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Wyszukujesz frazę "coacervation" wg kryterium: Temat


Wyświetlanie 1-2 z 2
Tytuł:
Formation and characterization of succinoyl chitosan particles loaded with warnerin
Autorzy:
Shagdarova, Balzhima Ts
Ilyina, Alla V.
Lopatin, Sergey A.
Korobov, Vladimir P.
Lemkina, Larisa M.
Varlamov, Valery P.
Powiązania:
https://bibliotekanauki.pl/articles/1034836.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan nanoparticles
coacervation method
succinoyl chitosan
warnerin
Opis:
This study aims to obtain nanoparticles based on succinoyl chitosan loaded with Warnerin (War-SCNPs), low molecular weight cationic peptide. The nanoparticles of succinoyl chitosan (SCNPs) were prepared by salt coacervation method, and Warnerin loading efficiency on SCNPs was reached 75% in the optimum conditions, particularly, ration (SCNPs : peptide) was equal to (1.75 : 1, μg / ml ). Formed War-SCNPs were stable, had a weak electric charge from (-4.4) to (-14,6) mV. Determining of SCNPs size showed that a main fraction of SCNPs had the size of 160 nm, and after the peptide sorption War-SCNPs size increased up to 330 nm. The experimental data of this study will likely impact War-SCNPs use as therapeutic delivery systems of the peptide to be administered parenteral.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 246-253
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wybrane strategie kapsułkowania polifenoli stosowane w celu poprawy ich stabilności
Selected polyphenol encapsulation strategies to improve their stability
Autorzy:
Oniszczuk, Anna
Kasprzak-Drozd, Kamila
Waksmundzka-Hajnos, Monika
Powiązania:
https://bibliotekanauki.pl/articles/1413239.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
związki polifenolowe
mikrokapsułkowanie
koacerwacja
polimeryzacja
suszenie rozpyłowe
polyphenolic compounds
microencapsulation
coacervation
polymerization
spray drying
Opis:
Polyphenols are one of the most numerous and ubiquitous groups of secondary plant metabolites, and constitute an integral part of both human and animal diets. These compounds possess a high spectrum of biological activities, including antioxidant, antibacterial, antiviral, anti-inflammatory, neuroprotective and cardioprotective. A lot of preclinical research and epidemiological data suggests that plant polyphenols reduce the risks of neurodegenerative diseases, cardiovascular disease, osteoporosis or diabetes and can slow the progression of cancers. These facts sugest that plant polyphenols might act as potential chemopreventive and anti-cancer agents. However, the levels of polyphenols that appear effective in vitro are often of an order of magnitude higher than the concentrations determined in vivo. This is a serious problem, as only a small part of the substance remain available following oral administration, due to insufficient gastric residence time, low permeability and solubility within the gut. An important element is polyphenols instability under conditions encountered in food processing and storage (oxygen, temperature, light), or in the gastrointestinal tract (enzymes, pH, other nutrients), all of which limit the activity of polyphenolic compounds. Another unfortunate trait of polypheonls is their potential unpleasant taste. In order to overcome these drawbacks, various formulation methods have been developed. Among them, encapsulation seems to be a promising technique to improve the effectiveness and the bioactivity of polyphenols. Moreover, it protects the core material from environmental factors. Microcapsules are small particulates that may range from submicron to several millimeters in size. Encapsulation methods can be classified in three groups: physical, physico-chemical, and chemical. The research studies reported in this paper revealed useful strategies to provide remarkable protection against harmful factors of polyphenolic compounds, avoiding the loss in activity and improving their bioavailability.
Źródło:
Wiadomości Chemiczne; 2021, 75, 7-8; 981-996
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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