- Tytuł:
- Conformational properties of N-acetyl-N-methyl-α,β-dehydroalanine N-methylamide
- Autorzy:
-
Macedowska, Agnieszka
Siodłak, Dawid
Rzeszotarska, Barbara - Powiązania:
- https://bibliotekanauki.pl/articles/1041296.pdf
- Data publikacji:
- 2006
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
ab initio/DFT calculations
N-alkylpeptides
cis-trans isomerisation
α,β-dehydroamino acids
peptide design - Opis:
- The conformational properties of Ac-Δ(Me)Ala-NHMe (N-acetyl-N-methyl-α,β-dehydroalanine N'-methylamide), as the simplest model of N-methyl-α,β-dehydroamino acids, was examined with theoretical methods and in comparison with Ac-ΔAla-NHMe and Ac-ΔAla-NMe2. The N-terminal amide of the Δ(Me)Ala residue easily adopts the configuration cis and the torsion angles φ, ψ are highly flexible. The Δ(Me)Ala residue is a conformational flexibilizer as compared to the parent ΔAla, which is a conformational stiffener. This seems to be the reason why Δ(Me)Ala is found in small natural cyclic peptides, where it ensures the conformational flexibility necessary for biological action.
- Źródło:
-
Acta Biochimica Polonica; 2006, 53, 1; 227-232
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł