/2047245.pdf
Data publikacji:
1996
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
chromosome sensitivity
lymphocyte
hereditary non-polyposis colorectal cancer
tumour
colorectal cancer
bleomycin
genotoxic effect
Opis:
It has been suggested that mutagen sensitivity is a constitutional factor which may be useful in identification of patients with an increased risk for the development of tumors. In this study, the chromosome sensitivity to bleomycin was measured according to Hsu in patients with hereditary non-polyposis colorectal cancer (HNPCC), sporadic colorectal cancer and in control persons with no tumor history in family. In vitro lymphocytes were exposed to bleomycin according to Hsu and chromosomal damage was quantified by scoring breaks of 100 cells. A significant difference (P < 0.01) in the mean number of breaks per cell (b/c) was found between HNPCC patients (0.59 ± 0.14; n = 12; mean age 55.4 yrs) and control individuals (0.35 ± 0.13: n = 12; mean age 55.8 yrs). In contrast, patients with sporadic colorectal cancer showed a mean b/c value of 0.43 ± 0.14 (n = 14; mean age 63.4 yrs) which was not significantly higher than that in control individuals for this group (0.42 ± 0.15; n = 14; mean age 63.1 yrs). Selenium protected lymphocytes of HNPCC patients against bleomycin activity in vitro.
Źródło:
Journal of Applied Genetics; 1996, 37, 4; 385-392
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prognostic significance of p53 protein accumulation in cancer cells obtained from selected group of patients with sporadic colorectal cancer
Autorzy:
Paluszkiewicz, P
Karski, J.
Berbec, H.
Pawlowska-Wakowicz, B.
Cybulski, M.
Karski, M.
Paszkowska, A.
Powiązania:
https://bibliotekanauki.pl/articles/2043897.pdf
Data publikacji:
1999
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
patient
cancer cell
monoclonal antibody
p53 protein
cancer prognosis
immunohistochemistry
sporadic colorectal cancer
accumulation
colorectal cancer
Źródło:
Journal of Applied Genetics; 1999, 40, 2; 135-144
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fungi of the genus Rhodotorula isolated from the oral cavity of oncologic patients with colorectal cancer
Autorzy:
Troska, Piotr
Sucharzewska, Ewa
Dynowska, Maria
Ejdys, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/972215.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Rhodotorula
oral cavity
enzymes
colorectal cancer
Opis:
This paper concerns the frequency of occurrence and enzymatic activity of fungi of the genus Rhodotorula isolated from the oral cavity of patients with colorectal cancer. Swabs from the oral cavity were subjected to standard mycological diagnostic procedures; enzymatic activity of the fungi was evaluated using and API Zym test by BioMereux. The fungi of the genus Rhodotorula were noted in 22.5% positive isolates originating from women and 25.7% positive isolates originating from men. They included mono-species isolates of: Rh. glutinis, Rh. minuta, Rh. mucilaginosa and two-species isolates: Rh. minuta + Candida dubliniensis, Rh. mucilaginosa + C. albicans and Rh. mucilaginosa + Saccharomyces cerevisiae. The enzymatic activity of the isolated fungi was evaluated as high and very high in the case of acidic and alkaline phosphatase, esterase lipase, lipase, as well as leucine, valine and cysteine arylamidase. The highest values were determined in Rh. mucilaginosa with co-occurrence of C. albicans and Rh. minuta with co-occurrence of C. dubliniensis. In the ontosphere of oncologic patients, the increasingly frequent appearance of the species of fungi with high and very high enzymatic activity indicates the progressing risk posed by opportunistic forms, which includes Rhodotorula species.
Źródło:
Annals of Parasitology; 2017, 63, 1; 57-62
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Risk of Surgical Treatment in Patients Aged 85+, with Special Consideration of Colorectal Cancer
Autorzy:
Stępień, Renata
Głuszek, Stanisław
Kozieł, Dorota
Kaczmarczyk, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1395734.pdf
Data publikacji:
2014-03-01
Wydawca:
Index Copernicus International
Tematy:
operative risk
age 85+
colorectal cancer
Opis:
The increase in prevalence of chronic diseases in old age is concomitant with increasing risk of neoplasms requiring surgical treatment. The aim of the study was to assess the indications, treatment outcomes, complications and mortality associated with surgical treatment of patients aged 85 or more, with special consideration of colorectal cancer. Material and methods. The retrospective analysis involved a group of 94 patents (x = 88.9) aged 85 or more and treated surgically in the years 2006-2011. The results were compared with a randomly selected control group of 91 patients aged 45-75 (x = 56,4) and treated surgically in the same period. Results. Neoplastic diseases in the study group (85 ≥), compared with the control group (< 75), were a significantly more frequent indication for surgical treatment (p < 0.01). In the group of patients aged 85 or more, the most frequent indications for elective surgery were neoplasms of the skin and subcutaneous tissue (26.4%) and gastrointestinal neoplasms, mainly colorectal cancer (23.5%). Postoperative complications were significantly more frequent (p < 0.01) among patients aged 85 or more (n = 27; 34.8%) than in the younger group (n = 17; 18.7%). Postoperative mortality among patients undergoing emergency surgery was significantly higher (p < 0.05) in the senior group than in the group of younger patients. Conclusions. Surgical procedures in patients aged 85 or more are most frequently performed in the emergency setting, and their most common cause are neoplastic diseases. Emergency surgical treatment in patients aged 85 or more is associated with a significantly higher risk, compared with younger age groups, of developing multi-organ postoperative complications, usually leading to death. Elective surgical treatment in patients aged 85+ after appropriate preoperative preparation and in the group of younger patients shows similar early outcomes.
Źródło:
Polish Journal of Surgery; 2014, 86, 3; 132-140
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Is Age a Risk Factor of Postoperative Complications in Colorectal Cancer?
Autorzy:
Wydra, Jacek
Kruszewski, Wiesław
Jasiński, Wojciech
Szajewski, Mariusz
Ciesielski, Maciej
Szefel, Jarosław
Walczak, Jakub
Powiązania:
https://bibliotekanauki.pl/articles/1396376.pdf
Data publikacji:
2013-09-01
Wydawca:
Index Copernicus International
Tematy:
elderly
colorectal cancer
surgical complications
morbidity
Opis:
Colorectal cancer is the most common malignant neoplasm in elderly with peak of incidence in 7. and 8. decade of life. Elderly patients with colorectal cancer more often require surgery. Advanced age of patients seems to increase the risk of postoperative complications. The aim of the study was to compare the frequency of early complications in two groups of patients: under 75 and over 75, undergoing elective colorectal cancer surgery. Material and methods. 440 consecutive adult patients subjected to colorectal cancer surgery between 08.2006 to 10.2011 in Oncological Surgery Department, Gdynia Centre of Oncology. Group A (over 75 year-of-life): 109 patients, median 79 and group B (up to 75 year-of-life): 331 patients, median 65. Patients requiring emergency surgery were excluded from the study. Postoperative 30-day mortality, anastomotic leakage, wound infection, bowel obstruction, postoperative respiratory and circulatory insufficiency were among analyzed complications. Results. Symptomatic disease was observed in 81.6% of group A and in 83% of group B. Groups A and B were comparable concerning: BMI, gender, tumor staging, rate of curative and palliative resections, and duration of hospital stay. Accompanying diseases were more common in group A (83% vs 65%; p<0.0002). Early complications occurred in 21.1% of patients from group A and in 19.9% from group B. The rate of reoperation in early perioperative period didn’t differ (6.4% vs 5.7%). Features like: age, gender, additional illnesses, tumor location and staging did not influence the occurrence of perioperative complications. Conclusions. Age itself is not a risk factor for postoperative complications in spite of higher rate of accompanying diseases in elderly.
Źródło:
Polish Journal of Surgery; 2013, 85, 9; 491-495
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
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